154 research outputs found

    Search for CP violation in D+→ϕπ+ and D+s→K0Sπ+ decays

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    A search for CP violation in D + → ϕπ + decays is performed using data collected in 2011 by the LHCb experiment corresponding to an integrated luminosity of 1.0 fb−1 at a centre of mass energy of 7 TeV. The CP -violating asymmetry is measured to be (−0.04 ± 0.14 ± 0.14)% for candidates with K − K + mass within 20 MeV/c 2 of the ϕ meson mass. A search for a CP -violating asymmetry that varies across the ϕ mass region of the D + → K − K + π + Dalitz plot is also performed, and no evidence for CP violation is found. In addition, the CP asymmetry in the D+s→K0Sπ+ decay is measured to be (0.61 ± 0.83 ± 0.14)%

    In vivo emergence of HIV-1 highly sensitive to neutralizing antibodies.

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    BACKGROUND: The rapid and continual viral escape from neutralizing antibodies is well documented in HIV-1 infection. Here we report in vivo emergence of viruses with heightened sensitivity to neutralizing antibodies, sometimes paralleling the development of neutralization escape. METHODOLOGY/PRINCIPAL FINDINGS: Sequential viral envs were amplified from seven HIV-1 infected men monitored from seroconversion up to 5 years after infection. Env-recombinant infectious molecular clones were generated and tested for coreceptor use, macrophage tropism and neutralization sensitivity to homologous and heterologous serum, soluble CD4 and monoclonal antibodies IgG1b12, 2G12 and 17b. We found that HIV-1 evolves sensitivity to contemporaneous neutralizing antibodies during infection. Neutralization sensitive viruses grow out even when potent autologous neutralizing antibodies are present in patient serum. Increased sensitivity to neutralization was associated with susceptibility of the CD4 binding site or epitopes induced after CD4 binding, and mediated by complex envelope determinants including V3 and V4 residues. The development of neutralization sensitive viruses occurred without clinical progression, coreceptor switch or change in tropism for primary macrophages. CONCLUSIONS: We propose that an interplay of selective forces for greater virus replication efficiency without the need to resist neutralizing antibodies in a compartment protected from immune surveillance may explain the temporal course described here for the in vivo emergence of HIV-1 isolates with high sensitivity to neutralizing antibodies

    Measurement of the Λb0, Ξb-, and Ωb- Baryon Masses

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    Bottom baryons decaying to a J/ψ meson and a hyperon are reconstructed using 1.0  fb-1 of data collected in 2011 with the LHCb detector. Significant Λb0→J/ψΛ, Ξb-→J/ψΞ- and Ωb-→J/ψΩ- signals are observed and the corresponding masses are measured to be M(Λb0)=5619.53±0.13(stat.)±0.45(syst.)  MeV/c2, M(Ξb-)=5795.8±0.9(stat.)±0.4(syst.)  MeV/c2, M(Ωb-)=6046.0±2.2(stat.)±0.5(syst.)  MeV/c2, while the differences with respect to the Λb0 mass are M(Ξb-)-M(Λb0)=176.2±0.9(stat.)±0.1(syst.)  MeV/c2, M(Ωb-)-M(Λb0)=426.4±2.2(stat.)±0.4(syst.)  MeV/c2. These are the most precise mass measurements of the Λb0, Ξb- and Ωb- baryons to date. Averaging the above Λb0 mass measurement with that published by LHCb using 35  pb-1 of data collected in 2010 yields M(Λb0)=5619.44±0.13(stat.)±0.38(syst.)  MeV/c2

    Precision measurement of CP\it{CP} violation in the penguin-mediated decay Bs0ϕϕB_s^{0}\rightarrow\phi\phi

