Short term outcome of myocarditis and pericarditis following COVID-19 vaccines: a cardiac magnetic resonance imaging study

To evaluate clinical and cardiac magnetic resonance (CMR) short-term follow-up (FU) in patients with vaccine-associated myocarditis, pericarditis or myo-pericarditis (VAMP) following COVID-19 vaccination. We retrospectively analyzed 44 patients (2 women, mean age: 31.7 +/- 15.1 years) with clinical and CMR manifestations of VAMP, recruited from 13 large tertiary national centers. Inclusion criteria were troponin raise, interval between the last vaccination dose and onset of symptoms < 25 days and symptoms-to-CMR < 20 days. 29/44 patients underwent a short-term FU-CMR with a median time of 3.3 months. Ventricular volumes and CMR findings of cardiac injury were collected in all exams. Mean interval between the last vaccination dose and the onset of symptoms was 6.2 +/- 5.6 days. 30/44 patients received a vaccination with Comirnaty, 12/44 with Spikevax, 1/44 with Vaxzevria and 1/44 with Janssen (18 after the first dose of vaccine, 20 after the second and 6 after the "booster" dose). Chest pain was the most frequent symptom (41/44), followed by fever (29/44), myalgia (17/44), dyspnea (13/44) and palpitations (11/44). At baseline, left ventricular ejection fraction (LV-EF) was reduced in 7 patients; wall motion abnormalities have been detected in 10. Myocardial edema was found in 35 (79.5%) and LGE in 40 (90.9%) patients. Clinical FU revealed symptoms persistence in 8/44 patients. At FU-CMR, LV-EF was reduced only in 2 patients, myocardial edema was present in 8/29 patients and LGE in 26/29. VAMPs appear to have a mild clinical presentation, with self-limiting course and resolution of CMR signs of active inflammation at short-term follow-up in most of the cases

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Study of the atmospheric boundary layer processes over sloping terrain covered by sparse canopy

The aim of this thesis is the study of the exchange processes at atmosphere/biosphere interface, with a particular focus on momentum and heat transport over complex terrain morphology, varying surface roughness, and a wide range of atmospheric thermal conditions. The surface roughness object of the research is a sparse canopy layer evolving in time along the vegetative season, and characterized by a multiplicity of temporal and spatial scales influencing the properties of the turbulent fluxes. Both experimental and modelling approaches characterize the study methodology. Measurements are first performed in laboratory in order to calibrate flux sensors (i.e., ultrasonic anemometers), and subsequently into three N-W Italy vineyards fields, collecting long term turbulent flux observations over the canopy. Bulk and higher order statistics are explored from these dataset to investigate the turbulent properties of the momentum and heat transfer processes. The analysis is carried out using a conventional quadrant analysis technique and is tested against two models approximating the joint probability density function of the flow variables. Because of direct measurements at field scale are too costly and time consuming, the need to more easily measured parameters for applications in the meteorological and agricultural fields has motivated the examination of a land-surface model, by performing a validation against vineyard data and a sensitivity analysis on canopy parameters. The overall results suggest an improvement procedure for the estimation of turbulent heat flux using sonic anemometers, an insight on the perturbing effect of coherent structures on gradient-diffusion theory, and the key role of canopy parameterizations in the applicative model

Preliminary Results on the Evaluation of Factors Influencing Evapotranspiration Processes in Vineyards

The paper summarizes the preliminary results from the analysis of data collected during the 2008 and 2009 vegetative seasons in a northern Italy vineyard (Vitis vinifera L., Barbera variety) and the simulations carried out in the same period with the land surface model UTOPIA. The aim of the work is to study the influence of the meteorological factors on the plant conditions. We collected a set of standard and advanced meteorological, physiological and physical data and we investigated the performance of UTOPIA in describing the different components of the energy and hydrological processes (in particular the evapotranspiration), with a special focus on the vegetation and soil. The comparison between observed data and UTOPIA simulations showed satisfactory results for the soil variables (RRMSE ranging between 15% and 40%, and correlation coefficients of 0.9). Net radiation and sensible heat fluxes RRMSE (30% and 63% respectively) suggest that both the calibration of the vegetation parameters (including the influence of the grass among vine rows) and the availability of more specific measurements are very important

Preliminary Results on the Evaluation of Factors Influencing Evapotranspiration Processes in Vineyards

The paper summarizes the preliminary results from the analysis of data collected during the 2008 and 2009 vegetative seasons in a northern Italy vineyard (Vitis vinifera L., Barbera variety) and the simulations carried out in the same period with the land surface model UTOPIA. The aim of the work is to study the influence of the meteorological factors on the plant conditions. We collected a set of standard and advanced meteorological, physiological and physical data and we investigated the performance of UTOPIA in describing the different components of the energy and hydrological processes (in particular the evapotranspiration), with a special focus on the vegetation and soil. The comparison between observed data and UTOPIA simulations showed satisfactory results for the soil variables (RRMSE ranging between 15% and 40%, and correlation coefficients of 0.9). Net radiation and sensible heat fluxes RRMSE (30% and 63% respectively) suggest that both the calibration of the vegetation parameters (including the influence of the grass among vine rows) and the availability of more specific measurements are very important

Preliminary Results on the Evaluation of Factors Influencing Evapotranspiration Processes in Vineyards

The paper summarizes the preliminary results from the analysis of data collected during the 2008 and 2009 vegetative seasons in a northern Italy vineyard (Vitis vinifera L., Barbera variety) and the simulations carried out in the same period with the land surface model UTOPIA. The aim of the work is to study the influence of the meteorological factors on the plant conditions. We collected a set of standard and advanced meteorological, physiological and physical data and we investigated the performance of UTOPIA in describing the different components of the energy and hydrological processes (in particular the evapotranspiration), with a special focus on the vegetation and soil. The comparison between observed data and UTOPIA simulations showed satisfactory results for the soil variables (RRMSE ranging between 15% and 40%, and correlation coefficients of 0.9). Net radiation and sensible heat fluxes RRMSE (30% and 63% respectively) suggest that both the calibration of the vegetation parameters (including the influence of the grass among vine rows) and the availability of more specific measurements are very important