7 research outputs found
Tailoring the molecular structure of crosslinked polymers for pervaporation desalination
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 19/03/2020
- Field of study
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem EM
- Abdullah AAN
- Abdullah MA
- Abdullah N
- Abdullah NAN
- Abdullah NAN
- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
- Abebe NS
- Abem OE
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga MS
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abu Qumbos A
- Abu-toyour M
- Abubakr M
- Abudeeb H
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abuseif M
- Abushamleh S
- Acharya P
- Ackom E
- Acquah E
- Adam A
- Adam N
- Adams R
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebanjo A
- Adebola O
- Adedeji A
- Adekoya A
- Adel A
- Adel A
- Adel BE
- Adel I
- Adella FJ
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
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- Adenekan B
- Adeniran J
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- Adeniyi A
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- Adesanya O
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- Adesina A
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- Adeyeye A
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- Adham W
- Adhitama N
- Adil M
- Adisa AO
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- Afana S
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
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- Agius M
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- Aguilera M
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- Ahlonsou G
- Ahlqvist S
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- Aigrain Y
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- Akeel N
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- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
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- Appiah EK
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- Aranzabal Durand SY
- Araujo R
- Arcudi C
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- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Ç
- Ö
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- Ž
- Ž
- &apos
- Aahlin Ek
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader Sm
- Abdel-Wahab Nye
- Abdelaal A
- Abdelaty M
- Abdelazeam Ar
- Abdelazim G
- Abdelaziz Ma
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf Am
- Abdelrouf Dm
- Abdelshafy M
- Abdelshakour M
- Abdrabou Ak
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem Em
- Abdullah Ma
- Abdullah N
- Abdullah Nan
- Abdullah Nan
- Abdullahi L
- Abdurrazzaaq A
- Abebe Ns
- Abebe Ns
- Abem Oe
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud Mr
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga Ms
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed Maf
- Abu-Toyour M
- Abubakr M
- Abudeeb H
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abuseif M
- Abushamleh S
- Acharya P
- Ackom E
- Acquah E
- Adı
- Adam A
- Adam N
- Adams R
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebanjo A
- Adebola O
- Adedeji A
- Adekoya A
- Adel A
- Adel A
- Adel Be
- Adel I
- Adella Fj
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
- Ademuyiwa Ao
- Ademuyiwa Ao
- Ademuyiwa Ao
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
- Adeyeye A
- Adeyeye A
- Adham W
- Adhitama N
- Adil M
- Adisa Ao
- Adisa Ao
- Adnan Ab
- Adu-Aryee N
- Afana S
- Afandy A
- Afifi Am
- Afzal M
- Agalianos C
- Agalianos C
- Agarwal A
- Agarwal A
- Agarwal A
- Agbedinu K
- Agius M
- Aglan A
- Aguilar Wlm
- Aguilar Wlm
- Aguilar-Jimenez J
- Aguilera M
- Aguilera Ml
- Aguilera Ml
- Aguilera O
- Aguilera-Arevalo Ml
- Ahlonsou G
- Ahlqvist S
- Ahlqvist S
- Ahlqvist S
- Ahmed A
- Ahmed A
- Ahmed A
- Ahmed Ea
- Ahmed H
- Ahmed H
- Ahmed H
- Ahmed Lam
- Ahmed S
- Ahmed S
- Ahmed Sm
- Ahounou Eys
- Aigrain Y
- Ajah J
- Ajai O
- Ajao A
- Ajao Ae
- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag Aa
- Al-Azraqi Iaa
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi Jj
- Al-Faqawi M
- Al-Farram H
- Al-Hameedi Hii
- Al-Hasani Rkmj
- Al-Khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-Saqqa S
- Al-Saqqa Sw
- Al-Shammari A
- Al-Slaibi I
- Al-Taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alexander P
- Alexander P
- Alexandre C
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- Alghamdi A
- Alghamdi B
- Alghamdi M
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- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali Cdm
- Ali E
- Ali Fm
- Ali H
- Ali S
- Ali Sawew
- Ali Ss
- Ali Tha
- Ali W
- Alihonou T
- Alimi Q
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
- Allegri A
- Allen Jly
- Allen-Ingabire Jc
- Allott R
- Almallah A
- Almanon Cl
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby Mh
- Alnawam E
- Alnuqaydan Sa
- Alnusairat A
- Alomar In
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf Mu
- Alsaggaf Mu
- Alser Oh
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry Am
- Altwijri A
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- Alvi Ar
- Alwafai Mg
- Aly Ak
- Aly Mym
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani M
- Alzahrani M
- Alzahrani Mna
- Alzayat T
- Aman Nf
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer Ma
- Amin Haa
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar Ms
- Amoah M
- Amoako J
- Amoako Pt
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika Ffa
- Andreotti D
- Andress C
- Andriola V
- Ang Yl
- Angelieri D
- Anis E
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- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar Aw
- Anwar N
- Anwer W
- Anyanwu Lj
- Anyanwu Lj
- Aonzo P
- Appeadu-Mensah W
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- Aql S
- Aquilino F
- Arachchi Pp
- Arachchige Lajj
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- Arango Mcm
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- Arshad Mm
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- Arulampalam T
- Aruldas N
- Asaat Ul Razi S
- Asal M
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- Asare-Bediako K
- Asele Fa
- Ashour A
- Ashour A
- Ashour K
- Ashraf Sf
- Ashtari M
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- Asilah Smd
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- Atobatele K
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- Attard M
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- Attia Am
- Augestad Km
- Aung Kp
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad Sa
- Awadallah S
- Awuku-Asabre J
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- Ayandipo O
- Ayandipo Oo
- Aydin Mc
- Ayyar S
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- Aziz Mra
- Aziz Na
- Azizeldine Mg
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- Azodo Ia
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- Azzie G
- Azzis O
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- Badr Mfm
- Badwi Nm
- Badwi Nm
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- Baillie K
- Baillie K
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- Bakr A
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- Baky Fahmy MA
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- Barreda Lma
- Barrientos Lam
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- Barrios E
- Barry J
- Basilicò
- Basir Erm
- Bassem M
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- Bautista Acm
- Bayram S
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- Bediako-Bowan A
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- Beisa V
- Bekhet Ah
- Bekhet Nm
- Beleñ
- Belkouchi A
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- Benammi S
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- Benevento A
- Benger M
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- Benyaiche C
- Bermú
- Bernardo Cg
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- Beuran M
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- Bhangu A
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- Bhat S
- Bhatnagar A
- Bhattacharya S
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- Bhopal Kf
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- Billy M
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- Birring A
- Bisset C
- Bjö
- Bjö
- Blacker S
- Blackwell J
- Blanco R
- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksø
- Blower E
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- Blundell R
- Boakye-Yiadom K
- Boal M
- Bocchetti T
- Boddy A
- Bode C
- Bode C
- Bodur S
- Boereboom C
- Boggon A
- Boijsen M
- Bokhari S
- Bonavia K
- Bonavina L
- Bonavina L
- Bond-Smith G
- Bondin J
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- Bondurri A
- Boni S
- Bonnard A
- Bonney W
- Borda-Luque G
- Borg E
- Borg E
- Borg E
- Borin E
- Bortolasi L
- Bortolasi L
- Boshnaq M
- Botero Jam
- Botes S
- Bottini C
- Botto N
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- Bougard H
