Diseño de Manual de Higiene y Seguridad Industrial para Minimizar los riesgos en el taller CUADRA ubicado en la ciudad de Managua

Presenta el diseño de un manual de higiene y seguridad industrial para minimizar el riesgo laboral en el taller Cuadra, ubicado en delicias del Volga, Managua, Nicaragua. Determina el ámbito de higiene y seguridad industrial en el taller Cuadra. Identifica y evalúa los riesgos, en forma inicial y periódica, con la finalidad de planificar adecuadamente los equipos de protección personal, inspección de seguridad, zonas de seguridad, rutas y plan de emergencia

Implementación y configuración de servicios TI en Nethserver

Figura 1. Configuración de memoria - Figura 67. Prueba de ConexionEl siguiente articulo indica el paso a paso con verificación de cómo se implementan los siguientes servicios en Nethserver Temática 1 (DHCP, DNS y controlador de Dominio) Temática 2 (Proxy) Temática 3 (Cortafuegos/Firewall) Temática 4 (File server y Print server) Temática 5 (VPN).The following article indicates the step by step with verification of how the following services are implemented in Nethserver Topic 1 (DHCP, DNS and Domain controller) Topic 2 (Proxy) Topic 3 (Firewall / Firewall) Topic 4 (File server and Print server ) Theme 5 (VPN)

Ensino, manuseio e manutenção adequada da artropofauna vivo em atividades educativas do Museu de História Natural da Universidade Pedagógica Nacional

The next workshop is an educational proposal aimed at regular teachers and teachers in training, built from the experience and reflections made by the members of the Arthropods to Educate seedbed, within the framework of the Natural History Museum of the National Pedagogical University (MHN-UPN). This activity aims to provide elements for the teaching, manipulation and maintenance of insects, based on a series of activities that allow, on the one hand, to discuss and reflect on the importance of arthropofauna for ecosystems and, in the same way, to recognize Its implications in the teaching of Biology. Finally, the participants provied comments and suggestions as part of the input to continue with the museum’s research and teaching activities. El siguiente taller es una propuesta educativa dirigida a maestros titulares y maestros en formación, construida a partir de la experiencia y reflexiones realizadas por parte de los integrantes del semillero Artrópodos para Educar, en el marco del Museo de Historia Natural de la Universidad Pedagógica Nacional (MHN-UPN). Dicha actividad tiene como objetivo brindar elementos para la enseñanza, manipulación y mantenimiento de insectos, a partir de una serie de actividades que permitan, por un lado, discutir y reflexionar la importancia de la artropofauna para los ecosistemas y, de la misma manera, reconocer sus implicaciones en la enseñanza de la Biología. Finalmente, los participantes proporcionaron comentarios y sugerencias como parte del insumo para continuar con las actividades de investigación y docencia del museo.A oficina a seguir é uma proposta educativa voltada para professores regulares e professores em formação, construída a partir da experiência e reflexões feitas pelos integrantes do canteiro Artrópodes para Educar, no âmbito do Museu de História Natural da Universidade Pedagógica Nacional (MHN-UPN). Esta atividade visa fornecer elementos para o ensino, manipulação e manutenção de insetos, a partir de uma série de atividades que permitem, por um lado, discutir e refletir sobre a importância da artropofauna para os ecossistemas e, da mesma forma, reconhecer suas implicações no ensino de Biologia. Por fim, os participantes forneceram comentários e sugestões como parte da contribuição para dar continuidade às atividades de pesquisa e ensino do museu.&nbsp

Trisubstituted Pyrimidines as Efficacious and Fast-acting Antimalarials

In this paper we describe the optimization of a phenotypic hit against Plasmodium falciparum, based on a trisubstituted pyrimidine scaffold. This led to compounds with good pharmacokinetics and oral activity in a P. berghei mouse model of malaria. The most promising compound (13) showed a reduction in parasitemia of 96% when dosed at 30 mg/kg orally once a day for 4 days in the P. berghei mouse model of malaria. It also demonstrated a rapid rate of clearance of the erythrocytic stage of P. falciparum in the SCID mouse model with an ED90 of 11.7 mg/kg when dosed orally. Unfortunately, the compound is a potent inhibitor of cytochrome P450 enzymes, probably due to a 4-pyridyl substituent. Nevertheless, this is a lead molecule with a potentially useful antimalarial profile, which could either be further optimized or be used for target hunting

