33 research outputs found
Atorvastatin Improves Survival in Septic Rats: Effect on Tissue Inflammatory Pathway and on Insulin Signaling
- Author
- A Herschkovitz
- A Niessner
- AC Thirone
- AL Spitzer
- Angélica Costa Aranha Camacho
- AP Liappis
- AS Baldwin Jr
- B He
- B Tian
- Bruno de Melo Carvalho
- C Li
- CC McGown
- CD Major
- CI Coleman
- D Rittirsch
- DG Hackam
- Dioze Guadagnini
- DL Williams
- DM Tsukumo
- DR Matthews
- E Bonora
- Eduardo Rochete Ropelle
- EM Mortensen
- EM Mortensen
- FJ Frost
- FM Brunkhorst
- Francine Cappa Mittestainer
- FY Liew
- G Boden
- G Schabbauer
- G Van den Berghe
- G Van den Berghe
- G Van den Berghe
- GS Hotamisligil
- H Ando
- H Schmidt
- H Shi
- I Breder
- IM Tleyjeh
- J Bultinck
- J Hirosumi
- JA Russell
- Jose A. L. Calbet
- José Barreto Campelo Carvalheira
- KD Copps
- Kelly Lima Calisto
- L Chang
- L Langouche
- LA Dostal
- LB Kidd
- M Guha
- M Guha
- M Guha
- M Hatherill
- M Martin
- M Terblanche
- MA Carvalho-Filho
- Mario José Abdalla Saad
- MG Jeschke
- MG Jeschke
- MW Merx
- MW Merx
- NI Shapiro
- P Dandona
- P Kruger
- PA Baeuerle
- PE Marik
- PO Prada
- R Fernandez
- R Gupta
- RG Schlienger
- RJ Davis
- RM Clarke
- RW Thomsen
- S Akira
- S Akira
- SE Shoelson
- SR Maitra
- SR Majumdar
- U Ozcan
- UG Kyle
- V Brix-Christensen
- V Brix-Christensen
- Y Almog
- YH Lee
- YT Ip
- Z Gao
- Z Gao
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
The aim of the present study was to investigate whether the survival-improving effect of atorvastatin in sepsis is accompanied by a reduction in tissue activation of inflammatory pathways and, in parallel, an improvement in tissue insulin signaling in rats. Diffuse sepsis was induced by cecal ligation and puncture surgery (CLP) in male Wistar rats. Serum glucose and inflammatory cytokines levels were assessed 24 h after CLP. The effect of atorvastatin on survival of septic animals was investigated in parallel with insulin signaling and its modulators in liver, muscle and adipose tissue. Atorvastatin improves survival in septic rats and this improvement is accompanied by a marked improvement in insulin sensitivity, characterized by an increase in glucose disappearance rate during the insulin tolerance test. Sepsis induced an increase in the expression/activation of TLR4 and its downstream signaling JNK and IKK/NF-κB activation, and blunted insulin-induced insulin signaling in liver, muscle and adipose tissue; atorvastatin reversed all these alterations in parallel with a decrease in circulating levels of TNF-α and IL-6. In summary, this study demonstrates that atorvastatin treatment increased survival, with a significant effect upon insulin sensitivity, improving insulin signaling in peripheral tissues of rats during peritoneal-induced sepsis. The effect of atorvastatin on the suppression of the TLR-dependent inflammatory pathway may play a central role in regulation of insulin signaling and survival in sepsis insult
Persistent left superior vena cava: Review of the literature, clinical implications, and relevance of alterations in thoracic central venous anatomy as pertaining to the general principles of central venous access device placement and venography in cancer patients
- Author
- A Chandra
- A Granata
- A Kaladji
- A Kumar
- A Murray
- A Orija
- A Pálinkás
- A Verniquet
- AB Leibowitz
- AC Fry
- AG Higgs
- AJ Romero-Puche
- AR Forauer
- AW Otto
- B Menéndez
- B Stoiser
- BD Sarodia
- BJ Sweitzer
- C Ferrer Gómez
- C Gonzalez-Juanatey
- C Male
- C Thompson
- CL Kao
- CN Le Cat
- CR Dinasarapu
- CWM Poynter
- CY Kim
- D Commandeur
- DG Ranatunga
- E Marret
- EM Kiely
- F Paoletti
- FJ de la Prada
- FS Winters
- G Buirski
- G Lacuey Lecumberri
- G Luckianow
- G Miller
- G Schelling
- H Awad
- H Jantsch
- H Wasse
- Hooman Khabiri
- I Steinberg
- J Baldirà Martínez de Irujo
- J Beattie
- J Bordes
- J Marshall
- J Paval
- J Peltier
- JF Paul
- JJ Konvicka
- JM Saunders
- JR Yarnal
- K Hyland
- K Stylianou
- KF Hsu
- KS Chouke
- L Avolio
- L Korkmaz
- L Laurenzi
- L Schiffmann
- LF Parreira
- LJ Perry
- LP Lawler
- M Biffi
- M Campbell
- M Caruselli
- M Erdoğan
- M Greenberg
- M Hachicha
- M Kowalski
- M Ould-Ahmed
- M Radovic
- M Rubenfire
- MA Sanders
- MC Crocker
- MG Coblentz
- MH Chasen
- MS Prows
- MW Taal
- N Ghadiali
- N Nand
- NK Shyamkumar
- NM Perera
- O Uçar
- P Ancel
- P Grise
- P Ou
- P Sriramnaveen
- PA Boehmer
- PA Kamola
- PA Lönnqvist
- PJ Danielpour
- PL Tan
- PN Odgers
- PW Brown
- R Carrillo-Esper
- R Pahwa
- R Zuha
- RE McCotter
- RJ Azocar
- RK Josloff
- RT Falltrick
- RV Hill
- S Bouhbouh
- S Carlsöö
- S Kula
- SK Goyal
- SM Wyles
- SP Povoski
- SP Povoski
- SP Povoski
- SP Povoski
- SP Povoski
- Stephen P. Povoski
- SW Khoo
- T Couvreur
- T Heye
- TA Treschan
- TC Demos
- TC Lim
- TS Kuppusamy
- V Hammerer
- V Srivastava
- VB Kute
- W Cheselden
- W Oczenski
- W Schummer
- W Schummer
- W Schummer
- W Schummer
- W Sipila
- WB Fye
- WC Smith
- WG Harris
- WH Fares
- WK Hutton
- Y Hara
- Y Masuda
- Y Page
- YC Lai
- YL Huang
- YO Kim
- YS Jang
- ZS Lim
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
