The central structure of Broad Absorption Line QSOs: observational characteristics in the cm-mm wavelength domain

Accounting for ~20% of the total QSO population, Broad Absorption Line QSOs are still an unsolved problem in the AGN context. They present wide troughs in the UV spectrum, due to material with velocities up to 0.2 c toward the observer. The two models proposed in literature try to explain them as a particular phase of the evolution of QSOs or as normal QSOs, but seen from a particular line of sight. We built a statistically complete sample of Radio-Loud BAL QSOs, and carried out an observing campaign to piece together the whole spectrum in the cm wavelength domain, and highlight all the possible differences with respect to a comparison sample of Radio-Loud non-BAL QSOs. VLBI observations at high angular resolution have been performed, to study the pc-scale morphology of these objects. Finally, we tried to detect a possible dust component with observations at mm-wavelengths. Results do not seem to indicate a young age for all BAL QSOs. Instead a variety of orientations and morphologies have been found, constraining the outflows foreseen by the orientation model to have different possible angles with respect to the jet axis

Combined effects of time spent in physical activity, sedentary behaviors and sleep on obesity and cardio-metabolic health markers: a novel compositional data analysis approach

<div><p>The associations between time spent in sleep, sedentary behaviors (SB) and physical activity with health are usually studied without taking into account that time is finite during the day, so time spent in each of these behaviors are codependent. Therefore, little is known about the combined effect of time spent in sleep, SB and physical activity, that together constitute a composite whole, on obesity and cardio-metabolic health markers. Cross-sectional analysis of NHANES 2005–6 cycle on N = 1937 adults, was undertaken using a compositional analysis paradigm, which accounts for this intrinsic codependence. Time spent in SB, light intensity (LIPA) and moderate to vigorous activity (MVPA) was determined from accelerometry and combined with self-reported sleep time to obtain the 24 hour time budget composition. The distribution of time spent in sleep, SB, LIPA and MVPA is significantly associated with BMI, waist circumference, triglycerides, plasma glucose, plasma insulin (all p<0.001), and systolic (p<0.001) and diastolic blood pressure (p<0.003), but not HDL or LDL. Within the composition, the strongest positive effect is found for the proportion of time spent in MVPA. Strikingly, the effects of MVPA replacing another behavior and of MVPA being displaced by another behavior are asymmetric. For example, re-allocating 10 minutes of SB to MVPA was associated with a lower waist circumference by 0.001% but if 10 minutes of MVPA is displaced by SB this was associated with a 0.84% higher waist circumference. The proportion of time spent in LIPA and SB were detrimentally associated with obesity and cardiovascular disease markers, but the association with SB was stronger. For diabetes risk markers, replacing SB with LIPA was associated with more favorable outcomes. Time spent in MVPA is an important target for intervention and preventing transfer of time from LIPA to SB might lessen the negative effects of physical inactivity.</p></div

Common Variants at 10 Genomic Loci Influence Hemoglobin A(1C) Levels via Glycemic and Nonglycemic Pathways

OBJECTIVE Glycated hemoglobin (HbA1c), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turnover, and abnormal glycation of hemoglobin could also be associated with increased levels of HbA1c. We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbA1c levels. RESEARCH DESIGN AND METHODS We studied associations with HbA1c in up to 46,368 nondiabetic adults of European descent from 23 genome-wide association studies (GWAS) and 8 cohorts with de novo genotyped single nucleotide polymorphisms (SNPs). We combined studies using inverse-variance meta-analysis and tested mediation by glycemia using conditional analyses. We estimated the global effect of HbA1c loci using a multilocus risk score, and used net reclassification to estimate genetic effects on diabetes screening. RESULTS Ten loci reached genome-wide significant association with HbA1c, including six new loci near FN3K (lead SNP/P value, rs1046896/P = 1.6 × 10−26), HFE (rs1800562/P = 2.6 × 10−20), TMPRSS6 (rs855791/P = 2.7 × 10−14), ANK1 (rs4737009/P = 6.1 × 10−12), SPTA1 (rs2779116/P = 2.8 × 10−9) and ATP11A/TUBGCP3 (rs7998202/P = 5.2 × 10−9), and four known HbA1c loci: HK1 (rs16926246/P = 3.1 × 10−54), MTNR1B (rs1387153/P = 4.0 × 10−11), GCK (rs1799884/P = 1.5 × 10−20) and G6PC2/ABCB11 (rs552976/P = 8.2 × 10−18). We show that associations with HbA1c are partly a function of hyperglycemia associated with 3 of the 10 loci (GCK, G6PC2 and MTNR1B). The seven nonglycemic loci accounted for a 0.19 (% HbA1c) difference between the extreme 10% tails of the risk score, and would reclassify ∼2% of a general white population screened for diabetes with HbA1c. CONCLUSIONS GWAS identified 10 genetic loci reproducibly associated with HbA1c. Six are novel and seven map to loci where rarer variants cause hereditary anemias and iron storage disorders. Common variants at these loci likely influence HbA1c levels via erythrocyte biology, and confer a small but detectable reclassification of diabetes diagnosis by HbA1c

Recent changes of water discharge and sediment load in the Yellow River basin, China

The Yellow River basin contributes approximately 6% of the sediment load from all river systems globally, and the annual runoff directly supports 12% of the Chinese population. As a result, describing and understanding recent variations of water discharge and sediment load under global change scenarios are of considerable importance. The present study considers the annual hydrologic series of the water discharge and sediment load of the Yellow River basin obtained from 15 gauging stations (10 mainstream, 5 tributaries). The Mann-Kendall test method was adopted to detect both gradual and abrupt change of hydrological series since the 1950s. With the exception of the area draining to the Upper Tangnaihai station, results indicate that both water discharge and sediment load have decreased significantly (p&lt;0.05). The declining trend is greater with distance downstream, and drainage area has a significant positive effect on the rate of decline. It is suggested that the abrupt change of the water discharge from the late 1980s to the early 1990s arose from human extraction, and that the abrupt change in sediment load was linked to disturbance from reservoir construction.Geography, PhysicalGeosciences, MultidisciplinarySCI(E)43ARTICLE4541-5613

Study of Bc+B_c^+ decays to the K+K−π+K^+K^-\pi^+ final state and evidence for the decay Bc+→χc0π+B_c^+\to\chi_{c0}\pi^+

A study of $B_c^+\to K^+K^-\pi^+$ decays is performed for the first time using data corresponding to an integrated luminosity of 3.0 $\mathrm{fb}^{-1}$ collected by the LHCb experiment in $pp$ collisions at centre-of-mass energies of $7$ and $8$ TeV. Evidence for the decay $B_c^+\to\chi_{c0}(\to K^+K^-)\pi^+$ is reported with a significance of 4.0 standard deviations, resulting in the measurement of $\frac{\sigma(B_c^+)}{\sigma(B^+)}\times\mathcal{B}(B_c^+\to\chi_{c0}\pi^+)$ to be $(9.8^{+3.4}_{-3.0}(\mathrm{stat})\pm 0.8(\mathrm{syst}))\times 10^{-6}$. Here $\mathcal{B}$ denotes a branching fraction while $\sigma(B_c^+)$ and $\sigma(B^+)$ are the production cross-sections for $B_c^+$ and $B^+$ mesons. An indication of $\bar b c$ weak annihilation is found for the region $m(K^-\pi^+)<1.834\mathrm{\,Ge\kern -0.1em V\!/}c^2$, with a significance of 2.4 standard deviations.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-022.html, link to supplemental material inserted in the reference

Influence of the Temperature and the Genotype of the HSP90AA1 Gene over Sperm Chromatin Stability in Manchega Rams

The present study addresses the effect of heat stress on males' reproduction ability. For that, we have evaluated the sperm DNA fragmentation (DFI) by SCSA of ejaculates incubated at 37°C during 0, 24 and 48 hours after its collection, as a way to mimic the temperature circumstances to which spermatozoa will be subject to in the ewe uterus. The effects of temperature and temperature-humidity index (THI) from day 60 prior collection to the date of semen collection on DFI were examined. To better understand the causes determining the sensitivity of spermatozoa to heat, this study was conducted in 60 males with alternative genotypes for the SNP G/C−660 of the HSP90AA1 promoter, which encode for the Hsp90α protein. The Hsp90α protein predominates in the brain and testis, and its role in spermatogenesis has been described in several species. Ridge regression analyses showed that days 29 to 35 and 7 to 14 before sperm collection (bsc) were the most critical regarding the effect of heat stress over DFI values. Mixed model analyses revealed that DFI increases over a threshold of 30°C for maximum temperature and 22 for THI at days 29 to 35 and 7 to 14 bsc only in animals carrying the GG−660 genotype. The period 29–35 bsc coincide with the meiosis I process for which the effect of the Hsp90α has been described in mice. The period 7–14 bsc may correspond with later stages of the meiosis II and early stages of epididymal maturation in which the replacement of histones by protamines occurs. Because of GG−660 genotype has been associated to lower levels of HSP90AA1 expression, suboptimal amounts of HSP90AA1 mRNA in GG−660 animals under heat stress conditions make spermatozoa DNA more susceptible to be fragmented. Thus, selecting against the GG−660 genotype could decrease the DNA fragmentation and spermatozoa thermal susceptibility in the heat season, and its putative subsequent fertility gainsPublishe

Validation of a method to estimate direct normal irradiance of UVA and PAR bands from global horizontal measurements for cloudless sky conditions in Valencia, Spain, by a measurement campaign

A method is proposed to provide measurement of direct normal solar irradiance of bands with wavelength ranges (315-400 nm, 400-700 nm) from measurements of global horizontal band irradiance for cloudless sky conditions in Valencia. Global and normal direct irradiance data for every air mass were obtained by applying the SMART2 model to the atmosphere of Valencia. The direct normal to global irradiance ratio was parameterized versus the relative optical air mass. A measurement campaign of global horizontal and diffuse irradiance of UVA and PAR bands was carried out in Valencia, after which, the inferred direct normal irradiance was compared with those provided by the method. The result of the comparison shows that the method is acceptably accurate. The proposed model tends to underestimate the direct normal irradiance of the UVA band by 6%, although for values below 25 W/m2 the model overestimates the direct irradiance by 6%, while for values above 25 W/m2 the model underestimates it by 10%. The other two error estimators used ranging from 11% to 15% are similar in the defined interval measurements in relation to the whole UVA band. Regarding the PAR band, the model overestimates the direct normal irradiance of the PAR band by only 2.2%. With this, the results of the PAR band are more conclusive, as it has been found that for direct normal irradiance values higher than 280 W/m2 the MBE error is almost zero and the other two estimator errors are small, about 5%. © 2010 Springer-Verlag.This work was supported by the Spanish Government through MEC grant MAT2009-14625-C03-03, and is a part of the activities of the Grup d'Optoelectronica i Semiconductors of the Polytechnic University of Valencia. The translation of this paper was funded by the Universidad Politecnica de Valencia, Spain.Serrano Jareño, MA.; Boscá Berga, JV. (2011). Validation of a method to estimate direct normal irradiance of UVA and PAR bands from global horizontal measurements for cloudless sky conditions in Valencia, Spain, by a measurement campaign. Theoretical and Applied Climatology. 103(1):95-101. https://doi.org/10.1007/s00704-010-0284-9S951011031Barth J, Cadet J, Césarini JP, Fitzpatrick TB, McKinlay A, Mutzhas M, Pathak M, Peak M, Sliney D, Urbach F (1999) TC 6-26 report: Standardization of the terms UV-A1, UV-A2 and UV-B, CIE 134-1999 ISBN 3-900-734-94-1Batlles FJ, Olmo FJ, Alados-Arboledas L (1995) On shadowband correction methods for diffuse irradiance measurements. Solar Energy 54(5):105–114Drummond AJ (1956) On the measurement of sky radiation. Arch 602 Meteor Geophys Bioklim B 7:413–436Gueymard C (1995) SMARTS2: a simple model of the atmospheric radiative transfer of sunshine: algorithms and performance assessment. FSEC-PF-270-95, Florida Solar Energy CenterGueymard C (2003) SMARTS2 code, versión 2.9.2. User’s Manual, Solar Consulting Services Bailey CO. Available from http://rredc.nrel.gov/solar/models/SMARTS/smarts_index.htmlGueymard C (2004) The sun’s total and spectral irradiance for solar energy applications and solar radiation models. Solar Energy 76:423–453Häder DP, Lebert M, Marangoni R, Colombetti G (1999) ELDONET-European light dosimeter network hardware and software. J Photochem Photobiol B: Biol 52:51–58Häder DP, Lebert M, Colombetti G, Figueroa F (2001) European light dosimeter network (ELDONET). Helgol Mar Res 55:35–44Iqbal M (1983) An introduction to solar radiation. Academic, TorontoKudish AI, Evseev EG (2008) The assessment of four different correction models applied to the diffuse radiation measured with a shadow ring using global and normal beam radiation measurements for Beer Sheva, Israel. Solar Energy 82(2):144–156LeBaron BA, Michalsky JJ, Perez R (1990) A simple procedure for correcting shadowband data for all sky conditions. Solar Energy 44:249–256Marín Fernández MJ (2007) Estudio de la irradiancia solar ultravioleta y eritemática en la Comunidad Valenciana. Doctoral Thesis University of Valencia (Spain)Perez R, Ineichen P, Seals R, Michalsky JJ, Stewart R (1990) Modelling daylight availability and irradiance components from direct and global irradiance. Sol Energy 44:271–289Pinazo JM, Cañada J, Bosca JV (1995) A new method to determine Ångström's turbidity coefficient: its application for Valencia. Solar Energy 54:219–226Serrano MA, Boscá JV, Cañada J (2008) The determination of a band factor to express irradiance of UV and PAR wavelength ranges in a clean and dry atmosphere at Valencia (Spain). Int J Ambient Energy 29(4):171–180Utrillas MP, Boscà JV, Martinez-Lozano JA, Cañada J, Tena F, Pinazo JM (1998) A comparative study of Spectral2, and Smarts2 parameterised models based on spectral irradiance measurements at Valencia, Spain. Solar Energy 63:161–171Utrillas MP, Marín MJ, Esteve AR, Tena F, Cañada J, Estellés V, Martínez Lozano JA (2007) Diffuse UV erythemal radiation experimental values. J Geophy Res 112:387–39

DNA microarray revealed and RNAi plants confirmed key genes conferring low Cd accumulation in barley grains

List of genes down-regulated in both W6nk2 and Zhenong8 after 15 days exposure to 5 ΟM Cd. (DOC 130 kb

Observation of Bc+ →j /ψD (∗)K (∗) decays

A search for the decays B+c→J/ψD(*)0K+ and B+c→J/ψD(*)+K*0 is performed with data collected at the LHCb experiment corresponding to an integrated luminosity of 3 fb−1. The decays B+c→J/ψ0K+ and B+c→J/ψD*0K+ are observed for the first time, while first evidence is reported for the B+c→JψD*+K*0 and B+c→J/ψD+K*0 decays. The branching fractions of these decays are determined relative to the B+c→J/ψπ+ decay. The B+c mass is measured, using the J/ψD0K+ final state, to be 6274.28±1.40(stat)±0.32(syst) MeV/c2. This is the most precise single measurement of the B+c mass to date

Lattice Boltzmann simulations of soft matter systems

This article concerns numerical simulations of the dynamics of particles immersed in a continuum solvent. As prototypical systems, we consider colloidal dispersions of spherical particles and solutions of uncharged polymers. After a brief explanation of the concept of hydrodynamic interactions, we give a general overview over the various simulation methods that have been developed to cope with the resulting computational problems. We then focus on the approach we have developed, which couples a system of particles to a lattice Boltzmann model representing the solvent degrees of freedom. The standard D3Q19 lattice Boltzmann model is derived and explained in depth, followed by a detailed discussion of complementary methods for the coupling of solvent and solute. Colloidal dispersions are best described in terms of extended particles with appropriate boundary conditions at the surfaces, while particles with internal degrees of freedom are easier to simulate as an arrangement of mass points with frictional coupling to the solvent. In both cases, particular care has been taken to simulate thermal fluctuations in a consistent way. The usefulness of this methodology is illustrated by studies from our own research, where the dynamics of colloidal and polymeric systems has been investigated in both equilibrium and nonequilibrium situations.Comment: Review article, submitted to Advances in Polymer Science. 16 figures, 76 page