Statistical Mechanics of Glass Formation in Molecular Liquids with OTP as an Example

We extend our statistical mechanical theory of the glass transition from examples consisting of point particles to molecular liquids with internal degrees of freedom. As before, the fundamental assertion is that super-cooled liquids are ergodic, although becoming very viscous at lower temperatures, and are therefore describable in principle by statistical mechanics. The theory is based on analyzing the local neighborhoods of each molecule, and a statistical mechanical weight is assigned to every possible local organization. This results in an approximate theory that is in very good agreement with simulations regarding both thermodynamical and dynamical properties

A Influência dos Aspectos Sociais na Competitividade das Redes Interorganizacionais: a Experiência da Rede dos Exportadores de Frango Halal Brasileiro

Inter-organizational networks are groups of legally independent organizations working together to achieve both their individual goals to the collective goals of the group. The focus of this research is the influence of social aspects on the competitiveness of inter-organizational networks, and the aim is to identify the contribution of the social aspects (strategy group, trust, commitment and cooperation) to the competitiveness of the network. It is about a qualitative, exploratory and descriptive study, through the case study of a single network of Brazilian poultry exporters of Halal. Primary data were collected through semi-structured interviews, in addition, the information obtained from these interviews were checked with information from other secondary sources such as reports and institutional materials. The results indicated that these social aspects are complementary and collaborate for a more competitive network. The contribution of this research indicates the existence of complementarities of the categories, wherein a positively reinforces the presence of another network.Redes interorganizacionais são grupos de organizações legalmente independentes que atuam em conjunto para alcançar seus objetivos individuais simultaneamente aos objetivos coletivos do grupo. O objeto de estudo desta pesquisa é a influência dos aspectos sociais na competitividade de redes interorganizacionais, e o objetivo é a identificação da contribuição dos aspectos sociais (estratégia de grupo, confiança, comprometimento e cooperação) para a competitividade da rede. Trata-se de uma pesquisa qualitativa, de natureza exploratória e descritiva, realizada por meio do estudo de caso único da rede dos exportadores de frango Halal brasileiro. Os dados primários foram coletados por meio de entrevistas semiestruturadas, além disso, as informações obtidas por meio dessas entrevistas foram checadas com informações de outras fontes secundárias, como relatórios e materiais institucionais. Os resultados indicaram que esses aspectos sociais são complementares e colaboram para uma maior competitividade da rede. A contribuição desta pesquisa aponta a existência da complementaridade das categorias, em que uma reforça positivamente a presença da outra na rede

Peri-conception and first trimester diet modifies reproductive development in bulls

Nutritional perturbation during gestation alters male reproductive development in rodents and sheep. In cattle both the developmental trajectory of the feto–placental unit and its response to dietary perturbations is dissimilar to that of these species. This study examined the effects of dietary protein perturbation during the peri-conception and first trimester periods upon reproductive development in bulls. Nulliparous heifers (n = 360) were individually fed a high- or low-protein diet (HPeri and LPeri) from 60 days before conception. From 24 until 98 days post conception, half of each treatment group changed to the alternative post-conception high- or low-protein diet (HPost and LPost) yielding four treatment groups in a 2 × 2 factorial design. A subset of male fetuses (n = 25) was excised at 98 days post conception and fetal testis development was assessed. Reproductive development of singleton male progeny (n = 40) was assessed until slaughter at 598 days of age, when adult testicular cytology was evaluated. Low peri-conception diet delayed reproductive development: sperm quality was lowered during pubertal development with a concomitant delay in reaching puberty. These effects were subsequent to lower FSH concentrations at 330 and 438 days of age. In the fetus, the low peri-conception diet increased the proportion of seminiferous tubules and decreased blood vessel area in the testis, whereas low first trimester diet increased blood vessel number in the adult testis. We conclude that maternal dietary protein perturbation during conception and early gestation may alter male testis development and delay puberty in bulls

Subwavelength anti-diffracting beams propagating over more than 1,000 Rayleigh lengths

Propagating light beams with widths down to and below the optical wavelength require bulky large-aperture lenses and remain focused only for micrometric distances. Here, we report the observation of light beams that violate this localization/depth- of-focus law by shrinking as they propagate, allowing resolution to be maintained and increased over macroscopic propagation lengths. In nanodisordered ferroelectrics we observe a non-paraxial propagation of a sub-micrometre-sized beam for over 1,000 diffraction lengths, the narrowest visible beam reported to date. This unprecedented effect is caused by the nonlinear response of a dipolar glass, which transforms the leading opticalwave equation into a Klein-Gordon-type equation that describes a massive particle field. Our findings open the way to high-resolution optics over large depths of focus, and a route to merging bulk optics into nanodevices

Epigenetics and developmental programming of welfare and production traits in farm animals

The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referred to as the ‘developmental origins of health and disease’ or ‘DOHaD’ hypothesis, the primary focus of large-animal studies until quite recently had been biomedical. Attention has since turned towards traits of commercial importance in farm animals. Herein we review the evidence that prenatal risk factors, including suboptimal parental nutrition, gestational stress, exposure to environmental chemicals and advanced breeding technologies, can determine traits such as postnatal growth, feed efficiency, milk yield, carcass composition, animal welfare and reproductive potential. We consider the role of epigenetic and cytoplasmic mechanisms of inheritance, and discuss implications for livestock production and future research endeavours. We conclude that although the concept is proven for several traits, issues relating to effect size, and hence commercial importance, remain. Studies have also invariably been conducted under controlled experimental conditions, frequently assessing single risk factors, thereby limiting their translational value for livestock production. We propose concerted international research efforts that consider multiple, concurrent stressors to better represent effects of contemporary animal production systems

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection