399 research outputs found
Men’s Physical Activity and Sleep Following a Workplace Health Intervention: Findings from the POWERPLAY STEP Up challenge
The workplace provides an important delivery point for health promotion, yet many programs fail to engage men. A gender-sensitive 8-week team challenge-based intervention targeting increased physical activity was delivered at a petrochemical worksite. The purpose of this study was to examine men’s pre–post physical activity and sleep following the intervention, as well as to explore program acceptability and gather men’s recommendations for health promotion. Pre–post surveys assessed physical activity, sleep, program exposure, acceptability, and suggestions for continued support. Overall, 328 men completed baseline surveys and 186 (57%) completed follow-up surveys. Walking increased by 156.5 min/week, 95% confidence interval (61.2, 251.8), p = .001. Men with higher program exposure increased moderate and vigorous activity 49.4 min more than those with low exposure (p = .026). Sleep duration and quality were higher postintervention, though changes were modest. Program acceptability was high as was intention to maintain physical activity. Men’s suggestions to enable physical activity involved workplace practices/resources, reducing workload, and leadership support. These findings suggest that a gender-sensitive physical activity workplace intervention showed promise for improving physical activity and sleep among men. The men’s suggestions reflected workplace health promotion strategies, reinforcing the need for employers to support ongoing health promotion efforts
A phenomenological model of the superconducting state of the Bechgaard salts
We present a group theoretical analysis of the superconducting state of the
Bechgaard salts, e.g., (TMTSF)_2PF_6 or (TMTSF)_2ClO_6. We show that there are
eight symmetry distinct superconducting states. Of these only the (fully
gapped, even frequency, p-wave, triplet) 'polar state' is consistent with the
full range of the experiments on the Bechgaard salts. The gap of the polar
state is d(k) (psi_uk,0,0), where psi_uk may be any odd parity function that is
translationally invariant.Comment: 4 pages, no figure
The Molecular Clockwork of the Fire Ant Solenopsis invicta
This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication
Bond operator theory of doped antiferromagnets: from Mott insulators with bond-centered charge order, to superconductors with nodal fermions
The ground states and excitations of two-dimensional insulating and doped
Mott insulators are described by a bond operator formalism. While the method
represents the degrees of freedom of an arbitrary antiferromagnet exactly, it
is especially suited to systems in which there is a natural pairing of sites
into bonds, as in states with spontaneous or explicit spin-Peierls order (or
bond-centered charge order). In the undoped insulator, as discussed previously,
we obtain both paramagnetic and magnetically-ordered states. We describe the
evolution of superconducting order in the ground state with increasing
doping--at low doping, the superconductivity is weak, can co-exist with
magnetic order, and there are no gapless spin 1/2 fermionic excitations; at
high doping, the magnetic order is absent and we obtain a BCS d-wave
superconductor with gapless spin 1/2, nodal fermions. We present the critical
theory describing the onset of these nodal fermionic excitations. We discuss
the evolution of the spin spectrum, and obtain regimes where a spin 1 exciton
contributes a sharp resonance in the dynamic spin susceptiblity. We also
discuss the experimental consequences of low-energy, dynamically fluctuating,
spin-Peierls order in an isotropic CuO_2 plane--we compute consequences for the
damping and dispersion of an optical phonon involving primarily the O ions, and
compare the results with recent neutron scattering measurements of phonon
spectra.Comment: 16 pages + 14 pages of appendices, 18 figures; (v3) expanded
discussion of theory and experimental implications; (v4) Removed some
introductory review discussion and moved it to cond-mat/010823
The Kuiper Belt and Other Debris Disks
We discuss the current knowledge of the Solar system, focusing on bodies in
the outer regions, on the information they provide concerning Solar system
formation, and on the possible relationships that may exist between our system
and the debris disks of other stars. Beyond the domains of the Terrestrial and
giant planets, the comets in the Kuiper belt and the Oort cloud preserve some
of our most pristine materials. The Kuiper belt, in particular, is a
collisional dust source and a scientific bridge to the dusty "debris disks"
observed around many nearby main-sequence stars. Study of the Solar system
provides a level of detail that we cannot discern in the distant disks while
observations of the disks may help to set the Solar system in proper context.Comment: 50 pages, 25 Figures. To appear in conference proceedings book
"Astrophysics in the Next Decade
A New Hybrid N-Body-Coagulation Code for the Formation of Gas Giant Planets
We describe an updated version of our hybrid N-body-coagulation code for
planet formation. In addition to the features of our 2006-2008 code, our
treatment now includes algorithms for the 1D evolution of the viscous disk, the
accretion of small particles in planetary atmospheres, gas accretion onto
massive cores, and the response of N-bodies to the gravitational potential of
the gaseous disk and the swarm of planetesimals. To validate the N-body portion
of the algorithm, we use a battery of tests in planetary dynamics. As a first
application of the complete code, we consider the evolution of Pluto-mass
planetesimals in a swarm of 0.1-1 cm pebbles. In a typical evolution time of
1-3 Myr, our calculations transform 0.01-0.1 solar mass disks of gas and dust
into planetary systems containing super-Earths, Saturns, and Jupiters. Low mass
planets form more often than massive planets; disks with smaller alpha form
more massive planets than disks with larger alpha. For Jupiter-mass planets,
masses of solid cores are 10-100 Earth masses.Comment: revised version; 52 pages, 1 table, 19 figures; accepted in Ap
Genetic Abolishment of Hepatocyte Proliferation Activates Hepatic Stem Cells
