The Governor-Generalship of Sir Lee Stack in the Sudan, 1917-1924.

The subject of this thesis is the history of the Anglo-Egyptian Sudan during the governor-generalship of Sir Lee Stack, 1917-1924. The study is based primarily on the unpublished records of the Sudan Government and various collected private papers. The first chapter deals with the appointment of Stack to succeed Sir Reginald Wingate; the economic and political effects on the Sudan of the first world war; the structure of the central government and the officials who directed it; and provincial administration. Stack's relations with Wingate and Viscount Allenby as high commissioners in Cairo are discussed. Among the most important developments of Stack's tenure were the emergence, on the one hand, of Sayyid 'Abd al-Rahman al-Mahdi as leader of the revivified Mahdist sect, and, on the other, of secular opposition to the Sudan Government. The second chapter traces the rise of Sayyid 'Abd al-Rahman, the nature of his support, and the government's attempts both to utilize and to limit his influence. The second part of the chapter charts the tentative beginnings, after the war, of secular opposition, and in focussing on the disturbances of 1924 attempts to analyse the motives of this opposition and the response of the government to it. The surge of Egyptian nationalism following the war led to a fundamental change in the relationship of Egypt and Britain, the co-domini in the Sudan. The Sudan's prominent place in the complicated series of negotiations before and especially after the British declaration to Egypt in February 1922, is considered in chapter three. An attempt is made to analyse the reasons for the breakdown in negotiations that culminated in the British ultimatum to Egypt in November 1924 following the assassination of Sir Lee Stack. The ultimatum itself and its consequences in the Sudan are considered in detail. Revived Mahdism, secular opposition, and Egyptian hostility, combined with a latent mistrust of educated Sudanese led the administration under Stack away from the direct, "bureaucratic" methods of the Wingate era toward Indirect Rule. This development is traced in the final chapter, in which conclusions are reached regarding the nature of Indirect Rule in the Sudan and its consequences for the political future of the country

An Introduction to the General Monotone Model with Application to Two Problematic Data Sets

We argue that the mismatch between data and analytical methods, along with common practices for dealing with “messy” data, can lead to inaccurate conclusions. Specifically, using previously published data on racial bias and culture of honor, we show that manifest effects, and therefore theoretical conclusions, are highly dependent on how researchers decide to handle extreme scores and nonlinearities when data are analyzed with traditional approaches. Within LS approaches, statistical effects appeared or disappeared on the basis of the inclusion or exclusion of as little as 1.5% (3 of 198) of the data, and highly predictive variables were masked by nonlinearities. We then demonstrate a new statistical modeling technique called the general monotone model (GeMM) and show that it has a number of desirable properties that may make it more appropriate for modeling messy data: It is more robust to extreme scores, less affected by outlier analyses, and more robust to violations of linearity on both the response and predictor variables compared with a variety of well-established statistical algorithms and frequently possesses greater statistical power. We argue that using procedures that make fewer assumptions about the data, such as GeMM, can lessen the need for researchers to use data-editing strategies (e.g., to apply transformations or to engage outlier analyses) on their data to satisfy often unrealistic statistical assumptions, leading to more consistent and accurate conclusions about data than traditional approaches of data analysis.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

A theoretical investigation of the low lying electronic structure of poly(p-phenylene vinylene)

The two-state molecular orbital model of the one-dimensional phenyl-based semiconductors is applied to poly(p-phenylene vinylene). The energies of the low-lying excited states are calculated using the density matrix renormalization group method. Calculations of both the exciton size and the charge gap show that there are both Bu and Ag excitonic levels below the band threshold. The energy of the 1Bu exciton extrapolates to 2.60 eV in the limit of infinite polymers, while the energy of the 2Ag exciton extrapolates to 2.94 eV. The calculated binding energy of the 1Bu exciton is 0.9 eV for a 13 phenylene unit chain and 0.6 eV for an infinite polymer. This is expected to decrease due to solvation effects. The lowest triplet state is calculated to be at ca. 1.6 eV, with the triplet-triplet gap being ca. 1.6 eV. A comparison between theory, and two-photon absorption and electroabsorption is made, leading to a consistent picture of the essential states responsible for most of the third-order nonlinear optical properties. An interpretation of the experimental nonlinear optical spectroscopies suggests an energy difference of ca. 0.4 eV between the vertical energy and ca. 0.8 eV between the relaxed energy, of the 1Bu exciton and the band gap, respectively.Comment: LaTeX, 19 pages, 7 eps figures included using epsf. To appear in Physical Review B, 199

Questioning the rise of gelatinous zooplankton in the World's oceans

During the past several decades, high numbers of gelatinous zooplankton species have been reported in many estuarine and coastal ecosystems. Coupled with media-driven public perception, a paradigm has evolved in which the global ocean ecosystems are thought to be heading toward being dominated by “nuisance” jellyfish. We question this current paradigm by presenting a broad overview of gelatinous zooplankton in a historicalcontext to develop the hypothesis that population changes reflect the human-mediated alteration of global ocean ecosystems. To this end, we synthesize information related to the evolutionary context of contemporary gelatinous zooplankton blooms, the human frame of reference forchanges in gelatinous zooplankton populations, and whether sufficient data are available to have established the paradigm. We conclude that the current paradigm in which it is believed that there has been a global increase in gelatinous zooplankton is unsubstantiated, and we develop a strategy for addressing the critical questions about long-term, human-related changes in the sea as they relate to gelatinous zooplankton blooms

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.

The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5-20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson's disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations

LSST: from Science Drivers to Reference Design and Anticipated Data Products

(Abridged) We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). A vast array of science will be enabled by a single wide-deep-fast sky survey, and LSST will have unique survey capability in the faint time domain. The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an inventory of the Solar System, exploring the transient optical sky, and mapping the Milky Way. LSST will be a wide-field ground-based system sited at Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg$^2$ field of view, and a 3.2 Gigapixel camera. The standard observing sequence will consist of pairs of 15-second exposures in a given field, with two such visits in each pointing in a given night. With these repeats, the LSST system is capable of imaging about 10,000 square degrees of sky in a single filter in three nights. The typical 5$\sigma$ point-source depth in a single visit in $r$ will be $\sim 24.5$ (AB). The project is in the construction phase and will begin regular survey operations by 2022. The survey area will be contained within 30,000 deg$^2$ with $\delta<+34.5^\circ$, and will be imaged multiple times in six bands, $ugrizy$, covering the wavelength range 320--1050 nm. About 90\% of the observing time will be devoted to a deep-wide-fast survey mode which will uniformly observe a 18,000 deg$^2$ region about 800 times (summed over all six bands) during the anticipated 10 years of operations, and yield a coadded map to $r\sim27.5$. The remaining 10\% of the observing time will be allocated to projects such as a Very Deep and Fast time domain survey. The goal is to make LSST data products, including a relational database of about 32 trillion observations of 40 billion objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures available from https://www.lsst.org/overvie

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis

Scoring System Prognostic of Outcome in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndrome

To develop a system prognostic of outcome in those undergoing allogeneic hematopoietic cell transplantation (allo HCT) for myelodysplastic syndrome (MDS)

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy

Peer reviewe