23 research outputs found
Why is the World Getting Older? The Influence of Happiness on Mortality
- Author
- A Clark
- A Lleras-Muney
- A R Thatcher
- A Sen
- Andrew J Oswald
- Andrew J Oswald
- C Graham
- C Guven
- Cahit Guven
- Christine E Eibner
- Christopher J Ruhm
- D Cutler
- Deborah D Danner
- Douglas L Miller
- E Rose
- Hugh S E Gravelle
- J Oeppen
- J Zhanga
- John F Forbes
- Micheal D Hurd
- Philip C Strike
- R Inglehart
- Rudolph Saloumidis
- S Kalemli-Ozcan
- Stephen E Snyder
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2009
- Field of study
Common Genetic Variation And Age at Onset Of Anorexia Nervosa
- Author
- Adan Roger A.H.
- Alfredsson Lars
- Andreassen Ole A.
- Ask Helga
- Baker Jessica H.
- Bergen Andrew W.
- Berrettini Wade H.
- Birgegård Andreas
- Boden Joseph M.
- Boehm Ilka
- Boehnke Michael
- Boni Claudette
- Brandt Harry
- Breen Gerome
- Buehren Katharina
- Bulant Josef
- Bulik Cynthia M.
- Burghardt Roland
- Chang Xiao
- Cichon Sven
- Coleman Jonathan R.I.
- Cone Roger D.
- Courtet Philippe
- Crawford Steven
- Crow Scott
- Crowley James J.
- Danner Unna N.
- de Zwaan Martina
- Dedoussis George
- DeSocio Janiece E.
- Dick Danielle M.
- Dikeos Dimitris
- Dina Christian
- Djurovic Srdjan
- Dmitrzak-Weglarz Monika
- Docampo-Martinez Elisa
- Duriez Philibert
- Egberts Karin
- Ehrlich Stefan
- Eriksson Johan G.
- Escaramís Geòrgia
- Esko Tõnu
- Estivill Xavier
- Farmer Anne
- Fernández-Aranda Fernando
- Fichter Manfred M.
- Foretova Lenka
- Forstner Andreas J.
- Frei Oleksandr
- Föcker Manuel
- Gallinger Steven
- Giegling Ina
- Giuranna Johanna
- Gonidakis Fragiskos
- Gordon Scott
- Gorwood Philip
- Gratacòs Mònica
- Guillaume Sébastien
- Guo Yiran
- Hakonarson Hakon
- Halmi Katherine A.
- Hauser Joanna
- Havdahl Alexandra
- Hebebrand Johannes
- Helder Sietske G.
- Herms Stefan
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Hinney Anke
- Horwood L. John
- Hudson James I.
- Hübel Christopher
- Imgart Hartmut
- Jamain Stephanie
- Janout Vladimir
- Jiménez-Murcia Susana
- Johnson Craig
- Jones Ian R.
- Jordan Jennifer
- Julià Antonio
- Kalsi Gursharan
- Kaminská Deborah
- Kaplan Allan S.
- Kaprio Jaakko
- Karhunen Leila
- Kas Martien J.H.
- Kaye Walter H.
- Keel Pamela K.
- Kennedy James L.
- Kennedy Martin
- Keski-Rahkonen Anna
- Kiezebrink Kirsty
- Klareskog Lars
- Klump Kelly L.
- Knudsen Gun Peggy S.
- La Via Maria C.
- Landén Mikael
- Larsen Janne T.
- Le Hellard Stephanie
- Leboyer Marion
- Li Dong
- Lichtenstein Paul
- Lilenfeld Lisa
- Lin Bochao
- Lissowska Jolanta
- Luykx Jurjen
- Magistretti Pierre
- Maguire Sarah
- Maj Mario
- Marsal Sara
- Marshall Christian R.
- Martin Nicholas G.
- Mattingsdal Morten
- Meulenbelt Ingrid
- Micali Nadia
- Mitchell James E.
- Mitchell Karen S.
- Monteleone Alessio Maria
- Monteleone Palmiero
- Mortensen Preben Bo
- Myers Richard
- Navratilova Marie
- Ntalla Ionna
- Olsen Catherine M.
- Ophoff Roel A.
- O’Toole Julie K.
- Padyukov Leonid
- Pantel Jacques
- Papežová Hana
- Parker Richard
- Pearson John F.
- Pedersen Nancy L.
- Petersen Liselotte V.
- Pinto Dalila
- Raevuori Anu
- Ramoz Nicolas
- Reichborn-Kjennerud Ted
- Ricca Valdo
- Ripatti Samuli
- Ripke Stephan
- Ritschel Franziska
- Roberts Marion
- Rotondo Alessandro
- Rujescu Dan
- Rybakowski Filip
- Scherag André
- Scherer Stephen W.
- Schmidt Ulrike
- Scott Laura J.
- Seitz Jochen
- Silén Yasmina
- Slagboom P. Eline
- Slof-Op ‘t Landt Margarita C.T.
- Slopien Agnieszka
- Sorbi Sandro
- Strober Michael
- Thornton Laura M.
- Tortorella Alfonso
- Tozzi Federica
- Treasure Janet
- Tsitsika Artemis
- Tyszkiewicz-Nwafor Marta
- Tziouvas Konstantinos
- van Elburg Annemarie A.
- van Furth Eric F.
- Wade Tracey D.
- Walton Esther
- Watson Hunna J.
- Werge Thomas
- Whiteman David C.
- Widen Elisabeth
- Woodside D. Blake
- Yilmaz Zeynep
- Zerwas Stephanie
- Zipfel Stephan
- Świątkowska Beata
- Šlachtová Lenka
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Genetics and biology may influence the age at onset of anorexia nervosa (AN). The aims of this study were to determine whether common genetic variation contributes to AN age at onset and to investigate the genetic associations between age at onset of AN and age at menarche. Methods A secondary analysis of the Psychiatric Genomics Consortium genome-wide association study (GWAS) of AN was performed which included 9,335 cases and 31,981 screened controls, all from European ancestries. We conducted GWASs of age at onset, early-onset AN (< 13 years), and typical-onset AN, and genetic correlation, genetic risk score, and Mendelian randomization analyses. Results Two loci were genome-wide significant in the typical-onset AN GWAS. Heritability estimates (SNP-h2) were 0.01-0.04 for age at onset, 0.16-0.25 for early-onset AN, and 0.17-0.25 for typical-onset AN. Early- and typical-onset AN showed distinct genetic correlation patterns with putative risk factors for AN. Specifically, early-onset AN was significantly genetically correlated with younger age at menarche, and typical-onset AN was significantly negatively genetically correlated with anthropometric traits. Genetic risk scores for age at onset and early-onset AN estimated from independent GWASs significantly predicted age at onset. Mendelian randomization analysis suggested a causal link between younger age at menarche and early-onset AN. Conclusions Our results provide evidence consistent with a common variant genetic basis for age at onset and implicate biological pathways regulating menarche and reproduction.Peer reviewe
Shared genetic risk between eating disorder- and substance-use-related phenotypes:Evidence from genome-wide association studies
- Author
- Adams Mark J.
- Adan Roger A.H.
- Adkins Amy E.
- Adkins Daniel E.
- Agrawal Arpana
- Alfredsson Lars
- Aliev Fazil
- Ando Tetsuya
- Andreassen Ole A.
- Bacanu Silviu-Alin
- Baker Jessica H.
- Batzler Anthony
- Bergen Andrew W.
- Berrettini Wade H.
- Bertelsen Sarah
- Biernacka Joanna M.
- Bierut Laura J.
- Bigdeli Tim B.
- Birgegård Andreas
- Boardman Jason D.
- Boden Joseph M.
- Boehm Ilka
- Boni Claudette
- Boomsma Dorret I.
- Brandt Harry
- Breen Gerome
- Brown Sandra A.
- Bryois Julien
- Bucholz Kathleen K.
- Buehren Katharina
- Bulik Cynthia M.
- Burghardt Roland
- Cassina Matgteo
- Chen Danfeng
- Chen Li-Shiun
- Choi Doo-Sup
- Chou Yi-Ling
- Cichon Sven
- Clarke Toni-Kim
- Clementi Maurizio
- Coleman Jonathan R.I.
- Cone Roger D.
- Copeland William E.
- Costello E. Jane
- Courtet Philippe
- Crawford Steven
- Crow Scott
- Crowley James J.
- Culverhouse Robert C.
- Dahmen Norbert
- Danner Unna N.
- Davis Oliver S.P.
- de Wit Harriet
- de Zwaan Martina
- Dedoussis George
- Degenhardt Franziska
- Degenhardt Louisa
- Degortes Daniela
- DeSocio Janiece E.
- Diazgranados Nancy
- Dick Danielle M.
- Dikeos Dimitris
- Dina Christian
- Dmitrzak-Weglarz Monika
- Docampo Elisa
- Docherty Anna R.
- Domingue Benjamin W.
- Duncan Laramie E.
- Edenberg Howard J.
- Edwards Alexis C.
- Egberts Karin
- Ehrlich Stefan
- Eriksson Johan G.
- Escaramís Geòrgia
- Esko Tõnu
- Estivill Xavier
- Farmer Anne
- Farrer Lindsay A.
- Favaro Angela
- Fernández-Aranda Fernando
- Fichter Manfred M.
- Fischer Krista
- Foo Jerome C.
- Foretova Lenka
- Foroud Tatiana M.
- Forstner Andreas J.
- Forzan Monica
- Fox Louis
- Frank Josef
- Franklin Christopher S.
- Frye Mark A.
- Föcker Manuel
- Gallinger Steven
- Gaspar Héléna A.
- Gelernter Joel
- Giegling Ina
- Gillespie Nathan A.
- Giuranna Johanna
- Giusti-Rodríguez Paola
- Goate Alison M.
- Goldman David
- Gonidakis Fragiskos
- Gordon Scott
- Gorwood Philip
- Grove Jakob
- Grucza Richard A.
- Guillaume Sébastien
- Guo Yiran
- Gäbel Wolfgang
- Hack Laura M.
- Hakonarson Hakon
- Halmi Katherine A.
- Hancock Dana B.
- Hanscombe Ken B.
- Harris Kathleen Mullan
- Hartmann Annette M.
- Hartz Sarah M.
- Hatzikotoulas Konstantinos
- Hauser Joanna
- Hayward Caroline
- Heath Andrew C.
- Hebebrand Johannes
- Heilmann-Heimbach Stefanie
- Helder Sietske G.
- Henders Anjali K.
- Herms Stefan
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Hesselbrock Victor
- Hewitt John K.
- Hinney Anke
- Hodgkinson Colin
- Hoffmann Per
- Hopfer Christian
- Horwood L. John
- Hottenga Jouke-Jan
- Huckins Laura M.
- Hudson James I.
- Hübel Christopher
- Iacono William G.
- Imgart Hartmut
- Inoko Hidetoshi
- Ising Marcus
- Janout Vladimir
- Jiménez-Murcia Susana
- Johnson Craig
- Johnson Emma C.
- Johnson Eric O.
- Jordan Jennifer
- Julià Antonio
- Kalsi Gursharan
- Kaminská Deborah
- Kaplan Allan S.
- Kaprio Jaakko
- Karhunen Leila
- Karpyak Victor M.
- Karwautz Andreas
- Kas Martien J.H.
- Kaye Walter H.
- Kendler Kenneth S.
- Kennedy James L.
- Kennedy Martin A.
- Keski-Rahkonen Anna
- Keyes Margaret
- Kiefer Falk
- Kiezebrink Kirsty
- Kim Youl-Ri
- Klump Kelly L.
- Knudsen Gun Peggy S.
- Koller Gabrielle
- Konte Bettina
- Kramer John
- Kranzler Henry R.
- Krauter Kenneth
- Kuperman Samuel
- La Via Maria C.
- Lahti Jari
- Lahti-Pulkkinen Marius
- Lai Dongbing
- Landén Mikael
- Larsen Janne T.
- Le Hellard Stephanie
- Leppä Virpi M.
- Levitan Robert D.
- Li Dong
- Lichtenstein Paul
- Ligthart Lannie
- Lilenfeld Lisa
- Lin Bochao Danae
- Lind Penelope A.
- Lissowska Jolanta
- Loukola Anu
- Lucae Susanne
- Luykx Jurjen
- Lynskey Michael T.
- MacKillop James
- Madden Pamela A.F.
- Maes Hermine H.
- Magistretti Pierre J.
- Magnusson Patrik K.E.
- Maher Brion S.
- Maier Wolfgang
- Maj Mario
- Mann Karl
- Mannik Katrin
- Marsal Sara
- Marshall Christian R.
- Martin Nicholas G.
- Mattheisen Manuel
- Mattingsdal Morten
- Mayora Monica Gratacos
- Mbarek Hamdi
- McClintick Jeanette N.
- McDevitt Sara
- McGue Matt
- McGuffin Peter
- McIntosh Andrew M.
- McQueen Matthew B.
- Medland Sarah E.
- Metspalu Andres
- Meulenbelt Ingrid
- Meyers Jacquelyn L.
- Micali Nadia
- Milaneschi Yuri
- Mitchell James
- Mitchell Karen
- Monteleone Alessio Maria
- Monteleone Palmiero
- Montgomery Grant W.
- Mortensen Preben Bo
- Munn-Chernoff Melissa A.
- Murray Alison D.
- Männistö Satu
- Müller-Myhsok Bertram
- Nacmias Benedetta
- Navratilova Marie
- Neale Benjamin M.
- Nelson Elliot C.
- Norring Claes
- Ntalla Ioanna
- Nurnberger John I.
- Nöthen Markus M.
- Olsen Catherine M.
- Ophoff Roel A.
- O’Toole Julie K.
- Padyukov Leonid
- Palmer Abraham A.
- Palotie Aarno
- Palviainen Teemu
- Pantel Jacques
- Papezova Hana
- Parker Richard
- Pearson John F.
- Pedersen Nancy L.
- Penninx Brenda W.J.H.
- Perica Vesna Boraska
- Petersen Liselotte V.
- Peterson Roseann E.
- Pinto Dalila
- Polimanti Renato
- Porjesz Bernice
- Preuss Ulrich
- Rabionet Raquel
- Raevuori Anu
- Ramoz Nicolas
- Reichborn-Kjennerud Ted
- Reynolds Maureen D.
- Ricca Valdo
- Rice John P.
- Ridinger Monika
- Rietschel Marcella
- Riley Brien P.
- Ripatti Samuli
- Ripke Stephan
- Ritschel Franziska
- Roberts Marion
- Rose Richard J.
- Rotondo Alessandro
- Rujescu Dan
- Rybakowski Filip
- Ryu Euijung
- Räikkönen Katri
- Saccone Nancy L.
- Salvatore Jessica E.
- Sanchez-Roige Sandra
- Santonastaso Paolo
- Scherag André
- Scherbaum Norbert
- Scherer Stephen W.
- Schmidt Ulrike
- Schork Nicholas J.
- Schosser Alexandra
- Schuckit Marc A.
- Schwandt Melanie
- Seitz Jochen
- Shen Pei-Hong
- Sherva Richard
- Silberg Judy
- Slachtova Lenka
- Slagboom P. Eline
- Slof-Op’t Landt Margarita C.T.
- Slopien Agnieszka
- Sorbi Sandro
- Soyka Michael
- Stallings Michael C.
- Streit Fabian
- Strober Michael
- Strohmaier Jana
- Stuber Garret D.
- Sullivan Patrick F.
- Szatkiewicz Jin P.
- Tachmazidou Ioanna
- Tarter Ralph E.
- Tenconi Elena
- Thomas Nathaniel
- Thornton Laura M.
- Tortorella Alfonso
- Tozzi Federica
- Treasure Janet
- Treutlein Jens
- Tsitsika Artemis
- Tyszkiewicz-Nwafor Marta
- Tziouvas Konstantinos
- van Elburg Annemarie A.
- van Furth Eric F.
- Vanyukov Michael M.
- Vrieze Scott
- Wade Tracey D.
- Wagner Gudrun
- Wall Tamara L.
- Walters Raymond K.
- Walton Esther
- Wang Jen-Chyong
- Watson Hunna J.
- Webb Bradley T.
- Wedow Robbee
- Werge Thomas
- Wetherill Leah
- Whiteman David C.
- Whitfield John B.
- Widen Elisabeth
- Wills Amanda G.
- Witt Stephanie H.
- Wodarz Norbert
- Woodside D. Blake
- Yao Shuyang
- Yilmaz Zeynep
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhao Hongyu
- Zhou Hang
- Zill Peter
- Zipfel Stephan
- Świątkowska Beata
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
First published: 16 February 202
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
- Author
- Adams Mark J
- Adan Roger A H
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Akil Huda
- Albani Diego
- Alda Martin
- Alexander Madeline
- Alfredsson Lars
- Als Thomas D
- Andlauer Till F M
- Ando Tetsuya
- Andreassen Ole A
- Androutsos Christos
- Anjorin Adebayo
- Anney Richard J L
- Anttila Verneri
- Arking Dan E
- Arnold Paul D
- Arranz M. J.
