Synthesis and in-vitro antimicrobial and antimutagenic activities of some novel 2-(2-hydroxybenzylideneamino)-5,7-dihydro-4hthieno[ 2,3-c]pyran-3-carbonitrile derivatives

In this investigation, a series of some novel 2-(2-hydroxybenzylideneamino)-5,7-dihydro-4Hthieno[ 2,3-c]pyran-3-carbonitriles (4a-f) have been synthesized. These substances have all been examined for antibacterial activities against pathogenic strains Listeria monocytogenes 4b, Staphylococcus aureus, Escherichia coli, Salmonella typhi H, Pseudomonas putida, Brucella abortus, Shigella dysenteriae.Thype 7, Staphylococcus epidermis, Micrococcus luteus, Bacillus cereus, Enterobacter aerogenes and antifungal activity against Candida albicans. Most of the studied compounds were found effective against bacteria and yeast. Compound 4f exhibited activity against Pseudomonas putida, Brucella abortus, Staphylococcus aureus, Candida albicans and 4c Brucella abortus, Staphylococcus epidermis comparable to standard antibiotics. In addition, the anti-genotoxic activity of these substances was evaluated by a micronucleus (MN) test. Among the synthesized compounds, 4c was found to have the most anti-mutagenic effect against AFB1. It was also found that different concentrations of these substances suppressed the mutagenic effects of Aflatoxin B1 (AFB1) in the MN test (however 10 µM is the most effective dose). It seems that the antimutagenic effects of these substances may originate from their antioxidant potency or reaction of the aflatoxine lactone carbonyl functional group

Search for supersymmetry in pp collisions at √s = 7 TeV in events with a single lepton, jets, and missing transverse momentum

Results are reported from a search for new physics processes in events containing a single isolated high-transverse-momentum lepton (electron or muon), energetic jets, and large missing transverse momentum. The analysis is based on a 4.98 fb-1 sample of proton-proton collisions at a center-of-mass energy of 7 TeV, obtained with the CMS detector at the LHC. Three separate background estimation methods, each relying primarily on control samples in the data, are applied to a range of signal regions, providing complementary approaches for estimating the background yields. The observed yields are consistent with the predicted standard model backgrounds. The results are interpreted in terms of limits on the parameter space for the constrained minimal supersymmetric extension of the standard model, as well as on cross sections for simplified models, which provide a generic description of the production and decay of new particles in specific, topology based final states. © 2013 CERN for the benefit of the CMS collaboration.0info:eu-repo/semantics/publishe

Measurement of dijet azimuthal decorrelation in pp collisions at √s=8TeV

A measurement of the decorrelation of azimuthal angles between the two jets with the largest transverse momenta is presented for seven regions of leading jet transverse momentum up to 2.2TeV. The analysis is based on the proton-proton collision data collected with the CMS experiment at a centre-of-mass energy of 8TeV corresponding to an integrated luminosity of 19.7fb-1. The dijet azimuthal decorrelation is caused by the radiation of additional jets and probes the dynamics of multijet production. The results are compared to fixed-order predictions of perturbative quantum chromodynamics (QCD), and to simulations using Monte Carlo event generators that include parton showers, hadronization, and multiparton interactions. Event generators with only two outgoing high transverse momentum partons fail to describe the measurement, even when supplemented with next-to-leading-order QCD corrections and parton showers. Much better agreement is achieved when at least three outgoing partons are complemented through either next-to-leading-order predictions or parton showers. This observation emphasizes the need to improve predictions for multijet production. © 2016, CERN for the benefit of the CMS collaboration