Digital platforms as a factor in strengthening national food security

Ensuring food security is one of the key areas in the management of economic security. Today, Russia's food security is sufficiently strengthened. However, a reasonable question arises about the promising directions of its development. The article explores the possibility of using digital platforms to improve the efficiency of national food security management. It is established that currently many countries of the world are betting on increasing the level of self-sufficiency in food as a fundamental condition for ensuring national food security. At the same time, the importance of criteria such as food quality and compliance of the domestic food market with the requirements of healthy nutrition is rapidly increasing. Using the example of the dairy market, it is shown that the Russian food market is quite stable and is characterized by the predominance of domestic production over imports in resources. There is an increase in exports. At the same time, there are no signs of active import substitution, the growth of domestic consumption lags behind the growth of production. To solve the current problems of food security, it is proposed to implement digital platforms in the agro-industrial complex at the stages of production of agricultural raw materials, its processing, consumption control and implementation of social policy to support the nutrition of socially vulnerable segments of the population. The use of digital platforms is aimed at improving the efficiency of national food security management

Tumor suppressor function of the SEMA3B gene in human lung and renal cancers

The SEMA3B gene is located in the 3p21.3 LUCA region, which is frequently affected in different types of cancer. The objective of our study was to expand our knowledge of the SEMA3B gene as a tumor suppressor and the mechanisms of its inactivation. In this study, several experimental approaches were used: tumor growth analyses and apoptosis assays in vitro and in SCID mice, expression and methylation assays and other. With the use of the small cell lung cancer cell line U2020 we confirmed the function of SEMA3B as a tumor suppressor, and showed that the suppression can be realized through the induction of apoptosis and, possibly, associated with the inhibition of angiogenesis. In addition, for the first time, high methylation frequencies have been observed in both intronic (32-39%) and promoter (44-52%) CpG-islands in 38 non-small cell lung carcinomas, including 16 squamous cell carcinomas (SCC) and 22 adenocarcinomas (ADC), and in 83 clear cell renal cell carcinomas (ccRCC). Correlations between the methylation frequencies of the promoter and the intronic CpG-islands of SEMA3B with tumor stage and grade have been revealed for SCC, ADC and ccRCC. The association between the decrease of the SEMA3B mRNA level and hypermethylation of the promoter and the intronic CpG-islands has been estimated in renal primary tumors (P < 0.01). Using qPCR, we observed on the average 10- and 14-fold decrease of the SEMA3B mRNA level in SCC and ADC, respectively, and a 4-fold decrease in ccRCC. The frequency of this effect was high in both lung (92-95%) and renal (84%) tumor samples. Moreover, we showed a clear difference (P < 0.05) of the SEMA3B relative mRNA levels in ADC with and without lymph node metastases. We conclude that aberrant expression and methylation of SEMA3B could be suggested as markers of lung and renal cancer progression

Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV

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