- Artigas Maria Soler
- Aschauer Harald
- Asherson Philip
- Backlund Lena
- Baker Jessica H
- Baldursson Gísli
- Banaschewski Tobias
- Barr Cathy L
- Barta Csaba
- Bass Nicholas
- Bauer Michael
- Baune Bernhard T
- Begemann Martin
- Belangero Sintia
- Bellgrove Mark
- Belliveau Richard A
- Bellivier Frank
- Bencko Vladimir
- Bergen Andrew W
- Bergen Sarah E
- Berger Klaus
- Berrettini Wade H
- Bettella Francesco
- Bey Katharina
- Bienvenu O Joseph
- Biernacka Joanna M
- Binder Elisabeth B
- Birgegård Andreas
- Black Donald W
- Blackwood Douglas H R
- Boomsma Dorret I
- Bramon Elvira
- Brandt Harry
- Breen Gerome
- Brown Lawrence W
- Buccola Nancy G
- Budde Monika
- Budman Cathy
- Buitelaar Jan
- Bulik Cynthia M
- Bunney William
- Burghardt Roland
- Burmeister Margit
- Burton Christie L
- Buxbaum Joseph D
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D
- Cairns Murray J
- Campion Dominique
- Carlberg Laura
- Carr Vaughan J
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Cath Danielle
- Cerrato Felecia
- Chambert Kimberly
- Cheon Keun-Ah
- Christensen Jane H
- Churchhouse Claire
- Cichon Sven
- Ciullo Valentina
- Clarke Toni-Kim
- Clementi Maurizio
- Cloninger C Robert
- Coffey Barbara J
- Cohen David
- Coleman Jonathan R I
- Collier David A
- Collins Ryan L
- Colodro-Conde Lucía
- Cook Edwin H
- Coon Hilary
- Coppola Giovanni
- Cormand Bru
- Corvin Aiden
- Courtet Philippe
- Craddock Nicholas
- Crawford Steven
- Crosbie Jennifer
- Crow Scott
- Crowley James J
- Curtis David
- Cusi Daniele
- Czerski Piotr M
- Dale Anders M
- Dalkner Nina
- Dalsgaard Søren
- Daly Mark J
- Danner Unna N
- Dannlowski Udo
- Davis Lea K
- Davis Oliver S P
- de Geus E. J. C.
- De Rubeis Silvia
- Degenhardt Franziska
- Degortes Daniela
- DeLisi Lynn E
- Delorme Richard
- Demontis Ditte
- Denys Damiaan
- Depienne Christel
- Derks Eske M
- DeSocio Janiece E
- Di Florio Arianna
- Dick Danielle M
- Dietrich Andrea
- Dina Christian
- Direk Nese
- Docampo Elisa
- Docherty Anna R
- Domenici Enrico
- Domschke Katharina
- Donohoe Gary
- Doyle Alysa E
- Duan Jubao
- Dudbridge Frank
- Dumont Ashley
- Duncan Laramie E
- Dunn Erin C
- Eapen Valsamma
- Edenberg Howard J
- Egberts Karin
- Ehrenreich Hannelore
- Ehrlich Stefan
- Elia Josephine
- Elvsåshagen Torbjørn
- Espeseth Thomas
- Etain Bruno
- Falkai Peter
- Fanous Ayman H
- Faraone Stephen V
- Feng Yen-Chen A
- Fernandez Thomas V
- Fernández-Aranda Fernando
- Fichter Manfred M
- Fischer Sascha B
- Foo Jerome C
- Foretova Lenka
- Forstner Andreas J
- Forty Liz
- Forzan Monica
- Frank Josef
- Franke Barbara
- Freedman Robert
- Frye Mark
- Fullerton Janice M
- Gade Katrin
- Gambaro Giovanni
- Garcia-Delgar Blanca
- Gaspar Héléna A
- Ge Tian
- Gejman Pablo V
- Gelernter Joel
- Geller Daniel A
- Gershon Elliot S
- Geschwind Daniel H
- Giegling Ina
- Gilbert Donald L
- Gill Michael
- Godard Stephanie
- Goes Fernando S
- Golimbet Vera
- Gonidakis Fragiskos
- Gordon Scott D
- Gordon-Smith Katherine
- Gorwood Philip
- Grabe Hans J
- Grados Marco A
- Green Melissa J
- Greenberg Erica
- Greenwood Tiffany A
- Grice Dorothy E
- Grigoroiu-Serbanescu Maria
- Grotzinger Andrew D
- Grove Jakob
- Grünblatt Edna
- Gudmundsson Olafur O
- Guo Yiran
- Guzman-Parra José
- Haavik Jan
- Hagstrøm Julie
- Hakonarson Hakon
- Halmi Katherine A
- Hamilton Steven P
- Hanna Gregory L
- Hansen Christine S
- Hansen Thomas F
- Hartman Catharina A
- Hartmann Andreas
- Hartmann Annette M
- Hatzikotoulas Konstantinos
- Hauser Joanna
- Hautzinger Martin
- Hawi Ziarih
- Hebebrand Johannes
- Hedderly Tammy
- Heilbronner Urs
- Heiman Gary A
- Helder Sietske G
- Henskens Frans A
- Herms Stefan
- Herpertz-Dahlmann Beate
- Hervás Amaia
