Cross hole seismic experiment with DAS/DTS data. Svelvik CO2 field lab

Primary purposes of the fieldwork at Svelvik include the provision of datasets which supports task 1.2 ‘determining the DAS transfer function’ and task 1.3 ‘develop DAS data processing techniques and workflow’. The fieldwork also serves as a test of the novel SV wave seismic source developed as part of Task 1.4. ‘Active source technology development and optimising monitoring design.Cross hole seismic experiment with DAS/DTS data. Svelvik CO2 field labpublishedVersio

The role of selected molecular factors in ovarian cancer metastasis

The main reason for treatment failure in ovarian cancer is chemoresistance and the presence of metastasis. Ascites, which allows the physical movement of cancer cells, the lymphovascular pathway, and several molecular factors and signalling axes, are involved in metastasis. Ascites, with the involvement of cytokines and chemokines, MAPK/STAT1 and NOTCH as well as CXCL12/CXCR4 signaling pathways and circulating anoikis induces cancer dissemination, in particular to the peritoneum and omentum. The spread of lymphatic and bloodstream cancer cells is a multi-stage process. Tumour infiltration of the stroma and lymphovascular space (LVSI) produces biologically active cancer-associated fibroblasts and macrophages (CAFs, TAMs) that secrete numerous cytokines, chemokines and growth factors, inhibit NK function, induce epithelial-mesenchymal transition (EMT), resulting in an increase of the metastatic potential of cancer cells and the formation of cancer stem cells (CSCs). Overexpression of some genes, and microRNAs, in LVSI-(LMGS) associated with metastasis has been identified. The role of extracellular vesicles (EVs) transporting metastasis-associated factors has been described as has the role of cancer stem cells (CSCs) in chemotherapy resistance and metastasis. Sirtuins, enzymes involved in metastasis formation, have also been detected. Certain types of microRNAs (miR-509-3p, microRNA-506-3p) and melatonin have been shown to inhibit metastasis.  

Kompetencje interpersonalne w przestrzeni szkoły

monografia wieloautorskaProblematyka kompetencji interpersonalnych albo – szerzej rzecz ujmując – tzw. „kompetencji miękkich” staje się na przestrzeni ostatnich kilku lat przedmiotem żywego społecznego zainteresowania. W różnych dziedzinach życia społecznego: w nauce, kulturze, gospodarce, a nawet – w sporcie dostrzegane są, analizowane i chwalone walory wysokiej sprawności komunikacyjnej i relacyjnej każdej osoby ludzkiej. Także w zakresie edukacji szkolnej problematyka ta stopniowo cieszy się coraz większym zainteresowaniem badaczy i praktyków. Odnoszona do przestrzeni szkoły refleksja nad różnymi aspektami pojęcia „umiejętności interpersonalnych” i towarzyszące jej staranie o skuteczne rozwijanie sprawności interpersonalnych uczniów i nauczycieli są godne aprobaty przynajmniej z dwóch powodów. Po pierwsze dlatego, że wyposażenie ucznia w te umiejętności i kompetencje osobiste wzbogaca go w trudny do przecenienia skarb na drogi i bezdroża dorosłego życia (nie tylko w wymiarze pracy zawodowej, ale również życia prywatnego). Drugim powodem jest fakt, że nabywane stopniowo w trakcie edukacji szkolnej sprawności interpersonalne znacząco ułatwiają proces zdobywania wiedzy. Wskazują na to badania prowadzone na różnych poziomach edukacji (przywoływane także w niniejszym zbiorze). Przedłożona Czytelnikom monografia niesie prace, które tematycznie łączy zasadnicze pytanie: jakie jest znaczenie umiejętności interpersonalnych ucznia/nauczyciela dla relacji interpersonalnych kreowanych w przestrzeni szkoły? Poszczególni autorzy poszukują odpowiedzi na to pytanie na różne sposoby, odnosząc je do wielorakich aspektów życia szkoły i etapów szkolnej edukacji. Jedni kładą nacisk na wymiar rozumienia, definiowania i dookreślania pojęć związanych z umiejętnościami i kompetencjami interpersonalnymi, a także próbują opisywać i precyzować ich swoisty charakter. Inni – opisują i analizują powiązania między sprawnością interpersonalną ucznia (także: ucznia bardzo zdolnego) a efektywnością szkolnej nauki. Jeszcze inni poszukują związków między mądrością/roztropnością interpersonalną a sztuką budowania wspólnoty, bliskich więzi i dobrej atmosfery w przestrzeni klasy szkolnej i grupy rówieśniczej. Wszystkich autorów łączy jednak, poza zainteresowaniem określonym wyżej tematem-pytaniem, troska o naszą szkołę na różnych poziomach edukacji. Staranie o to, by szkoła stawała się miejscem przyjaznym uczniowi, aby nauczanie szkolne i edukacja akademicka niosły nie tylko wszechstronną wiedzę, lecz także wpływały na to, żeby absolwentów szkół cechowała bogata osobowość – „bogata” również w umiejętności interpersonalne

Critical technology elements (WP1)