Persistent left superior vena cava (PLSVC) represents the most common congenital venous anomaly of the thoracic systemic venous return, occurring in 0.3% to 0.5% of individuals in the general population, and in up to 12% of individuals with other documented congential heart abnormalities. In this regard, there is very little in the literature that specifically addresses the potential importance of the incidental finding of PLSVC to surgeons, interventional radiologists, and other physicians actively involved in central venous access device placement in cancer patients. In the current review, we have attempted to comprehensively evaluate the available literature regarding PLSVC. Additionally, we have discussed the clinical implications and relevance of such congenital aberrancies, as well as of treatment-induced or disease-induced alterations in the anatomy of the thoracic central venous system, as they pertain to the general principles of successful placement of central venous access devices in cancer patients. Specifically regarding PLSVC, it is critical to recognize its presence during attempted central venous access device placement and to fully characterize the pattern of cardiac venous return (i.e., to the right atrium or to the left atrium) in any patient suspected of PLSVC prior to initiation of use of their central venous access device
The Early Data Release of the Dark Energy Spectroscopic Instrument
- Author
- Adame AG
- Aguilar J
- Ahlen S
- Alam S
- Aldering G
- Alexander DM
- Alfarsy R
- Allende Prieto C
- Alvarez M
- Alves O
- Anand A
- Andrade-Oliveira F
- Armengaud E
- Asorey J
- Avila S
- Aviles A
- Bailey S
- Balaguera-Antolinez A
- Ballester O
- Baltay C
- Bault A
- Bautista J
- Behera J
- Beltran SF
- BenZvi S
- Beraldo e Silva L
- Bermejo-Climent JR
- Berti A
- Besuner R
- Beutler F
- Bianchi D
- Blake C
- Blum R
- Bolton AS
- Brieden S
- Brodzeller A
- Brooks D
- Brown Z
- Buckley-Geer E
- Burtin E
- Cabayol-Garcia L
- Cai Z
- Canning R
- Cardiel-Sas L
- Carnero Rosell A
- Castander FJ
- Cervantes-Cota JL
- Chabanier S
- Chaussidon E
- Chaves-Montero J
- Chen S
- Chen X
- Chuang C
- Claybaugh T
- Cole S
- Cooper AP
- Cuceu A
- Davis TM
- Dawson K
- de Belsunce R
- de la Cruz R
- de la Macorra A
- de Mattia A
- Della Costa J
- Demina R
- Demirbozan U
- DeRose J
- Dey A
- Dey B
- Dhungana G
- Ding J
- Ding Z
- Doel P
- Doshi R
- Douglass K
- Edge A
- Eftekharzadeh S
- Eisenstein DJ
- Elliott A
- Ereza J
- Escoffier S
- Fagrelius P
- Fan X
- Fanning K
- Fawcett VA
- Ferraro S
- Flaugher B
- Font-Ribera A
- Forero-Romero JE
- Forero-Sanchez D
- Frenk CS
- Gansicke BT
- Garcia LA
- Garcia-Bellido J
- Garcia-Quintero C
- Garrison LH
- Gil-Marin H
- Golden-Marx J
- Gontcho Gontcho SA
- Gonzalez-Morales AX
- Gonzalez-Perez V
- Gordon C
- Graur O
- Green D
- Gruen D
- Guy J
- Hadzhiyska B
- Hahn C
- Han JJ
- Hanif MMS
- Herrera-Alcantar HK
- Honscheid K
- Hou J
- Howlett C
- Huterer D
- Irsic V
- Ishak M
- Jacques A
- Jana A
- Jiang L
- Jimenez J
- Jing YP
- Joudaki S
- Joyce R
- Jullo E
- Juneau S
- Karacayli NG
- Karim T
- Kehoe R
- Kent S
- Khederlarian A
- Kim S
- Kirkby D
- Kisner T
- Kitaura F
- Kizhuprakkat N
- Kneib J
- Koposov SE
- Kovacs A
- Kremin A
- Krolewski A
- L'Huillier B
- Lahav O
- Lambert A
- Lamman C
- Lan T-W
- Landriau M
- Lang D
- Lange JU
- Lasker J
- Le Guillou L
- Leauthaud A
- Levi ME
- Li TS
- Linder E
- Lyons A
- Magneville C
- Manera M
- Manser CJ
- Margala D
- Martini P
- McDonald P
- Medina GE
- Medina-Varela L
- Meisner A
- Mena-Fernandez J
- Meneses-Rizo J
- Mezcua M
- Miquel R
- Montero-Camacho P
- Moon J
- Moore S
- Moustakas J
- Mueller E
- Mundet J
- Munoz-Gutierrez A
- Myers AD
- Nadathur S
- Napolitano L
- Neveux R
- Newman JA
- Nie J
- Nikutta R
- Niz G
- Norberg P
- Noriega HE
- Paillas E
- Palanque-Delabrouille N
- Palmese A
- Pan Z
- Parkinson D
- Penmetsa S
- Percival WJ
- Perez-Fernandez A
- Perez-Rafols I
- Pieri M
- Poppett C
- Porredon A
- Pothier S
- Prada F
- Pucha R
- Raichoor A
- Ramirez-Perez C
- Ramirez-Solano S
- Rashkovetskyi M
- Ravoux C
- Rocher A
- Rockosi C
- Ross AJ
- Rossi G
- Ruggeri R
- Ruhlmann-Kleider V
- Sabiu CG
- Said K
- Saintonge A
- Samushia L
- Sanchez E
- Saulder C
- Schaan E
- Schlafly EF
- Schlegel D
- Scholte D
- Schubnell M
- Seo H
- Shafieloo A
- Sharples R
- Sheu W
- Silber J
- Sinigaglia F
- Siudek M
- Slepian Z
- Smith A
- Soumagnac MT
- Sprayberry D
- Stephey L
- Suarez-Perez J
- Sun Z
- Tan T
- Tarle G
- Tojeiro R
- Urena-Lopez LA
- Vaisakh R
- Valcin D
- Valdes F
- Valluri M
- Vargas-Magana M
- Variu A
- Verde L
- Walther M
- Wang B
- Wang MS
- Weaver BA
- Weaverdyck N
- Wechsler RH
- White M
- Xie Y
- Yang J
- Yeche C
- Yu J
- Yuan S
- Zhang H
- Zhang Z
- Zhao C
- Zheng Z
- Zhou R
- Zhou Z
- Zou H
- Zou S
- Zu Y
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/08/2024
- Field of study
\ua9 2024. The Author(s). Published by the American Astronomical Society. The Dark Energy Spectroscopic Instrument (DESI) completed its 5 month Survey Validation in 2021 May. Spectra of stellar and extragalactic targets from Survey Validation constitute the first major data sample from the DESI survey. This paper describes the public release of those spectra, the catalogs of derived properties, and the intermediate data products. In total, the public release includes good-quality spectral information from 466,447 objects targeted as part of the Milky Way Survey, 428,758 as part of the Bright Galaxy Survey, 227,318 as part of the Luminous Red Galaxy sample, 437,664 as part of the Emission Line Galaxy sample, and 76,079 as part of the Quasar sample. In addition, the release includes spectral information from 137,148 objects that expand the scope beyond the primary samples as part of a series of secondary programs. Here, we describe the spectral data, data quality, data products, Large-Scale Structure science catalogs, access to the data, and references that provide relevant background to using these spectra
RNA delivery by extracellular vesicles in mammalian cells and its applications.