- Boukhal K
- Bowabsak A
- Bowe R
- Bowley D
- Bowling K
- Bowman C
- Boyce T
- Bré
- Bradulskis S
- Bradulskis S
- Bratu M
- Bratu Mr
- Bratu Rm
- Braungart S
- Bravo Jac
- Bray Ld
- Breistrand M
- Breitenstein S
- Breslin R
- Brincat Sd
- Broch A
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
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- Bugaev N
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- Buisson P
- Bukari M
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- Burger S
- Burmistrovas A
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- Bustangi N
- Butt Mt
- Cabrera Ccrr
- Cacurri A
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- Cahill R
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- Camacho R
- Cameron B
- Camilleri Gm
- Camilleri-Brennan J
- Camilleri-Brennan J
- Camilleri-Brennan Jf
- Campagnaro T
- Canto Md
- Capito C
- Capleton P
- Carabott K
- Cardozo Jt
- Cardozo Ram
- Careta Mc
- Carlucci M
- Carmona Jm
- Carneros Vj
- Carpio J
- Carrasco N
- Carreira Ja
- Cassar K
- Castillo Vdp
- Castro Mr
- Catani M
- Cautiero R
- Caydiid H
- Cecilia T
- Celik S
- Celis Jmv
- Cengiz Tb
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Ceriani C
- Cevik M
- Chabok A
- Chachulski W
- Chai Ca
- Chai Fy
- Chambers A
- Chambers A
- Chan E
- Chan L
- Chan Tk
- Chan Xw
- Chan Z
- Chandrakumar C
- Chang K
- Chang Ky
- Chapman A
- Chapman Sj
- Charles A
- Cheah Aez
- Chen Cy
- Chen Jhc
- Chen Ky
- Chen Tl
- Chenn R
- Cheong Yj
- Chetta N
- Cheung Yhe
- Chew Ls
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
- Chilton G
- Chin Px
- Chin Yr
- Chiong Jac
- Chiong Jac
- Chiu S
- Chiu S
- Chiu Smy
- Choi J
- Choi P
- Chong Bfhk
- Chong Cl
- Chong Cl
- Chong Cl
- Chong Cs
- Chong Hy
- Chong Hy
- Choudhry A
- Chow Cyn
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung Kj
- Chung S
- Ciccioli E
- Cirocchi R
- Ciubotaru C
- Claire R
- Clarissa A
- Clark Dj
- Clark T
- Clegg-Lampety Jn
- Clegg-Lamptey Jn
- Clement Kd
- Clements Jm
- Clerico G
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- Coccolini F
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- Cohen F
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- Coletta D
- Coletti M
- Collado Mv
- Colombani Jf
- Cona C
- Conci S
- Confalonieri G
- Conlon Kc
- Connor K
- Connor K
- Contreras E
- Contreras-Vergara Al
- Coomber R
- Coompson Cl
- Corbellini C
- Corbellino M
- Cornick J
- Coronel J
- Correa Jc
- Corro-Diaz S
- Costa C
- Costa-Maia J
- Costa-Maia J
- Costas-Chavarri A
- Costas-Chavarri A
- Courboin E
- Court E
- Cox D
- Cox M
- Coyoy-Gaitan O
- Cragg J
- Craus-Miguel A
- Cross K
- Cruz Dh
- Cruz H
- Cucumazzo S
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- Curletti G
- Currow C
- Currow C
- Cury Adl
- Dé
- D&apos
- D&apos
- D&apos
- D&apos
- D&apos
- D&apos
- Da Silva LA
- Dabboor M
- Dabbour K
- Dabessa D
- Dablouk M
- Dablouk Mo
- Dagoe E
- Dahy A
- Dainius E
- Dakubo J
- Dalli J
- Dally C
- Dambrauskas Z
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daniyan M
- Danys D
- Dao W
- Daqeeq A
- Dar M
- Dar W
- Dardenne S
- Darweesh M
- Darwish Ak
- Das A
- Das K
- Das S
- Dasari M
- Dashnyam E
- Dassah V
- Datta U
- Davenport R
- Davies J
- Davies R
- Davor A
- Dawnay G
- Dawood K
- Dawoud H
- Dayie M
- De Boni D
- De Bono P
- De Bono P
- De Castro Segundo LCB
- De Franciscis S
- De Freitas AVC
- De La Medina AR
- de Leó
- De Leon MZP
- De Leon MZP
- de Lima CVB
- De Luca E
- De Marco P
- De Sousa AV
- Deal R
- Dean R
- Deane C
- Debrah S
- Deckelbaum Dl
- Decker E
- Decoud Hp
- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- Del Pilar Paucar A
- Delforge X
- Delgado Jm
- Delgado Msftl
- Dell A
- Dempster E
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu Ib
- Dias S
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dindyal S
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani Rmnr
- Dorismé
- Dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake Tm
- Drake Tm
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Dueñ
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Durand Sya
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy Mm
- Ebrahim Os
- Eduard P
- Edwards J
- Edye M
- Eid Mm
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Galeel AA
- El Gendy NH
- El Gendy A
- El Halawany M
- El Hameed OSA
- El Hamid NA
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Salam YA
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El Slam MA
- El-Badawy Ha
- El-Dien Ks
