Consistent responses of soil microbial taxonomic and functional attributes to mercury pollution across China

Background: The ecological consequences of mercury (Hg) pollution—one of the major pollutants worldwide—on microbial taxonomic and functional attributes remain poorly understood and largely unexplored. Using soils from two typical Hg-impacted regions across China, here, we evaluated the role of Hg pollution in regulating bacterial abundance, diversity, and co-occurrence network. We also investigated the associations between Hg contents and the relative abundance of microbial functional genes by analyzing the soil metagenomes from a subset of those sites. Results: We found that soil Hg largely influenced the taxonomic and functional attributes of microbial communities in the two studied regions. In general, Hg pollution was negatively related to bacterial abundance, but positively related to the diversity of bacteria in two separate regions. We also found some consistent associations between soil Hg contents and the community composition of bacteria. For example, soil total Hg content was positively related to the relative abundance of Firmicutes and Bacteroidetes in both paddy and upland soils. In contrast, the methylmercury (MeHg) concentration was negatively correlated to the relative abundance of Nitrospirae in the two types of soils. Increases in soil Hg pollution correlated with drastic changes in the relative abundance of ecological clusters within the co-occurrence network of bacterial communities for the two regions. Using metagenomic data, we were also able to detect the effect of Hg pollution on multiple functional genes relevant to key soil processes such as element cycles and Hg transformations (e.g., methylation and reduction). Conclusions: Together, our study provides solid evidence that Hg pollution has predictable and significant effects on multiple taxonomic and functional attributes including bacterial abundance, diversity, and the relative abundance of ecological clusters and functional genes. Our results suggest an increase in soil Hg pollution linked to human activities will lead to predictable shifts in the taxonomic and functional attributes in the Hg-impacted areas, with potential implications for sustainable management of agricultural ecosystems and elsewhere

Antisymmetric tensor unparticle and the radiative lepton flavor violating decays

We study the contribution of the tensor unparticle mediation to the branching ratios of the radiative lepton flavor violating decays and predict a restriction region for free parameters of the scenario by using experimental upper limits. We observe that the branching ratios of the radiative lepton flavor violating decays are sensitive to the fundamental mass scales of the scenario and to the scale dimension of antisymmetric tensor unparticle. We obtain a more restricted set for the free parameters in the case of the \mu\rightarrow e \gamma decayComment: 15 pages, 10 figure

Control of sunroof buffeting noise by optimizing the flow field characteristics of a commercial vehicle

When a commercial vehicle is driving with the sunroof open, it is easy for the problem of sunroof buffeting noise to occur. This paper establishes the basis for the design of a commercial vehicle model that solves the problem of sunroof buffeting noise, which is based on computational fluid dynamics (CFD) numerical simulation technology. The large eddy simulation (LES) method was used to analyze the characteristics of the buffeting noise with different speed conditions while the sunroof was open. The simulation results showed that the small vortex generated in the cab forehead merges into a large vortex during the backward movement, and the turbulent vortex causes a resonance response in the cab cavity as the turbulent vortex moves above the sunroof and falls into the cab. Improving the flow field characteristics above the cab can reduce the sunroof buffeting noise. Focusing on the buffeting noise of commercial vehicles, it is proposed that the existing accessories, including sun visors and roof domes, are optimized to deal with the problem of sunroof buffeting noise. The sound pressure level of the sunroof buffeting noise was reduced by 6.7 dB after optimization. At the same time, the local pressure drag of the commercial vehicle was reduced, and the wind resistance coefficient was reduced by 1.55% compared to the original commercial vehicle. These results can be considered as relevant, with high potential applicability, within this field of researchThis work was supported by the National Natural Science Foundation of China (No. 52065013), the Guangxi Youth Science Fund Project (2018GXNSFBA281012), the Innovation-Driven Development Special Fund Project of Guangxi (Guike AA19182004), and the Liuzhou Scientific Research and Planning Development Project (2018AA20301)S

Excitation spectrum and ground state properties of the S=1/2 Heisenberg ladder with staggered dimerization

We have studied the excitation spectrum of the $S=1/2$ quantum spin ladder with staggered dimerization by dimer series expansions, diagrammatic analysis of an effective interacting Bose gas of local triplets, and exact diagonalization of small clusters. We find that the model has two massive phases, with predominant inter-chain (rung) or intra-chain correlations. The transition from the rung dimer into the intra-chain dimer phase is characterized by softening of the triplet spectrum at $k=\pi$. The excitation spectrum as well as the spin correlations away from and close to the critical line are calculated. The location of the phase boundary is also determined.Comment: 13 pages, 7 figure

Therapeutic Efficacy of Stable Analogues of Vasoactive Intestinal Peptide against Pathogens

Vasoactive intestinal peptide (VIP) is an anti-inflammatory neuropeptide recently identified as a potential antimicrobial peptide. To overcome the metabolic limitations of VIP, we modified the native peptide sequence and generated two stable synthetic analogues (VIP51 and VIP51(6–30)) with better antimicrobial profiles. Herein we investigate the effects of both VIP analogues on cell viability, membrane integrity, and ultrastructure of various bacterial strains and Leishmania species. We found that the two VIP derivatives kill various non-pathogenic and pathogenic Gram-positive and Gram-negative bacteria as well as the parasite Leishmania major through a mechanism that depends on the interaction with certain components of the microbial surface, the formation of pores, and the disruption of the surface membrane. The cytotoxicity of the VIP derivatives is specific for pathogens, because they do not affect the viability of mammalian cells. Docking simulations indicate that the chemical changes made in the analogues are critical to increase their antimicrobial activities. Consequently, we found that the native VIP is less potent as an antibacterial and fails as a leishmanicidal. Noteworthy from a therapeutic point of view is that treatment with both derivatives increases the survival and reduces bacterial load and inflammation in mice with polymicrobial sepsis. Moreover, treatment with VIP51(6–30) is very effective at reducing lesion size and parasite burden in a model of cutaneous leishmaniasis. These results indicate that the VIP analogues emerge as attractive alternatives for treating drug-resistant infectious diseases and provide key insights into a rational design of novel agents against these pathogens.This work was supported, in whole or in part, by National Institutes of Health Grant RO1 AI031078 (to S. M. B.). This work was also supported by Excellence Grants from Junta de Andalucia (P09/CTS-4705) (to E. G.-R.) and European Cost Action (BM0802) (to E. G.-R.).Peer reviewe

Strong tree level unitarity violations in the extra dimensional Standard Model with scalars in the bulk

We show how the tree level unitarity violations of compactified extra dimensional extensions of the Standard Model become much stronger when the scalar sector is included in the bulk. This effect occurs when the couplings are not suppressed for larger Kaluza-Klein levels, and could have relevant consequences for the phenomenology of the next generation of colliders. We also introduce a simple and generic formalism to obtain unitarity bounds for finite energies, taking into account coupled channels including the towers of Kaluza-Klein excitations.Comment: Version to appear in Phys. Rev. D Typos corrected and remarks added to clarify figure

Elliptical Galaxies with Emission Lines from the Sloan Digital Sky Survey

We present the results of 11 elliptical galaxies with strong nebular emission lines during our study of star formation history along the Hubble sequence. After removing the dilution from the underlying old stellar populations by use of stellar population synthesis model, we derive the accurate fluxes of all emission lines for these objects, which are later classified with emission line ratios into one Seyfert 2, six LINERs and four HII galaxies. We also identify one HII galaxy (A1216+04) as a hitherto unknown Wolf-Rayet galaxy from the presence of the Wolf-Rayet broad bump at 4650 \AA. We propose that the star-forming activities in elliptical galaxies are triggered by either galaxy-galaxy interaction or the merging of a small satellite/a massive star cluster, as already suggested by recent numerical simulations

Experimental study on dielectric relaxation of SiO2 nano-particle suspensions for developing a particle characterization method based on electrical impedance spectroscopy

In this paper, the dielectric relaxation of SiO2 nano-particle suspensions is studied by electrical impedance spectroscopy method. The case of suspension composed of particles with thick double layer is concerned. The objective of this study is to find out the relationship between particle properties (size and concentration) and electrical impedance spectroscopy for developing a particle characterization method based on electrical impedance spectroscopy/tomography. The influences of particle size on electrical impedance spectroscopy (EIS) and relaxation frequency are investigated and analyzed. The experimental results indicate that impedance phase angle and α relaxation frequency are functions of particle size. α relaxation frequency is proportionally changing with (a+ κ-1)-n (a is particle radius, κ-1 is double layer thickness, n equals 0.344 for 4.76% suspension and 0.308 for 2.38% suspension). The exponent term, n, is smaller than the one in dilute suspensions (n=2), which is possibly due to decreasing of diffusion distance of ions around the particles in concentrated suspensions with thick double layer. The impedance parameters, including conductivity increment, δK', and α relaxation frequency are influenced by particle volume fraction. The conductivity increment, δK' becomes less negative with increasing particle volume fraction due to the positive contribution of double layer charge on the conductivity increment. The α relaxation frequency increases with increasing particle volume fraction and the small particles show a more significant increase than large particles. The experimental result on the differential electrical impedance tomographic images between the silica suspension and water (with same conductivity value) shows that small differences on the values of impedance imaginary part and phase can be observed at the upper right corner in the EIT images, which represent a small differentiation on the dielectric property caused by the electrical polarization of double layer on the particle surface

Transition between child and adult services for young people with ADHD: findings from a British national surveillance study

This is the author accepted manuscript. The final version is available from Cambridge University Press via the DOI in this record.Data Availability: Data is currently stored securely by the University of Exeter Medical School, under embargo until the end of the CATCh-uS project (2019).Background: Optimal transition involves continuity, joint care, planning meetings and information transfer. To plan services, commissioners and service providers need data on how many people require that service. Although Attention-Deficit/Hyperactivity Disorder (ADHD) frequently persists into adulthood, evidence is limited on transitions between child and adult services. Aims: To estimate the national incidence of young people taking medication for ADHD that require and complete transition, and describe the proportion that experienced optimal transition. Methods: Surveillance over twelve months using the British Paediatric Surveillance Unit and the Child and Adolescent Psychiatry Surveillance System, including baseline notification and follow up questionnaires. Results: Questionnaire response was 79% at baseline and 82% at follow up. For cases aged 17-19, incident rate (range adjusted for non-response) of transition need was 202-511 per 100,000 people aged 17-19 per year, with successful transition of 38-96 per 100,000 people aged 17-19 per year. Cases were mostly male (77%) with a comorbid condition (62%). Half were referred to specialist adult ADHD and 25% to general adult mental health services; 64% had referral accepted but only 22% attended a first appointment. Only 6% met optimal transition criteria. Conclusions: As inclusion criteria required eligible cases to be on medication, these estimates will represent the lower limit of the need for transition. Two critical points were apparent; referral acceptance and first appointment attendance. The low rate of successful transition and limited guideline adherence indicates significant need for commissioners and service providers to improve service transition experiences.National Institute for Health Research (NIHR

Measuring the Behavioural Component of the S&P 500 and its Relationship to Financial Stress and Aggregated Earnings Surprises

Scholars in management and economics have shown increasing interest in isolating the behavioural dimension of market evolution. Indeed, by improving forecast accuracy and precision, this exercise would certainly help firms to anticipate economic fluctuations, thus leading to more profitable business and investment strategies. Yet, how to extract the behavioural component from real market data remains an open question. By using monthly data on the returns of the constituents of the S&P 500 index, we propose a Bayesian methodology to measure the extent to which market data conform to what is predicted by prospect theory (the behavioural perspective), relative to the (standard) subjective expected utility theory baseline.We document a significant behavioural component that reaches its peaks during recession periods and is correlated to measures of financial volatility, market sentiment and financial stress with expected sign. Moreover, the behavioural component decreases around macroeconomic corporate earnings news, while it reacts positively to the number of surprising announcements