- Author
- A Ahadi
- A Buonfiglioli
- A Datta
- A Gori
- A Herrmann
- A Hoshino
- A Iavello
- A Khvorova
- A Longatti
- A Mondal
- A Montecalvo
- A Morales-Kastresana
- A Rustom
- A Savina
- A Varcianna
- A Wittrup
- A Yeri
- A Zomer
- AD Flynn
- AD Grabarek
- AF Saleh
- AH Van Craenenbroeck
- AJ McKenzie
- AK Rupp
- AL Blasius
- AM Leidal
- AM Marleau
- AR Soares
- AT Da Poian
- B Escudier
- B György
- B György
- B Mannerström
- B Mateescu
- B Meehan
- B Shen
- BH Sung
- BM Lehrich
- BN Hannafon
- BWM Van Balkom
- BY Nabet
- C Eliscovich
- C Escrevente
- C Geoffroy
- C Gong
- C Grange
- C Lässer
- C Ma
- C Meyer
- C Théry
- C Villarroya-Beltri
- C Williams
- C Williams
- CA Thompson
- CC Chen
- CG Liu
- CM Di Liegro
- CP Lai
- CP Lai
- D Choi
- D De Gonzalo-Calvo
- D Fanale
- D Granchi
- D Hoshino
- D Planchon
- D Shukla
- DD Yanshina
- DE Murphy
- DJ Gibbings
- DK Jeppesen
- DK Struck
- DM Jones
- DX Zhang
- E Reátegui
- E Rohde
- E Tutucci
- E van der Pol
- ED Pastuzyn
- EJ Im
- EM Guerreiro
- EN Hoen
- ENM Nolte’T Hoen
- ER Abels
- F Chen
- F De La Cuesta
- F Ghamloush
- F Gámbaro
- F Hobor
- F Kenneweg
- F Pi
- F Royo
- FJ Giles
- FM Khan
- G Haimovich
- G Van Niel
- H Goodarzi
- H Persson
- H Pollet
- H Ragelle
- H Shao
- H Sork
- H Valadi
- H Yu
- H Yuhua
- H Zhang
- H Zhang
- H Zhang
- HC Christianson
- HM van Dongen
- HW King
- I Nakase
- I Nakase
- I Nakase
- I Parolini
- I Prada
- IKH Poon
- J Ashley
- J Grove
- J Guduric-Fuchs
- J He
- J Jiang
- J Karttunen
- J Kowal
- J Liu
- J Matsuzaki
- J McKiernan
- J Schorey
- J Skog
- J Van Deun
- J Van Deun
- J Wang
- J Wang
- J Zou
- JA Tsatsaronis
- JC Akers
- JC Akers
- JD Arroyo
- JD Martin-Rufino
- JE Freedman
- JF Quinn
- JM Rimer
- JM Wahlberg
- JPK Armstrong
- JR Chevillet
- JR Edgar
- JR Schnell
- JW Clancy
- K Burgos
- K Ekström
- K Glebov
- K Hagiwara
- K Koga
- K Lee
- K Miyauchi
- K Mukherjee
- K Otake
- K Ridder
- K Yin
- KC Vickers
- KM Danielson
- KW Witwer
- L Alvarez-Erviti
- L Antoury
- L Morel
- L Pigati
- L Santangelo
- L Statello
- L Wang
- L Zhang
- LA Beninson
- LA Mulcahy
- M Alexander
- M Fabbri
- M Gimona
- M Li
- M Mathieu
- M Maugeri
- M Mendt
- M Mittelbrunn
- M Mittelbrunn
- M Miyanishi
- M Panasiuk
- M Ragusa
- M Shen
- M Tkach
- MAC Pomatto
- MC Boelens
- MC Didiot
- MD Giraldez
- ME Hung
- MF Bolukbasi
- MJ Shurtleff
- MJ Shurtleff
- ML Squadrito
- MM Temoche-Diaz
- MP Hardy
- MP Zaborowski
- MS Joerger-Messerli
- N Heath
- N Jabbari
- N Karimi
- N Kosaka
- N Sadik
- NT Chiou
- O Markov
- O Oleksiuk
- OA Kossinova
- OD Murillo
- OPB Wiklander
- OPB Wiklander
- P Gangadaran
- P Gaurivaud
- P Lönn
- P Song
- PE Mangeot
- PJ Quesenberry
- PM Godoy
- PM Godoy
- Q Liu
- Q Wang
- Q Wang
- Q Zhang
- R Bayraktar
- R Crescitelli
- R Horos
- R Kojima
- R Lucero
- R Munagala
- R Shah
- R Xu
- RA Haraszti
- RA Haraszti
- RF D’souza
- RK Tweten
- RL Maute
- S Atienzar-Aroca
- S Bala
- S Caruso
- S Chen
- S Das
- S Gerstberger
- S Kamerkar
- S Sinha
- S Srinivasan
- SA Melo
- SAA Kooijmans
- SAA Kooijmans
- SAA Kooijmans
- SAA Kooijmans
- SC Jang
- SG Antimisiaris
- SI Ohno
- SK Chakrabortty
- SM Kim
- SM Lehmann
- SN Hurwitz
- SR Baglio
- SR Baglio
- T Janas
- T Thomou
- T Tian
- TAP Driedonks
- TG Iversen
- TJ Antes
- TN Bukong
- TN Lamichhane
- V Bhaskaran
- V Ramakrishnaiah
- V Toribio
- VD Atayde
- VR Minciacchi
- W Aoi
- W Heusermann
- W Ying
- WD Gray
- WM Usman
- WP Kuo
- X Gao
- X Huang
- X Liu
- X Zhu
- X Zou
- Y Lin
- Y Long
- Y Ma
- Y Tao
- Y Teng
- Y Wang
- YY Jhan
- Z Feng
- Z Wei
- Z Wei
- ZW Luo
- Publication venue
- eScholarship, University of California
- Publication date
- 01/10/2020
- Field of study
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of cellular origin that derive either from the endosomal compartment (exosomes) or as a result of shedding from the plasma membrane (microvesicles, oncosomes and apoptotic bodies). Extracellular vesicles carry a variety of cargo, including RNAs, proteins, lipids and DNA, which can be taken up by other cells, both in the direct vicinity of the source cell and at distant sites in the body via biofluids, and elicit a variety of phenotypic responses. Owing to their unique biology and roles in cell-cell communication, extracellular vesicles have attracted strong interest, which is further enhanced by their potential clinical utility. Because extracellular vesicles derive their cargo from the contents of the cells that produce them, they are attractive sources of biomarkers for a variety of diseases. Furthermore, studies demonstrating phenotypic effects of specific extracellular vesicle-associated cargo on target cells have stoked interest in extracellular vesicles as therapeutic vehicles. There is particularly strong evidence that the RNA cargo of extracellular vesicles can alter recipient cell gene expression and function. During the past decade, extracellular vesicles and their RNA cargo have become better defined, but many aspects of extracellular vesicle biology remain to be elucidated. These include selective cargo loading resulting in substantial differences between the composition of extracellular vesicles and source cells; heterogeneity in extracellular vesicle size and composition; and undefined mechanisms for the uptake of extracellular vesicles into recipient cells and the fates of their cargo. Further progress in unravelling the basic mechanisms of extracellular vesicle biogenesis, transport, and cargo delivery and function is needed for successful clinical implementation. This Review focuses on the current state of knowledge pertaining to packaging, transport and function of RNAs in extracellular vesicles and outlines the progress made thus far towards their clinical applications
SPARC: a matricellular regulator of tumorigenesis
- Author
- A Bellahcene
- A Bergamaschi
- A Chlenski
- A Chlenski
- A Chlenski
- A Chlenski
- A Desmouliere
- A Francki
- A Francki
- A Guweidhi
- A Kram
- A Luo
- A Pen
- A Schulz
- A Takeno
- A Zalatnai
- AD Bradshaw
- AD Bradshaw
- AD Bradshaw
- AD Bradshaw
- AD Bradshaw
- AD Bradshaw
- AD Bradshaw
- AH Beck
- AH Wiese
- AJ Minn
- AL Berrier
- AM Delany
- B Bail Le
- B Farrow
- B Ryu
- B St Croix
- BJ Schiemann
- BP Eliceiri
- BS Parker
- C Gilles
- C Jones
- C Kupprion
- C Lussier
- C Schultz
- CA Dalla-Torre
- CA Iacobuzio-Donahue
- CH Streuli
- CH Streuli
- CJ Best
- CJ Clark
- CK Yunker
- CP Lau
- CS Wang
- CV Hedvat
- D Chin
- D Goldenberg
- D Massi
- D Porter
- D Sarrio
- DA Campo McKnight
- DA Zajchowski
- DB Mendis
- DG Stupack
- DJ Smit
- DT Gilmour
- DY Huang
- E Ioachim
- E Yang
- EW Raines
- F Ledda
- F Prada
- F Siddiq
- F Taghizadeh
- F Verrecchia
- FH Wong
- FJ Rodriguez-Jimenez
- FT Bosman
- G Lorusso
- G Robert
- G Rumpler
- G Watkins
- GE Davis
- GK Yiu
- GS Schultz
- H Huang
- H Inoue
- H Porte
- H Porte
- H Sage
- HC Lien
- HE Gruber
- HF Dvorak
- HM McClung
- HY Maeng
- HY Maeng
- IT Tai
- J Brabender
- J Briggs
- J Helleman
- J Lapointe
- J Madoz-Gurpide
- J Nie
- J Timar
- JA Bassuk
- JA Engbring
- JA Joyce
- JC Fanburg-Smith
- JC Porter
- JE Koblinski
- JF DiMartino
- JL Wrana
- JN Rich
- JN Rich
- JR Infante
- K Brune
- K Jacob
- K Motamed
- K Motamed
- K Norose
- K Yamashita
- KL Prenzel
- L Bullinger
- LA Liotta
- LY Xue
- M Bloomston
- M Larsen
- M Mitas
- M Moser
- M Nozaki
- M Suzuki
- M Tian
- M Yamanaka
- MA Gieseg
- ME Ross
- MF Ledda
- MI Koukourakis
- MJ Alvarez
- MJ Reed
- MJ Reed
- MJ Socha
- MR Pan
- MS Sosa
- MS Weaver
- MW Volmer
- N Chen
- N Dhanesuan
- N Martinez
- N Said
- N Said
- N Said
- N Sakai
- N Sato
- N Wernert
- O Fromigue
- OJ Sansom
- OL Podhajcer
- P Bornstein
- P Bornstein
- P Bornstein
- P Choi
- P Hasselaar
- P Pavasant
- P Puolakkainen
- P Sova
- PA Puolakkainen
- PE Framson
- PJ Barth
- PJ Paley
- PL Porter
- PR Somanath
- Q Shi
- Q Shi
- Q Yan
- Q Yan
- R Ford
- R Thomas
- RA Brekken
- RA Brekken
- RA Sturm
- RL Aycock
- RL Juliano
- Rolf A. Brekken
- S Amatschek
- S Arnold
- S Cheetham
- S De
- S Kaiser
- S Kumar
- S Kunigal
- S Kuphal
- S Sangaletti
- S Sangaletti
- SA Rempel
- SA Rempel
- SA Rempel
- SC Mok
- Shanna A. Arnold
- SL Bull Phelps
- SL Kahn
- SM Hong
- SR Alonso
- T Fujita
- T Sasaki
- T Sasaki
- T Seno
- T Takano
- TH Barker
- TJ Brown
- TL Whiteside
- U Woelfle
- UM Wewer
- UT Shankavaram
- W Nimphius
- W Shan
- WA Golembieski
- WA Golembieski
- Y Che
- Y Chen
- Y Ikuta
- Y Kato
- Y Kato
- Y Kato
- Y Kato
- Y Wang
- YD Jung
- Publication venue
- Springer Netherlands
- Publication date
- 01/01/2009
- Field of study
Although many clinical studies have found a correlation of SPARC expression with malignant progression and patient survival, the mechanisms for SPARC function in tumorigenesis and metastasis remain elusive. The activity of SPARC is context- and cell-type-dependent, which is highlighted by the fact that SPARC has shown seemingly contradictory effects on tumor progression in both clinical correlative studies and in animal models. The capacity of SPARC to dictate tumorigenic phenotype has been attributed to its effects on the bioavailability and signaling of integrins and growth factors/chemokines. These molecular pathways contribute to many physiological events affecting malignant progression, including extracellular matrix remodeling, angiogenesis, immune modulation and metastasis. Given that SPARC is credited with such varied activities, this review presents a comprehensive account of the divergent effects of SPARC in human cancers and mouse models, as well as a description of the potential mechanisms by which SPARC mediates these effects. We aim to provide insight into how a matricellular protein such as SPARC might generate paradoxical, yet relevant, tumor outcomes in order to unify an apparently incongruent collection of scientific literature
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