- El-Dien Ks
- El-Din Ra
- El-Din Sa
- El-Gizawy E
- El-Hamouly As
- El-Kashef H
- El-Latif Nka
- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
- El-Salam Fa
- El-Sawy A
- El-Sehily A
- El-Shahat Ns
- El-Sheemy H
- El-Taher E
- Elabdin Hz
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem Aa
- Elazoul M
- Elbanby E
- Elbanby Es
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy Kh
- Eldafrawy M
- Eldamaty L
- Eldeeb Az
- Eldeen Ea
- Eldin Mab
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy Ah
- Elgendy Fi
- Elgheriany M
- Elhadad A
- Elhadary Nm
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy Ms
- Elhendawy A
- Elhendawy Aoa
- Elhoseny G
- Elhusseiny Aae
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek Ea
- Elkholy A
- Elkholy Ss
- Elkolaly Ss
- Elkorashy Am
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
- Elsameea Aa
- Elsawahly Dme
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed Nar
- Elsayed Zm
- Elsebaaye Ao
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay Ae
- Elshami M
- Elshanwany S
- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
- Espinoza Kt
- Essam A
- Essam Aa
- Essam M
- Essoun S
- Esteban E
- Estee Mm
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat Mm
- Faraz A
- Fares M
- Farfan Esf
- Farhad M
- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferreira Sak
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
- Frade F
- Fraga Gp
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan Mm
- Gü
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- Gaafar S
- Gaarder T
- Gad A
- Gad Mo
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
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- Gala T
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- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez Cp
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
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- Gani Ma
- Garaycochea O
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- Garcia-Marin Ja
- Garcia-Perez Jm
- Garland A
- Gash K
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- Gastaldi P
- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi Dg
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
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- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
- Ghanem S
- Ghannam M
- Gharib A
- Gharib A
- Ghazy Aa
- Gheith A
- Ghetia M
- Ghetia M
- Ghonaim Ma
- Ghoneem M
- Ghoneim O
- Giacci L
- Giardino Fr
- Giavarini L
- Giglio Mc
- Gilbert R
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- Giles J
- Gillespie M
- Gimzewska M
- Giraldo Rsr
- Giuliani S
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- Giuriato Tf
- Gkiokas G
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- Gohar Meam
- Gokani S
- Goldin E
- Golding D
- Gomaa A
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- Gouldthorpe C
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- Gran M
- Grandinetti Pp
- Grant A
- Grasset E
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- Grassi V
- Gratton R
- Gravante G
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- Gray D
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- Gribauskaite J
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- Grizhja B
- Grobler Dc
- Grosos C
- Grossart C
- Guasti Bpsj
- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Guglielmo V
- Gui D
- Gulbinas A
- Gulcicek Ob
- Gulielmi A
- Gultom Pa
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- Gunawan R
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- Guo W
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- Gustafsson U
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- Habeebullah A
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- Haddad N
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- Haffreingue A
- Hafiz S
- Hagan R
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- Haines M
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- Hajeh H
- Hakim H
- Halhouli O
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- Halicioglu I
- Hall E
- Hall N
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- Hamaguchi Jlh
- Hamarshi A
- Hamasaki J
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- Hany E
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- Hasanah A
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- Hascoet J
- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
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- Haslegrave A
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- Hassaan A
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- Hassan A
- Hassan Ata
- Hassan I
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- Hassan Z
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- Hassanein Ab
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- Horobjowsky A
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- Houlden C
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- Iannone I
- Ibraheem Aa
- Ibraheem Hi
- Ibrahem Aa
- Ibrahem Aa
- Ibrahim A
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- Ibrahim A
- Ibrahim Am
- Ibrahim E
- Ibrahim Em
- Ibrahim I
- Ibrahim K
- Ibrahim M
- Ibrahim Mh
- Ibrahim Y
- Idress T
- Idris F
- Idris Sai
- Iftekhar F
- Iftikhar Z
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- Ignatavicius P
- Ihediwa G
- Imoro O
- Ingabire Jca
- Ingabire Jca
- Ingabire Jca
- Ioannidis O
- Iordache Fm
- Iqbal Fm
- Iqbal Mr
- Ireland P
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- Irwin G
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- Kamarajah Sk
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- Karabelias G
- Karabulut K
- Karahan Sr
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- Kasputyte S
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- Khedr Aeh
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- Kiasat A
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- Kim My
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- King R
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- Klappenbach R
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- Komolafe O
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- Kostov E
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- Kotecha D
- Koto Mz
- Kotobi H
- Koumpa F
- Kouraklis G
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- Kwatiwani C
- Kwizera S
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- Kyriazanos I
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- Kyziridis D
- Ló
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- La Brocca A
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- Ladukas A
- Lafferty K
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- Lakshmi Hn
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- Landolfo G
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- Law Jh
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- Lawal T
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- Lawani I
- Lawther R
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- Leal A
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- Lee C
- Lee Ex
- Lee F
- Lee K
- Lee Kc
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- Leone N
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- Leppä
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- Leung Kw
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- Leusink A
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- Limoges B
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- Lo Conte A
- Loaloa Mr
- Lockey J
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- Loizides S
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- Macfarlane A
- Machaca M
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- Margaritis M
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- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret Jb
- Marshall Dc
- Martian Bv
- Martin A
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- Mirza A
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- Mistry A
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- Mohamed F
- Mohamed I
- Mohamed M
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- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
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- Mohammad A
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- Monteleone M
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- Moodley Y
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- Mosalum O
- Mostafa Ha
- Mostafa M
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- Mshelbwala P
- Msiska N
- Msosa V
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- Nanthakumaran S
- Napolitano L
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- Narayanan R
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- Nazir M
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- Ndegwa W
- Ndlovu Sr
- Ndwambi P
- Ne&apos
- Negida A
- Negoi I
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- Nesaratnam A
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- Nevieraite V
- Newton T
- Ng S
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- Njokanma I
- Nnajiuba H
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- Nofal E
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- Nouh T
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- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana Vjp
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- Ntirenganya F
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- Nymo L
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- Odutola O
- Ogunsua O
- Ogunyemi A
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- Ozben V
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- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Metabolic crosstalk between host and parasitic pathogens
- Author
- A Kalender
- A Kaushansky
- A Omsland
- A Orlofsky
- A Pol
- A Rodriguez
- A Rodriguez-Acosta
- A-K Mueller
- ACWCSDM Efeyan
- AF Francisco
- AF Gomes
- AJ Charron
- AM Dvorak
- AP Bailey
- AP Long
- AP Simões
- AP Sinai
- AR Tee
- AV Budanov
- AVM Ferreira
- B Frank
- B Franke-Fayard
- B Jayabalasingham
- BD Beaumelle
- BM Castellano
- C Johndrow
- C-I Suh
- CD Rodrigues
- CE Caffaro
- CG Freire-de-Lima
- CJ Potter
- CS Lal
- CS Zhang
- D Chakraborty
- D Kim
- D Moreira
- D Moreira
- D Sunnemark
- DAM Toledo
- DD Sarbassov
- DE Dobson
- DF Cunha Da
- DF Egan
- DG Hardie
- DG Hardie
- DJ Murphy
- DL Brasaemle
- DL Sacks
- DM Gwinn
- E Anes
- E Jacinto
- EB Gordon
- EC Saunders
- F Debierre-Grockiego
- F Nagajyothi
- F Nagajyothi
- F Nagajyothi
- G Freire-de-lima
- G Sarnáglia
- G Semini
- G Vilar-Pereira
- GA Kumar
- GM Reeves
- GR Steinberg
- H D’Avila
- H D’Avila
- H Lecoeur
- H-C Wan
- HB Tanowitz
- HH Zhang
- HJ Vial
- I Coppens
- I Coppens
- I Coppens
- I Rabhi
- IG Ganley
- IJ Blader
- J Ghosh
- J Ghosh
- J Kim
- JC Schwab
- JD Romano
- JI MacRae
- JP Shoemaker
- JS Silva
- K Düvel
- K Hara
- K Inoki
- K Kirk
- K Lingelbach
- K Slavic
- K Tauchi-Sato
- KE Jackson
- KK Hanson
- KL Caradonna
- KL Spalding
- L Bar-Peled
- L Bar-Peled
- L Bougnères
- L Chantranupong
- L Schofield
- L Shang
- LAM Mota
- LD Sibley
- LH Miller
- LR Portugal
- M Blume
- M Foretz
- M Jaramillo
- M Labaied
- M Laplante
- M Laplante
- M Ming
- M Mukherjee
- M Ndao
- M Pulido-Mendez
- M Triggiani
- MA Itoe
- MA Pfaller
- ME Cabalén
- ME Dumont
- MH Brok den
- MJ Crawford
- MJ Soares
- MJ Soares
- ML Ginger
- MTG Ruivo
- N Bano
- N Campanale
- N Dinesh
- N Hosokawa
- NE Wolins
- NMQ Palacpac
- NNT Cicco De
- P Loria
- P Mejia
- P Nievelstein-Post
- P Prioli
- P Tewary
- P Wilairatana
- PJ Rosenthal
- PP Roux
- PS Romano
- PT Bozza
- PT Bozza
- Q Gao
- Q Miao
- QA Wang
- RC Melo
- RCN Melo
- RCN Melo
- RL Wolfson
- RM Martins
- RO Pinheiro
- S Banerjee
- S Itani
- S Rabhi
- S Ramakrishnan
- S Trindade
- S Yalaoui
- SA Mikolajczak
- SE Wilkowsky
- SJ Nolan
- SS Albuquerque
- SS Jäger
- SSC Rubin-de-celis
- T Araújo-Santos
- T Kaizuka
- T Naderer
- T Nebl
- TP Combs
- TR Peterson
- TR Peterson
- V Robert
- V Stambolic
- V Zuzarte-Luis
- X Hu
- Y Sancak
- Y Wang
- Y Wang
- Y Wang
- Z Wang
- ZA Andrade
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
A complex network that embraces parasite-host intrinsic factors and the microenvironment regulated the interaction between a parasite and its host. Nutritional pressures exerted by both elements of this duet thus dictate this host-parasite niche. To survive and proliferate inside a host and a harsh nutritional environment, the parasites modulate different nutrient sensing pathways to subvert host metabolic pathways. Such mechanism is able to change the flux of distinct nutrients/metabolites diverting them to be used by the parasites. Apart from this nutritional strategy, the scavenging of nutrients, particularly host fatty acids, constitutes a critical mechanism to fulfil parasite nutritional requirements, ultimately defining the host metabolic landscape. The host metabolic alterations that result from host-parasite metabolic coupling can certainly be considered important targets to improve diagnosis and also for the development of future therapies. Metabolism is in fact considered a key element within this complex interaction, its modulation being crucial to dictate the final infection outcome.(undefined)info:eu-repo/semantics/publishedVersio
Active galactic nuclei: what’s in a name?
