142 research outputs found
Implications of the Fermi-LAT diffuse gamma-ray measurements on annihilating or decaying Dark Matter
We analyze the recently published Fermi-LAT diffuse gamma-ray measurements in
the context of leptonically annihilating or decaying dark matter (DM) with the
aim to explain simultaneously the isotropic diffuse gamma-ray and the PAMELA,
Fermi and HESS (PFH) anomalous data. Five different DM
annihilation/decay channels , , , , or (the latter
two via an intermediate light particle ) are generated with PYTHIA. We
calculate both the Galactic and extragalactic prompt and inverse Compton (IC)
contributions to the resulting gamma-ray spectra. To find the Galactic IC
spectra we use the interstellar radiation field model from the latest release
of GALPROP. For the extragalactic signal we show that the amplitude of the
prompt gamma-emission is very sensitive to the assumed model for the
extragalactic background light. For our Galaxy we use the Einasto, NFW and
Isothermal DM density profiles and include the effects of DM substructure
assuming a simple subhalo model. Our calculations show that for the
annihilating DM the extragalactic gamma-ray signal can dominate only if rather
extreme power-law concentration-mass relation is used, while more
realistic relations make the extragalactic component comparable or
subdominant to the Galactic signal. For the decaying DM the Galactic signal
always exceeds the extragalactic one. In the case of annihilating DM the PFH
favored parameters can be ruled out only if power-law relation is
assumed. For DM decaying into or the PFH favored DM parameters
are not in conflict with the Fermi gamma-ray data. We find that, due to the
(almost) featureless Galactic IC spectrum and the DM halo substructure,
annihilating DM may give a good simultaneous fit to the isotropic diffuse
gamma-ray and to the PFH data without being in clear conflict with the
other Fermi-LAT gamma-ray measurements.Comment: Accepted for publication in JCAP, added missing references, new Figs.
9 \& 10, 35 page
Precision Measurement of PArity Violation in Polarized Cold Neutron Capture on the Proton: the NPDGamma Experiment
The NPDGamma experiment at the Los Alamos Neutron Science Center (LANSCE) is
dedicated to measure with high precision the parity violating asymmetry in the
emission after capture of spin polarized cold neutrons in
para-hydrogen. The measurement will determine unambiguously the weak
pion-nucleon-nucleon () coupling constant {\it f}Comment: Proceedings of the PANIC'05 Conference, Santa Fe, NM, USA, October
24-28, 2005, 3 pages, 2 figure
Background model systematics for the Fermi GeV excess
The possible gamma-ray excess in the inner Galaxy and the Galactic center
(GC) suggested by Fermi-LAT observations has triggered a large number of
studies. It has been interpreted as a variety of different phenomena such as a
signal from WIMP dark matter annihilation, gamma-ray emission from a population
of millisecond pulsars, or emission from cosmic rays injected in a sequence of
burst-like events or continuously at the GC. We present the first comprehensive
study of model systematics coming from the Galactic diffuse emission in the
inner part of our Galaxy and their impact on the inferred properties of the
excess emission at Galactic latitudes and 300 MeV to 500
GeV. We study both theoretical and empirical model systematics, which we deduce
from a large range of Galactic diffuse emission models and a principal
component analysis of residuals in numerous test regions along the Galactic
plane. We show that the hypothesis of an extended spherical excess emission
with a uniform energy spectrum is compatible with the Fermi-LAT data in our
region of interest at CL. Assuming that this excess is the extended
counterpart of the one seen in the inner few degrees of the Galaxy, we derive a
lower limit of ( CL) on its extension away from the GC. We
show that, in light of the large correlated uncertainties that affect the
subtraction of the Galactic diffuse emission in the relevant regions, the
energy spectrum of the excess is equally compatible with both a simple broken
power-law of break energy GeV, and with spectra predicted by the
self-annihilation of dark matter, implying in the case of final
states a dark matter mass of GeV.Comment: 65 pages, 28 figures, 7 table
The unexpected resurgence of Weyl geometry in late 20-th century physics
Weyl's original scale geometry of 1918 ("purely infinitesimal geometry") was
withdrawn by its author from physical theorizing in the early 1920s. It had a
comeback in the last third of the 20th century in different contexts: scalar
tensor theories of gravity, foundations of gravity, foundations of quantum
mechanics, elementary particle physics, and cosmology. It seems that Weyl
geometry continues to offer an open research potential for the foundations of
physics even after the turn to the new millennium.Comment: Completely rewritten conference paper 'Beyond Einstein', Mainz Sep
2008. Preprint ELHC (Epistemology of the LHC) 2017-02, 92 pages, 1 figur
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10-11 to 5.0 × 10-21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10-6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation
Associations of autozygosity with a broad range of human phenotypes
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (F-ROH) for >1.4 million individuals, we show that F-ROH is significantly associated (p <0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: F-ROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of F-ROH are confirmed within full-sibling pairs, where the variation in F-ROH is independent of all environmental confounding.Peer reviewe
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
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