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of high priority; however, there are few chemically validated targets. The natural product cladosporin is active against blood- and liver-stage; Plasmodium falciparum; and; Cryptosporidium parvum; in cell-culture studies. Target deconvolution in; P. falciparum; has shown that cladosporin inhibits lysyl-tRNA synthetase (; Pf; KRS1). Here, we report the identification of a series of selective inhibitors of apicomplexan KRSs. Following a biochemical screen, a small-molecule hit was identified and then optimized by using a structure-based approach, supported by structures of both; Pf; KRS1 and; C. parvum; KRS (; Cp; KRS). In vivo proof of concept was established in an SCID mouse model of malaria, after oral administration (ED; 90; = 1.5 mg/kg, once a day for 4 d). Furthermore, we successfully identified an opportunity for pathogen hopping based on the structural homology between; Pf; KRS1 and; Cp; KRS. This series of compounds inhibit; Cp; KRS and; C. parvum; and; Cryptosporidium hominis; in culture, and our lead compound shows oral efficacy in two cryptosporidiosis mouse models. X-ray crystallography and molecular dynamics simulations have provided a model to rationalize the selectivity of our compounds for; Pf; KRS1 and; Cp; KRS vs. (human); Hs; KRS. Our work validates apicomplexan KRSs as promising targets for the development of drugs for malaria and cryptosporidiosis

The Reading Palaeofire Database : an expanded global resource to document changes in fire regimes from sedimentary charcoal records

Sedimentary charcoal records are widely used to reconstruct regional changes in fire regimes through time in the geological past. Existing global compilations are not geographically comprehensive and do not provide consistent metadata for all sites. Furthermore, the age models provided for these records are not harmonised and many are based on older calibrations of the radiocarbon ages. These issues limit the use of existing compilations for research into past fire regimes. Here, we present an expanded database of charcoal records, accompanied by new age models based on recalibration of radiocarbon ages using IntCal20 and Bayesian age-modelling software. We document the structure and contents of the database, the construction of the age models, and the quality control measures applied. We also record the expansion of geographical coverage relative to previous charcoal compilations and the expansion of metadata that can be used to inform analyses. This first version of the Reading Palaeofire Database contains 1676 records (entities) from 1480 sites worldwide. The database (RPDv1b - Harrison et al., 2021) is available at https://doi.org/10.17864/1947.000345.Peer reviewe

Perspectivas de innovación en gestión, educación ambiental para la adaptación y la mitigación

Esta publicación del libro-foro sobre ciudad y cambio climático responde al aporte de los diferentes profesionales de las entidades públicas y privadas que participaron en calidad de conferencistas, ponentes, panelistas y expositores y compartieron sus experiencias en la ciudad como una contribución al conocimiento de las comunidades acerca de la creciente importancia y consideración de la adaptación y mitigación. Se consideraron acciones de políticas públicas por parte de las administraciones públicas, los sectores económicos y la sociedad, grupos ecológicos y fundaciones ecológicas y de igual forma las acciones y grandes esfuerzos realizados por el Ministerio del Ambiente, el IDEAM, la CAR, la Secretaría de Ambiente, el Jardín Botánico, la Red RAUS y de los grupos de investigación de las universidades

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group. Interpretation: In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes. Funding: GlaxoSmithKline

4to. Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad. Memoria académica

Este volumen acoge la memoria académica de la Cuarta edición del Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad, CITIS 2017, desarrollado entre el 29 de noviembre y el 1 de diciembre de 2017 y organizado por la Universidad Politécnica Salesiana (UPS) en su sede de Guayaquil. El Congreso ofreció un espacio para la presentación, difusión e intercambio de importantes investigaciones nacionales e internacionales ante la comunidad universitaria que se dio cita en el encuentro. El uso de herramientas tecnológicas para la gestión de los trabajos de investigación como la plataforma Open Conference Systems y la web de presentación del Congreso http://citis.blog.ups.edu.ec/, hicieron de CITIS 2017 un verdadero referente entre los congresos que se desarrollaron en el país. La preocupación de nuestra Universidad, de presentar espacios que ayuden a generar nuevos y mejores cambios en la dimensión humana y social de nuestro entorno, hace que se persiga en cada edición del evento la presentación de trabajos con calidad creciente en cuanto a su producción científica. Quienes estuvimos al frente de la organización, dejamos plasmado en estas memorias académicas el intenso y prolífico trabajo de los días de realización del Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad al alcance de todos y todas

El estandar 802.11n

e la creciente necesidad y revolución de las comunicaciones, nace la necesidad de tener un punto de acceso a Internet a alta velocidad desde nuestro hogar, pero eso no era suficiente ya que estaban atados a un punto (cables). De ahí nació la necesidad de brindar un servicio wireless, con su estándar 802.11como ha sido definido por la IEEE() con esto se revoluciono los sistemas de Internet inalámbrico y a medida que crecían los usuarios crecía la demanda, cobertura, disponibilidad, técnica, velocidad, seguridad movilidad, compatibilidad con tecnologías anteriores entre otra palabras QOS/calidad de servicio debido a esta demandas se han ido implementando los estándares 802.11a, 802.11b, 802.11g, los cuales ya han sido aprobados y están en funcionamiento en al actualidad