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- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Ko SB
- Kobayashi A
- Koco E
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- Kodate A
- Kodate A
- Kokkini S
- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
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- Kox M
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- Krishna B
- Kristof J
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- Kubik M
- Kubota K
- Kuebler WM
- Kulaga EV
- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
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- Kwon HM
- Kwon WY
- Kwon WY
- Kwon WY
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- Kyle UG
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- Labra C
- Lacerda P
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- Lafuente E
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- Lagos R
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- Lesmes SP
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- Lischinsky A
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- Llorente MÁ
- Lobato MS
- Lobo-Civico A
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- Lombardo MD
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- Lukaszewicz AC
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- MacKay A
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- Mackey G
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- Macrì M
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- Maekawa K
- Maekawa K
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- Maghsoudi B
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- Maistry N
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- Merino-Vega D
- Messenger D
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- Michel L
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- Mihara Y
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- Sprung CL
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- Stocchetti N
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- Stubbs C
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- Tabei SH
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- Tapponnier R
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- Tena SA
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- Tjepkema-Cloostermans MC
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- Tofiño AL
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- Tonetti T
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- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
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- Adekanmbi V
- Adelson JD
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- Ahmadpour E
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- Alcalde-Rabanal JE
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- Alemu BW
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- Alicandro G
- Alijanzadeh M
- Alinia C
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- Alizade H
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- Doyle KE
- Driscoll TR
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- Edvardsson D
- Effiong A
- Ehrlich JR
- El Nahas N
- El Sayed I
- El Tantawi M
- El-Jaafary SI
- Elbarazi I
- Elgendy IY
- Elhabashy HR
- Elsharkawy A
- Elyazar IRF
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- Erskine HE
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- Umeokonkwo CD
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- Wondmieneh AB
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- Wu C
- Wu J
- Wunrow HY
- Xie Y
- Xu G
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- Yamagishi K
- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
- Yearwood JA
- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
- Yoon S-J
- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
- Ariani F
- Aripov T
- Armoon B
- Arnlov J
- Arowosegbe OO
- Aryal KK
- Arzani A
- Asaad M
- Asadi-Aliabadi M
- Asadi-Pooya AA
- Asgari S
- Asghari B
- Ashbaugh C
- Assmus M
- Atafar Z
- Athari SS
- Atnafu DD
- Atout MMW
- Atre SR
- Atteraya MS
- Ausloos F
- Ausloos M
- Avila-Burgos L
- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Aynalem GL
- Aynalem YA
- Ayza MA
- Azari S
- Azarian G
- Azene ZN
- Azhar G
- Azzopardi PS
- Babaee E
- Badawi A
- Badiye AD
- Bagherzadeh M
- Bagli E
- Bahrami MA
- Baig AA
- Bairwa M
- Bakhshaei MH
- Bakhtiari A
- Bakkannavar SM
- Balachandran A
- Balakrishnan S
- Balalla S
- Balassyano S
- Baldasseroni A
- Bali AO
- Ball K
- Ballew SH
- Balzi D
- Banach M
- Bandpei MAM
- Banerjee SK
- Banik PC
- Bannick MS
- Bante AB
- Bante SA
- Baraki AG
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barrero LH
- Barthelemy CM
- Barua L
- Barzegar A
- Basaleem H
- Bassat Q
- Basu S
- Baune BT
- Bayati M
- Baye BA
- Bazmandegan G
- Becker JS
- Bedi N
- Beghi E
- Behzadifar M
- Bejot Y
- Bekuma TTT
- Bell ML
- Bello AK