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    A flavor-tagged time-dependent angular analysis of the decay Bs0ϕϕB_s^{0}\rightarrow\phi\phi is performed using pppp collision data collected by the LHCb experiment at % at s=13\sqrt{s}=13 TeV, the center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 6 fb^{-1}. The CP\it{CP}-violating phase and direct CP\it{CP}-violation parameter are measured to be ϕssˉs=0.042±0.075±0.009\phi_{s\bar{s}s} = -0.042 \pm 0.075 \pm 0.009 rad and λ=1.004±0.030±0.009|\lambda|=1.004\pm 0.030 \pm 0.009 , respectively, assuming the same values for all polarization states of the ϕϕ\phi\phi system. In these results, the first uncertainties are statistical and the second systematic. These parameters are also determined separately for each polarization state, showing no evidence for polarization dependence. The results are combined with previous LHCb measurements using pppp collisions at center-of-mass energies of 7 and 8 TeV, yielding ϕssˉs=0.074±0.069\phi_{s\bar{s}s} = -0.074 \pm 0.069 rad and lambda=1.009±0.030|lambda|=1.009 \pm 0.030. This is the most precise study of time-dependent CP\it{CP} violation in a penguin-dominated BB meson decay. The results are consistent with CP\it{CP} symmetry and with the Standard Model predictions.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-001.html (LHCb public pages

    First observation of a doubly charged tetraquark and its neutral partner

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    A combined amplitude analysis is performed for the decays B0D0Ds+πB^0 \rightarrow \overline{D}^0 D^+_s\pi^- and B+DDs+π+B^+\rightarrow D^- D^+_s\pi^+, which are related by isospin symmetry. The analysis is based on data collected by the LHCb detector in proton-proton collisions at center-of-mass energies of 7, 8 and 13TeV\,\rm{TeV}. The full data sample corresponds to an integrated luminosity of 9fb1\,\rm{fb^{-1}}. Two new resonant states with masses of 2.908±0.011±0.020GeV2.908\pm0.011\pm0.020\,\rm{GeV} and widths of 0.136±0.023±0.011GeV0.136\pm0.023\pm0.011\,\rm{GeV} are observed, which decay to Ds+π+D^+_s\pi^+ and Ds+πD^+_s\pi^- respectively. The former state indicates the first observation of a doubly charged open-charm tetraquark state with minimal quark content [csˉudˉ][c\bar{s}u\bar{d}], and the latter state is a neutral tetraquark composed of [csˉuˉd][c\bar{s}\bar{u}d] quarks. Both states are found to have spin-parity 0+0^+, and their resonant parameters are consistent with each other, which suggests that they belong to an isospin triplet.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-026.html (LHCb public pages

    Measurement of the ratios of branching fractions R(D*) and R(D0)

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    The ratios of branching fractions R ( D ∗ ) ≡ B ( ¯ B → D ∗ τ − ¯ ν τ ) / B ( ¯ B → D ∗ μ − ¯ ν μ ) and R ( D 0 ) ≡ B ( B − → D 0 τ − ¯ ν τ ) / B ( B − → D 0 μ − ¯ ν μ ) are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0     fb − 1 of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode τ − → μ − ν τ ¯ ν μ . The measured values are R ( D ∗ ) = 0.281 ± 0.018 ± 0.024 and R ( D 0 ) = 0.441 ± 0.060 ± 0.066 , where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is ρ = − 0.43 . The results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the standard model

    Search for rare decays of D0 mesons into two muons

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    A search for the very rare D 0 → μ + μ − decay is performed using data collected by the LHCb experiment in proton-proton collisions at √ s = 7 , 8, and 13 TeV, corresponding to an integrated luminosity of 9     fb − 1 . The search is optimized for D 0 mesons from D * + → D 0 π + decays but is also sensitive to D 0 mesons from other sources. No evidence for an excess of events over the expected background is observed. An upper limit on the branching fraction of this decay is set at B ( D 0 → μ + μ − ) < 3.1 × 10 − 9 at a 90% C.L. This represents the world’s most stringent limit, constraining models of physics beyond the standard model
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