3,044 research outputs found
Measuring the permeability of thin solid layers of natural waxes
Hypothesis:
Previous experimental work has shown that microcapsule walls, made by solidification of a molten wax, are unexpectedly permeable. The hypothesis was that this was due more to the structure of the wall than the material itself.
Experiments:
The permeability of thin (sub and low micron thickness) natural waxes was measured where a membrane was placed between two cells and the diffusion of a dye (fluorescein) measured. A filter paper was used to support the membranes. Two methods were used to coat the filter paper; simple dipping and spin coating. The resulting surfaces were examined using SEM, XRD and contact angle.
Findings:
Results indicate that the permeability of very thin walled capsules can be investigated by forming a layer on a porous support and measuring diffusion rates. Both the composition of the wax and the sample preparation is extremely important to the structure and resulting permeability of the membranes. Spin coating was much more effective than dip coating in reducing permeability. Carnauba wax had a much lower permeability than beeswax.
A difference in levels between the two cells was observed, indicating a potential Osmotic pressure difference at play which should be further investigated
Persistence of environmental DNA in marine systems
As environmental DNA (eDNA) becomes an increasingly valuable resource for marine ecosystem monitoring, understanding variation in its persistence across contrasting environments is critical. Here, we quantify the breakdown of macrobial eDNA over a spatio-temporal axis of locally extreme conditions, varying from ocean-influenced offshore to urban-inshore, and between winter and summer. We report that eDNA degrades 1.6 times faster in the inshore environment than the offshore environment, but contrary to expectation we find no difference over season. Analysis of environmental covariables show a spatial gradient of salinity and a temporal gradient of pH, with salinity—or the biotic correlates thereof—most important. Based on our estimated inshore eDNA half-life and naturally occurring eDNA concentrations, we estimate that eDNA may be detected for around 48 h, offering potential to collect ecological community data of high local fidelity. We conclude by placing these results in the context of previously published eDNA decay rates
Disease control across urban–rural gradients
Controlling the regional re-emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after its initial spread in ever-changing personal contact networks and disease landscapes is a challenging task. In a landscape context, contact opportunities within and between populations are changing rapidly as lockdown measures are relaxed and a number of social activities re-activated. Using an individual-based metapopulation model, we explored the efficacy of different control strategies across an urban–rural gradient in Wales, UK. Our model shows that isolation of symptomatic cases or regional lockdowns in response to local outbreaks have limited efficacy unless the overall transmission rate is kept persistently low. Additional isolation of non-symptomatic infected individuals, who may be detected by effective test-and-trace strategies, is pivotal to reducing the overall epidemic size over a wider range of transmission scenarios. We define an ‘urban–rural gradient in epidemic size' as a correlation between regional epidemic size and connectivity within the region, with more highly connected urban populations experiencing relatively larger outbreaks. For interventions focused on regional lockdowns, the strength of such gradients in epidemic size increased with higher travel frequencies, indicating a reduced efficacy of the control measure in the urban regions under these conditions. When both non-symptomatic and symptomatic individuals are isolated or regional lockdown strategies are enforced, we further found the strongest urban–rural epidemic gradients at high transmission rates. This effect was reversed for strategies targeted at symptomatic individuals only. Our results emphasize the importance of test-and-trace strategies and maintaining low transmission rates for efficiently controlling SARS-CoV-2 spread, both at landscape scale and in urban areas
A supersonic crowdion in mica: Ultradiscrete kinks with energy between K recoil and transmission sputtering
In this chapter we analyze in detail the behaviour and properties of the
kinks found in an one dimensional model for the close packed rows of potassium
ions in mica muscovite. The model includes realistic potentials obtained from
the physics of the problem, ion bombardment experiments and molecular dynamics
fitted to experiments. These kinks are supersonic and have an unique velocity
and energy. They are ultradiscrete involving the translation of an interstitial
ion, which is the reason they are called 'crowdions'. Their energy is below the
most probable source of energy, the decay of the K isotope and above the
energy needed to eject an atom from the mineral, a phenomenon that has been
observed experimentallyComment: 28 pages, 15 figure
Coupled ocean-atmosphere modeling and predictions
Key aspects of the current state of the ability of global and regional climate models to represent dynamical processes and precipitation variations are summarized. Interannual, decadal, and globalwarming timescales, wherein the influence of the oceans is relevant and the potential for predictability is highest, are emphasized. Oceanic influences on climate occur throughout the ocean and extend over land to affect many types of climate variations, including monsoons, the El Niño Southern Oscillation, decadal oscillations, and the response to greenhouse gas emissions. The fundamental ideas of coupling between the ocean-atmosphere-land system are explained for these modes in both global and regional contexts. Global coupled climate models are needed to represent and understand the complicated processes involved and allow us to make predictions over land and sea. Regional coupled climate models are needed to enhance our interpretation of the fine-scale response. The mechanisms by which large-scale, low-frequency variations can influence shorter timescale variations and drive regionalscale effects are also discussed. In this light of these processes, the prospects for practical climate predictability are also presented.AJMwas supported by theNSFEarth System Modeling Program (OCE1419306)
and the NOAA Climate Variability and Prediction Program (NA14OAR4310276). HS thanks the
Office of Naval Research for support under N00014-15-1-2588. LPP was supported by “Advanced
Studies in Medium and High Latitudes Oceanography” (CAPES 23038.004304/2014-28) and
“National Institute of Science andTechnology of the Cryosphere” (CNPq/PROANTAR704222/2009).
