254 research outputs found
Direct and Fast Screening of New Psychoactive Substances Using Medical Swabs and Atmospheric Solids Analysis Probe Triple Quadrupole with Data-Dependent Acquisition
New psychoactive substances (NPS) have become a serious public health problem, as they are continuously changing their structures and modifying their potency and effects on humans, and therefore, novel compounds are unceasingly appearing. One of the major challenges in forensic analysis, particularly related to the problem of NPS, is the development of fast screening methodologies that allow the detection of a wide variety of compounds in a single analysis. In this study, a novel application of the atmospheric solids analysis probe (ASAP) using medical swabs has been developed. The swabâASAP was coupled to a triple quadrupole mass analyzer working under a data-dependent acquisition mode in order to perform a suspect screening of NPS in different types of samples as well as on surfaces. The compounds were automatically identified based on the observed fragmentation spectra using an in-house built MS/MS spectra library. The developed methodology was applied for the identification of psychoactive substances in research chemicals and herbal blends. The sensitivity of the method, as well as its applicability for surface analysis, was also assessed by identifying down to 1 ÎŒg of compound impregnated onto a laboratory table. Another remarkable application was the identification of cathinones and synthetic cannabinoids on the fingers of potential consumers. Interestingly, our data showed that NPS could be identified on the fingers after being in contact with the product and even after cleaning their hands by shaking off with a cloth. The methodology proposed in this paper can be applied for routine analyses of NPS in different matrix samples without the need to establish a list of target compounds prior to analysis
Draft Genome Sequence of Bacillus coagulans GBI-30, 6086, a Widely Used Spore-Forming Probiotic Strain.
Bacillus coagulans GBI-30, 6086 is a safe strain, already available on the market, and characterized by certified beneficial effects.The draft genome sequence presented here constitutes the first pillar toward the identification of the molecular mechanisms responsiblefor its positive features and safety
Search for muon-neutrino emission from GeV and TeV gamma-ray flaring blazars using five years of data of the ANTARES telescope
The ANTARES telescope is well-suited for detecting astrophysical transient
neutrino sources as it can observe a full hemisphere of the sky at all times
with a high duty cycle. The background due to atmospheric particles can be
drastically reduced, and the point-source sensitivity improved, by selecting a
narrow time window around possible neutrino production periods. Blazars, being
radio-loud active galactic nuclei with their jets pointing almost directly
towards the observer, are particularly attractive potential neutrino point
sources, since they are among the most likely sources of the very high-energy
cosmic rays. Neutrinos and gamma rays may be produced in hadronic interactions
with the surrounding medium. Moreover, blazars generally show high time
variability in their light curves at different wavelengths and on various time
scales. This paper presents a time-dependent analysis applied to a selection of
flaring gamma-ray blazars observed by the FERMI/LAT experiment and by TeV
Cherenkov telescopes using five years of ANTARES data taken from 2008 to 2012.
The results are compatible with fluctuations of the background. Upper limits on
the neutrino fluence have been produced and compared to the measured gamma-ray
spectral energy distribution.Comment: 27 pages, 16 figure
The Antares Collaboration : Contributions to the 34th International Cosmic Ray Conference (ICRC 2015, The Hague)
The ANTARES detector, completed in 2008, is the largest neutrino telescope in the Northern hemisphere. Located at a depth of 2.5 km in the Mediterranean Sea, 40 km off the Toulon shore, its main goal is the search for astrophysical high energy neutrinos. In this paper we collect the 21 contributions of the ANTARES collaboration to the 34th International Cosmic Ray Conference (ICRC 2015). The scientific output is very rich and the contributions included in these proceedings cover the main physics results, ranging from steady point sources, diffuse searches, multi-messenger analyses to exotic physics
All-sky Search for High-Energy Neutrinos from Gravitational Wave Event GW170104 with the ANTARES Neutrino Telescope
Advanced LIGO detected a significant gravitational wave signal (GW170104)
originating from the coalescence of two black holes during the second
observation run on January 4, 2017. An all-sky high-energy
neutrino follow-up search has been made using data from the ANTARES neutrino
telescope, including both upgoing and downgoing events in two separate
analyses. No neutrino candidates were found within s around the GW
event time nor any time clustering of events over an extended time window of
months. The non-detection is used to constrain isotropic-equivalent
high-energy neutrino emission from GW170104 to less than
erg for a spectrum
The ANTARES Collaboration: Contributions to ICRC 2017 Part I: Neutrino astronomy (diffuse fluxes and point sources)
Papers on neutrino astronomy (diffuse fluxes and point sources, prepared for
the 35th International Cosmic Ray Conference (ICRC 2017, Busan, South Korea) by
the ANTARES Collaboratio
The ANTARES Collaboration: Contributions to ICRC 2017 Part III: Searches for dark matter and exotics, neutrino oscillations and detector calibration
Papers on the searches for dark matter and exotics, neutrino oscillations and
detector calibration, prepared for the 35th International Cosmic Ray Conference
(ICRC 2017, Busan, South Korea) by the ANTARES Collaboratio
The ANTARES Collaboration: Contributions to ICRC 2017 Part II: The multi-messenger program
Papers on the ANTARES multi-messenger program, prepared for the 35th
International Cosmic Ray Conference (ICRC 2017, Busan, South Korea) by the
ANTARES Collaboratio
Interlaboratory study for coral Sr/Ca and other element/Ca ratio measurements
The Sr/Ca ratio of coral aragonite is used to reconstruct past sea surface temperature (SST). Twentyone
laboratories took part in an interlaboratory study of coral Sr/Ca measurements. Results show
interlaboratory bias can be significant, and in the extreme case could result in a range in SST estimates of
7°C. However, most of the data fall within a narrower range and the Porites coral reference material JCp-
1 is now characterized well enough to have a certified Sr/Ca value of 8.838 mmol/mol with an expanded
uncertainty of 0.089 mmol/mol following International Association of Geoanalysts (IAG) guidelines.
This uncertainty, at the 95% confidence level, equates to 1.5°C for SST estimates using Porites, so is
approaching fitness for purpose. The comparable median within laboratory error is <0.5°C. This
difference in uncertainties illustrates the interlaboratory bias component that should be reduced through
the use of reference materials like the JCp-1. There are many potential sources contributing to biases in
comparative methods but traces of Sr in Ca standards and uncertainties in reference solution composition
can account for half of the combined uncertainty. Consensus values that fulfil the requirements to be
certified values were also obtained for Mg/Ca in JCp-1 and for Sr/Ca and Mg/Ca ratios in the JCt-1 giant
clam reference material. Reference values with variable fitness for purpose have also been obtained for
Li/Ca, B/Ca, Ba/Ca, and U/Ca in both reference materials. In future, studies reporting coral element/Ca
data should also report the average value obtained for a reference material such as the JCp-1
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