Development and validation of the Nottingham Auditory Milestones (NAMES) profile for deaf children under 2 years old, using cochlear implants

Objectives: Clinicians face considerable challenges in setting appropriate auditory goals for babies and young children who receive cochlear implants. This paper describes the rationale, organisation, implementation and validation of the Nottingham Auditory Milestones profile that was developed to address these challenges. Methods: The use of the profile has been fully integrated into the post-operative pathway at the Nottingham Auditory Implant Programme since 2009. Data is presented on a cohort of 30 children who received bilateral cochlear implants under the age of two and who have no other diagnosed difficulties. The data was used to validate the profile's structure and characterise the expected development trajectory for this population of children. Results: The analysis of routine data from the children confirmed that the profile's structure reflected the typical order and rate at which skills emerged and were acquired over the first three years following cochlear implantation. The distribution of profile scores across five assessment time-points established a developmental trajectory for typically-developing children. Three case studies describe the use of the profile to set consistent expectations for progress for a wide range of children. Discussion: The development trajectory established using the profile provides a mechanism to identify children not making the expected progress, in order to support the need for a review of approach or a differential diagnosis. Conclusion: The Nottingham Auditory Milestones profile is an accessible and practical tool for identifying, monitoring and appraising the auditory achievements of deaf babies and young children in the first three years following cochlear implantation

Gender differences in reactions to feedback and willingness to compete

In Western societies, it is generally known that men have a greater taste for competition than women. However, the determinants of the decision to enter competitions are still not fully understood. The aim of this paper is twofold. We first evaluate how participants update their beliefs after receiving feedback informing them of whether their performance is below or above the median performance. Second, we are interested in how men and women react to this information in terms of competitive entry. Our first result is that participants, and women in particular, react more strongly to the feedback they receive than would a Bayesian agent. As far as entry into competition is concerned, below-median participants adjust their entry decision according to the competition they expect to face, while above-median participants do not. However, the behaviour behind these results is quite different for men and women: women mainly react to information on their own performance, while men seem to respond more to their beliefs over the competition they will face. Moreover, most of the effect of feedback and the information regarding the level of the competition on the decision to compete seems to operate via beliefs

Grassmann-Gaussian integrals and generalized star products

In quantum scattering on networks there is a non-linear composition rule for on-shell scattering matrices which serves as a replacement for the multiplicative rule of transfer matrices valid in other physical contexts. In this article, we show how this composition rule is obtained using Berezin integration theory with Grassmann variables.Comment: 14 pages, 2 figures. In memory of Al.B. Zamolodichiko

Discrete Flavor Symmetry, Dynamical Mass Textures, and Grand Unification

Discrete flavor symmetry is explored for an intrinsic property of mass matrix forms of quarks and leptons. In this paper we investigate the S3 permutation symmetry and derive the general forms of mass matrices in various types of S3 theories. We also exhibit particular realizations of previous ansatze of mass matrices, which have often been applied in the literature to the standard model Yukawa sector. Discrete flavor symmetry is also advantageous for vanishing matrix elements being dynamically generated in the vacuum of scalar potential. This is due to the fact that group operations are discrete. While zero elements themselves do not explain mass hierarchies, we introduce an abelian flavor symmetry. A non-trivial issue is whether successful quantum numbers can be assigned so that they are compatible with other (non-abelian) flavor symmetries. We show typical examples of charge assignments which not only produce hierarchical orders of mass eigenvalues but also prohibit non-renormalizable operators which disturb the hierarchies in first-order estimation. As an explicit application, a flavor model is constructed in grand unification scheme with S3 and U(1) (or Z_N) flavor symmetries.Comment: 40 pages, references adde

Unwinding of primer-templates by archaeal family-B DNA polymerases in response to template-strand uracil

Archaeal family-B DNA polymerases bind tightly to deaminated bases and stall replication on encountering uracil in template strands, four bases ahead of the primer-template junction. Should the polymerase progress further towards the uracil, for example, to position uracil only two bases in front of the junction, 3′–5′ proof-reading exonuclease activity becomes stimulated, trimming the primer and re-setting uracil to the +4 position. Uracil sensing prevents copying of the deaminated base and permanent mutation in 50% of the progeny. This publication uses both steady-state and time-resolved 2-aminopurine fluorescence to show pronounced unwinding of primer-templates with Pyrococcus furiosus (Pfu) polymerase–DNA complexes containing uracil at +2; much less strand separation is seen with uracil at +4. DNA unwinding has long been recognized as necessary for proof-reading exonuclease activity. The roles of M247 and Y261, amino acids suggested by structural studies to play a role in primer-template unwinding, have been probed. M247 appears to be unimportant, but 2-aminopurine fluorescence measurements show that Y261 plays a role in primer-template strand separation. Y261 is also required for full exonuclease activity and contributes to the fidelity of the polymerase

Laser capture microdissection in forensic research: a review

In forensic sciences, short tandem repeat (STR) analysis has become the prime tool for DNA-based identification of the donor(s) of biological stains and/or traces. Many traces, however, contain cells and, hence, DNA, from more than a single individual, giving rise to mixed genotypes and the subsequent difficulties in interpreting the results. An even more challenging situation occurs when cells of a victim are much more abundant than the cells of the perpetrator. Therefore, the forensic community seeks to improve cell-separation methods in order to generate single-donor cell populations from a mixed trace in order to facilitate DNA typing and identification. Laser capture microdissection (LCM) offers a valuable tool for precise separation of specific cells. This review summarises all possible forensic applications of LCM, gives an overview of the staining and detection options, including automated detection and retrieval of cells of interest, and reviews the DNA extraction protocols compatible with LCM of cells from forensic samples

Measurement of the branching fraction and CP content for the decay B(0) -> D(*+)D(*-)

This is the pre-print version of the Article. The official published version can be accessed from the links below. Copyright @ 2002 APS.We report a measurement of the branching fraction of the decay B0→D*+D*- and of the CP-odd component of its final state using the BABAR detector. With data corresponding to an integrated luminosity of 20.4  fb-1 collected at the Υ(4S) resonance during 1999–2000, we have reconstructed 38 candidate signal events in the mode B0→D*+D*- with an estimated background of 6.2±0.5 events. From these events, we determine the branching fraction to be B(B0→D*+D*-)=[8.3±1.6(stat)±1.2(syst)]×10-4. The measured CP-odd fraction of the final state is 0.22±0.18(stat)±0.03(syst).This work is supported by DOE and NSF (USA), NSERC (Canada), IHEP (China), CEA and CNRS-IN2P3 (France), BMBF (Germany), INFN (Italy), NFR (Norway), MIST (Russia), and PPARC (United Kingdom). Individuals have received support from the A.P. Sloan Foundation, Research Corporation, and Alexander von Humboldt Foundation

Measurement of the Branching Fraction for B- --> D0 K*-

We present a measurement of the branching fraction for the decay B- --> D0 K*- using a sample of approximately 86 million BBbar pairs collected by the BaBar detector from e+e- collisions near the Y(4S) resonance. The D0 is detected through its decays to K- pi+, K- pi+ pi0 and K- pi+ pi- pi+, and the K*- through its decay to K0S pi-. We measure the branching fraction to be B.F.(B- --> D0 K*-)= (6.3 +/- 0.7(stat.) +/- 0.5(syst.)) x 10^{-4}.Comment: 7 pages, 1 postscript figure, submitted to Phys. Rev. D (Rapid Communications

Measurement of Branching Fraction and Dalitz Distribution for B0->D(*)+/- K0 pi-/+ Decays

We present measurements of the branching fractions for the three-body decays B0 -> D(*)-/+ K0 pi^+/-$and their resonant submodes$B0 -> D(*)-/+ K*+/- using a sample of approximately 88 million BBbar pairs collected by the BABAR detector at the PEP-II asymmetric energy storage ring. We measure: B(B0->D-/+ K0 pi+/-)=(4.9 +/- 0.7(stat) +/- 0.5 (syst)) 10^{-4} B(B0->D*-/+ K0 pi+/-)=(3.0 +/- 0.7(stat) +/- 0.3 (syst)) 10^{-4} B(B0->D-/+ K*+/-)=(4.6 +/- 0.6(stat) +/- 0.5 (syst)) 10^{-4} B(B0->D*-/+ K*+/-)=(3.2 +/- 0.6(stat) +/- 0.3 (syst)) 10^{-4} From these measurements we determine the fractions of resonant events to be : f(B0-> D-/+ K*+/-) = 0.63 +/- 0.08(stat) +/- 0.04(syst) f(B0-> D*-/+ K*+/-) = 0.72 +/- 0.14(stat) +/- 0.05(syst)Comment: 7 pages, 3 figures submitted to Phys. Rev. Let

Measurement of the quasi-elastic axial vector mass in neutrino-oxygen interactions

The weak nucleon axial-vector form factor for quasi-elastic interactions is determined using neutrino interaction data from the K2K Scintillating Fiber detector in the neutrino beam at KEK. More than 12,000 events are analyzed, of which half are charged-current quasi-elastic interactions nu-mu n to mu- p occurring primarily in oxygen nuclei. We use a relativistic Fermi gas model for oxygen and assume the form factor is approximately a dipole with one parameter, the axial vector mass M_A, and fit to the shape of the distribution of the square of the momentum transfer from the nucleon to the nucleus. Our best fit result for M_A = 1.20 \pm 0.12 GeV. Furthermore, this analysis includes updated vector form factors from recent electron scattering experiments and a discussion of the effects of the nucleon momentum on the shape of the fitted distributions.Comment: 14 pages, 10 figures, 6 table