SARS-CoV-2 Vaccination in Solid-Organ Transplant Recipients

The coronavirus disease 2019 (COVID-19) pandemic has posed significant global challenges for solid organ transplant (SOT) recipients. Mortality rates of COVID-19 in this patient population remain high, despite new available therapeutic options and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccination. Priority access to SARS-CoV-2 vaccination for waitlisted candidates and for SOT patients and their family members is recommended since the advantage from vaccination reduces the risk of COVID-19-related complications. However, immunogenicity and efficacy of COVID-19 vaccines are lower in waitlisted candidates and SOT recipients than in the general population. Routine systematic assessment of humoral and cellular immune responses after SARS-CoV-2 vaccination is controversial, although highly recommended for investigation and improvement of knowledge. SOT recipients should continue to adhere to preventive protective measures despite vaccination and may undergo passive antibody prophylaxis. This article seeks to provide an update on SARS-CoV-2 vaccination and preventive measures in SOT recipients based on existing literature and international guidelines

Rankings for smart city dialogue? Opening up a critical scrutiny

Author's accepted version (postprint).This is an Accepted Manuscript of an article published by Emerald Publishing Limited inournal of Public Budgeting, Accounting and Financial Management on 27/01/2022.Available online: https://www.emerald.com/insight/content/doi/10.1108/JPBAFM-03-2021-0059/full/htmlacceptedVersio

Simple planar graph partition into three forests

AbstractWe describe a simple way of partitioning a planar graph into three edge-disjoint forests in O(n log n) time, where n is the number of its vertices. We can use this partition in Kannan et al.'s graph representation (1992) to label the planar graph vertices so that any two vertices' adjacency can be tested locally by comparing their names in constant time

Desarrollo y morfología del fruto y la semilla del género hemiparásito <i>Jodina</i> (Cervantesiaceae)

The monotypic genus Jodina is endemic to central and southeastern South America, common in forests and scrubland environments. The fruit type in Jodina is controversial since it has been described at different stages of development. The main objective of this work was to analyze the morphology of the fruit of J. rhombifolia during its maturation to attain a consensus about its type. Also characteristics of seed development and anatomy were analyzed in detail. Material was processed according to conventional techniques for LM and SEM studies. The fruit of J. rhombifolia is a pseudodrupe since the ovary is half-inferior; the fleshy layer of the pericarp is constituted by an increase of the nectary disk whereas the stony layer is represented by the mesocarp. Participation of the nectary disk as part of the fruit wall has not been mentioned previously. The seed is "naked" -the integument disintegrates during development- and the resulting structure is a pyrene. The interpretations made by other authors on the fruit of Jodina are also discussed.El género monotípico Jodina es endémico del centro y sureste de América central, común en bosques y ambientes de matorral. El tipo de fruto en Jodina es controvertido, ya que se ha descrito en diferentes etapas de su desarrollo. El principal objetivo de este trabajo fue analizar la morfología del fruto de J. rhombifolia durante su maduración para alcanzar un consenso sobre su tipo. Asimismo, se analizaron en detalle diferentes características del desarrollo y la anatomía de la semilla. El material se estudió de acuerdo con las técnicas convencionales utilizadas en estudios con MO y MEB. El fruto de J. rhombifolia es una pseudodrupa, dado que el ovario es semiínfero; la capa carnosa del pericarpio está constituida por un engrosamiento del disco y la capa dura está representada por el mesocarpio. La participación del disco como parte de la pared del fruto no se ha mencionado anteriormente. La semilla es “desnuda” —el tegumento se desintegra durante el desarrollo— y la estructura resultante es un pireno. Se discuten asimismo las interpretaciones realizadas por otros autores acerca del fruto de Jodina.Facultad de Ciencias Naturales y Muse

Desarrollo y morfología del fruto y la semilla del género hemiparásito <i>Jodina</i> (Cervantesiaceae)

The monotypic genus Jodina is endemic to central and southeastern South America, common in forests and scrubland environments. The fruit type in Jodina is controversial since it has been described at different stages of development. The main objective of this work was to analyze the morphology of the fruit of J. rhombifolia during its maturation to attain a consensus about its type. Also characteristics of seed development and anatomy were analyzed in detail. Material was processed according to conventional techniques for LM and SEM studies. The fruit of J. rhombifolia is a pseudodrupe since the ovary is half-inferior; the fleshy layer of the pericarp is constituted by an increase of the nectary disk whereas the stony layer is represented by the mesocarp. Participation of the nectary disk as part of the fruit wall has not been mentioned previously. The seed is "naked" -the integument disintegrates during development- and the resulting structure is a pyrene. The interpretations made by other authors on the fruit of Jodina are also discussed.El género monotípico Jodina es endémico del centro y sureste de América central, común en bosques y ambientes de matorral. El tipo de fruto en Jodina es controvertido, ya que se ha descrito en diferentes etapas de su desarrollo. El principal objetivo de este trabajo fue analizar la morfología del fruto de J. rhombifolia durante su maduración para alcanzar un consenso sobre su tipo. Asimismo, se analizaron en detalle diferentes características del desarrollo y la anatomía de la semilla. El material se estudió de acuerdo con las técnicas convencionales utilizadas en estudios con MO y MEB. El fruto de J. rhombifolia es una pseudodrupa, dado que el ovario es semiínfero; la capa carnosa del pericarpio está constituida por un engrosamiento del disco y la capa dura está representada por el mesocarpio. La participación del disco como parte de la pared del fruto no se ha mencionado anteriormente. La semilla es “desnuda” —el tegumento se desintegra durante el desarrollo— y la estructura resultante es un pireno. Se discuten asimismo las interpretaciones realizadas por otros autores acerca del fruto de Jodina.Facultad de Ciencias Naturales y Muse