- Ben L
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- Bennett DA
- Bennitt FB
- Bensenor IM
- Benziger CP
- Berhe K
- Berman AE
- Bernabe E
- Bernstein RS
- Bertolacci GJ
- Bhagavathula AS
- Bhageerathy R
- Bhala N
- Bhandari D
- Bhardwaj P
- Bhat AG
- Bhattacharyya K
- Bhattarai S
- Bhutta ZA
- Bibi S
- Bicer BK
- Biehl MH
- Bijani A
- Bikbov B
- Bilano V
- Bin Sayeed MS
- Bin Zaman S
- Biondi A
- Birihane BM
- Bisanzio D
- Bisignano C
- Biswas RK
- Bitew H
- Bjorge T
- Bockarie MJ
- Bohlouli S
- Bohluli M
- Bojia HA
- Bolla SR
- Boloor A
- Boon-Dooley AS
- Borges G
- Borzi AM
- Borzouei S
- Bose D
- Bosetti C
- Boston S
- Boufous S
- Bourne R
- Brady OJ
- Braithwaite D
- Brauer M
- Brayne C
- Breitborde NJK
- Breitner S
- Brenner H
- Breusov AV
- Briant PS
- Briggs AM
- Briko AN
- Briko NI
- Britton GB
- Brugha T
- Bryazka D
- Buchbinder R
- Bumgarner BR
- Burkart K
- Burnett RT
- Busse R
- Butt ZA
- Caetano dos Santos FL
- Cahill LE
- Cahuana-Hurtado L
- Cai T
- Callender CSKH
- Camera LA
- Campos-Nonato IR
- Cao J
- Car J
- Car LT
- Cardenas R
- Carreras G
- Carrero JJ
- Carvalho F
- Castaldelli-Maia JM
- Castaneda-Orjuela CA
- Castelpietra G
- Castle CD
- Castro E
- Castro F
- Catala-Lopez F
- Causey K
- Cederroth CR
- Cercy KM
- Cerin E
- Chalek J
- Chandan JS
- Chang AR
- Chang AY
- Chang J-C
- Chang K-L
- Charan J
- Charlson FJ
- Chattu VK
- Chaturvedi S
- Cherbuin N
- Chimed-Ochir O
- Chin KL
- Chirinos-Caceres JL
- Cho DY
- Choi J-YJ
- Christensen H
- Chu D-T
- Chung MT
- Chung S-C
- Cicuttini FM
- Ciobanu LG
- Cirillo M
- Cislaghi B
- Classen TKD
- Cohen AJ
- Collins EL
- Comfort H
- Compton K
- Conti S
- Cooper OR
- Corso B
- Cortesi PA
- Costa VM
- Cousin E
- Cowden RG
- Cowie BC
- Cromwell EA
- Croneberger AJ
- Cross DH
- Cross M
- Crowe CS
- Cruz JA
- Cummins S
- Cunningham M
- D'Amico E
- da Silva DD
- Dahlawi SMA
- Dai H
- Dai H
- Damasceno AAM
- Damiani G
- Dandona L
- Dandona R
- Daneshpajouhnejad P
- Dangel WJ
- Danielsson A-K
- Dargan PI
- Darshan BB
- Darwesh AM
- Daryani A
- Das Gupta R
- Das Neves J
- Das JK
- Dash AP
- Davey G
- Davila-Cervantes CA
- Davis AC
- Davitoiu DV
- Davletov K
- De Leo D
- De Neve J-W
- Dean FE
- DeCleene NK
- Deen A
- Defo BK
- Degenhardt L
- DeLang M
- Dellavalle RP
- Demeke FM
- Demoz GT
- Demsie DG
- Denova-Gutierrez E
- Dereje ND
- Deribe K
- Dervenis N
- Desai R
- Desalew A
- Dessie GA
- Deuba K
- Dharmaratne SD
- Dhungana GP
- Dianatinasab M
- Diaz D
- Dichgans M
- Didarloo A
- Dingels ZV
- Dippenaar IN
- Dirac MA
- Djalalinia S
- Do HT
- Dokova K
- Doku DT
- Dolecek C
- Dolgert AJ
- Dorostkar F
- Doshi CP
- Doshi PP
- Doshmangir L
- Douiri A
- Doxey MC
- Doyle KE
- Driscoll TR
- Dubljanin E
- Dunachie SJ
- Duncan BB
- Duraes AR
- Eagan AW
- Ebrahimi H
- Edvardsson D
- Effiong A
- Ehrlich JR
- El Nahas N
- El Sayed I
- El Tantawi M
- El-Jaafary SI
- Elbarazi I
- Elgendy IY
- Elhabashy HR
- Elsharkawy A
- Elyazar IRF
- Emamian MH
- Emmons-Bell S
- Erskine HE
- Eshrati B
- Eskandari K
- Eskandarieh S
- Esmaeilnejad S
- Esmaeilzadeh F
- Esteghamati A
- Esteghamati S
- Estep K
- Etemadi A
- Etisso AE
- Ezekannagha O
- Fanzo J
- Farag T
- Farahmand M
- Faraj A
- Faraon EJA
- Fareed M
- Faridnia R
- Farinha CSES
- Farioli A
- Faris PS
- Faro A
- Faruque M
- Farzadfar F
- Fattahi N
- Fazaeli AA
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
- Author
- Aikawa E
- Alcaraz MJ
- Anderson JD
- Andriantsitohaina R
- Antoniou A
- Arab T
- Archer F
- Atkin-Smith GK
- Ayre DC
- Bach J-M
- Bachurski D
- Baharvand H
- Balaj L
- Baldacchino S
- Bauer NN
- Baxter AA
- Bebawy M
- Beckham C
- Bedina Zavec A.
- Benmoussa A.
- Berardi AC
- Bergese P
- Bielska E
- Blenkiron C
- Bobis-Wozowicz S
- Boilard E
- Boireau W
- Bongiovanni A
- Borràs FE
- Bosch S
- Boulanger CM
- Breakefield X
- Breglio AM
- Brennan MÁ
- Brigstock DR
- Brisson A
- Broekman MLD
- Bromberg JF
- Bryl-Górecka P
- Buch S
- Buck AH
- Burger D
- Busatto S
- Buschmann D
- Bussolati B
- Buzás Edit Irén
- Byrd JB
- Camussi G
- Carter DRF
- Caruso S
- Chamley LW
- Chang Y-T
- Chaudhuri AD
- Chen C
- Chen S
- Cheng L
- Chin AR
- Clayton A
- Clerici SP
- Cocks A
- Cocucci E
- Coffey RJ
- Cordeiro-da-Silva A
- Couch Y
- Coumans FAW
- Coyle B
- Crescitelli R
- Criado MF
- Das S
- de Candia P
- De Santana EF Jr.
- De Wever O
- del Portillo HA
- Demaret T
- Deville S
- Devitt A
- Dhondt B
- Di Vizio D
- Dieterich LC
- Dolo V
- Dominguez Rubio AP
- Dominici M
- Dourado MR
- Driedonks TAP
- Duarte FV
- Duncan HM
- D’Souza-Schorey C
- Eichenberge r RM
- Ekström K
- EL Andaloussi S
- Elie-Caille C
- Erdbrügger U
- Falcón-Pérez JM
- Fatima F
- Fish JE
- Flores-Bellver M
- Frelet-Barrand A
- Fricke F
- Fuhrmann G
- Försönits András
- Gabrielsson S
- Gardiner C
- Gaudin R
- Gho YS
- Giebel B
- Gilbert C
- Gimona M
- Giusti I
- Goberdhan DCI
- Gorski SM
- Greening DW
- Gross JC
- Gualerzi A
- Gupta GN
- Gustafson D
- Gámez-Valero A
- Gärtner K.
