821 research outputs found
Introduction to special issue: Aesthetics in mathematics
Mathematicians often appreciate the beauty and elegance of particular theorems, proofs, and definitions, attaching importance not only to the truth but also to the aesthetic merit of their work. As Henri Poincaré [1930, p. 59] put it, mathematical beauty is a ‘real aesthetic feeling that all true mathematicians recognise’. Others went further, regarding mathematical beauty as a key motivation driving the formulation of mathematical proofs and even as a criterion for choosing one proof over another. As Hermann Weyl famously and provocatively declared, ‘My work always tried to unite the true with the beautiful, but when I had to choose one or the other, I usually chose the beautiful’ (cited [Chandrasekhar, 1987, p. 52])....Talk of the beauty of mathematical theorems, proofs, and definitions may thus be commonplace
Use of Cross-Species Amplification Markers for Pollen-Medicated Gene Flow Determination in \u3cem\u3eTrifolium Polymorphum\u3c/em\u3e Poiret
The species Trifolium polymorphum Poiret is endemic to Uruguay and is widespread in native grasslands throughout the country. Preliminary observations suggested that the aerial flowers are chasmogamous (open at maturity for potential cross-pollination) while the basal flowers are cleistogamous. Several approaches have been practised to determine the reproductive system of forage legumes by the aid of co-dominant markers (Real et al., 2004; Dalla Rizza et al., 2004). The aim of this study is to explore cross-species amplification as a quick approach to obtain co-dominant markers to study the breeding system of T. polymorphum
X-ray and Radio Interactions in the Cores of Cooling Flow Clusters
We present high resolution ROSAT x-ray and radio observations of three
cooling flow clusters containing steep spectrum radio sources at their cores.
All three systems exhibit strong signs of interaction between the radio plasma
and the hot intracluster medium. Two clusters, A133 and A2626, show enhanced
x-ray emission spatially coincident with the radio source whereas the third
cluster, A2052, exhibits a large region of x-ray excess surrounding much of the
radio source. Using 3-D numerical simulations, we show that a perturbed jet
propagating through a cooling flow atmosphere can give rise to amorphous radio
morphologies, particularly in the case where the jet was ``turned off'' and
allowed to age passively. In addition, the simulated x-ray surface brightness
produced both excesses and deficits as seen observationally.Comment: 25 pages, 10 figures, accepted for publication in A
Zonal shear and super-rotation in a magnetized spherical Couette flow experiment
We present measurements performed in a spherical shell filled with liquid
sodium, where a 74 mm-radius inner sphere is rotated while a 210 mm-radius
outer sphere is at rest. The inner sphere holds a dipolar magnetic field and
acts as a magnetic propeller when rotated. In this experimental set-up called
DTS, direct measurements of the velocity are performed by ultrasonic Doppler
velocimetry. Differences in electric potential and the induced magnetic field
are also measured to characterize the magnetohydrodynamic flow. Rotation
frequencies of the inner sphere are varied between -30 Hz and +30 Hz, the
magnetic Reynolds number based on measured sodium velocities and on the shell
radius reaching to about 33. We have investigated the mean axisymmetric part of
the flow, which consists of differential rotation. Strong super-rotation of the
fluid with respect to the rotating inner sphere is directly measured. It is
found that the organization of the mean flow does not change much throughout
the entire range of parameters covered by our experiment. The direct
measurements of zonal velocity give a nice illustration of Ferraro's law of
isorotation in the vicinity of the inner sphere where magnetic forces dominate
inertial ones. The transition from a Ferraro regime in the interior to a
geostrophic regime, where inertial forces predominate, in the outer regions has
been well documented. It takes place where the local Elsasser number is about
1. A quantitative agreement with non-linear numerical simulations is obtained
when keeping the same Elsasser number. The experiments also reveal a region
that violates Ferraro's law just above the inner sphere.Comment: Phys Rev E, in pres
TRAIL Dependent Fratricidal Killing of gp120 Primed Hepatocytes by HCV Core Expressing Hepatocytes
The mechanism by which HIV and HCV cooperatively accelerate hepatocyte damage is not clearly understood; however, each virus affects the TRAIL: TRAIL- receptor system. We, therefore, questioned whether the independent effects of HCV and HIV combine to synergistically result in TRAIL dependent hepatocyte killing. We describe that Huh7 hepatocytes treated with HIV gp120 results in both increase TRAIL-R2 expression and an acquired sensitivity to TRAIL mediated killing. Moreover HCV infection and HCV core expression alone in Huh7 cells upregulates TRAIL. Co-incubation of HIV gp120 primed hepatocytes with HCV core expressing hepatocytes results in the selective death of the HIV gp120 primed hepatocytes that is selectively blocked by TRAIL–R2-Fc fusion protein. Liver biopsies from HIV mono-infected patients have increased TRAIL-R2; biopsies from HCV infected patients have increased TRAIL, while co-infected liver biopsies have increased PARP cleavage within hepatocytes indicating enhanced apoptosis. These findings suggest a pathogenic model to understand why HIV/HCV co-infection accelerates liver injury
Analysis of HIV Protease Killing Through Caspase 8 Reveals a Novel Interaction Between Caspase 8 and Mitochondria
Human Immunodeficiency Virus (HIV) protease initiates apoptosis of HIV-infected cells by proteolytic cleavage of procaspase 8, creating a novel peptide termed casp8p41. Expression of casp8p41 alone is sufficient to initiate caspase-dependent cell death associated with mitochondrial depolarization. Since casp8p41 does not contain the catalytic cysteine at position 360, the mechanism by which casp8p41 initiates apoptosis is unclear. We demonstrate that casp8p41 directly causes mitochondrial depolarization and release of cytochrome c with downstream caspase 9 activation. Moreover, death induced by casp8p41 requires the presence of mitochondria, and in intact cells, casp8p41 colocalizes with mitochondria. These results illuminate a novel mechanism of cell death induced by a caspase 8 cleavage fragment whereby mitochondrial interaction leads to depolarization and cytochrome c release
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