65 research outputs found
La creación de la empresa Eco Reverse Vending basada en el análisis estadístico de la gestión de residuos y reciclaje
‘Eco Reverse Vending’ es una empresa que se propone fomentar el reciclaje a través de máquinas reverse vending. Estas máquinas permiten a los usuarios depositar sus residuos a cambio de un beneficio. El proyecto se basa en un análisis estadístico de los datos de los municipios de la provincia de Córdoba. El estudio ha demostrado que la tasa de reciclaje en la provincia es baja, y que el uso de máquinas reverse vending podría ayudar a aumentarla. El plan de empresa de ‘Eco Reverse Vendin’g incluye la instalación de máquinas en diferentes puntos de la provincia, así como la promoción de la empresa entre los ciudadanos. El proyecto ‘Eco Reverse Vending’ es innovador y beneficioso para la sociedad, las empresas y el medio ambiente. Tiene un gran potencial para su implementación y expansión en el mercado actual
The registry of home artificial nutrition and ambulatory of the Spanish society of parenteral and enteral nutrition: Swot analysis
Objetivo: Evidenciar mediante un análisis DAFO-R
realizado por consenso de expertos las características
más acuciantes del registro de Nutrición Artificial Domiciliaria
y Ambulatoria.
Material y método: Análisis DAFO-R por consenso de
expertos. Se solicitó la participación de los miembros del
grupo NADYA activos en los últimos 5 años bajo la premisa
de estructurar el DAFO-R sobre las características
del registro NADYA desde su inicio.
Resultados: Han participado 18 expertos de diferentes
hospitales de la geografía española. El análisis interno se
inclina positivamente presentando al registro con recursos
importantes. En el análisis externo no son numerosas
las amenazas, hay factores de gran potencia, “la voluntariedad
del registro” y la “dependencia externa de financiación”.
Las oportunidades identificadas son importantes.
Las recomendaciones se dirigen a la estabilización del
sistema disminuyendo las amenazas como foco principal
de las estrategias a desarrollar al mismo tiempo que se
debe potenciar los puntos identificados en oportunidades
y fortalezas.
Conclusiones: El registro NADYA se muestra en el
análisis con gran potencialidad de mejora. Las recomendaciones
propuestas deberán estructurarse para continuar
la tendencia de desarrollo y perfeccionamiento de la
calidad que ha caracterizado al registro NADYA desde su
inicio.Objective: To evidence by means of a SWOT-R analysis
performed by an expert consensus the most worrying
characteristics of the register on Home-based and Outpatient
Artificial Nutrition.
Material and methods: SWOT-R analysis with expert
consensus. We requested the participation of the active
members of the NADYA group within the last 5 years
with the premise of structuring the SWOT-R based on the
characteristics of the NADYA registry from its beginning.
Results: 18 experts from hospitals all over Spain have
participated. The internal analysis seems to be positive,
presenting the registry as having important resources.
The external analysis did not show a great number of
threats, there are very potent factors, “the voluntariness”
of the registry and the “dependence on external financing”.
The opportunities identified are important. The
recommendations are aimed at stabilizing the system by
decreasing the threats as one of the main focus of the strategies
to develop as well as promoting the items identified
as opportunities and strengths.
Conclusions: The analysis shows that the NADYA
register shows a big potentiality for improvement. The
proposed recommendations should be structured in
order to stay on the track of development and quality
improvement that has characterized the NADYA register
from the beginnin
Home parenteral nutrition (HPN) registry in spain for the years 2007, 2008 and 2009 (Nadya-SENPE group)
Objetivo: Comunicar los datos del registro de Nutrición
Parenteral Domiciliaria (NPD) del grupo de trabajo
NADYA-SENPE de los años 2007, 2008 y 2009.
Material y métodos: Recopilación de los datos del registro
“on-line” introducidos por las Unidades responsables
del seguimiento de la NPD desde el 1 de enero de 2007 al 31
de diciembre de 2009 dividido por años naturales.