- Görgens A
- Handberg A
- Haraszti RA
- Harrison P
- Hegyesi Hargita
- Hendrix A
- Hill AF
- Hochberg FH
- Hoffmann KF
- Holder B
- Holthofer H
- Hooten NN
- Hosseinkhani B
- Hu G
- Huang Y
- Huber V
- Hunt S
- Ibrahim AG-E
- Ikezu T
- Inal JM
- Isin M
- Ivanova A
- Jackson HK
- Jacobsen S
- Jay SM
- Jayachandran M
- Jenster G
- Jiang L
- Johnson SM
- Jones JC
- Jong A
- Jovanovic-Talisman T
- Jung S
- Kalluri R
- Kano S-I
- Kaur S
- Kawamura Y
- Keller ET
- Khamari Delaram
- Khomyakova E
- Khvorova A
- Kierulf P
- Kim KP
- Kislinger T
- Klingeborn M
- Klinke DJ II
- Kornek M
- Kosanović MM
- Kovács Árpád.Ferenc
- Krasemann S
- Krause M
- Krämer-Albers E-M
- Kurochkin IV
- Kusuma GD
- Kuypers S
- Laitinen S
- Langevin SM
- Languino LR
- Lannigan J
- Laurent LC
- Lavieu G
- Le Lay S
- Lee M-S
- Lee YXF
- Lemos DS
- Lenassi M
- Leszczynska A
- Li ITS
- Liao K
- Libregts SF
- Ligeti Erzsébet
- Lim R
- Lim SK
- Linnemannstöns K
- Linē A
- Llorente A
- Lombard CA
- Lorenowicz MJ
- Lovett J
- Lowry MC
- Loyer X
- Lu Q
- Lukomska B
- Lunavat TR
- Lázaro-Ibáñez E
- Lässer C
- Lötvall J
- Lőrincz Ádám Márton
- Maas SLN
- Malhi H
- Marcilla A
- Mariani J
- Mariscal J
- Martens-Uzunova ES
- Martin-Jaular L
- Martinez MC
- Martins VR
- Mathieu M
- Mathivanan S
- Maugeri M
- McGinnis LK
- McVey MJ
- Meckes DG Jr
- Meehan KL
- Mertens I
- Minciacchi VR
- Morales-Kastresana A
- Morhayim J
- Mullier F
- Muraca M
- Musante L
- Mussack V
- Muth DC
- Myburgh KH
- Möller A
- Møller Jørgensen M
- Najrana T
- Nawaz M
- Nazarenko I
- Nejsum P
- Neri C
- Neri T
- Nieuwland R
- Nimrichter L
- Nolan JP
- Nolte-’t Hoen ENM
- Ochiya T
- Olivier M
- Ortiz A
- Ortiz LA
- Ostegaard O
- Osteikoetxea Xabier
- Ostrowski M
- O’Driscoll L
- O’Grady T
- O’Loghlen A
- Park J
- Pegtel DM
- Peinado H
- Perut F
- Pfaffl MW
- Phinney DG
- Pieters BCH
- Pink RC
- Pisetsky DS
- Pogge von Strandmann E
- Polakovicova I
- Poon IKH
- Powell BH
- Prada I
- Pulliam L
- Quesenberry P
- Radeghieri A
- Raffai RL
- Raimondo S
- Rak J
- Ramirez MI
- Raposo G
- Rayyan MS
- Regev-Rudzki N
- Ricklefs FL
- Robbins PD
- Roberts DD
- Rodrigues SC
- Rohde E
- Rome S
- Rouschop KMA
- Rughetti A
- Russell AE
- Sahoo S
- Salas-Huenuleo E
- Saugstad JA
- Saul MJ
- Saá P
- Schiffelers RM
- Schneider R
- Schøyen TH
- Scott A
- Shahaj E
- Sharma S
- Shatnyeva O
- Shekari F
- Shelke GV
- Shetty AK
- Shiba K
- Siljander PR-M
- Silva AM
- Skowronek A
- Snyder OL II
- Soares RP
- Soekmadji C
- Sotillo J
- Stah lPD
- Stoorvogel W
- Stott SL
- Strasser EF
- Swift S
- Sánchez C
- Sódar Barbara
- Tahara H
- Tewari M
- Théry C
- Timms K
- Tiwari S
- Tixeira R
- Tkach M
- Toh WS
- Tomasini R
- Torrecilhas AC
- Tosar JP
- Toxavidis V
- Urbanelli L
- Vader P
- van Balkom BWM
- van der Grein SG
- Van Deun J
- van Herwijnen MJC
- Van Keuren-Jensen K
- van Niel G
- van Royen ME
- van Wijnen AJ
- Vasconcelos MH
- Vechetti IJ Jr
- Veit TD
- Vella LJ
- Velot É
- Verweij FJ
- Vestad B
- Visnovitz Tamás
- Visnovitzné Dr Vukman Krisztina
- Viñas JL
- Wahlgren J
- Watson DC
- Wauben MHM
- Weaver A
- Webber JP
- Weber V
- Wehman AM
- Weiss DJ
- Welsh JA
- Wendt S
- Wheelock AM
- Wiener Zoltán
- Witte L
- Witwer KW
- Wolfram J
- Xagorari A
- Xander P
- Xu J
- Yan X
- Yin H
- Yuana Y
- Yáñez-Mó M
- Zappulli V
- Zarubova J
- Zhang J-Y
- Zhao Z
- Zheng L
- Zheutlin AR
- Zickler AM
- Zimmermann P
- Zivkovic AM
- Zocco D
- Zuba-Surma EK
- Žėkas V
- Publication venue
- 'Informa UK Limited'
- Publication date
- 29/01/2019
- Field of study
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
- Author
- Aikawa E
- Andaloussi SEL
- Anderson JD
- Andriantsitohaina R
- Antoniou A
- Arab T
- Archer F
- Atkin-Smith GK
- Ayre DC
- Bach J-M
- Bachurski D
- Baharvand H
- Balaj L
- Baldacchino S
- Bauer NN
- Baxter AA
- Bebawy M
- Beckham C
- Benmoussa A
- Berardi AC
- Bergese P
- Bielska E
- Blenkiron C
- Bobis-Wozowicz S
- Boilard E
- Boireau W
- Bongiovanni A
- Borras FE
- Bosch S
- Boulanger CM
- Breakefield X
- Breglio AM
- Brennan MA
- Brigstock DR
- Brisson A
- Broekman MLD
- Bromberg JF
- Bryl-Gorecka P
- Buch S
- Buck AH
- Burger D
- Busatto S
- Buschmann D
- Bussolati B
- Buzas E
- Byrd JB
- Camussi G
- Carter DRF
- Caruso S
- Chamley LW
- Chang Y-T
- Chaudhuri AD
- Chen C
- Chen S
- Cheng L
- Chin AR
