Differential Geometry of the Vortex Filament Equation

Differential calculus on the space of asymptotically linear curves is developed. The calculus is applied to the vortex filament equation in its Hamiltonian description. The recursion operator generating the infinite sequence of commuting flows is shown to be hereditary. The system is shown to have a description with a Hamiltonian pair. Master symmetries are found and are applied to deriving an expression of the constants of motion in involution. The expression agrees with the inspection of Langer and Perline.Comment: 20 pages, LaTeX, no figure

Vortex Filament in Three-manifold and the Duistermaat-Heckman Formula

Symplectic geometry of the vortex filament in a curved three-manifold is investigated. There appears an infinite sequence of constants of motion in involution in the case of constant curvature. The Duistermaat-Heckman formula is examined perturbatively for the classical partition function in our model and verified up to the 3-loop order.Comment: Revised to include Figure2 (a PostScript file). 15 pages, LaTex2e, 2 figure

Epi-fingerprinting and epi-interventions for improved crop production and food quality

Increasing crop production at a time of rapid climate change represents the greatest challenge facing contemporary agricultural research. Our understanding of the genetic control of yield derives from controlled field experiments designed to minimise environmental variance. In spite of these efforts there is substantial residual variability among plants attributable to Genotype x Environment (GxE) interactions. Recent advances in the field of epigenetics have revealed a plethora of gene control mechanisms that could account for much of this unassigned variation. These systems act as a regulatory interface between the perception of the environment and associated alterations in gene expression. Direct intervention of epigenetic control systems hold the enticing promise of creating new sources of variability that could enhance crop performance. Equally, understanding the relationship between various epigenetic states and responses of the crop to specific aspects of the growing environment (epigenetic fingerprinting) could allow for a more tailored approach to plant agronomy. In this review, we explore the many ways in which epigenetic interventions and epigenetic fingerprinting can be deployed for the improvement of crop production and quality

Dissecting Biological Dark Matter: Single Cell Genetic Analysis of TM7, a Rare and Uncultivated Microbe from the Human Mouth

Este artigo possui o objetivo de resgatar a Memória e História de uma importante trajetória da cidade de Araraquara – SP, a existência dos trólebus ou ônibus elétricos, permitindo com que esse período histórico não fique esquecido. Foi uma fase de crescimento e avanço tecnológico para a população araraquarense, pois era um meio de transporte coletivo movido à energia elétrica e que não poluía o meio ambiente. Esse meio de transporte foi projeto de um prefeito da época, Sr Rômulo Lupo que, ao fazer uma viagem à Itália, ficou interessado por ele e o implantou em Araraquara. O conhecimento referente à fabricação e o modo de funcionamento do sistema trólebus, com seus avanços tecnológicos e inovações que ocorreram no decorrer dos anos, demonstrar as vantagens e desvantagens deste sistema e a sua desativação são o objetivo dessa pesquisa. A metodologia utilizada foi a pesquisa de campo por meio de entrevistas realizadas na Companhia Trólebus de Araraquara-SP onde se desenvolveu o projeto de implantação dos ônibus elétricos na cidade, que entrou para a história do Sistema Trólebus Brasileiro, sendo a única cidade a possuir 100% de ônibus elétricos. Os sujeitos da pesquisa foram ex-funcionários que vivenciaram a implantação desse sistema, no decorrer desses 40 anos, dentre eles os diretores, motoristas e o encarregado da manutenção elétrica. Mesmo tendo suas desvantagens, as vantagens se mostraram substanciais e os trólebus ficaram décadas circulando na cidade – de 1959 a 1999. Além de não serem poluentes, eram silenciosos, sua manutenção era barata e os assentos eram confortáveis. Somando tudo isso, ele foi um patrimônio da cidade, deixando registrada a sua história no museu histórico na Fonte Luminosa. Foi um exemplo nacional, uma referência de transporte urbano

Práticas baseadas em evidências publicadas no Brasil: identificação e análise de suas vertentes e abordagens metodológicas

Revisão integrativa de estudos brasileiros sobre práticas baseadas em evidências (PBE) em saúde, publicados em periódicos ISI/JCR, nos últimos 10 anos. O objetivo foi identificar as especialidades que mais realizaram estes estudos, seus enfoques e abordagens metodológicas. A partir de critérios de inclusão, foram selecionados 144 trabalhos. Os resultados indicam que a maior quantidade de estudos feitos em PBE foram sobre infância e adolescência, infectologia, psiquiatria/saúde mental e cirurgia. Os enfoques predominantes foram prevenção, tratamento/reabilitação, diagnóstico e avaliação. As metodologias mais empregadas foram revisão sistemática sem ou com metanálise, revisão de protocolos ou síntese de estudos de evidências já disponíveis, e revisão integrativa. Constata-se forte expansão multiprofissional da PBE no Brasil, contribuindo para a busca de práticas mais criteriosas pela reunião, reconhecimento e análise crítica dos conhecimentos produzidos. O estudo contribui também para a própria análise dos modos de fazer pesquisa e novas possibilidades de investigação

The ASOS Surgical Risk Calculator: development and validation of a tool for identifying African surgical patients at risk of severe postoperative complications

Background: The African Surgical Outcomes Study (ASOS) showed that surgical patients in Africa have a mortality twice the global average. Existing risk assessment tools are not valid for use in this population because the pattern of risk for poor outcomes differs from high-income countries. The objective of this study was to derive and validate a simple, preoperative risk stratification tool to identify African surgical patients at risk for in-hospital postoperative mortality and severe complications. Methods: ASOS was a 7-day prospective cohort study of adult patients undergoing surgery in Africa. The ASOS Surgical Risk Calculator was constructed with a multivariable logistic regression model for the outcome of in-hospital mortality and severe postoperative complications. The following preoperative risk factors were entered into the model; age, sex, smoking status, ASA physical status, preoperative chronic comorbid conditions, indication for surgery, urgency, severity, and type of surgery. Results: The model was derived from 8799 patients from 168 African hospitals. The composite outcome of severe postoperative complications and death occurred in 423/8799 (4.8%) patients. The ASOS Surgical Risk Calculator includes the following risk factors: age, ASA physical status, indication for surgery, urgency, severity, and type of surgery. The model showed good discrimination with an area under the receiver operating characteristic curve of 0.805 and good calibration with c-statistic corrected for optimism of 0.784. Conclusions: This simple preoperative risk calculator could be used to identify high-risk surgical patients in African hospitals and facilitate increased postoperative surveillance. © 2018 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Medical Research Council of South Africa gran

Maternal and neonatal outcomes after caesarean delivery in the African Surgical Outcomes Study: a 7-day prospective observational cohort study.

BACKGROUND: Maternal and neonatal mortality is high in Africa, but few large, prospective studies have been done to investigate the risk factors associated with these poor maternal and neonatal outcomes. METHODS: A 7-day, international, prospective, observational cohort study was done in patients having caesarean delivery in 183 hospitals across 22 countries in Africa. The inclusion criteria were all consecutive patients (aged ≥18 years) admitted to participating centres having elective and non-elective caesarean delivery during the 7-day study cohort period. To ensure a representative sample, each hospital had to provide data for 90% of the eligible patients during the recruitment week. The primary outcome was in-hospital maternal mortality and complications, which were assessed by local investigators. The study was registered on the South African National Health Research Database, number KZ_2015RP7_22, and on ClinicalTrials.gov, number NCT03044899. FINDINGS: Between February, 2016, and May, 2016, 3792 patients were recruited from hospitals across Africa. 3685 were included in the postoperative complications analysis (107 missing data) and 3684 were included in the maternal mortality analysis (108 missing data). These hospitals had a combined number of specialist surgeons, obstetricians, and anaesthetists totalling 0·7 per 100 000 population (IQR 0·2-2·0). Maternal mortality was 20 (0·5%) of 3684 patients (95% CI 0·3-0·8). Complications occurred in 633 (17·4%) of 3636 mothers (16·2-18·6), which were predominantly severe intraoperative and postoperative bleeding (136 [3·8%] of 3612 mothers). Maternal mortality was independently associated with a preoperative presentation of placenta praevia, placental abruption, ruptured uterus, antepartum haemorrhage (odds ratio 4·47 [95% CI 1·46-13·65]), and perioperative severe obstetric haemorrhage (5·87 [1·99-17·34]) or anaesthesia complications (11·47 (1·20-109·20]). Neonatal mortality was 153 (4·4%) of 3506 infants (95% CI 3·7-5·0). INTERPRETATION: Maternal mortality after caesarean delivery in Africa is 50 times higher than that of high-income countries and is driven by peripartum haemorrhage and anaesthesia complications. Neonatal mortality is double the global average. Early identification and appropriate management of mothers at risk of peripartum haemorrhage might improve maternal and neonatal outcomes in Africa. FUNDING: Medical Research Council of South Africa.Medical Research Council of South Africa