43 research outputs found
Stellar structure and compact objects before 1940: Towards relativistic astrophysics
Since the mid-1920s, different strands of research used stars as "physics
laboratories" for investigating the nature of matter under extreme densities
and pressures, impossible to realize on Earth. To trace this process this paper
is following the evolution of the concept of a dense core in stars, which was
important both for an understanding of stellar evolution and as a testing
ground for the fast-evolving field of nuclear physics. In spite of the divide
between physicists and astrophysicists, some key actors working in the
cross-fertilized soil of overlapping but different scientific cultures
formulated models and tentative theories that gradually evolved into more
realistic and structured astrophysical objects. These investigations culminated
in the first contact with general relativity in 1939, when J. Robert
Oppenheimer and his students George Volkoff and Hartland Snyder systematically
applied the theory to the dense core of a collapsing neutron star. This
pioneering application of Einstein's theory to an astrophysical compact object
can be regarded as a milestone in the path eventually leading to the emergence
of relativistic astrophysics in the early 1960s.Comment: 83 pages, 4 figures, submitted to the European Physical Journal
Influência das coletas sistemáticas e parciais na seleção de codornas por meio de curvas de probabilidade de postura
Prominence seismology using small amplitude oscillations
Quiescent prominences are thin slabs of cold, dense plasma embedded in the
much hotter and rarer solar corona. Although their global shape is rather
irregular, they are often characterised by an internal structure consisting of
a large number of thin, parallel threads piled together. Prominences often
display periodic disturbances mostly observed in the Doppler displacement of
spectral lines and with an amplitude typically of the order of or smaller than
2--3 km s, a value which seems to be much smaller than the
characteristic speeds of the prominence plasma (namely the Alfv\'en and sound
velocities). Two particular features of these small amplitude prominence
oscillations is that they seem to damp in a few periods and that they seem not
to affect the whole prominence structure. In addition, in high spatial
resolution observations, in which threads can be discerned, small amplitude
oscillations appear to be clearly associated to these fine structure
constituents. Prominence seismology tries to bring together the results from
these observations (e.g. periods, wavelengths, damping times) and their
theoretical modeling (by means of the magnetohydrodynamic theory) to gain
insight into physical properties of prominences that cannot be derived from
direct observation. In this paper we discuss works that have not been described
in previous reviews, namely the first seismological application to solar
prominences and theoretical advances on the attenuation of prominence
oscillations
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.
BACKGROUND: Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk. METHOD: We performed a fine-scale mapping study of a 700 kb region including 441 genotyped and more than 1300 imputed genetic variants in 48,155 cases and 43,612 controls of European descent, 6269 cases and 6624 controls of East Asian descent and 1116 cases and 932 controls of African descent in the Breast Cancer Association Consortium (BCAC; http://bcac.ccge.medschl.cam.ac.uk/ ), and in 15,252 BRCA1 mutation carriers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Stepwise regression analyses were performed to identify independent association signals. Data from the Encyclopedia of DNA Elements project (ENCODE) and the Cancer Genome Atlas (TCGA) were used for functional annotation. RESULTS: Analysis of data from European descendants found evidence for four independent association signals at 12p11, represented by rs7297051 (odds ratio (OR) = 1.09, 95 % confidence interval (CI) = 1.06-1.12; P = 3 × 10(-9)), rs805510 (OR = 1.08, 95 % CI = 1.04-1.12, P = 2 × 10(-5)), and rs1871152 (OR = 1.04, 95 % CI = 1.02-1.06; P = 2 × 10(-4)) identified in the general populations, and rs113824616 (P = 7 × 10(-5)) identified in the meta-analysis of BCAC ER-negative cases and BRCA1 mutation carriers. SNPs rs7297051, rs805510 and rs113824616 were also associated with breast cancer risk at P < 0.05 in East Asians, but none of the associations were statistically significant in African descendants. Multiple candidate functional variants are located in putative enhancer sequences. Chromatin interaction data suggested that PTHLH was the likely target gene of these enhancers. Of the six variants with the strongest evidence of potential functionality, rs11049453 was statistically significantly associated with the expression of PTHLH and its nearby gene CCDC91 at P < 0.05. CONCLUSION: This study identified four independent association signals at 12p11 and revealed potentially functional variants, providing additional insights into the underlying biological mechanism(s) for the association observed between variants at 12p11 and breast cancer risk.UK funding includes Cancer Research UK and NIH.This is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1186/s13058-016-0718-
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers