Conocimientos y prácticas del personal de Enfermería sobre el manejo del recién nacido con asfixia neonatal-Hospital Gaspar García Laviana-Rivas-II semestre 2019

Tema: Conocimientos y prácticas del personal de Enfermería sobre el manejo del recién nacido con asfixia neonatal-Hospital Gaspar García Laviana-Rivas-II semestre 2019. Autoras: López Calvo Yara Alejandra; Reyes Bermúdez Darling Karina. La asfixia neonatal representa una de las primeras causas de morbimortalidad a nivel internacional y nacional, siendo uno de los principales problemas de salud pública, con el objetivo de evaluar los conocimientos y práctica del personal de enfermería al neonato asfíctico se realizó un estudio con el tema “Conocimiento y práctica del personal de Enfermería sobre el manejo del recién nacido con asfixia neonatal-Hospital Gaspar García Laviana-Rivas- II semestre 2019”, ya que actualmente existe una incidencia significativa de muerte por asfixia, valorando así la calidad de conocimiento que posee el personal de enfermería y como estos a nivel práctico actúan para salvar la vida del recién nacido, permitiendo así proponer información que incida sobre las intervenciones de acuerdo a la práctica para dar respuesta a dicha problemática aumentando la posibilidad de sobrevivencia de todo bebé asfíctico que nazca en ese lugar. Este estudio es de enfoque cuantitativo, retro prospectivo, descriptivo, corte trasversal; la población de estudio fue de 5 Lic. que laboran en el área de labor y parto, los instrumentos fueron guía de encuesta 18 preguntas cerradas de selección múltiple y revisión documental compuesto por 29 ítem, para triangular la información se realizó la comparación de lo teórico-práctico a las variables de estudio: conocimiento científico sobre asfixia neonatal y técnica ABR y práctica en el manejo de recién nacido con asfixia. Predominando el sexo femenino, edad 46-55, procedencia urbana,25 a 30 años de experiencia, estas poseen conocimiento sobre la asfixia, concepto, clasificación y parámetros a tomar en cuenta, respecto al conocimiento de la técnica ABR no manejan el orden a seguir, sin embargo en la práctica mediante revisión documental se encontró que aplicaron correctamente dicha técnica.. Es importante que el hospital continúe con capacitación sobre la asfixia neonatal y la aplicación correcta del ABR; al personal de enfermería cumplir con el rol de investigadores para mejorar la calidad y calidez en la atención. Palabras Claves: Conocimiento, práctica, asfixia neonatal

Impaired proteasome activity and neurodegeneration with brain iron accumulation in FBXO7 defect

Altres ajuts: This work was funded by Instituto de Salud Carlos III; Ministerio de Educación, Cultura y Deporte; Spanish Foundation per Amor a l'Art (FPAA) grant ; Fundació la Marató de TV3 grants 20143130; and 20143131; Generalitat Valenciana grants OP ERDF of Comunitat Valenciana 2014-2020; and PROMETEO/2018/135.FBXO7 is implicated in the ubiquitin-proteasome system and parkin-mediated mitophagy. FBXO7defects cause a levodopa-responsive parkinsonian-pyramidal syndrome(PPS). Methods: We investigated the disease molecular bases in a child with PPS and brain iron accumulation. Results: A novel homozygous c.368C>G (p.S123*) FBXO7 mutation was identified in a child with spastic paraplegia, epilepsy, cerebellar degeneration, levodopa nonresponsive parkinsonism, and brain iron deposition. Patient's fibroblasts assays demonstrated an absence of FBXO7 RNA expression leading to impaired proteasome degradation and accumulation of poly-ubiquitinated proteins. Conclusion: This novel FBXO7 phenotype associated with impaired proteasome activity overlaps with neurodegeneration with brain iron accumulation disorders

Flexible high efficiency perovskite solar cells

Flexible perovskite based solar cells with power conversion efficiencies of 7% have been prepared on PET based conductive substrates. Extended bending of the devices does not deteriorate their performance demonstrating their suitability for roll to roll processing

