A reestruturação do meio rural: implicações para o zoneamento ecológico-econômico brasileiro.

Resumo: Desde meados dos anos 80s, observa-se UMA redução da população ocupada em atividades agropecuárias no país. Apesar da sistemática redução dos ocupados na agricultura, a população residente no meio rural brasileiro vem se mantendo, e em algumas regiões tem até aumentado, como no estado de São Paulo. Essa ?nova? capacidade de absorção de mão-de-obra no meio rural está ligada à expansão das atividades não-agrícolas e ao do número de aposentados e de desempregados residentes no meio rural Neste texto, abordam-se, além das ocupações agrícolas e não-agrícolas que mais crescem e decrescem no meio rural brasileiro, as principais dinâmicas que contribuem para esses acontecimentos. Os resultados permitem traçar premissas a serem consideradas no Zoneamento Ecológico-Econômico, quais sejam: o meio rural não é mais exclusivamente agrícola e não há mais uma separação nítida entre os meios urbano e rural, havendo praticamente um continuum de ocupações e de interações socioeconômicas. No final do texto, apresentam-se algumas propostas de políticas públicas a serem implementadas no curto e médio prazos. Em uma estratégia de desenvolvimento rural sustentável é fundamental priorizar e valorizar o papel dos agricultores familiares, melhorar as condições de vida das comunidades rurais e melhorar a qualidade dos recursos naturais, em um processo articulado de participação dos diferentes atores sociais interessados. Nesse sentido, o zoneamento ecológico-econômico deve se constituir, acima de tudo, em instrumento do desenvolvimento loc

Sign-changing tower of bubbles for a sinh-Poisson equation with asymmetric exponents

Motivated by the statistical mechanics description of stationary 2D-turbulence, for a sinh-Poisson type equation with asymmetric nonlinearity, we construct a concentrating solution sequence in the form of a tower of singular Liouville bubbles, each of which has a different degeneracy exponent. The asymmetry parameter $\gamma\in(0,1]$ corresponds to the ratio between the intensity of the negatively rotating vortices and the intensity of the positively rotating vortices. Our solutions correspond to a superposition of highly concentrated vortex configurations of alternating orientation; they extend in a nontrivial way some known results for $\gamma=1$. Thus, by analyzing the case $\gamma\neq1$ we emphasize specific properties of the physically relevant parameter $\gamma$ in the vortex concentration phenomena

Variação estacional e margem de comercialização dos preços do tomate de mesa pagos aos produtores e comercializados aos consumidores no Brasil, no período de 2013 a 2017.

Neste trabalho, objetivou-se analisar a variação estacional dos preços pagos ao produtor de tomate de mesa situados nos principais polos de produção do Brasil, e comparar com a variação estacional dos preços pagos pelo consumidor final, ambos no período de janeiro de 2013 a dezembro de 2017.bitstream/item/198156/1/BPD-177.pd

Variação estacional e margem de comercialização dos preços do tomate de mesa pagos aos produtores e comercializados aos consumidores no Brasil, no período de 2013 a 2017.

Neste trabalho, objetivou-se analisar a variação estacional dos preços pagos ao produtor de tomate de mesa situados nos principais polos de produção do Brasil, e comparar com a variação estacional dos preços pagos pelo consumidor final, ambos no período de janeiro de 2013 a dezembro de 2017

Targeting SMYD3 to sensitize homologous recombination-proficient tumors to PARP-mediated synthetic lethality

SMYD3 is frequently overexpressed in a wide variety of cancers. Indeed, its inactivation reduces tumor growth in preclinical in vivo animal models. However, extensive characterization in vitro failed to clarify SMYD3 function in cancer cells, although confirming its importance in carcinogenesis. Taking advantage of a SMYD3 mutant variant identified in a high-risk breast cancer family, here we show that SMYD3 phosphorylation by ATM enables the formation of a multiprotein complex including ATM, SMYD3, CHK2, and BRCA2, which is required for the final loading of RAD51 at DNA double-strand break sites and completion of homologous recombination (HR). Remarkably, SMYD3 pharmacological inhibition sensitizes HR-proficient cancer cells to PARP inhibitors, thereby extending the potential of the synthetic lethality approach in human tumors

Grapevine field experiments reveal the contribution of genotype, the influence of environment and the effect of their interaction (GXE) on the berry transcriptome

Changes in the performance of genotypes in different environments are defined as genotype x environment (G x E) interactions. In grapevine (Vitis vinifera), complex interactions between different genotypes and cli- mate, soil and farming practices yield unique berry qualities. However, the molecular basis of this phe- nomenon remains unclear. To dissect the basis of grapevine G x E interactions we characterized berry transcriptome plasticity, the genome methylation landscape and within-genotype allelic diversity in two genotypes cultivated in three different environments over two vintages. We identified, through a novel data-mining pipeline, genes with expression profiles that were: unaffected by genotype or environment, genotype-dependent but unaffected by the environment, environmentally-dependent regardless of geno- type, and GxE-related. The GxE-related genes showed different degrees of within-cultivar allelic diversity in the two genotypes and were enriched for stress responses, signal transduction and secondary metabo- lism categories. Our study unraveled the mutual relationships between genotypic and environmental vari- ables during GxE interaction in a woody perennial species, providing a reference model to explore how cultivated fruit crops respond to diverse environments. Also, the pivotal role of vineyard location in deter- mining the performance of different varieties, by enhancing berry quality traits, was unraveled

Salivary proteomic profile of young healthy subjects

Background: The incidence of noncommunicable diseases (NCDs) has been rapidly ramped up worldwide. Hence, there is an urgent need to non-invasively detect NCDs possibly by exploiting saliva as a ‘liquid biopsy’ to identify biomarkers of the health status. Since, the absence of standardized procedures of collection/analysis and the lack of normal ranges makes the use of saliva still tricky, our purpose was to outline a salivary proteomic profile which features healthy individuals.Methods: We collected saliva samples from 19 young blood donors as reference population and the proteomic profile was investigated through mass-spectrometry.Results: We identified 1,004 proteins of whose 243 proteins were shared by all subjects. By applying a data clustering approach, we found a set of six most representative proteins across all subjects including Coronin-1A, F-actin-capping protein subunit alpha, Immunoglobulin J chain, Prosaposin, 78 kDa glucose-regulated protein and Heat shock 70 kDa protein 1A and 1B.Conclusion: All of these proteins are involved in immune system activation, cellular stress responses, proliferation, and invasion thus suggesting their use as biomarkers in patients with NCDs

Measurement of χ c1 and χ c2 production with s√ = 7 TeV pp collisions at ATLAS

The prompt and non-prompt production cross-sections for the χ c1 and χ c2 charmonium states are measured in pp collisions at s√ = 7 TeV with the ATLAS detector at the LHC using 4.5 fb−1 of integrated luminosity. The χ c states are reconstructed through the radiative decay χ c → J/ψγ (with J/ψ → μ + μ −) where photons are reconstructed from γ → e + e − conversions. The production rate of the χ c2 state relative to the χ c1 state is measured for prompt and non-prompt χ c as a function of J/ψ transverse momentum. The prompt χ c cross-sections are combined with existing measurements of prompt J/ψ production to derive the fraction of prompt J/ψ produced in feed-down from χ c decays. The fractions of χ c1 and χ c2 produced in b-hadron decays are also measured