Evolution of seaward-dipping reflectors at the onset of oceanic crust formation at volcanic passive margins: Insights from the South Atlantic

Seaward-dipping reflectors (SDRs) have long been recognized as a ubiquitous feature of volcanic passive margins, yet their evolution is much debated, and even the subject of the nature of the underlying crust is contentious. This uncertainty significantly restricts our understanding of continental breakup and ocean basin–forming processes. Using high-fidelity reflection data from offshore Argentina, we observe that the crust containing the SDRs has similarities to oceanic crust, albeit with a larger proportion of extrusive volcanics, variably interbedded with sediments. Densities derived from gravity modeling are compatible with the presence of magmatic crust beneath the outer SDRs. When these SDR packages are restored to synemplacement geometry we observe that they thicken into the basin axis with a nonfaulted, diffuse termination, which we associate with dikes intruding into initially horizontal volcanics. Our model for SDR formation invokes progressive rotation of these horizontal volcanics by subsidence driven by isostasy in the center of the evolving SDR depocenter as continental lithosphere is replaced by more dense oceanic lithosphere. The entire system records the migration of >10-km-thick new magmatic crust away from a rapidly subsiding but subaerial incipient spreading center at rates typical of slow oceanic spreading processes. Our model for new magmatic crust can explain SDR formation on magma-rich margins globally, but the estimated crustal thickness requires elevated mantle temperatures for their formation

Implications of structural inheritance in oblique rift zones for basin compartmentalization: Nkhata Basin, Malawi Rift (EARS)

The Cenozoic East African Rift System (EARS) is an exceptional example of active continental extension, providing opportunities for furthering our understanding of hydrocarbon plays within rifts. It is divided into structurally distinct western and eastern branches. The western branch comprises deep rift basins separated by transfer zones, commonly localised onto pre-existing structures, offering good regional scale hydrocarbon traps. At a basin-scale, local discrete inherited structures might also play an important role on fault localisation and hydrocarbon distribution. Here, we consider the evolution of the Central basin of the Malawi Rift, in particular the influence of pre-existing structural fabrics.Integrating basin-scale multichannel 2D, and high resolution seismic datasets we constrain the border, Mlowe-Nkhata, fault system (MNF) to the west of the basin and smaller Mbamba fault (MF) to the east and document their evolution. Intra basin structures define a series of horsts, which initiated as convergent transfers, along the basin axis. The horsts are offset along a NE-SW striking transfer fault parallel to and along strike of the onshore Karoo (Permo-Triassic) Ruhuhu graben. Discrete pre-existing structures probably determined its location and, oriented obliquely to the extension orientation it accommodated predominantly strike-slip deformation, with more slowly accrued dip-slip.To the north of this transfer fault, the overall basin architecture is asymmetric, thickening to the west throughout; while to the south, an initially symmetric graben architecture became increasingly asymmetric in sediment distribution as strain localised onto the western MNF. The presence of the axial horst increasingly focussed sediment supply to the west. As the transfer fault increased its displacement, so this axial supply was interrupted, effectively starving the south-east while ponding sediments between the western horst margin and the transfer fault. This asymmetric bathymetry and partitioned sedimentation continues to the present-day, overprinting the early basin symmetry and configuration. Sediments deposited earlier become increasingly dissected and fault juxtapositions changed at a small (10-100 m) scale. The observed influence of basin-scale transfer faults on sediment dispersal and fault compartmentalization due to pre-existing structures oblique to the extension orientation is relevant to analogous exploration settings

Whole-exome sequencing and targeted copy number analysis in primary ciliary dyskinesia

Primary ciliary dyskinesia (PCD) is an autosomal-recessive disorder resulting from loss of normal ciliary function. Symptoms include neonatal respiratory distress, chronic sinusitis, bronchiectasis, situs inversus, and infertility. Clinical features may be subtle and highly variable, making the diagnosis of PCD challenging. The diagnosis can be confirmed with ciliary ultrastructure analysis and/or molecular genetic testing of 32 PCD-associated genes. However, because of this genetic heterogeneity, comprehensive molecular genetic testing is not considered the standard of care, and the most efficient molecular approach has yet to be elucidated. Here, we propose a cost-effective and time-efficient molecular genetic algorithm to solve cases of PCD. We conducted targeted copy number variation (CNV) analysis and/or whole-exome sequencing on 20 families (22 patients) from a subset of 45 families (52 patients) with a clinical diagnosis of PCD who did not have a molecular genetic diagnosis after Sanger sequencing of 12 PCD-associated genes. This combined molecular genetic approach led to the identification of 4 of 20 (20%) families with clinically significant CNVs and 7 of 20 (35%) families with biallelic pathogenic mutations in recently identified PCD genes, resulting in an increased molecular genetic diagnostic rate of 55% (11/20). In patients with a clinical diagnosis of PCD, whole-exome sequencing followed by targeted CNV analysis results in an overall molecular genetic yield of 76% (34/45)

Effects of Intermittent IL-2 Alone or with Peri-Cycle Antiretroviral Therapy in Early HIV Infection: The STALWART Study

The Study of Aldesleukin with and without antiretroviral therapy (STALWART) evaluated whether intermittent interleukin-2 (IL-2) alone or with antiretroviral therapy (ART) around IL-2 cycles increased CD4+ counts compared to no therapy

Global Retinoblastoma Presentation and Analysis by National Income Level

Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4) were female. Most patients (n = 3685 84.7%) were from low-and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 62.8%), followed by strabismus (n = 429 10.2%) and proptosis (n = 309 7.4%). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 95% CI, 12.94-24.80, and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 95% CI, 4.30-7.68). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs. © 2020 American Medical Association. All rights reserved

Influence of mechanical stratigraphy on multi-layer gravity collapse structures : insights from the Orange Basin, South Africa

Gravity collapse structures are common features on passive margins and typically have a tripartite configuration including an updip extensional domain, a transitional domain and a downdip compressional domain with a common detachment underlying the system. A number of studies have classified these systems, yet few document the wide variations in geometry. This study documents the gravity collapse structures of the Namibian and South African Orange Basin; these structures represent some of the best imaged examples of this important process. We first demonstrate the geometry and kinematic evolution of these systems, focusing on examples of the tripartite configuration from a typical collapse. We then highlight the significant variability in the structures of the system and describe features such as cross-cutting in margin-parallel sections, portions of the system with multiple detachments, systems with stacked synchronous detachments and the temporal evolution of faults within the system. By integrating our observations from a number of sections, we present a model explaining the spatial and temporal evolution of the system. This enables us to discuss likely causes of collapse structures and also, by placing the system into a well-constrained stratigraphic context, how the presence of both maximum flooding surfaces and early margin deltaic sequences have a fundamental control on the resulting collapse geometry

Comparative cavitation erosion test on steels produced by ESR and AOD refining

Cavitation erosion studies of steels produced by Electroslag Refining (ESR) and Argon Oxygen Decarburization (AOD refining) have been carried out. The experiments were conducted using the modified ultrasonically induced cavitation test method. Erosion rates were measured and the morphology of damages under cavitation action was studied by scanning electron microscopy and optical microscopy techniques. The present work is aimed at understanding the cavitation erosion behaviour of electroslag refined steel (ESR) compared with the steel produced by Argon Oxygen Decarburization (AOD refining), commonly used in the production of hydraulic machinery parts (Pelton blades). The results exhibited lower cavitation rate of ESR steel compared with AOD steel, as a consequence of its better mechanical properties and homogeneous and fine-grained microstructure