- Clayton A
- Clerici SP
- Cocks A
- Cocucci E
- Coffey RJ
- Cordeiro-da-Silva A
- Couch Y
- Coumans FAW
- Coyle B
- Crescitelli R
- Criado MF
- D'Souza-Schorey C
- Das S
- de Candia P
- De Santana Junior EF
- De Wever O
- del Portillo HA
- Demaret T
- Deville S
- Devitt A
- Dhondt B
- Di Vizio D
- Dieterich LC
- Dolo V
- Dominguez Rubio AP
- Dominici M
- Dourado MR
- Driedonks TAP
- Duarte F
- Duncan HM
- Eichenberger RM
- Ekstrom K
- Elie-Caille C
- Erdbrugger U
- Falcon-Perez JM
- Fatima F
- Fish JE
- Flores-Bellver M
- Forsonits A
- Frelet-Barrand A
- Fricke F
- Fuhrmann G
- Gabrielsson S
- Gaertner K
- Gamez-Valero A
- Gardiner C
- Gaudin R
- Gho YS
- Giebel B
- Gilbert C
- Gimona M
- Giusti I
- Goberdhan DC
- Goergens A
- Gorski SM
- Greening DW
- Gross JC
- Gualerzi A
- Gupta GN
- Gustafson D
- Handberg A
- Haraszti RA
- Harrison P
- Hegyesi H
- Helena Vasconcelos M
- Hendrix A
- Hill AF
- Hochberg FH
- Hoen ENMN-T
- Hoffmann KF
- Holder B
- Holthofer H
- Hooten NN
- Hosseinkhani B
- Hu G
- Huang Y
- Huber V
- Hunt S
- Ibrahim AG-E
- Ikezu T
- Inal JM
- Isin M
- Ivanova A
- Jackson HK
- Jacobsen S
- Jay SM
- Jayachandran M
- Jenster G
- Jiang L
- Johnson SM
- Jones JC
- Jong A
- Jorgensen MM
- Jose Alcaraz M
- Jovanovic-Talisman T
- Jung S
- Kalluri R
- Kano S-I
- Kaur S
- Kawamura Y
- Keller ET
- Khamari D
- Khomyakova E
- Khvorova A
- Kierulf P
- Kim KP
- Kislinger T
- Klingeborn M
- Klinke DJ
- Kornek M
- Kosanovic MM
- Kovacs AF
- Kraemer-Albers E-M
- Krasemann S
- Krause M
- Kurochkin I
- Kusuma GD
- Kuypers S
- Laitinen S
- Langevin SM
- Languino LR
- Lannigan J
- Lasser C
- Laurent LC
- Lavieu G
- Lazaro-Ibanez E
- Le Lay S
- Lee M-S
- Lee YXF
- Lemos DS
- Lenassi M
- Leszczynska A
- Li ITS
- Liao K
- Libregts SF
- Ligeti E
- Lim R
- Lim SK
- Line A
- Linnemannstoens K
- Llorente A
- Lombard CA
- Lorenowicz MJ
- Lorincz AM
- Lotvall J
- Lovett J
- Lowry MC
- Loyer X
- Lu Q
- Lukomska B
- Lunavat TR
- Maas SLN
- Malhi H
- Marcilla A
- Mariani J
- Mariscal J
- Martens-Uzunova ES
- Martin-Jaular L
- Martinez MC
- Martins VR
- Mathieu M
- Mathivanan S
- Maugeri M
- McGinnis LK
- McVey MJ
- Meckes DG
- Meehan KL
- Mertens I
- Minciacchi VR
- Moller A
- Morales-Kastresana A
- Morhayim J
- Mullier F
- Muraca M
- Musante L
- Mussack V
- Muth DC
- Myburgh KH
- Najrana T
- Nawaz M
- Nazarenko I
- Nejsum P
- Neri C
- Neri T
- Nieuwland R
- Nimrichter L
- Nolan JP
- O'Driscoll L
- O'Grady T
- O'Loghlen A
- Ochiya T
- Olivier M
- Ortiz A
- Ortiz LA
- Ostegaard O
- Osteikoetxea X
- Ostrowski M
- Pablo Tosar J
- Park J
- Pegtel DM
- Peinado H
- Perut F
- Pfaffl MW
- Phinney DG
- Pieters BCH
- Pink RC
- Pisetsky DS
- Polakovicova I
- Poon IKH
- Powell BH
- Prada I
- Pulliam L
- Quesenberry P
- Radeghieri A
- Raffai RL
- Raimondo S
- Rak J
- Ramirez M
- Raposo G
- Rayyan MS
- Regev-Rudzki N
- Ricklefs FL
- Robbins PD
- Roberts DD
- Rodrigues SC
- Rohde E
- Rome S
- Rouschop KMA
- Rughetti A
- Russell AE
- Saa P
- Sahoo S
- Salas-Huenuleo E
- Sanchez C
- Saugstad JA
- Saul MJ
- Schiffelers RM
- Schneider R
- Schoyen TH
- Scott A
- Shahaj E
- Sharma S
- Shatnyeva O
- Shekari F
- Shelke GV
- Shetty AK
- Shiba K
- Siljander PR-M
- Silva AM
- Skowronek A
- Snyder OL
- Soares RP
- Sodar BW
- Soekmadji C
- Sotillo J
- Stahl PD
- Stoorvogel W
- Stott SL
- Strasser EF
- Swift S
- Tahara H
- Tewari M
- Thery C
- Timms K
- Tiwari S
- Tixeira R
- Tkach M
- Toh WS
- Tomasini R
- Torrecilhas AC
- Toxavidis V
- Urbanelli L
- Vader P
- van Balkom BWM
- van der Grein SG
- Van Deun J
- van Herwijnen MJC
- Van Keuren-Jensen K
- van Niel G
- van Royen ME
- van Wijnen AJ
- Vechetti IJ
- Veit TD
- Vella LJ
- Velot E
- Verweij FJ
- Vestad B
- Vinas JL
- Visnovitz T
- von Strandmann EP
- Vukman KV
- Wahlgren J
- Watson DC
- Wauben MHM
- Weaver A
- Webber JP
- Weber V
- Wehman AM
- Weiss DJ
- Welsh JA
- Wendt S
- Wheelock AM
- Wiener Z
- Witte L
- Witwer KW
- Wolfram J
- Xagorari A
- Xander P
- Xu J
- Yan X
- Yanez-Mo M
- Yin H
- Yuana Y
- Zappulli V
- Zarubova J
- Zavec AB
- Zekas V
- Zhang J-Y
- Zhao Z
- Zheng L
- Zheutlin AR
- Zickler AM
- Zimmermann P
- Zivkovic AM
- Zocco D
- Zuba-Surma EK
- Publication venue
- TAYLOR & FRANCIS LTD
- Publication date
- 23/11/2018
- Field of study
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points