PAHA study (Psychological active and healthy ageing): Psychological wellbeing, proactive attitude and happiness effects of whole-body vibration versus multi-component training in aged women: study protocol for a randomized controlled trial

Background Evidence demonstrates that physical exercise and psychological wellbeing are closely interlinked, particularly in older-aged women. However, research investigating how different forms of exercise influence mental health in older-aged women is underdeveloped. Methods/Design A randomized controlled trial (N = 300) will assess the relative effectiveness of two different exercise programs (whole-body vibration and Multicomponent Training) for improving psychological wellbeing in older-aged women. The following outcomes will be assessed at three time points (that is, pre, post, and follow-up): psychological wellbeing, proactive attitude, quality of life, and happiness. Discussion Results will have important implications for preventing psychological and physiological disease in older-aged women and for managing health-related costs for this population group.Actividad Física y Deport

Structural connectivity in a single case of progressive prosopagnosia: The role of the right inferior longitudinal fasciculus

Progressive prosopagnosia (PP) is a clinical syndrome characterized by a progressive and selective inability to recognize and identify faces of familiar people. Here we report a patient (G.S.) with PP, mainly related to a prominent deficit in recognition of familiar faces, without a semantic (cross-modal) impairment. An in-depth evaluation showed that his deficit extended to other classes of objects, both living and non-living. A follow-up neuropsychological assessment did not reveal substantial changes after about 1 year. Structural MRI showed predominant right temporal lobe atrophy. Diffusion tensor imaging was performed to elucidate structural connectivity of the inferior longitudinal fasciculus (ILF) and the inferior fronto-occipital fasciculus (IFOF), the two major tracts that project through the core fusiform region to the anterior temporal and frontal cortices, respectively. Right ILF was markedly reduced in G.S., while left ILF and IFOFs were apparently preserved. These data are in favour of a crucial role of the neural circuit subserved by right ILF in the pathogenesis of PP

Artificial neural networks allow the use of simultaneous measurements of Alzheimer Disease markers for early detection of the disease

BACKGROUND: Previous studies have shown that in platelets of mild Alzheimer Disease (AD) patients there are alterations of specific APP forms, paralleled by alteration in expression level of both ADAM 10 and BACE when compared to control subjects. Due to the poor linear relation among each key-element of beta-amyloid cascade and the target diagnosis, the use of systems able to afford non linear tasks, like artificial neural networks (ANNs), should allow a better discriminating capacity in comparison with classical statistics. OBJECTIVE: To evaluate the accuracy of ANNs in AD diagnosis. METHODS: 37 mild-AD patients and 25 control subjects were enrolled, and APP, ADM10 and BACE measures were performed. Fifteen different models of feed-forward and complex-recurrent ANNs (provided by Semeion Research Centre), based on different learning laws (back propagation, sine-net, bi-modal) were compared with the linear discriminant analysis (LDA). RESULTS: The best ANN model correctly identified mild AD patients in the 94% of cases and the control subjects in the 92%. The corresponding diagnostic performance obtained with LDA was 90% and 73%. CONCLUSION: This preliminary study suggests that the processing of biochemical tests related to beta-amyloid cascade with ANNs allows a very good discrimination of AD in early stages, higher than that obtainable with classical statistics methods

Desarrollo y morfología del fruto y la semilla del género hemiparásito <i>Jodina</i> (Cervantesiaceae)

The monotypic genus Jodina is endemic to central and southeastern South America, common in forests and scrubland environments. The fruit type in Jodina is controversial since it has been described at different stages of development. The main objective of this work was to analyze the morphology of the fruit of J. rhombifolia during its maturation to attain a consensus about its type. Also characteristics of seed development and anatomy were analyzed in detail. Material was processed according to conventional techniques for LM and SEM studies. The fruit of J. rhombifolia is a pseudodrupe since the ovary is half-inferior; the fleshy layer of the pericarp is constituted by an increase of the nectary disk whereas the stony layer is represented by the mesocarp. Participation of the nectary disk as part of the fruit wall has not been mentioned previously. The seed is "naked" -the integument disintegrates during development- and the resulting structure is a pyrene. The interpretations made by other authors on the fruit of Jodina are also discussed.El género monotípico Jodina es endémico del centro y sureste de América central, común en bosques y ambientes de matorral. El tipo de fruto en Jodina es controvertido, ya que se ha descrito en diferentes etapas de su desarrollo. El principal objetivo de este trabajo fue analizar la morfología del fruto de J. rhombifolia durante su maduración para alcanzar un consenso sobre su tipo. Asimismo, se analizaron en detalle diferentes características del desarrollo y la anatomía de la semilla. El material se estudió de acuerdo con las técnicas convencionales utilizadas en estudios con MO y MEB. El fruto de J. rhombifolia es una pseudodrupa, dado que el ovario es semiínfero; la capa carnosa del pericarpio está constituida por un engrosamiento del disco y la capa dura está representada por el mesocarpio. La participación del disco como parte de la pared del fruto no se ha mencionado anteriormente. La semilla es “desnuda” —el tegumento se desintegra durante el desarrollo— y la estructura resultante es un pireno. Se discuten asimismo las interpretaciones realizadas por otros autores acerca del fruto de Jodina.Facultad de Ciencias Naturales y Muse