Quiescent hepatic stem cells (HSCs) can be activated when hepatocyte proliferation is compromised. Chemical injury rodent models have been widely used to study the localization, biomarkers, and signaling pathways in HSCs, but these models usually exhibit severe promiscuous toxicity and fail to distinguish damaged and non-damaged cells. Our goal is to establish new animal models to overcome these limitations, thereby providing new insights into HSC biology and application. We generated mutant mice with constitutive or inducible deletion of Damaged DNA Binding protein 1 (DDB1), an E3 ubiquitin ligase, in hepatocytes. We characterized the molecular mechanism underlying the compensatory activation and the properties of oval cells (OCs) by methods of mouse genetics, immuno-staining, cell transplantation and gene expression profiling. We show that deletion of DDB1 abolishes self-renewal capacity of mouse hepatocytes in vivo, leading to compensatory activation and proliferation of DDB1-expressing OCs. Partially restoring proliferation of DDB1-deficient hepatocytes by ablation of p21, a substrate of DDB1 E3 ligase, alleviates OC proliferation. Purified OCs express both hepatocyte and cholangiocyte markers, form colonies in vitro, and differentiate to hepatocytes after transplantation. Importantly, the DDB1 mutant mice exhibit very minor liver damage, compared to a chemical injury model. Microarray analysis reveals several previously unrecognized markers, including Reelin, enriched in oval cells. Here we report a genetic model in which irreversible inhibition of hepatocyte duplication results in HSC-driven liver regeneration. The DDB1 mutant mice can be broadly applied to studies of HSC differentiation, HSC niche and HSCs as origin of liver cancer
Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability
The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-PTSD) combined genome-wide case-control molecular genetic data across 11 multiethnic studies to quantify PTSD heritability, to examine potential shared genetic risk with schizophrenia, bipolar disorder, and major depressive disorder and to identify risk loci for PTSD. Examining 20 730 individuals, we report a molecular genetics-based heritability estimate (h 2 SNP) for European-American females of 29% that is similar to h 2 SNP for schizophrenia and is substantially higher than h 2 SNP in European-American males (estimate not distinguishable from zero). We found strong evidence of overlapping genetic risk between PTSD and schizophrenia along with more modest evidence of overlap with bipolar and major depressive disorder. No single-nucleotide polymorphisms (SNPs) exceeded genome-wide significance in the transethnic (overall) meta-analysis and we do not replicate previously reported associations. Still, SNP-level summary statistics made available here afford the best-available molecular genetic index of PTSD - for both European- and African-American individuals - and can be used in polygenic risk prediction and genetic correlation studies of diverse phenotypes. Publication of summary statistics for 1/410 000 African Americans contributes to the broader goal of increased ancestral diversity in genomic data resources. In sum, the results demonstrate genetic influences on the development of PTSD, identify shared genetic risk between PTSD and other psychiatric disorders and highlight the importance of multiethnic/racial samples. As has been the case with schizophrenia and other complex genetic disorders, larger sample sizes are needed to identify specific risk loci
A molecular roadmap of the AGM region reveals BMP ER as a novel regulator of HSC maturation
In the developing embryo, hematopoietic stem cells (HSCs) emerge from the aorta-gonad-mesonephros (AGM) region, but the molecular regulation of this process is poorly understood. Recently, the progression from E9.5 to E10.5 and polarity along the dorso-ventral axis have been identified as clear demarcations of the supportive HSC niche. To identify novel secreted regulators of HSC maturation, we performed RNA sequencing over these spatiotemporal transitions in the AGM region and supportive OP9 cell line. Screening several proteins through an ex vivo reaggregate culture system, we identify BMP ER as a novel positive regulator of HSC development. We demonstrate that BMP ER is associated with BMP signaling inhibition, but is transcriptionally induced by BMP4, suggesting that BMP ER contributes to the precise control of BMP activity within the AGM region, enabling the maturation of HSCs within a BMP-negative environment. These findings and the availability of our transcriptional data through an accessible interface should provide insight into the maintenance and potential derivation of HSCs in culture.Peer reviewe
A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder
Background: The nature and underlying mechanisms of the observed increased vulnerability to posttraumatic stress disorder (PTSD) in women are unclear. Methods: We investigated the genetic overlap of PTSD with anthropometric traits and reproductive behaviors and functions in women. The analysis was conducted using female-specific summary statistics from large genome-wide association studies (GWAS) and a cohort of 3577 European American women (966 PTSD cases and 2611 trauma-exposed controls). We applied a high-resolution polygenic score approach and Mendelian randomization analysis to investigate genetic correlations and causal relationships. Results: We observed an inverse association of PTSD with genetically determined anthropometric traits related to body shape, independent of body mass index (BMI). The top association was related to BMI-adjusted waist circumference (WCadj; R = -0.079, P < 0.001, Q = 0.011). We estimated a relative decrease of 64.6% (95% confidence interval = 27.5-82.7) in the risk of PTSD per 1-SD increase in WCadj. MR-Egger regression intercept analysis showed no evidence of pleiotropic effects in this association (Ppleiotropy = 0.979). We also observed associations of genetically determined WCadj with age at first sexual intercourse and number of sexual partners (P = 0.013 and P < 0.001, respectively). Conclusions: There is a putative causal relationship between genetically determined female body shape and PTSD, which could be mediated by evolutionary mechanisms involved in human sexual behaviors
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