Successful Leptogenesis in SO(10) Unification with a Left-Right Symmetric Seesaw Mechanism

We study thermal leptogenesis in a broad class of supersymmetric SO(10) models with a left-right symmetric seesaw mechanism, taking into account flavour effects and the contribution of the next-to-lightest right-handed neutrino supermultiplet. Assuming M_D = M_u and a normal hierarchy of light neutrino masses, we show that four out of the eight right-handed neutrino mass spectra reconstructed from low-energy neutrino data can lead to successful leptogenesis with a reheating temperature in the (10^9 - 10^10) GeV range. In the remaining four solutions, leptogenesis is dominated by N_2 decays, as in the type I seesaw case. We find that some of these spectra can generate the observed baryon asymmetry for reheating temperatures above 10^10 GeV, in contrast to the type I case. Together with flavour effects, an accurate description of charged fermion masses turns out to be a crucial ingredient in the analysis.Comment: 32 pages, 23 figures. v2: 2 comments [below Eq. (53) and at the end of the conclusions] and 1 reference added, typos corrected. Version to be published in Nucl. Phys.

Truly Distributed Optical Fiber Sensors for Structural Health Monitoring: From the Telecommunication Optical Fiber Drawling Tower to Water Leakage Detection in Dikes and Concrete Structure Strain Monitoring

Although optical fiber sensors have been developed for 30 years, there is a gap between lab experiments and field applications. This article focuses on specific methods developed to evaluate the whole sensing chain, with an emphasis on (i) commercially-available optoelectronic instruments and (ii) sensing cable. A number of additional considerations for a successful pairing of these two must be taken into account for successful field applications. These considerations are further developed within this article and illustrated with practical applications of water leakage detection in dikes and concrete structures monitoring, making use of distributed temperature and strain sensing based on Rayleigh, Raman, and Brillouin scattering in optical fibers. They include an adequate choice of working wavelengths, dedicated localization processes, choices of connector type, and further include a useful selection of traditional reference sensors to be installed nearby the optical fiber sensors, as well as temperature compensation in case of strain sensing

Capteurs à fibre optique pour la surveillance et l’observation du stockage de déchets radioactifs en couche géologique profonde

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Application des fibres optiques à l'instrumentation des structures de chaussées

L'instrumentation des chaussées, habituellement réalisée grâce à des jauges à fil résistant, est un outil indispensable aux recherches expérimentales visant à l'optimisation des techniques de construction et d'entretien des réseaux routiers. Cet article porte sur la possibilité de remplacer des capteurs électriques par des fibres optiques noyées dans des enrobés bitumineux mis en oeuvre soit à chaud (technique de référence), soit à froid tels que les graves-émulsion afin de bénéficier des facilités de multiplexage, voire même de mesures réparties sur des distances kilométriques. Nous avons démontré, à travers des essais de laboratoire puis deux tests sur chantier en vraie grandeur, la faisabilité d'introduire des fibres optiques dans des chaussées, malgré des conditions très sévères de mise en oeuvre. Les réponses des extensomètres à fibre optique de type Bragg sont en bon accord avec celles des capteurs usuels à fils résistants ; les tous premiers tests mettant à profit la technologie de mesure répartie «Optical Backscattered Reflectometry» sont encourageants

Combined Radiation and Temperature Effects on Brillouin Scattering based Sensing with Ge-Doped Optical Fibers

International audienceTemperature impacts the sensing performances under radiation of distributed optical fiber sensors exploiting Stimulated Brillouin Scattering in Ge-doped SMFs: SNR is improved at 100°C while frequency shift is about 4 MHz at 1 MGy whatever the temperature

Prognostic value of high-sensitivity measurable residual disease assessment after front-line chemoimmunotherapy in chronic lymphocytic leukemia.

Measurable residual disease (MRD) status is widely adopted in clinical trials in patients with chronic lymphocytic leukemia (CLL). Findings from FILO group trials (CLL2007FMP, CLL2007SA, CLL2010FMP) enabled investigation of the prognostic value of high-sensitivity (0.7 × 10) MRD assessment using flow cytometry, in blood (N = 401) and bone marrow (N = 339), after fludarabine, cyclophosphamide, and rituximab (FCR)-based chemoimmunotherapy in a homogeneous population with long follow-up (median 49.5 months). Addition of low-level positive MRD < 0.01% to MRD ≥ 0.01% increased the proportion of cases with positive MRD in blood by 39% and in bone marrow by 27%. Compared to low-level positive MRD < 0.01%, undetectable MRD was associated with significantly longer progression-free survival (PFS) when using blood (72.2 versus 42.7 months; hazard ratio 0.40, p = 0.0003), but not when using bone marrow. Upon further stratification, positive blood MRD at any level, compared to undetectable blood MRD, was associated with shorter PFS irrespective of clinical complete or partial remission, and a lower 5-year PFS rate irrespective of IGHV-mutated or -unmutated status (all p < 0.05). In conclusion, high-sensitivity (0.0007%) MRD assessment in blood yielded additional prognostic information beyond the current standard sensitivity (0.01%). Our approach provides a model for future determination of the optimal MRD investigative strategy for any regimen

Prognostic value of high-sensitivity measurable residual disease assessment after front-line chemoimmunotherapy in chronic lymphocytic leukemia

International audienceMeasurable residual disease (MRD) status is widely adopted in clinical trials in patients with chronic lymphocytic leukemia (CLL). Findings from FILO group trials (CLL2007FMP, CLL2007SA, CLL2010FMP) enabled investigation of the prognostic value of high-sensitivity (0.7 × 10-5) MRD assessment using flow cytometry, in blood (N = 401) and bone marrow (N = 339), after fludarabine, cyclophosphamide, and rituximab (FCR)-based chemoimmunotherapy in a homogeneous population with long follow-up (median 49.5 months). Addition of low-level positive MRD < 0.01% to MRD ≥ 0.01% increased the proportion of cases with positive MRD in blood by 39% and in bone marrow by 27%. Compared to low-level positive MRD < 0.01%, undetectable MRD was associated with significantly longer progression-free survival (PFS) when using blood (72.2 versus 42.7 months; hazard ratio 0.40, p = 0.0003), but not when using bone marrow. Upon further stratification, positive blood MRD at any level, compared to undetectable blood MRD, was associated with shorter PFS irrespective of clinical complete or partial remission, and a lower 5-year PFS rate irrespective of IGHV-mutated or -unmutated status (all p < 0.05). In conclusion, high-sensitivity (0.0007%) MRD assessment in blood yielded additional prognostic information beyond the current standard sensitivity (0.01%). Our approach provides a model for future determination of the optimal MRD investigative strategy for any regimen

Temporal Trends in Transcatheter Aortic Valve Replacement in France: FRANCE 2 to FRANCE TAVI

International audienceBackground - Transcatheter aortic valve replacement (TAVR) is standard therapy for patients with severe aortic stenosis who are at high surgical risk. However, national data regarding procedural characteristics and clinical outcomes over time are limited. Objectives - The aim of this study was to assess nationwide performance trends and clinical outcomes of TAVR during a 6-year period. Methods - TAVRs performed in 48 centers across France between January 2013 and December 2015 were prospectively included in the FRANCE TAVI (French Transcatheter Aortic Valve Implantation) registry. Findings were further compared with those reported from the FRANCE 2 (French Aortic National CoreValve and Edwards 2) registry, which captured all TAVRs performed from January 2010 to January 2012 across 34 centers. Results - A total of 12,804 patients from FRANCE TAVI and 4,165 patients from FRANCE 2 were included in this analysis. The median age of patients was 84.6 years, and 49.7% were men. FRANCE TAVI participants were older but at lower surgical risk (median logistic European System for Cardiac Operative Risk Evaluation [EuroSCORE]: 15.0% vs. 18.4%; p < 0.001). More than 80% of patients in FRANCE TAVI underwent transfemoral TAVR. Transesophageal echocardiography guidance decreased from 60.7% to 32.3% of cases, whereas more recent procedures were increasingly performed in hybrid operating rooms (15.8% vs. 35.7%). Rates of Valve Academic Research Consortium-defined device success increased from 95.3% in FRANCE 2 to 96.8% in FRANCE TAVI (p < 0.001). In-hospital and 30-day mortality rates were 4.4% and 5.4%, respectively, in FRANCE TAVI compared with 8.2% and 10.1%, respectively, in FRANCE 2 (p < 0.001 for both). Stroke and potentially life-threatening complications, such as annulus rupture or aortic dissection, remained stable over time, whereas rates of cardiac tamponade and pacemaker implantation significantly increased. Conclusions - The FRANCE TAVI registry provided reassuring data regarding trends in TAVR performance in an all-comers population on a national scale. Nonetheless, given that TAVR indications are likely to expand to patients at lower surgical risk, concerns remain regarding potentially life-threatening complications and pacemaker implantation. (Registry of Aortic Valve Bioprostheses Established by Catheter [FRANCE TAVI]; NCT01777828)