4 research outputs found
Research in design Thinking
Proceedings of a Workshop meeting held at the Faculty of Industrial Design Engineering, Delft University of Technology, The Netherlands, May 29-31, 1991.Industrial Design Engineerin
The t(14;20) is a poor prognostic factor in myeloma but is associated with long term stable disease in MGUS
A large series of plasma cell dyscrasias (n=2207) was examined for translocations which deregulate the MAF genes, t(14;20)(q32;q12) and t(14;16)(q32;q23), and their disease behaviour was compared to a group characterised by the t(4;14)(p16;q32) where CCND2 is also up-regulated. The t(14;20) showed low prevalence in myeloma (27/1830, 1.5%) and smoldering myeloma (1/148, <1%) with a higher incidence in MGUS (9/193, 5% p=0.005). Strong associations with del(13) (76%), nonhyperdiploidy (83%) and gain of 1q (58%) were seen but no association with an IgA M-protein or absence of bone disease was noted. All three translocations were associated with poor outcome in myeloma, but strikingly all t(14;20) MGUS/smouldering myeloma cases (n=10) had stable, low level disease. In contrast, the 10 t(14;16) and 25 t(4;14), MGUS/smoldering myeloma cases were associated with both evolving and non-evolving disease. None of the associated genetic abnormalities helped to predict for progression from MGUS or smoldering myeloma
Measurement of the diffractive cross-section in deep inelastic scattering
Diffractive scattering of , where is either a
proton or a nucleonic system with ~GeV has been measured in deep
inelastic scattering (DIS) at HERA. The cross section was determined by a novel
method as a function of the c.m. energy between 60 and 245~GeV
and of the mass of the system up to 15~GeV at average values of
14 and 31~GeV. The diffractive cross section is,
within errors, found to rise linearly with . Parameterizing the
dependence by the form d\sigma^{diff}/dM_X \propto
(W^2)^{(2\overline{\mbox{\alpha_{_{I\hspace{-0.2em}P}}}} -2)} the DIS data
yield for the pomeron trajectory
\overline{\mbox{\alpha_{_{I\hspace{-0.2em}P}}}} = 1.23 \pm 0.02(stat) \pm
0.04 (syst) averaged over in the measured kinematic range assuming the
longitudinal photon contribution to be zero. This value for the pomeron
trajectory is substantially larger than
\overline{\mbox{\alpha_{_{I\hspace{-0.2em}P}}}} extracted from soft
interactions. The value of \overline{\mbox{\alpha_{_{I\hspace{-0.2em}P}}}}
measured in this analysis suggests that a substantial part of the diffractive
DIS cross section originates from processes which can be described by
perturbative QCD. From the measured diffractive cross sections the diffractive
structure function of the proton F^{D(3)}_2(\beta,Q^2,
\mbox{x_{_{I\hspace{-0.2em}P}}}) has been determined, where is the
momentum fraction of the struck quark in the pomeron. The form F^{D(3)}_2 =
constant \cdot (1/ \mbox{x_{_{I\hspace{-0.2em}P}}})^a gives a good fit to
the data in all and intervals with $a = 1.46 \pm 0.04 (stat) \pmComment: 45 pages, including 16 figure