72 research outputs found
Mass Renormalization in the Su-Schrieffer-Heeger Model
This study of the one dimensional Su-Schrieffer-Heeger model in a weak
coupling perturbative regime points out the effective mass behavior as a
function of the adiabatic parameter , is the
zone boundary phonon energy and is the electron band hopping integral.
Computation of low order diagrams shows that two phonons scattering processes
become appreciable in the intermediate regime in which zone boundary phonons
energetically compete with band electrons. Consistently, in the intermediate
(and also moderately antiadiabatic) range the relevant mass renormalization
signals the onset of a polaronic crossover whereas the electrons are
essentially undressed in the fully adiabatic and antiadiabatic systems. The
effective mass is roughly twice as much the bare band value in the intermediate
regime while an abrupt increase (mainly related to the peculiar 1D dispersion
relations) is obtained at .Comment: To be published in Phys.Rev.B - 3 figure
Lattice dynamics effects on small polaron properties
This study details the conditions under which strong-coupling perturbation
theory can be applied to the molecular crystal model, a fundamental theoretical
tool for analysis of the polaron properties. I show that lattice dimensionality
and intermolecular forces play a key role in imposing constraints on the
applicability of the perturbative approach. The polaron effective mass has been
computed in different regimes ranging from the fully antiadiabatic to the fully
adiabatic. The polaron masses become essentially dimension independent for
sufficiently strong intermolecular coupling strengths and converge to much
lower values than those tradition-ally obtained in small-polaron theory. I find
evidence for a self-trapping transition in a moderately adiabatic regime at an
electron-phonon coupling value of .3. Our results point to a substantial
independence of the self-trapping event on dimensionality.Comment: 8 pages, 5 figure
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk
Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020
We show the distribution of SARS-CoV-2 genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three available genomic nomenclature systems for SARS-CoV-2 to all sequence data from the WHO European Region available during the COVID-19 pandemic until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation. We provide a comparison of the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.Peer reviewe
Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry
Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase
Clinical features of Legionnaires’ disease at three Belgian university hospitals, a retrospective study
info:eu-repo/semantics/publishe
Emission of forward neutrons by 158A GeV indium nuclei in collisions with Al, Cu, Sn and Pb
The cross sections of forward emission of one, two and three neutrons by 158A
GeV 115In nuclei in collisions with Al, Cu, Sn and Pb targets are reported. The
measurements were performed in the framework of the ALICE-LUMI experiment at
the SPS facility at CERN. Various corrections accounting for the absorption of
beam nuclei and produced neutrons in target material and surrounding air were
introduced. The corrected cross section data are compared with the predictions
of the RELDIS model for electromagnetic fragmentation of 115In in
ultraperipheral collisions, as well as with the results of the
abrasion-ablation model for neutron emission in hadronic interactions. The
measured neutron emission cross sections well agree with the RELDIS results,
with the exception of In-Al collisions where the measured cross sections are
larger compared to RELDIS. This is attributed to a relatively large
contribution of hadronic fragmentation of In on Al target with respect to
electromagnetic fragmentation, on the contrary to similar measurements
performed earlier with 30A GeV 208Pb colliding with Al.Comment: 14 pages, 9 figures, 11 tables: updates to the paper structure, typos
fixed in version
Inhibition of biofilm formation by Camelid single-domain antibodies against the flagellum of Pseudomonas aeruginosa
Reprint of “Inhibition of biofilm formation by Camelid single-domain antibodies against the flagellum of Pseudomonas aeruginosa”
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