Heated indoor swimming pools, infants, and the pathogenesis of adolescent idiopathic scoliosis: a neurogenic hypothesis

<p>Abstract</p> <p>Background</p> <p>In a case-control study a statistically significant association was recorded between the introduction of infants to heated indoor swimming pools and the development of adolescent idiopathic scoliosis (AIS). In this paper, a neurogenic hypothesis is formulated to explain how toxins produced by chlorine in such pools may act deleteriously on the infant's immature central nervous system, comprising brain and spinal cord, to produce the deformity of AIS.</p> <p>Presentation of the hypothesis</p> <p>Through vulnerability of the developing central nervous system to circulating toxins, and because of delayed epigenetic effects, the trunk deformity of AIS does not become evident until adolescence. In mature healthy swimmers using such pools, the circulating neurotoxins detected are chloroform, bromodichloromethane, dibromochloromethane, and bromoform. Cyanogen chloride and dichloroacetonitrile have also been detected.</p> <p>Testing the hypothesis</p> <p>In infants, the putative portals of entry to the blood could be dermal, oral, or respiratory; and entry of such circulating small molecules to the brain are via the blood-brain barrier, blood-cerebrospinal fluid barrier, and circumventricular organs. Barrier mechanisms of the developing brain differ from those of adult brain and have been linked to brain development. During the first 6 months of life cerebrospinal fluid contains higher concentrations of specific proteins relative to plasma, attributed to mechanisms continued from fetal brain development rather than immaturity.</p> <p>Implications of the hypothesis</p> <p>The hypothesis can be tested. If confirmed, there is potential to prevent some children from developing AIS.</p

Building more effective partnerships for innovation in urban water management 1

Abstract This paper discusses experiences within the Sustainable Water Improves Tomorrow&apos;s Cities&apos; Health (SWITCH) consortium -a research partnership focused on long-term improvements in urban water management in developed and developing countries -to apply innovative research methodologies that may lead to more effective urban water science and wider and more integrated use of research findings. It introduces learning alliances as an attempt to build multi-stakeholder partnerships for demand-led research and the scaling-up of research impacts, and several related tools used to date to underpin an action research process: visioning and scenario-based planning with stakeholders, scoring ladders to monitor outcomes, process documentation to record change and matrix management to guide a diverse consortium. Examples drawn from the SWITCH project illustrate successes and failures from which the project aims to learn and improve its own effectiveness

Building more effective partnerships for innovation in urban water management 1

Abstract This paper discusses experiences within the Sustainable Water Improves Tomorrow&apos;s Cities&apos; Health (SWITCH) consortium -a research partnership focused on long-term improvements in urban water management in developed and developing countries -to apply innovative research methodologies that may lead to more effective urban water science and wider and more integrated use of research findings. It introduces learning alliances as an attempt to build multi-stakeholder partnerships for demand-led research and the scaling-up of research impacts, and several related tools used to date to underpin an action research process: visioning and scenario-based planning with stakeholders, scoring ladders to monitor outcomes, process documentation to record change and matrix management to guide a diverse consortium. Examples drawn from the SWITCH project illustrate successes and failures from which the project aims to learn and improve its own effectiveness

Multilocus ISSR Markers Reveal Two Major Genetic Groups in Spanish and South African Populations of the Grapevine Fungal Pathogen Cadophora luteo-olivacea

Cadophora luteo-olivacea is a lesser-known fungal trunk pathogen of grapevine which has been recently isolated from vines showing decline symptoms in grape growing regions worldwide. In this study, 80 C. luteo-olivacea isolates (65 from Spain and 15 from South Africa) were studied. Inter-simple-sequence repeat-polymerase chain reaction (ISSR-PCR) generated 55 polymorphic loci from four ISSR primers selected from an initial screen of 13 ISSR primers. The ISSR markers revealed 40 multilocus genotypes (MLGs) in the global population. Minimum spanning network analysis showed that the MLGs from South Africa clustered around the most frequent genotype, while the genotypes from Spain were distributed all across the network. Principal component analysis and dendrograms based on genetic distance and bootstrapping identified two highly differentiated genetic clusters in the Spanish and South African C. luteo-olivacea populations, with no intermediate genotypes between these clusters. Movement within the Spanish provinces may have occurred repeatedly given the frequent retrieval of the same genotype in distant locations. The results obtained in this study provide new insights into the population genetic structure of C. luteo-olivacea in Spain and highlights the need to produce healthy and quality planting material in grapevine nurseries to avoid the spread of this fungus throughout different grape growing regions

Inferring Attribute Non-attendance from Discrete Choice Experiments: Implications for Benefit Transfer

Typical convergent validity tests of benefit transfer based on stated preference data assume that willingness to pay (WTP) estimates have been accurately measured, and that differences in WTP arise from differences in observable and unobservable characteristics between the study and the policy sites. In this paper, we conduct a convergent validity test assuming equality of underlying preferences, but allow for the possibility that transfer errors arise from differences in the way that respondents process information in the preference elicitation tasks. Using data from an identical survey instrument applied to the population of two river basins in Spain, we obtain marginal and total WTP estimates for ecological improvements of water bodies and the corresponding transfer errors across sites. Results of equality constrained latent class (ECLC) models that infer attribute non-attendance (AN-A) are compared to results from mixed logit (MXL) models in WTP space. We find large absolute and relative differences in marginal and total WTP between sites for the MXL models, and significantly reduced transfer errors for the ECLC models. This paper therefore provides further evidence that AN-A can significantly affect environmental values derived from attribute-based stated preference methods and is the first to investigate the implications for benefit transfer