- Herzog Wolfgang
- Heyman Isobel
- Hinney Anke
- Hoekstra Pieter J
- Hoffmann Per
- Holland Dominic
- Holmans Peter A
- Hong Hyun Ju
- Hope Sigrun
- Horn Carsten
- Hottenga Jouke-Jan
- Hougaard David M
- Howard David
- Howrigan Daniel P
- Huang Alden
- Huang Hailiang
- Hultman Christina M
- Huyser Chaim
- Ibanez-Gomez Laura
- Ikeda Masashi
- Imgart Hartmut
- Ising Marcus
- Iwata Nakao
- Jablensky Assen V
- Jamain Stéphane
- Jiménez-Murcia Susana
- Joa Inge
- Joachim Oedegaard Ketil
- Johnson Craig
- Jones Ian
- Jones Lisa A
- Jordan Jennifer
- Julià Antonio
- Jönsson Erik G
- Kaminská Deborah
- Kandaswamy Radhika
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien J H
- Kaye Walter H
- Kelly Brian J
- Kelsoe John R
- Kendler Kenneth S
- Kennedy James L
- Kennedy Martin A
- Keski-Rahkonen Anna
- Khramtsova Ekaterina A
- Kim Youl-Ri
- Kim Young Key
- Kim Young-Shin
- King Robert A
- Kirov George
- Kittel-Schneider Sarah
- Klareskog Lars
- Klei Lambertus
- Kloiber Stefan
- Klump Kelly L
- Knight Jo
- Knudsen Gun Peggy S
- Kogevinas Manolis
- Koh Yun-Joo
- Koller Anna C
- Konstantinidis Anastasios
- Konte Bettina
- Kook Sodahm
- Kranzler Henry R
- Kuntsi Jonna
- Kuperman Samuel
- Ladd-Acosta Christine
- Landén Mikael
- Langley Kate
- Laurent-Levinson Claudine
- Lavebratt Catharina
- Le Hellard Stephanie
- Lee Jimmy
- Lee Phil H
- Lencz Todd
- Lerer Bernard
- Lesch Klaus-Peter
- Leung Patrick W L
- Leventhal Bennett L
- Levinson Douglas F
- Levitan Robert D
- Lewis Cathryn M
- Lewis Cathryn M
- Lewis Glyn
- Li Dong
- Li Qingqin S
- Lichtenstein Paul
- Lissowska Jolanta
- Lochner Christine
- Loo Sandra K
- Loohuis Loes M O
- Loughland Carmel M
- Lucae Susanne
- Ludolph Andrea G
- Luykx Jurjen J
- Maaser Anna
- Madruga-Garrido Marcos
- Magnusson Pall
- Magnusson Patrik K E
- Maj Mario
- Malaty Irene
- Malhotra Anil K
- Mallet Jacques
- Malt Ulrik F
- Maras Athanasios
- Marsal Sara
- Martin Alicia R
- Martin Joanna
- Martin Nicholas G
- Martinsson Lina
- Mathews Carol A
- Mattheisen Manuel
- Mayora Monica Gratacos
- Mbarek Hamdi
- McCracken James T
- McDevitt Sara
- McDonald Colm
- McElroy Susan L
- McGough James J
- McIntosh Andrew M
- McMahon Francis J
- McQuillin Andrew
- Medland Sarah E
- Meijer Inge A
- Melle Ingrid
- Metspalu Andres
- Middeldorp Christel M
- Millischer Vincent
- Mir Pablo
- Mitchell James
- Mitchell Karen S
- Mitchell Philip B
- Mitjans Marina
- Monteleone Alessio Maria
- Monteleone Palmiero
- Montgomery Grant W
- Moran Jennifer L
- Morer Astrid
- Morken Gunnar
- Morris Derek W
- Mors Ole
- Mortensen Preben B
- Mostafavi Sara
- Mowry Bryan J
- Mullins Niamh
- Munn-Chernoff Melissa A
- Murphy Kieran C
- Murphy Tara L
- Murray Robin M
- Myers Richard M
- Müller-Myhsok Bertram
- Müller-Vahl Kirsten R
- Münchau Alexander
- Naarden Allan
- Nacmias Benedetta
- Nagy Peter
- Navratilova Marie
- Neale Benjamin M
- Neale Michael C
- Nestadt Gerald
- Nestadt Paul S
- Nicolini Humberto
- Nievergelt Caroline M
- Nivard Michel G
- Nordentoft Merete
- Nurmi Erika L
- Nurnberger John I
- Nyegaard Mette
- Nyholt Dale R
- Nærland Terje
- Nöthen Markus M
- O'Donovan Michael C
- O'Neill F Anthony
- O'Toole Julie K
- Oades Robert D
- Oh Sang-Yun
- Okun Michael S
- Ophoff Roel A
- Owen Michael J
- Paciga Sara A
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- Zai Gwyneth
- Zandi Peter
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- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Fuquan
- Zheutlin Amanda
- Zhu Zhaozhong
- Zinner Samuel H
- Zipfel Stephan
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
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- Woodside D. Blake
- Wray Naomi R.