Resultados: Año 2007: Se registraron 133 pacientes
con NPD (61 hombres y 72 mujeres), de 21 hospitales. La
edad media de los 119 pacientes mayores de 13 años fue de
53,7 ± 14,9 años, y de 3,6 ± 3,6 años la de los 14 pacientes
que no los superaban. La patología más frecuente fue la
neoplasia (24%) seguida de las alteraciones de la motilidad
intestinal y la enteritis posradiación (ambas 14%).
En el 43% de los casos el motivo de indicación fue el síndrome
de intestino corto, seguido de malabsorción (27%)
y obstrucción intestinal (23%). Los catéteres más utilizados
fueron los tunelizados (69%) y los reservorios subcutáneos
(27%). Las complicaciones mas frecuentes fueron
las sépticas relacionadas con el catéter con una tasa de
0,92 infecciones por cada mil días de NPD. La duración de
la NPD fue superior a los dos años en el 50% de los casos.
Al acabar el año seguía en activo el 71,4% de los pacientes;
la muerte fue la principal causa de la finalización de
la NPD (57,5%). El 26% de los pacientes se consideraron
candidatos al trasplante intestinal.
Año 2008: Se registraron 143 pacientes con NPD (62
hombres y 81mujeres), de 24 hospitales. La edad media
de los 133 pacientes mayores de 13 años fue de 54,7 ± 13,9
años, y de 3,7 ± 0,6 años la de los 10 pacientes que no los
superaban. La patología más frecuente fue la neoplasia
(20%) seguida de la enteritis rádica (14%) y las alteraciones
de la motilidad intestinal (13%). En el 44% de los
casos el motivo de indicación fue el síndrome de intestino
corto, seguido de malabsorción (28%) y obstrucción
Nutriintestinal
(20%). Los catéteres más utilizados fueron los
tunelizados (60%) y los reservorios subcutáneos (29%).
Las complicaciones mas frecuentes fueron las sépticas
relacionadas con el catéter con una tasa de 0,50 infecciones
por cada mil días de NPD. La duración de la NPD fue
superior a los dos años en el 67% de los casos. Al acabar el
año seguía en activo el 71,6% de los pacientes; la muerte
fue la principal causa de la finalización de la NPD
(52,4%). El 29% de los pacientes se consideraron candidatos
al trasplante intestinal.
Año 2009: Se registraron 158 pacientes con NPD (62
hombres y 96 mujeres), de 24 hospitales. La edad media
de los 149 pacientes mayores de 13 años fue de 55,2 ± 13,0
años. La patología más frecuente fue la neoplasia (25%)
seguida de la enteritis rádica (12%) y las alteraciones de
la motilidad intestinal (11%). En el 42% de los casos el
motivo de indicación fue el síndrome de intestino corto,
seguido de malabsorción y obstrucción intestinal (ambas
23%). Los catéteres más utilizados fueron los tunelizados
(60%) y los reservorios subcutáneos (36%). Las complicaciones
mas frecuentes fueron las sépticas relacionadas
con el catéter con una tasa de 0,67 infecciones por cada
mil días de NPD. La duración de la NPD fue superior a los
dos años en el 58% de los casos. Al acabar el año seguía en
activo el 79,2% de los pacientes; el paso a alimentación
oral fue la principal causa de la finalización de la NPD
(48%). El 23% de los pacientes se consideraron candidatos
a trasplante intestinal.
Conclusiones: Se observa un aumento progresivo de
los pacientes registrados respecto a años anteriores con
una prevalencia muy variable según comunidades autónomas.
La principal patología sigue siendo la neoplasia,
que ocupa el primer lugar desde 2003. Se aprecia una disminución
de las complicaciones sépticas relacionadas con
el catéter en los dos últimos años, siendo la tasa de 2008 la
más baja desde la creación del registroObjective: To report the data of the Home Parenteral
Nutrition (HPN) registry of the NADYA-SENPE working
group for the years 2007, 2008 and 2009.
Methodology: We compiled the data from the on-line
registry introduced by the responsible Units for the monitoring
of HPN from January 1st 2007 to December 31st
2009. Included fields were: age, sex, diagnosis and reason
for HPN, access path, complications, beginning and end
dates, complementary oral or enteral nutrition, activity
level, autonomy degree, product and fungible material
supply, withdrawal reason and intestinal transplant indication.