VM was supported by NOAA grant NA12OAR4310078. TGJ was supported by the U. S. Naval
Research Laboratory 6.2 project “Fresh Water Balance in the Coupled Ocean-Atmosphere System”
(BE-435-040-62435N-6777) YHT was supported by the MOST grant 106-2111-M-002-001,
Taiwan
Claudins in intestines
Intestines are organs that not only digest food and absorb nutrients, but also provide a defense barrier against pathogens and noxious agents ingested. Tight junctions (TJs) are the most apical component of the junctional complex, providing one form of cell-cell adhesion in enterocytes and playing a critical role in regulating paracellular barrier permeability. Alteration of TJs leads to a number of pathophysiological diseases causing malabsorption of nutrition and intestinal structure disruption, which may even contribute to systemic organ failure. Claudins are the major structural and functional components of TJs with at least 24 members in mammals. Claudins have distinct charge-selectivity, either by tightening the paracellular pathway or functioning as paracellular channels, regulating ions and small molecules passing through the paracellular pathway. In this review, we have discussed the functions of claudin family members, their distribution and localization in the intestinal tract of mammals, their alterations in intestine-related diseases and chemicals/agents that regulate the expression and localization of claudins as well as the intestinal permeability, which provide a therapeutic view for treating intestinal diseases
A questionnaire to identify patellofemoral pain in the community: an exploration of measurement properties
Background
Community-based studies of patellofemoral pain (PFP) need a questionnaire tool that discriminates between those with and those without the condition. To overcome these issues, we have designed a self-report questionnaire which aims to identify people with PFP in the community.
Methods
Study designs: comparative study and cross-sectional study.
Study population: comparative study: PFP patients, soft-tissue injury patients and adults without knee problems. Cross-sectional study: adults attending a science festival.
Intervention: comparative study participants completed the questionnaire at baseline and two weeks later. Cross-sectional study participants completed the questionnaire once.
The optimal scoring system and threshold was explored using receiver operating characteristic curves, test-retest reliability using Cohen’s kappa and measurement error using Bland-Altman plots and standard error of measurement. Known-group validity was explored by comparing PFP prevalence between genders and age groups.
Results
Eighty-four participants were recruited to the comparative study. The receiver operating characteristic curves suggested limiting the questionnaire to the clinical features and knee pain map sections (AUC 0.97 95 % CI 0.94 to 1.00). This combination had high sensitivity and specificity (over 90 %). Measurement error was less than the mean difference between the groups. Test–retest reliability estimates suggest good agreement (N = 51, k = 0.74, 95 % CI 0.52–0.91). The cross-sectional study (N = 110) showed expected differences between genders and age groups but these were not statistically significant.
Conclusion
A shortened version of the questionnaire, based on clinical features and a knee pain map, has good measurement properties. Further work is needed to validate the questionnaire in community samples
The epidemiology of patellar luxation in dogs attending primary-care veterinary practices in England
Bessel-Weighted Asymmetries in Semi Inclusive Deep Inelastic Scattering
The concept of weighted asymmetries is revisited for semi-inclusive deep
inelastic scattering. We consider the cross section in Fourier space, conjugate
to the outgoing hadron's transverse momentum, where convolutions of transverse
momentum dependent parton distribution functions and fragmentation functions
become simple products. Individual asymmetric terms in the cross section can be
projected out by means of a generalized set of weights involving Bessel
functions. Advantages of employing these Bessel weights are that they suppress
(divergent) contributions from high transverse momentum and that soft factors
cancel in (Bessel-) weighted asymmetries. Also, the resulting compact
expressions immediately connect to previous work on evolution equations for
transverse momentum dependent parton distribution and fragmentation functions
and to quantities accessible in lattice QCD. Bessel weighted asymmetries are
thus model independent observables that augment the description and our
understanding of correlations of spin and momentum in nucleon structure.Comment: Matches published version, JHEP style, 36 pages and 2 figures, minor
correction
Challenges and Opportunities: What Can We Learn from Patients Living with Chronic Musculoskeletal Conditions, Health Professionals and Carers about the Concept of Health Literacy Using Qualitative Methods of Inquiry?
The field of health literacy continues to evolve and concern public health researchers and yet remains a largely overlooked concept elsewhere in the healthcare system. We conducted focus group discussions in England UK, about the concept of health literacy with older patients with chronic musculoskeletal conditions (mean age = 73.4 years), carers and health professionals. Our research posed methodological, intellectual and practical challenges. Gaps in conceptualisation and expectations were revealed, reiterating deficiencies in predominant models for understanding health literacy and methodological shortcomings of using focus groups in qualitative research for this topic. Building on this unique insight into what the concept of health literacy meant to participants, we present analysis of our findings on factors perceived to foster and inhibit health literacy and on the issue of responsibility in health literacy. Patients saw health literacy as a result of an inconsistent interactive process and the implications as wide ranging; healthcare professionals had more heterogeneous views. All focus group discussants agreed that health literacy most benefited from good inter-personal communication and partnership. By proposing a needs-based approach to health literacy we offer an alternative way of conceptualising health literacy to help improve the health of older people with chronic conditions
- …