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- Yao Shuyang
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- Young Allan H.
- Young Hannah
- Zablocki Clement J.
- Zai Clement C.
- Zandi Peter P.
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Futao
- Zhao Hongyu
- Zhou Hang
- Zillich Lea
- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa
- Author
- Abramovic Lucija
- Adams Hieab HH
- Adan Roger
- Agartz Ingrid
- Alfredsson Lars
- Alhusaini Saud
- Almasy Laura
- Ames David
- Andersson Micael
- Ando Tetsuya
- Andreassen Ole
- Andreassen Ole A
- Anttila Verneri
- Arepalli Sampath
- Arias-Vasquez Alejandro
- Aribisala Benjamin S
- Armstrong Nicola J
- Aschauer Harald
- Ashbrook David G
- Assareh Amelia A
- Athanasiu Lavinia
- Baker Jessica
- Barrett Jeffrey
- Bastin Mark E
- Batury V-L
- Becker James T
- Bencko Vladimir
- Bergen Andrew
- Bernard Manon
- Berrettini Wade
- Birgegard Andreas
- Bis Joshua C
- Blangero John
- Bohlken Marc M
- Boks Marco P
- Boni Claudette
- Boomsma Dorret I
- Bralten Janita
- Brandt Harry
- Breen Gerome
- Brodaty Henry
- Brouwer Rachel M
- Brown Andrew A
- Brunner Han G
- Buckner Randy L
- Buitelaar Jan K
- Bulayeva Kazima B
- Bulik CM
- Bulik Cynthia M
- Bulik-Sullivan Brendan
- Burghardt Roland
- Cahn Wiepke
- Calhoun Vince D
- Cannon Dara M
- Carlberg Laura
- Carless Melanie A
- Cassina Matteo
- Cavalleri Gianpiero L
- Chakravarty M Mallar
- Chauhan Ganesh
- Chen Qiang
- Cheung J
- Ching Christopher RK
- Cichon Carolyn Cesta Sven
- Cichon Sven
- Clementi Maurizio
- Cohen-Woods Sarah
- Coleman Joni
- Cone Roger
- Cookson Mark R
- Corvin Aiden
- Courtet Philippe
- Crawford Steven
- Crespo-Facorro Benedicto
- Crow Scott
- Crowley Jim
- Cuellar-Partida Gabriel
- Curran Joanne E
- Czisch Michael
- Dale Anders M
- Danner Unna
- Davies Gareth E
- Davis Oliver
- de Geus Eco JC
- de Zubicaray Greig I
- de Zwaan Martina
- Deary Ian J
- Dedoussis George
- Degortes Daniela
- Delanty Norman
- Den Braber Anouk
- Depondt Chantal
- DeSocio Janiece
- Desrivieres Sylvane
- Dick Danielle
- Dikeos Dimitris
- Dillman Allissa
- Dina Christian
- Ding Bo
- Djurovic Srdjan
- Dmitrzak-Weglarz Monika
- Docampo Elisa
- Donohoe Gary
- Drevets Wayne C
- Duggirala Ravi
- Duncan Laramie
- Dyer Thomas D
- Ebling Maritza
- Egberts Karin
- Ehrlich Stefan
- Ehrlich Stefan
- Ehrlich Stefan
- Erk Susanne
- Escaramis Georgia
- Esko Tonu
- Espeseth Thomas
- Espeseth Thomas
- Estivill Xavier
- Favaro Angela
- Fedko Iryna O
- Fernandez Guillen
- Fernandez-Aranda Fernando
- Ferrucci Luigi
- Fichter Manfred
- Finan Chris
- Fischer Krista
- Fischl Bruce
- Fisher Simon E
- Floyd James
- Focker Manuel
- Foretova Lenka
- Foroud Tatiana M
- Forzan Monica
- Fox Caroline
- Fox Peter T
- Francks Clyde
- Franke Barbara
- Franklin Christopher
- Fukunaga Masaki
- Gallinger Valerie Gaborieau Steven
- Gambaro Giovanni
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- Gibbs J Raphael
- Giddaluru Sudheer
- Giegling Ina
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- Goldman Aaron L
- Goldstein Jackie
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- Gonidakis Fragiskos
- Goring Harald HH
- Gorwood Philip
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- Greve Douglas
- Grimm Oliver
- Grp ENIGMA Genetics Working
- Gruber Oliver
- Guadalupe Tulio
- Gudnason Vilmundur
- Guelfi Sebastian
- Guillaume Sebastien
- Guo Yiran
- Hager Reinmar
- Hakobjan Marina MH
- Hakonarson Hakon
- Halmi Katherine
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- Hatzikotoulas Konstantinos
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- Hegenscheid Katrin
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- Kaprio Jaakko
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- Kasperaviciute Dalia