The overall objective of the DigiMon project is to “accelerate the implementation of CCS by developing and demonstrating an affordable, flexible, societally embedded and smart Digital Monitoring early warning system”, for monitoring any CO2 storage reservoir and subsurface barrier system. Within the project the objective of WP1 was to develop individual technologies, data acquisition, analysis techniques and workflows in preparation for inclusion in the DigiMon system. The technologies and data processing techniques developed as part of WP1 include distributed fibre-optic sensing (DFOS) for seismic surveys and chemical sensing, 4D gravity and seafloor deformation measurements, a new seismic source and seismic monitoring survey design. For these technologies the key targets for WP1 were • Develop individual components of the system to raise individual technology readiness levels (TRLs), • Validate and optimise processing software for individual system components, • Develop an effective Distributed Acoustic Sensing (DAS) data interpretation workflow. This work was performed with the expected outcomes of • Raising the DAS TRL for passive seismic monitoring, • An assessment the feasibility of using Distributed Chemical Sensing (DCS) for CO2 detection, • Reducing the cost of 4D gravity and seafloor deformation measurements

Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming

Protein modification with ISG15 (ISGylation) represents a major type I IFN–induced antimicrobial system. Common mechanisms of action and species-specific aspects of ISGylation, however, are still ill defined and controversial. We used a multiphasic coxsackievirus B3 (CV) infection model with a first wave resulting in hepatic injury of the liver, followed by a second wave culminating in cardiac damage. This study shows that ISGylation sets nonhematopoietic cells into a resistant state, being indispensable for CV control, which is accomplished by synergistic activity of ISG15 on antiviral IFIT1/3 proteins. Concurrent with altered energy demands, ISG15 also adapts liver metabolism during infection. Shotgun proteomics, in combination with metabolic network modeling, revealed that ISG15 increases the oxidative capacity and promotes gluconeogenesis in liver cells. Cells lacking the activity of the ISG15-specific protease USP18 exhibit increased resistance to clinically relevant CV strains, therefore suggesting that stabilizing ISGylation by inhibiting USP18 could be exploited for CV-associated human pathologies

Bright Metal-Poor Stars from the Hamburg/ESO Survey. I. Selection and Follow-up Observations from 329 Fields

We present a sample of 1777 bright (9<B<14) metal-poor candidates selected from the Hamburg/ESO Survey (HES). Despite saturation effects present in the red portion of the HES objective-prism spectra, the data were recoverable and quantitative selection criteria could be applied to select the sample. Analyses of medium-resolution (~2 A) follow-up spectroscopy of the entire sample, obtained with several 2 to 4 m class telescopes, yielded 145 new metal-poor stars with metallicity [Fe/H]<-2.0, of which 79 have [Fe/H]<-2.5, and 17 have [Fe/H]<-3.0. We also obtained C/Fe estimates for all these stars. From this, we find a frequency of C-enhanced ([C/Fe]>1.0) metal-poor ([Fe/H]<-2.0) giants of 9% +- 2%, which is lower than previously reported. However, the frequency raises to similar (>20%) and higher values with increasing distance from the Galactic plane. Although the numbers of stars at low metallicity are falling rapidly at the lowest metallicities, there is evidence that the fraction of carbon-enhanced metal-poor stars is increasing rapidly as a function of declining metallicity. For ~60 objects, high-resolution data have already been obtained; one of these, HE 1327-2326, is the new record holder for the most iron-deficient star known.Comment: 29 pages (emulateapj), accepted for publication in Ap

Uniparental Genetic Heritage of Belarusians: Encounter of Rare Middle Eastern Matrilineages with a Central European Mitochondrial DNA Pool

Ethnic Belarusians make up more than 80% of the nine and half million people inhabiting the Republic of Belarus. Belarusians together with Ukrainians and Russians represent the East Slavic linguistic group, largest both in numbers and territory, inhabiting East Europe alongside Baltic-, Finno-Permic- and Turkic-speaking people. Till date, only a limited number of low resolution genetic studies have been performed on this population. Therefore, with the phylogeographic analysis of 565 Y-chromosomes and 267 mitochondrial DNAs from six well covered geographic sub-regions of Belarus we strove to complement the existing genetic profile of eastern Europeans. Our results reveal that around 80% of the paternal Belarusian gene pool is composed of R1a, I2a and N1c Y-chromosome haplogroups – a profile which is very similar to the two other eastern European populations – Ukrainians and Russians. The maternal Belarusian gene pool encompasses a full range of West Eurasian haplogroups and agrees well with the genetic structure of central-east European populations. Our data attest that latitudinal gradients characterize the variation of the uniparentally transmitted gene pools of modern Belarusians. In particular, the Y-chromosome reflects movements of people in central-east Europe, starting probably as early as the beginning of the Holocene. Furthermore, the matrilineal legacy of Belarusians retains two rare mitochondrial DNA haplogroups, N1a3 and N3, whose phylogeographies were explored in detail after de novo sequencing of 20 and 13 complete mitogenomes, respectively, from all over Eurasia. Our phylogeographic analyses reveal that two mitochondrial DNA lineages, N3 and N1a3, both of Middle Eastern origin, might mark distinct events of matrilineal gene flow to Europe: during the mid-Holocene period and around the Pleistocene-Holocene transition, respectively

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bluetongue

Non peer reviewe

Systemic therapy for cervical cancer with potentially regulatable oncolytic adenoviruses

Peer reviewe