What a pity, Pepper! How warmth in robot's language impacts reactions to errors during a collaborative task

Hoffmann L, Derksen M, Kopp S. What a pity, Pepper! How warmth in robot's language impacts reactions to errors during a collaborative task. In: HRI '20 Companion. ACM; 2020

Virtuelles Training in der Krankenpflege: Erste Erfahrungen mit Ultra-mobilen Head-Mounted-Displays

Derksen M, Zhang L, Schäfer M, Schröder D, Pfeiffer T. Virtuelles Training in der Krankenpflege: Erste Erfahrungen mit Ultra-mobilen Head-Mounted-Displays. In: Pfeiffer T, Fröhlich J, Kruse R, eds. Virtuelle und Erweiterte Realität - 13. Workshop der GI-Fachgruppe VR/AR. Berichte aus der Informatik. Aachen: Shaker Verlag; 2016: 137-144.In einem kooperativen Lehrprojekt zwischen Fachhochschule und Universität wurde ein immersives Trainingsprogramm für das Head-Mounted-Display (HMD) Samsung Gear VR entwickelt. Anwendungsbeispiel ist die Vorbereitung einer Infusion, wie sie im Rahmen der Lehre für die Pflege geschult wird. Motivatoren sind Einsparungen von Kosten, sowie das Bereitstellen von flexiblen, selbstgesteuerten Trainingsformen für die berufsbegleitende Ausbildung. Das Paper beschreibt einen ersten funktionalen Prototypen, der die Machbarkeit demonstriert, und zeigt anhand einer Nutzerstudie, dass die Technologie von der Zielgruppe akzeptiert wird

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

State of the climate in 2018

In 2018, the dominant greenhouse gases released into Earth’s atmosphere—carbon dioxide, methane, and nitrous oxide—continued their increase. The annual global average carbon dioxide concentration at Earth’s surface was 407.4 ± 0.1 ppm, the highest in the modern instrumental record and in ice core records dating back 800 000 years. Combined, greenhouse gases and several halogenated gases contribute just over 3 W m−2 to radiative forcing and represent a nearly 43% increase since 1990. Carbon dioxide is responsible for about 65% of this radiative forcing. With a weak La Niña in early 2018 transitioning to a weak El Niño by the year’s end, the global surface (land and ocean) temperature was the fourth highest on record, with only 2015 through 2017 being warmer. Several European countries reported record high annual temperatures. There were also more high, and fewer low, temperature extremes than in nearly all of the 68-year extremes record. Madagascar recorded a record daily temperature of 40.5°C in Morondava in March, while South Korea set its record high of 41.0°C in August in Hongcheon. Nawabshah, Pakistan, recorded its highest temperature of 50.2°C, which may be a new daily world record for April. Globally, the annual lower troposphere temperature was third to seventh highest, depending on the dataset analyzed. The lower stratospheric temperature was approximately fifth lowest. The 2018 Arctic land surface temperature was 1.2°C above the 1981–2010 average, tying for third highest in the 118-year record, following 2016 and 2017. June’s Arctic snow cover extent was almost half of what it was 35 years ago. Across Greenland, however, regional summer temperatures were generally below or near average. Additionally, a satellite survey of 47 glaciers in Greenland indicated a net increase in area for the first time since records began in 1999. Increasing permafrost temperatures were reported at most observation sites in the Arctic, with the overall increase of 0.1°–0.2°C between 2017 and 2018 being comparable to the highest rate of warming ever observed in the region. On 17 March, Arctic sea ice extent marked the second smallest annual maximum in the 38-year record, larger than only 2017. The minimum extent in 2018 was reached on 19 September and again on 23 September, tying 2008 and 2010 for the sixth lowest extent on record. The 23 September date tied 1997 as the latest sea ice minimum date on record. First-year ice now dominates the ice cover, comprising 77% of the March 2018 ice pack compared to 55% during the 1980s. Because thinner, younger ice is more vulnerable to melting out in summer, this shift in sea ice age has contributed to the decreasing trend in minimum ice extent. Regionally, Bering Sea ice extent was at record lows for almost the entire 2017/18 ice season. For the Antarctic continent as a whole, 2018 was warmer than average. On the highest points of the Antarctic Plateau, the automatic weather station Relay (74°S) broke or tied six monthly temperature records throughout the year, with August breaking its record by nearly 8°C. However, cool conditions in the western Bellingshausen Sea and Amundsen Sea sector contributed to a low melt season overall for 2017/18. High SSTs contributed to low summer sea ice extent in the Ross and Weddell Seas in 2018, underpinning the second lowest Antarctic summer minimum sea ice extent on record. Despite conducive conditions for its formation, the ozone hole at its maximum extent in September was near the 2000–18 mean, likely due to an ongoing slow decline in stratospheric chlorine monoxide concentration. Across the oceans, globally averaged SST decreased slightly since the record El Niño year of 2016 but was still far above the climatological mean. On average, SST is increasing at a rate of 0.10° ± 0.01°C decade−1 since 1950. The warming appeared largest in the tropical Indian Ocean and smallest in the North Pacific. The deeper ocean continues to warm year after year. For the seventh consecutive year, global annual mean sea level became the highest in the 26-year record, rising to 81 mm above the 1993 average. As anticipated in a warming climate, the hydrological cycle over the ocean is accelerating: dry regions are becoming drier and wet regions rainier. Closer to the equator, 95 named tropical storms were observed during 2018, well above the 1981–2010 average of 82. Eleven tropical cyclones reached Saffir–Simpson scale Category 5 intensity. North Atlantic Major Hurricane Michael’s landfall intensity of 140 kt was the fourth strongest for any continental U.S. hurricane landfall in the 168-year record. Michael caused more than 30 fatalities and $25 billion (U.S. dollars) in damages. In the western North Pacific, Super Typhoon Mangkhut led to 160 fatalities and$6 billion (U.S. dollars) in damages across the Philippines, Hong Kong, Macau, mainland China, Guam, and the Northern Mariana Islands. Tropical Storm Son-Tinh was responsible for 170 fatalities in Vietnam and Laos. Nearly all the islands of Micronesia experienced at least moderate impacts from various tropical cyclones. Across land, many areas around the globe received copious precipitation, notable at different time scales. Rodrigues and Réunion Island near southern Africa each reported their third wettest year on record. In Hawaii, 1262 mm precipitation at Waipā Gardens (Kauai) on 14–15 April set a new U.S. record for 24-h precipitation. In Brazil, the city of Belo Horizonte received nearly 75 mm of rain in just 20 minutes, nearly half its monthly average. Globally, fire activity during 2018 was the lowest since the start of the record in 1997, with a combined burned area of about 500 million hectares. This reinforced the long-term downward trend in fire emissions driven by changes in land use in frequently burning savannas. However, wildfires burned 3.5 million hectares across the United States, well above the 2000–10 average of 2.7 million hectares. Combined, U.S. wildfire damages for the 2017 and 2018 wildfire seasons exceeded $40 billion (U.S. dollars)