- Author
- A Akylas
- A Alonso-Herrero
- A Annuar
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- A Bongiorno
- A Comastri
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- A Hernán-Caballero
- A Hernán-Caballero
- A Ingram
- A Kirkpatrick
- A Laor
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- A Lawrence
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- A Merloni
- A Moro Del
- A Moro Del
- A Moro Del
- A Schulze
- A Tchekhovskoy
- A Treves
- A Zoghbi
- AA Abdo
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- AA Esin
- AC Fabian
- AD Goulding
- AD Goulding
- AE Hornschemeier
- AE Kimball
- AE Kimball
- AH Bridle
- AJ Mendez
- AP Marscher
- AT Steffen
- B Arsioli
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- B Czerny
- B Luo
- B Luo
- B Magnelli
- B Marco De
- B Marco De
- B Mingo
- B Trakhtenbrot
- B Vazquez
- B. De Marco
- BC Kelly
- BC Kelly
- BD Lehmer
- BD Lehmer
- BD Simmons
- BL Fanaroff
- BM Peterson
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- C Bertemes
- C Breuck De
- C Done
- C Laigle
- C Pittori
- C Ricci
- C Simpson
- C Tadhunter
- C Wolf
- C-TJ Chen
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- CH Chan
- CJ Conselice
- CJ Willott
- CK Seyfert
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- D. M. Alexander
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- DL Meier
- DM Alexander
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- E Breedt
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- E Kara
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- F Hamann
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- F Panessa
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- G Fabbiano
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- G Matt
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- G Ponti
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- G Yang
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- GG Fazio
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- GH Rieke
- GP Szokoly
- GS Novak
- GT Richards
- GT Richards
- GT Richards
- GT Richards
- GT Richards
- GT Richards
- GT Richards
- GT Richards
- H Ebeling
- H Hao
- H Hao
- H Jud
- H Kühr
- H Messias
- H Murakami
- H Netzer
- H Netzer
- HD Jun
- HJ Lehto
- HWW Spoon
- I Delvecchio
- I Delvecchio
- I Georgantopoulos
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- I Hubeny
- I Morić
- I Pâris
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- I Waddington
- ID McGreer
- IE Papadakis
- IG Roseboom
- IM Hook
- IM McHardy
- IM McHardy
- IM McHardy
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- Imanishi M Nakanishi K, Izumi T (2016) ALMA 0.1-0.2 arcsec resolution imaging of the NGC
- J Aird
- J Albert
- J Biteau
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- J Buchner
- J Dennett-Thorpe
- J Fritz
- J Lyu
- J Magorrian
- J Malzac
- J Manners
- J Melbourne
- J Schaye
- J Terrell
- J Wilms
- J Wu
- J Wu
- JA Baldwin
- JA Baldwin
- JA Peacock
- JA Peacock
- JC Runnoe
- JD Hogg
- JE Greene
- JE Mejia-Restrepo
- JF Gallimore
- JH Krolik
- JJ Condon
- JJ Condon
- JJ Ruan
- JL Donley
- JL Donley
- JP Gagne
- JP Gardner
- JR Houck
- JS Dunlop
- JV Wall
- JW Sulentic
- JW Sulentic
- JW Sulentic
- JX Wang
- K Gültekin
- K Mannheim
- K Nandra
- K Schawinski
- K Wada
- KD Denney
- KD Denney
- KI Kellermann
- KI Kellermann
- KJ Leech
- KL Smith
- KM Leighly
- KN Hainline
- KRW Tristram
- L Armus
- L Burtscher
- L Coatman
- L Coatman
- L Hao
- L Hernández-García
- L Jiang
- L Maraschi
- L Miller
- L-T Hsu
- LC Ho
- LHAASO Collaboration
- LJ Kewley
- LJ Kewley
- M Ackermann
- M Ackermann
- M Ackermann
- M Ackermann
- M Ackermann
- M Ackermann
- M Ackermann
- M Ajello
- M Amenomori
- M Azadi
- M Baloković
- M Baloković
- M Banerji
- M Banerji
- M Bonzini
- M Bonzini
- M Brescia
- M Brusa
- M Böttcher
- M Böttcher
- M Cappi
- M Chiaberge
- M Chiaberge
- M Dadina
- M Elitzur
- M Elitzur
- M Elvis
- M Gierliński
- M Gierliński
- M Gilfanov
- M Hirschmann
- M Lacy
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- M Young
- M-H Ulrich
- M. Salvato
- MA DiPompeo
- MA Gendre
- MA Nowak
- MA Sobolewska
- MB Pracy
- MC Bentz
- MC Weisskopf
- MD Johnson
- ME Filho
- MHK Grijp de
- MHK Grijp de
- MJ Hardcastle
- MJ Hardcastle
- MJ Koss
- MJ Ledlow