- Kaye Walter
- Keil Maria
- Kennedy James
- Kennedy Martin
- Keski-Rahkonen Anna
- Kiezebrink Kirsty
- Kim Sungeun
- Kim Youl-Ri
- Klareskog Lars
- Klein Marieke
- Kloszewska Iwona
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- Luting Xue
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- Palotie Aarno
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- Papmeyer Martina
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- Perez-Iglesias Rocio
- Perica Vesna Boraska
- PGC-ED
- Pike G Bruce
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- Pol Hilleke E Hulshoff
- Potkin Steven G
- Putz Benno
- Rabionet Raquel
- Raevuori Anu
- Rajewski Andrzej
- Ramasamy Adaikalavan
- Ramoz Nicolas
- Rayner N William
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- Reinvang Ivar
- Renteria Miguel E
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- Ritschel Franziska
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- Romanczuk-Seiferth Nina
- Rose Emma J
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- Rotondo Alessandro
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- Ryten Mina
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- Salami Alireza
- Samann Philipp G
- Santonastaso Paolo
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- Scherag Andre
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- Schumann Gunter
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- Seshadri Sudha
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- Shin Jean
- Simmons Andrew
- Singleton Andrew
- Sisodiya Sanjay M
- Slachtova Lenka
- Sladek Robert
- Slagboom P Eline
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- Slopien Agnieszka
- Smith Colin
- Smith Tosha
- Smoller Jordan W
- Soininen Hilkka
- Soranzo Nicole
- Sorbi Sandro
- Southam Lorraine
- Sprooten Emma
- Steen Vidar
- Steen Vidar M
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- Strengman Eric
- Strike Lachlan T
- Strober Michael
- Sussmann Jessika E
- Szatkiewicz Jin
- Szeszenia-Dabrowska Neonila
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- Tenconi Elena
- Teumer Alexander
- Thalamuthu Anbupalam
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- Thompson PM
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- Toga Arthur W
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- Tschop Matthias
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- Vinke Louis N
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- Wade Tracey
- Wagner Gudrun
- Walter Henrik
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- Walters Raymond K
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- Walton Esther
- Walton Esther
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- Watson Hunna
- Weale Michael E
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- Wen Wei
- Westlye Lars T
- Westman Eric
- Whelan Christopher D
- White Tonya
- Wichmann H-Erich
- Widen Elisabeth
- Williams Robert W
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- Wittfeld Katharina
- Woldehawariat Girma
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- Yanovski Jack
- Yao Shuyang
- Yilmaz Z
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- Zerwas Stephanie
- Zielke Ronald H
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- Zonderman Alan B
- Zwiers Marcel P
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/07/2019
- Field of study
African American Participation in Alzheimer’s Disease Research That Includes Brain Donation
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
African Americans with Memory Loss: Findings from a Community Clinic in Lexington, Kentucky
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study