D'Or : Notes on Collaboration

This catalogue contains essays and images related to exhibitions presented at the Or Gallery in 2002. Includes 16 texts, covering a wide range of issues in relation to selected artists' projects (the majority of which are collaborative in nature). Biographical notes. 49 bibl. ref

Comparative study of five antiepileptic drugs on a translational cognitive measure in the rat: relationship to antiepileptic property.

International audienceRATIONALE: Antiepileptic drugs (AEDs) have been available for many years; yet, new members of this class continue to be identified and developed due to the limitations of existing drugs, which include a propensity for cognitive impairment. However, there is little preclinical information about the cognitive effects they produce, which clinically include deficits in attention and slowing of reaction time. OBJECTIVES: The purpose of this study was to profile two first-generation AEDs, phenytoin and valproate, and three second-generation AEDs, levetiracetam, pregabalin and lacosamide. Initially, each drug was examined across a range of well characterised preclinical seizure tests, and then each drug was evaluated in the five-choice serial reaction time test (5-CSRTT) based on efficacious doses from the seizure tests. MATERIALS AND METHODS: Each AED was tested for anti-seizure efficacy in either (1) the maximal electroshock seizure test, (2) s.c. PTZ seizure test, (3) amygdala-kindled seizures and (4) the genetic absence epilepsy rat of Strasbourg model of absence seizures. On completion of these studies, each drug was tested in rats trained to asymptotic performance in the 5-CSRTT (0.5 s SD, 5 s ITI, 100 trials). Male rats were used in all studies. RESULTS: Each AED was active in at least one of the seizure tests, although only valproate was active in each test. In the 5-CSRT test, all drugs with the exception of levetiracetam, significantly slowed reaction time and increased omissions. Variable effects were seen on accuracy. The effect on omissions was reversed by increasing stimulus duration from 0.5 to 5 s, supporting a drug-induced attention deficit. Levetiracetam had no negative effect on performance; indeed, reaction time was slightly increased (i.e. faster). CONCLUSIONS: These results highlight somewhat similar effects of phenytoin, valproate, pregabalin and lacosamide on attention and reaction time, and comparison to efficacious doses from the seizure tests support the view that there may be a better separation with the newer AEDs. Levetiracetam had no detrimental effect in the 5-CSRTT, which may be consistent with clinical experience where the drug is considered to be well tolerated amongst the AED class

Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma

Inappropriate activation of MET, the receptor tyrosine kinase for hepatocyte growth factor (HGF), has been implicated in tumorigenesis. Although we have previously shown that HGF/MET signaling controls survival and proliferation of multiple myeloma (MM), its role in the pathogenesis of other B-cell malignancies has remained largely unexplored. Here, we have examined a panel of 110 B-cell malignancies for MET expression, which, apart from MM (48%), was found to be largely confined to diffuse large B-cell lymphomas (DLBCLs) (30%). No amplification of the MET gene was found; however, mutational analysis revealed 2 germ-line missense mutations: R1166Q in the tyrosine kinase domain in 1 patient, and R988C in the juxtamembrane domain in 4 patients. The R988C mutation has recently been shown to enhance tumorigenesis. In MET-positive DLBCL cells, HGF induces MEK-dependent activation of ERK and PI3K-dependent phosphorylation of PKB, GSK3, and FOXO3a. Furthermore, HGF induces PI3K-dependent alpha4beta1 integrin-mediated adhesion to VCAM-1 and fibronectin. Within the tumor microenvironment of DLBCL, HGF is provided by macrophages, whereas DLBCL cells themselves produce the serine protease HGF activator (HGFA), which autocatalyzes HGF activation. Taken together, these data indicate that HGF/MET signaling, and secretion of HGFA by DLBCL cells, contributes to lymphomagenesis in DLBC

Virtual Reality Based Access to Knowledge Graphs for History Research

Becker J, Botsch M, Cimiano P, et al. Virtual Reality Based Access to Knowledge Graphs for History Research. In: Acosta M, Peroni S, Vahdati S, Gentile A-L, Pellegrini T, Kalo J-C, eds. Knowledge Graphs: Semantics, Machine Learning, and Languages. Proceedings of the 19th International Conference on Semantic Systems, 20–22 September 2023, Leipzig, Germany. Studies on the Semantic Web. IOS Press; 2023.Purpose: Knowledge graphs have so far been intensively used in the cultural heritage domain. Current interaction paradigms and interfaces however are often limited to textual representations or 2D visualizations, not taking into account the 4D nature of data. In digital history in particular, where events as well as geographical and temporal relationships play an important role, exploration paradigms that take into account the 4D nature of event-related data are important, as they have the potential to support historians in generating new knowledge and discovering new relationships. In this paper, we explore the potential of virtual reality as a paradigm allowing digital humanities researchers, historians in particular, to explore a semantic 4D space defined by knowledge graphs from an egocentric perspective. Methodology: We present eTaRDiS: a virtual reality based tool supporting immersive exploration of knowledge graphs. We evaluate the tool in the context of a task in which historians and laypersons with a history background explore DBpedia and Wikidata. We report results of a study involving 13 subjects that interacted with the data in eTaRDiS in the context of a specific task, in order to gain insights regarding the interaction patterns of users with our system. The usability of the tool was evaluated using a questionnaire including questions from the System Usability Scale (SUS) in addition to task-specific questions. Findings: The usability evaluation showed that our tool achieved an overall SUS score of 71.92, corresponding to a ‘satisfactory’ rating. While the mean score reached with laypersons with a history background was quite high with 76.0, corresponding to a rating of ‘excellent’, the score for historians was lower with 69.4, corresponding to a ‘sufficient to satisfactory’ rating. A qualitative analysis of the interaction data revealed that participants quickly identified the relevant information in the tasks using a variety of strategies and taking advantage of the features provided in eTaRDiS. Value: eTaRDiS is to our knowledge the first virtual reality based exploration tool supporting the exploration of knowledge graphs. The findings of the usability evaluation and the qualitative analysis of exploration patterns show that the system could potentially be a valuable tool for allowing digital humanities researchers to explore knowledge graphs as a way to discover new relationships between historical events and persons of interest