Results: 2007: 133 patients with HPN were registered
(61 males and 72 females), belonging to 21 hospitals.
Average age for the 119 patients older than 13 years old
was 53.7 ± 14.9 years, and 3.6 ± 3.6 y. for the 14 patients
under 14 years old. Most frequent pathology was neoplasm
(24%), followed by intestinal motility disorders
and actinic enteritis (14% both). The reason for HPN provision
was short bowel syndrome (43%), malabsorption
(27%), and intestinal obstruction (23%). Tunnelled
catheters were mostly used (69%), followed by implanted
port-catheters (27%). Catheter related infections were
the most frequent complications, with a rate of 0.92
episodes/103 HPN days. HPN was provided for more than
two years in 50% of the cases. By the end of 2007, 71.4%
of the patients remained active; exitus was the most frequent
reason to end HPN (57.5%). 26% of the patients
were eligible for intestinal transplant.
2008: 143 patients with HPN were registered (62 males
and 81 females), belonging to 24 hospitals. Average age
for the 133 patients older than 13 years old was 54.7 ± 13.9
years, and 3.7 ± 0.6 y. for the 10 patients under 14 years
old. Most frequent pathology was neoplasm (20%), followed
by actinic enteritis (14%) and intestinal motility
disorders (13% ). The reason for HPN provision was
short bowel syndrome (44%), malabsorption (28%), and
intestinal obstruction (20%). Tunnelled catheters were
mostly used (60%), followed by implanted port-catheters
(29%). Catheter related infections were the most frequent
complications, with a rate of 0.50 episodes/103 HPN
days. HPN was provided for more than two years in 67%
of the cases. By the end of 2008, 71.6% of the patients
remained active; exitus was the most frequent reason to
end HPN (52.4%). 29% of the patients were eligible for
intestinal transplant.
2009: 158 patients with HPN were registered (62 males
and 96 females), belonging to 24 hospitals. Average age
for the 149 patients older than 13 years old was 55.2 ± 13.0
years. Most frequent pathology was neoplasm (25%), followed
by actinic enteritis (12%) and intestinal motility
disorders (11%). The reason for HPN provision was short
bowel syndrome (42%), malabsorption, and intestinal
obstruction (23% both). Tunnelled catheters were mostly
used (60%), followed by implanted port-catheters (36%).
Catheter related infections were the most frequent complications,
with a rate of 0.67 episodes/103 HPN days.
HPN was provided for more than two years in 58% of the
cases. By the end of 2009, 79.2% of the patients remained
active; full oral nutrition was the most frequent reason to
end HPN (48%). 23% of the patients were eligible for
intestinal transplant.
Conclusions: We observe an increase in registered
patients with respect to previous years, with a very different
prevalence among regions. Neoplasia remains as the
main pathology since 2003. We observe a decrease in
catheter-related infections in the last two years, being the
2008 rate the smallest since the register’s beginning
Home parenteral nutrition registry in Spain for the year 2010: NADYA-SENPE group
Objetivos: Comunicar los datos del Registro del Grupo
NADYA SENPE de Nutrición Parenteral Domiciliaria
NPD en España del año 2010.
Material y métodos: Estudio descriptivo de la base de
datos del Registro de ámbito nacional de NPD del grupo
NADYA-SENPE (1 de enero de 2010 al 31 de diciembre de
2010). Para el cálculo de prevalencias se utilizó los últimos
datos publicados por el Instituto Nacional de Estadística.
Resultados: Se registraron 148 pacientes procedentes de
23 hospitales, 86 mujeres (58,11%) y 9 niños (6,08%). La
edad media de los 139 pacientes adultos fue de 53,06 ±
15,41 años. La duración media de la NPD fue de 316,97
días/paciente. El diagnóstico más frecuente en los niños
(menores de 14 años) fue intestino corto traumático con 5
casos (55,55%) y en los adultos la neoplasia en tratamiento
paliativo 29 (19,59%). El motivo de la indicación de la NPD
fue el síndrome de intestino corto en 74 ocasiones (47%).
La vía de acceso más frecuentemente registrada fue el catéter
tunelizado en 36 (22,78%) casos seguido del reservorio
en 13 (8,23%) y otras vías en 3 ocasiones (1,90%). Se registraron
23 infecciones relacionadas con el catéter (82,14%),
lo que representa 0,49/1000 días de NP y todas ellas ocurrieron
en los adultos. A lo largo del año finalizaron 24 episodios
de NPD, la causa más frecuente fue el paso a la vía
oral en 12 episodios (50%). Se registró que los pacientes
tenían una actividad normal en 70 episodios de NPD
(44,30%) con una total autonomía en 88 de episodios
(55,69%). Se identificaron 39 (24,68%) posibles candidatos
para trasplante intestinal.
Conclusiones: El número de pacientes registrados es
discretamente inferior al del año anterior, aunque el
número de hospitales participantes es el mismo. La complicación
más frecuente sigue siendo la infección relacionada
con el catéter aunque ha disminuido su incidencia
respecto a años anteriores, presentándose la tasa más
baja desde la creación del registro.
Las diferencias en la participación en el registro observadas
por Comunidades Autónomas lleva a plantear el
desarrollo de estrategias de implementación del registro.
Se observa un aumento progresivo de la duración de los
días de NPD a lo largo de los años que hace pensar en la
cronicidad de algunos pacientes, pero nos obliga a estudiar
la existencia de un posible factor de confusión, en el
caso de que existiera un olvido de cierre de algún episodio
por lo que se hace necesario actualizar el registro con sistemas
de alertas periódicas que faciliten la revisión de los
pacientes incluidos y optimice la validez del registroObjectives: To report the Group Registry NADYASENPE
data about home parenteral nutrition (HPN) in
Spain in 2010.
Material and methods: A descriptive study of the database
of the national registry of HPN of NADYA-SENPE
(December 10, 2009 to December 10, 2010). For the calculation
of prevalence the latest data published by the Institute
National Statistics Office (01/01/2009) was used.
Results: There were registered 148 patients from 23
hospitals, 86 women (58.11%) and 9 children (6.08%).
The average age of the 139 patients older than 14 years
was 53.06 ± 15.41 years. The average duration of HPN
was 316.97 days/patient. The most common diagnosis in
those younger than 14 years was short bowel traumatic
with 5 cases (55.55%) and in those older than 14 years,
palliative care cancer with 29 cases (19.59%). The reason
for the indication for HPN was short bowel syndrome in
74 cases (47%). The access via most frequently recorded
was tunneled catheter in 36 cases (22.78%) followed by
implanted port-catheters in 13 cases (8.23%) and other
pathways in 3 cases (1.90%). There were 23 catheterrelated
infections (82.14%) which represented 0.49 /1,000
days of PN, all of which occurred in cases older than 14
years. During the year 24 episodes of HPN ended, the
most frequent cause was the transition to oral nutrition in
12 episodes (50%). It was reported that patients had a
normal activity in 70 episodes of HPN (44.30%) with complete
autonomy in 88 episodes (55.69%). Some patients 39
(24.68%) were potential candidates for intestinal transplantation.
Conclusions: The number of registered patients is
slightly lower than the previous year, although the number
of participating hospitals is the same. The most frequent
complication remains catheter-related infection
but its incidence has decreased from previous years, presenting
the lowest rate since the creation of the record.
Differences in participation in the registry observed in
the Autonomous Communities causes the development of
implementation strategies. There is a gradual increase in
day length of HPN over the years, which suggests the
chronic treatments of some patients and obliges to study
the existence of a possible confounding factor, in case
there is an oversight of closing an episode. Therefore, it is
necessary to update the registry with warning systems
that facilitate periodic review of the patients and optimize
the validity of registratio
Izaña Atmospheric Research Center. Activity Report 2019-2020
Editors: Emilio Cuevas, Celia Milford and Oksana Tarasova.[EN]The Izaña Atmospheric Research Center (IARC), which is part of the State Meteorological Agency of Spain (AEMET), is a site of excellence in atmospheric science. It manages four observatories in Tenerife including the high altitude Izaña Atmospheric Observatory. The Izaña Atmospheric Observatory was inaugurated in 1916 and since that date has carried out uninterrupted meteorological and climatological observations, contributing towards a unique 100-year record in 2016.
This reports are a summary of the many activities at the Izaña Atmospheric Research Center to the broader community. The combination of operational activities, research and development in state-of-the-art measurement techniques, calibration and validation and international cooperation encompass the vision of WMO to provide world leadership in expertise and international cooperation in weather, climate, hydrology and related environmental issues.[ES]El Centro de Investigación Atmosférica de Izaña (CIAI), que forma parte de la Agencia Estatal de Meteorología de España (AEMET), representa un centro de excelencia en ciencias atmosféricas. Gestiona cuatro observatorios en Tenerife, incluido el Observatorio de Izaña de gran altitud, inaugurado en 1916 y que desde entonces ha realizado observaciones meteorológicas y climatológicas ininterrumpidas y se ha convertido en una estación centenaria de la OMM.
Estos informes resumen las múltiples actividades llevadas a cabo por el Centro de Investigación Atmosférica de Izaña. El liderazgo del Centro en materia de investigación y desarrollo con respecto a las técnicas de medición, calibración y validación de última generación, así como la cooperación internacional, le han otorgado una reputación sobresaliente en lo que se refiere al tiempo, el clima, la hidrología y otros temas ambientales afines
Izaña Atmospheric Research Center. Activity Report 2015-2016
This report is a summary of the many activities at the Izaña Atmospheric Research Center to the broader community. The combination of operational activities, research and development in state-of-the-art measurement techniques, calibration and validation and international cooperation encompass the vision of WMO to provide world leadership in expertise and international cooperation in weather, climate, hydrology and related environmental issues
Multi-ancestry genome-wide association study of asthma exacerbations
Altres ajuts: European Regional Development Fund "ERDF A way of making Europe"; Allergopharma-EAACI award 2021; SysPharmPedia grant from the ERACoSysMed 1st Joint Transnational Call from the European Union under the Horizon 2020; Sandler Family Foundation; American Asthma Foundation; RWJF Amos Medical Faculty Development Program; National Heart, Lung, and Blood Institute of the National Institutes of Health (R01HL117004, R01HL128439, R01HL135156, X01HL134589, R01HL141992, R01HL141845); National Institute of Health and Environmental Health Sciences (R01ES015794, R21ES24844); National Institute on Minority Health and Health Disparities (NIMHD) (P60MD006902, R01MD010443, R56MD013312); National Institute of General Medical Sciences (NIGMS) (RL5GM118984); Tobacco-Related Disease Research Program (24RT-0025, 27IR-0030); National Human Genome Research Institute (NHGRI) (U01HG009080); GlaxoSmithKline and Utrecht Institute for Pharmaceutical Sciences; Slovenian Research Agency (P3-0067); SysPharmPediA grant, co-financed by the Ministry of Education, Science and Sport Slovenia (MIZS) (C3330-16-500106); NHS Research Scotland; Wellcome Trust Biomedical Resource (099177/Z/12/Z); Genotyping National Centre (CeGEN) CeGen-PRB3-ISCIII (AC15/00015); UK Medical Research Council and Wellcome (102215/2/13/2); University of Bristol; Swedish Heart-Lung Foundation, Swedish Research Council; Region Stockholm (ALF project and database maintenance); NHS Chair of Pharmacogenetics via the UK Department of Health; Innovative Medicines Initiative (IMI) (115010); European Federation of Pharmaceutical Industries and Associations (EFPIA); Spanish National Cancer Research Centre; Fundación Canaria Instituto de Investigación Sanitaria de Canarias (PIFIISC19/17); Erasmus Medical Center; Erasmus University Rotterdam; Netherlands Organization for the Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly (RIDE); Ministry of Education, Culture and Science; Ministry for Health, Welfare and Sports; European Commission (DG XII); Municipality of Rotterdam; German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF); U.S. National Institutes of Health (HL07966); European Social Fund "ESF Investing in your future"; Ministerio de Ciencia, Innovación y Universidades; Universidad de La Laguna (ULL); European Academy of Allergy and Clinical Immunology (EAACI); European Respiratory Society (ERS) (LTRF202101-00861); Ministry of Education, Science and Sport of the Republic of Slovenia (C3330-19-252012); Singapore