Self-reported side effects after vaccination against COVID-19 in Honduras

Background: In December 2019, in the community of Wuhan, in Hubei, China, a series of atypical pneumonia cases with severe course was identified and the new disease was called COVID-19. By March 2020, the World Health Organization declared a pandemic. Understanding SARS-CoV2 genomic allowed the scientific community to develop vaccine candidates against COVID-19. Over 41 scientific groups conducted clinical trials to prove vaccines efficiency, efficacy, and safety.Method: A cross sectional retrospective study performed in Honduras since July 21st, 2021, to December 1st, 2021. This study included the population who received at least one dose of any COVID-19 vaccine. The data were collected using an online survey using Google Forms and a QR code to make it easier for the participants to access the survey and to avoid collecting any personal data from the participants. The symptoms were self-reported. A total of 2108 participants were included in the study through the online survey.Results: The average age of the participants was 34.61±11.129 years with higher frequency of people between 20-29 years old. In 60.7% of the cases, side effects were reported after the first dose of COVID-19 vaccine or in cases when only one dose was required. Only 1916 received a second dose of COVID-19 vaccine and 38.9% of them presented side effects after that second dose. The most common side effect is pain in the injection site (49.7% and 30.7%). The most common systemic side effects are fever (34.8% and 17.5%), headache (33.5% and 19.1%) and myalgia (32.8% and 17.6%). Conclusions: The side effects reported by the population after any vaccination against COVID-19 are mainly systemic effects like fever, myalgia and headache, while the most common local side effect is pain in the injection site. The rates of side effects are higher in females, and younger participants after both doses, the differences are statistically significant

Molecular techniques and their limitations shape our view of the holobiont

It is now recognised that the biology of almost any organism cannot be fully understood without recognising the existence and potential functional importance of associated microbes. Arguably, the emergence of this holistic viewpoint may never have occurred without the development of a crucial molecular technique, 16S rDNA amplicon sequencing, which allowed microbial communities to be easily profiled across a broad range of contexts. A diverse array of molecular techniques are now used to profile microbial communities, infer their evolutionary histories, visualise them in host tissues, and measure their molecular activity. In this review, we examine each of these categories of measurement and inference with a focus on the questions they make tractable, and the degree to which their capabilities and limitations shape our view of the holobiont

Clinical rating scale for pantothenate kinase-associated neurodegeneration: A pilot study

Pantothenate kinase-associated neurodegeneration is a progressive neurological disorder occurring in both childhood and adulthood. The objective of this study was to design and pilot-test a disease-specific clinical rating scale for the assessment of patients with pantothenate kinase-associated neurodegeneration.info:eu-repo/semantics/publishedVersio

Mutations, Genes, and Phenotypes Related to Movement Disorders and Ataxias

26 páginas, 4 figuras, 3 tablasOur clinical series comprises 124 patients with movement disorders (MDs) and/or ataxia with cerebellar atrophy (CA), many of them showing signs of neurodegeneration with brain iron accumulation (NBIA). Ten NBIA genes are accepted, although isolated cases compatible with abnormal brain iron deposits are known. The patients were evaluated using standardised clinical assessments of ataxia and MDs. First, NBIA genes were analysed by Sanger sequencing and 59 patients achieved a diagnosis, including the detection of the founder mutation PANK2 p.T528M in Romani people. Then, we used a custom panel MovDisord and/or exome sequencing; 29 cases were solved with a great genetic heterogeneity (34 different mutations in 23 genes). Three patients presented brain iron deposits with Fe-sensitive MRI sequences and mutations in FBXO7, GLB1, and KIF1A, suggesting an NBIA-like phenotype. Eleven patients showed very early-onset ataxia and CA with cortical hyperintensities caused by mutations in ITPR1, KIF1A, SPTBN2, PLA2G6, PMPCA, and PRDX3. The novel variants were investigated by structural modelling, luciferase analysis, transcript/minigenes studies, or immunofluorescence assays. Our findings expand the phenotypes and the genetics of MDs and ataxias with early-onset CA and cortical hyperintensities and highlight that the abnormal brain iron accumulation or early cerebellar gliosis may resembling an NBIA phenotype.This work was supported by the Instituto de Salud Carlos III (ISCIII)—Subdirección General de Evaluación y Fomento de la Investigación within the framework of the National R + D+I Plan co-funded with European Regional Development Funds (ERDF) [Grants PI18/00147 and PI21/00103 to CE]; the Fundació La Marató TV3 [Grants 20143130 and 20143131 to BPD and CE]; and by the Generalitat Valenciana [Grant PROMETEO/2018/135 to CE]. Part of the equipment employed in this work was funded by Generalitat Valenciana and co-financed with ERDF (OP ERDF of Comunitat Valenciana 2014–2020). PS had an FPU-PhD fellowship funded by the Spanish Ministry of Education, Culture and Sport [FPU15/00964]. IH has a PFIS-PhD fellowship [FI19/00072]. ASM has a contract funded by the Spanish Foundation Per Amor a l’Art (FPAA)Peer reviewe

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries