Quantum chaos and nuclear mass systematics

The presence of quantum chaos in nuclear mass systematics is analyzed by considering the differences between measured and calculated nuclear masses as a time series described by the power law 1/ f^alpha. While for the liquid droplet model plus shell corrections a quantum chaotic behavior alpha approx 1 is found, errors in the microscopic mass formula have alpha approx 0.5, closer to white noise. The chaotic behavior seems to arise from many body effects not included in the mass formula.Comment: 4 pages, 6 figures, replaced to match the published versio

Residual correlations in liquid drop mass calculations

A systematic study of correlations in the chart of calculated masses of Moller and Nix is presented. It is shown that the differences between the masses calculated by Moller at al and the measured ones have a well defined oscillatory component as function of N and Z, which can be removed with an appropriate fit, reducing significantly the error width, and concentrating the error distribution on a single peak around zero. The residual correlations can have important consequences in the errors as signaling the presence of chaos, as was recently proposed.Comment: 23 pages, 18 figures. A more focused article with imporved figure

Nuclear masses set bounds on quantum chaos

It has been suggested that chaotic motion inside the nucleus may significantly limit the accuracy with which nuclear masses can be calculated. Using a power spectrum analysis we show that the inclusion of additional physical contributions in mass calculations, through many-body interactions or local information, removes the chaotic signal in the discrepancies between calculated and measured masses. Furthermore, a systematic application of global mass formulas and of a set of relationships among neighboring nuclei to more than 2000 nuclear masses allows to set an unambiguous upper bound for the average errors in calculated masses which turn out to be almost an order of magnitude smaller than estimated chaotic components.Comment: 4 pages, Accepted for publication in Physical Review Letter

Ground state energy fluctuations in the Nuclear Shell Model

Statistical fluctuations of the nuclear ground state energies are estimated using shell model calculations in which particles in the valence shells interact through well defined forces, and are coupled to an upper shell governed by random 2-body interactions. Induced ground-state energy fluctuations are found to be one order of magnitude smaller than those previously associated with chaotic components, in close agreement with independent perturbative estimates based on the spreading widths of excited states.Comment: 4 pages, 4 figures, to be published in Physics Leters

Sustainable conditions for the development of renewable energy systems : a triple bottom line perspective

Renewable energy systems (RES) have been proposed as an effective solution for sustainable development. However, the impact of municipal contextual conditions on the development of RES is still unclear. One of the literature gaps is the lack of understanding of whether the balanced development of economic, social, and environmental aspects of sustainability – the triple bottom line (TBL) perspective – can support RES policy. We conducted a quantitative analysis of 727 medium- and large-sized German municipalities to understand whether municipalities should create contextual conditions around the TBL dimensions to support RES policy. Furthermore, we applied a cluster analysis to establish the patterns of RES adoption supported by the TBL. Our results document that advanced adopters of RES are more advanced regarding the economic and environmental aspects of the TBL, and their RES development outperforms in the development of a knowledge-base and social cooperation. In contrast, regions with less RES development primarily emphasize reducing energy dependency and increasing social acceptance. As the main contribution, the study provides a novel view on how sustainability and RES development work together by providing details about the connection between specific TBL dimensions and elements with different maturity levels of RES policy implementation

Chitosan gel containing polymeric nanocapsules: a new formulation for vaginal drug delivery

The vaginal route of administration is an alternative for several treatments for either local or systemic pharmacological effects. However, the permanence of a drug in this route represents a challenge for formulation development that can be overcome by using nanoencapsulation and chitosan gel. Thus, this work aimed to evaluate the performance of chitosan hydrogels containing cationic and anionic acrylic-based nanocapsules (Eudragit® RS 100 and Eudragit® S 100, respectively) with Nile red as a model of lipophilic substance in the vaginal route of administration, as measured by increases in the residence time and the penetration of these formulations. Several formulations were prepared with increasing chitosan concentrations, and were analyzed in terms of pH and rheological behavior so that the most suitable formulation could be selected. The enhancement of the adhesion (tensile stress test and washability profile) and penetration (confocal laser scanning microscopy and extraction followed by quantification) properties of the formulations, when applied to porcine vaginal mucosa, were evaluated. The nanocapsule suspensions produced presented adequate properties: size of approximately 200 nm (polydispersity index of≤0.2); zeta potential around +10 mV for the cationic formulation and -10 mV for the anionic formulation; and pH values of 6.1±0.1 (Eudragit RS 100), 5.3±0.2 (Eudragit S 100), 6.2±0.1 (Nile red loaded Eudragit RS 100), and 5.1±0.1 (Nile red loaded Eudragit S 100). The chitosan formulation presented suitable viscosity for vaginal application and acidic pH (approximately 4.5). The tensile stress test showed that both formulations containing polymeric nanocapsules presented higher mucoadhesion when compared with the formulation without nanocapsules. In the washability experiment, no significant differences were found between formulations. Confocal microscopy and fluorescence quantification after extraction from the mucosa showed higher penetration of Nile red when it was nanoencapsulated, particularly in cationic nanocapsules. The formulations developed based on chitosan gel vehicle at 2.5% weight/weight containing polymeric nanocapsules, especially the cationic nanocapsules, demonstrated applicability for the vaginal delivery of hydrophobic substances

Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries

IMPORTANCE: Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS). OBJECTIVES: To evaluate intensive care unit (ICU) incidence and outcome of ARDS and to assess clinician recognition, ventilation management, and use of adjuncts-for example prone positioning-in routine clinical practice for patients fulfilling the ARDS Berlin Definition. DESIGN, SETTING, AND PARTICIPANTS:The Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients undergoing invasive or noninvasive ventilation, conducted during 4 consecutive weeks in the winter of 2014 in a convenience sample of 459 ICUs from 50 countries across 5 continents. EXPOSURES:Acute respiratory distress syndrome. MAIN OUTCOMES AND MEASURES: The primary outcome was ICU incidence of ARDS. Secondary outcomes included assessment of clinician recognition of ARDS, the application of ventilatory management, the use of adjunctive interventions in routine clinical practice, and clinical outcomes from ARDS. RESULTS: Of 29,144 patients admitted to participating ICUs, 3022 (10.4%) fulfilled ARDS criteria. Of these, 2377 patients developed ARDS in the first 48 hours and whose respiratory failure was managed with invasive mechanical ventilation. The period prevalence of mild ARDS was 30.0% (95% CI, 28.2%-31.9%); of moderate ARDS, 46.6% (95% CI, 44.5%-48.6%); and of severe ARDS, 23.4% (95% CI, 21.7%-25.2%). ARDS represented 0.42 cases per ICU bed over 4 weeks and represented 10.4% (95% CI, 10.0%-10.7%) of ICU admissions and 23.4% of patients requiring mechanical ventilation. Clinical recognition of ARDS ranged from 51.3% (95% CI, 47.5%-55.0%) in mild to 78.5% (95% CI, 74.8%-81.8%) in severe ARDS. Less than two-thirds of patients with ARDS received a tidal volume 8 of mL/kg or less of predicted body weight. Plateau pressure was measured in 40.1% (95% CI, 38.2-42.1), whereas 82.6% (95% CI, 81.0%-84.1%) received a positive end-expository pressure (PEEP) of less than 12 cm H2O. Prone positioning was used in 16.3% (95% CI, 13.7%-19.2%) of patients with severe ARDS. Clinician recognition of ARDS was associated with higher PEEP, greater use of neuromuscular blockade, and prone positioning. Hospital mortality was 34.9% (95% CI, 31.4%-38.5%) for those with mild, 40.3% (95% CI, 37.4%-43.3%) for those with moderate, and 46.1% (95% CI, 41.9%-50.4%) for those with severe ARDS. CONCLUSIONS AND RELEVANCE: Among ICUs in 50 countries, the period prevalence of ARDS was 10.4% of ICU admissions. This syndrome appeared to be underrecognized and undertreated and associated with a high mortality rate. These findings indicate the potential for improvement in the management of patients with ARDS

Herschel ATLAS: The cosmic star formation history of quasar host galaxies

We present a derivation of the star formation rate per comoving volume of quasar host galaxies, derived from stacking analyses of far-infrared to mm-wave photometry of quasars with redshifts 0 IAB >-32 We use the science demonstration observations of the first ~16 deg2 from the Herschel Astrophysical Terahertz Large Area Survey (H-ATLAS) in which there are 240 quasars from the Sloan Digital Sky Survey (SDSS) and a further 171 from the 2dF-SDSS LRG and QSO (2SLAQ) survey. We supplement this data with a compilation of data from IRAS, ISO, Spitzer, SCUBA and MAMBO. H-ATLAS alone statistically detects the quasars in its survey area at > 5σ at 250, 350 and 500 μm. From the compilation as a whole we find striking evidence of downsizing in quasar host galaxy formation: low-luminosity quasars with absolute magnitudes in the range 22 > IAB > -24 have a comoving star formation rate (derived from 100 μm rest-frame luminosities) peaking between redshifts of 1 and 2, while high-luminosity quasars with IAB IAB >-24 quasars evolves as (1 + z)2.3±0.7 at z I > -28. We tentatively interpret this as a combination of gas consumption reducing fuel for both black hole accretion and star formation.We thank the anonymous referee for useful comments. This work was funded in part by STFC (grants PP/D002400/1 and ST/G002533/1). Funding for the SDSS and SDSS-II has been provided by the Alfred P. Sloan Foundation, the Participating Institutions, the NSF, the U.S. Department of Energy, NASA, the Japanese Monbukagakusho, the Max Planck Society, and HEFCE