41 research outputs found
SLC2A9 Is a High-Capacity Urate Transporter in Humans
Get PDFSerum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have found common genetic variants of SLC2A9 to be associated with increased serum urate level and gout. The SLC2A9 gene encodes a facilitative glucose transporter, and it has two splice variants that are highly expressed in the proximal nephron, a key site for urate handling in the kidney. We investigated whether SLC2A9 is a functional urate transporter that contributes to the longstanding association between urate and blood pressure in man
Unprecedented snow darkening and melting in New Zealand due to 2019–2020 Australian wildfires
No full textPreparation of camptothecin micelles self-assembled from disodium glycyrrhizin and tannic acid with enhanced antitumor activity
No full textTemper outbursts in Prader-Willi syndrome: causes, behavioural and emotional sequence and responses by carers
No full textDVL1 and DVL3 differentially localize to CYP19A1 promoters and regulate aromatase mRNA in breast cancer cells
No full textManagerial performance and cost efficiency of Japanese local public hospitals: A latent class stochastic frontier model
No full textEvaluation of climate change impacts and adaptation strategies for maize cultivation in the Himalayan foothills of India
No full textFavorable angiogenic properties of the borosilicate bioactive glass 0106-B1 result in enhanced in vivo
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