Ministry of Education Academic Research Fund; Singapore Immunology Network (SIgN); National Medical Research Council (NMRC Singapore); Biomedical Research Council (BMRC Singapore); Agency for Science Technology and Research (A*STAR Singapore, N-154-000-038-001, R-154-000-191-112, R-154-000-404-112, R-154-000-553-112, R-154-000-565-112, R-154-000-630-112, R-154-000-A08-592, R-154-000-A27-597, R-154-000-A91-592, R-154-000-A95-592, R-154-000-B99-114, BMRC/01/1/21/18/077, BMRC/04/1/21/19/315, SIgN-06-006, SIgN-08-020, NMRC/1150/2008, H17/01/a0/008); Sime Darby Technology Centre; First Resources Ltd; Genting Plantation; Olam International; U.S. National Institutes of Health (HL138098).Background: Asthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on quality of life, and risk of mortality. The genetic basis of asthma exacerbations has been studied in several populations, but no prior study has performed a multi-ancestry meta-analysis of genome-wide association studies (meta-GWAS) for this trait. We aimed to identify common genetic loci associated with asthma exacerbations across diverse populations and to assess their functional role in regulating DNA methylation and gene expression. Methods: A meta-GWAS of asthma exacerbations in 4989 Europeans, 2181 Hispanics/Latinos, 1250 Singaporean Chinese, and 972 African Americans analyzed 9.6 million genetic variants. Suggestively associated variants (p ≤ 5 × 10) were assessed for replication in 36,477 European and 1078 non-European asthma patients. Functional effects on DNA methylation were assessed in 595 Hispanic/Latino and African American asthma patients and in publicly available databases. The effect on gene expression was evaluated in silico. Results: One hundred and twenty-six independent variants were suggestively associated with asthma exacerbations in the discovery phase. Two variants independently replicated: rs12091010 located at vascular cell adhesion molecule-1/exostosin like glycosyltransferase-2 (VCAM1/EXTL2) (discovery: odds ratio (OR) = 0.82, p = 9.05 × 10 and replication: OR = 0.89, p = 5.35 × 10) and rs943126 from pantothenate kinase 1 (PANK1) (discovery: OR = 0.85, p = 3.10 × 10 and replication: OR = 0.89, p = 1.30 × 10). Both variants regulate gene expression of genes where they locate and DNA methylation levels of nearby genes in whole blood. Conclusions: This multi-ancestry study revealed novel suggestive regulatory loci for asthma exacerbations located in genomic regions participating in inflammation and host defense
The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment
The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in
operation since July 2014. This paper describes the second data release from
this phase, and the fourteenth from SDSS overall (making this, Data Release
Fourteen or DR14). This release makes public data taken by SDSS-IV in its first
two years of operation (July 2014-2016). Like all previous SDSS releases, DR14
is cumulative, including the most recent reductions and calibrations of all
data taken by SDSS since the first phase began operations in 2000. New in DR14
is the first public release of data from the extended Baryon Oscillation
Spectroscopic Survey (eBOSS); the first data from the second phase of the
Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2),
including stellar parameter estimates from an innovative data driven machine
learning algorithm known as "The Cannon"; and almost twice as many data cubes
from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous
release (N = 2812 in total). This paper describes the location and format of
the publicly available data from SDSS-IV surveys. We provide references to the
important technical papers describing how these data have been taken (both
targeting and observation details) and processed for scientific use. The SDSS
website (www.sdss.org) has been updated for this release, and provides links to
data downloads, as well as tutorials and examples of data use. SDSS-IV is
planning to continue to collect astronomical data until 2020, and will be
followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14
happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov
2017 (this is the "post-print" and "post-proofs" version; minor corrections
only from v1, and most of errors found in proofs corrected
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality
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