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- ML Jones
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- NI Shakura
- NL Zakamska
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- NP Ross
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- P Gandhi
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- P Giommi
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- TM Heckman
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- Y Shen
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- Y Ueda
- Y Ueda
- Y-L Chang
- YE Lyubarskii
- YQ Xue
- Ž Ivezić
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 22/07/2017
- Field of study
Active Galactic Nuclei (AGN) are energetic astrophysical sources powered by
accretion onto supermassive black holes in galaxies, and present unique
observational signatures that cover the full electromagnetic spectrum over more
than twenty orders of magnitude in frequency. The rich phenomenology of AGN has
resulted in a large number of different "flavours" in the literature that now
comprise a complex and confusing AGN "zoo". It is increasingly clear that these
classifications are only partially related to intrinsic differences between
AGN, and primarily reflect variations in a relatively small number of
astrophysical parameters as well the method by which each class of AGN is
selected. Taken together, observations in different electromagnetic bands as
well as variations over time provide complementary windows on the physics of
different sub-structures in the AGN. In this review, we present an overview of
AGN multi-wavelength properties with the aim of painting their "big picture"
through observations in each electromagnetic band from radio to gamma-rays as
well as AGN variability. We address what we can learn from each observational
method, the impact of selection effects, the physics behind the emission at
each wavelength, and the potential for future studies. To conclude we use these
observations to piece together the basic architecture of AGN, discuss our
current understanding of unification models, and highlight some open questions
that present opportunities for future observational and theoretical progress.Comment: Accepted for publication in Astronomy & Astrophysics Review, 56
pages, 25 figure
Recommended from our members
Observation of the J/ψ → μ+μ−μ+μ− decay in proton-proton collisions at s = 13 TeV
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- Zuolo D
- Zygala L
- Publication venue
- American Physical Society (APS)
- Publication date
- 06/06/2024
- Field of study
A preprint version of the article is available at arXiv:2403.11352v2 [hep-ex], https://arxiv.org/abs/2403.11352. Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/BPH-22-006 (CMS Public Pages). Report number: CMS-BPH-22-006, CERN-EP-2024-058.The /→+−+− decay has been observed with a statistical significance in excess of five standard deviations. The analysis is based on an event sample of proton-proton collisions at a center-of-mass energy of 13 TeV, collected by the CMS experiment in 2018 and corresponding to an integrated luminosity of 33.6 fb−1. Normalizing to the /→+− decay mode leads to a branching fraction of [10.1+3.3
−2.7(stat)±0.4(syst)]×10−7, a value that is consistent with the standard model prediction.SCOAP3
Edoxaban versus warfarin in patients with atrial fibrillation
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- Yakusevich V
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- Young C
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- Yukhno E
- Yukihiro Koretsune
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- Zachar A
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- Zamlynskyy M
- Zamorano JL
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- Zarpentin C
- Zateyshchikov D
- Zateyshchikova A
- Zeig S
- Zellner C
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- Zhang HQ
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- Zimmermann EB
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- Zubeeva G
- Zyatenkova E
- Åkerberg A
- Östberg S
- Ŝpinar J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2013
- Field of study
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125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)