Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Desarrollo de la Escala Expectativa de Comportamiento Ambiental de Otros con adultos jóvenes mexicanos

The purpose of this study was to develop an instrument to measure expectation of others’ environmental behavior, and notice if there is a relationship between this variable and self-report of pro-environmental behaviors. Thirteen items Likert-type were development, and was applied to a sample of two hundred eighteen Mexican young adults. The exploratory factor analysis shows a bi-factorial structure distinguishes between, expectation of pro-environmental behavior, and expectation of anti-environmental behavior. Their Cronbach’s alpha score was 0.77 and 0.79; both factors accounted for 57.65% of the variance. A scale of pro-environmental actions was applied too. A structural equation model showed that the factor expectation of pro-environmental behavior has a significant effect on pro-environmental actions. The result shows evidence for bi-factorial scale with acceptable psychometrics properties.El propósito del estudio es conocer las propiedades psicométricas de una escala que mide la expectativa de comportamiento proambiental de otros, y observar si se con la conducta proambiental autoreportada. Se generaron 13 reactivos de escala tipo likert, aplicados a una muestra de 210 adultos. A través del análisis factorial exploratorio se obtuvo una estructura bifactorial que distingue entre la expectativa de comportamiento proambiental y anti-ambiental, cuyos índices de consistencia interna fueron alfa=.77 y alfa=.79, que explican el 57.65% de la varianza. Se les aplicó también una escala de conductas proambientales. Mediante un modelo de ecuaciones estructurales se mostró que el factor de expectativa de CPA tuvo un efecto significativo sobre la conducta proambiental. Los resultados muestran evidencia de una escala bifactorial con propiedades psicométricas aceptables

Desarrollo de la Escala Expectativa de Comportamiento Ambiental de Otros con adultos jóvenes mexicanos

The purpose of this study was to develop an instrument to measure expectation of others’ environmental behavior, and notice if there is a relationship between this variable and self-report of pro-environmental behaviors. Thirteen items Likert-type were development, and was applied to a sample of two hundred eighteen Mexican young adults. The exploratory factor analysis shows a bi-factorial structure distinguishes between, expectation of pro-environmental behavior, and expectation of anti-environmental behavior. Their Cronbach’s alpha score was 0.77 and 0.79; both factors accounted for 57.65% of the variance. A scale of pro-environmental actions was applied too. A structural equation model showed that the factor expectation of pro-environmental behavior has a significant effect on pro-environmental actions. The result shows evidence for bi-factorial scale with acceptable psychometrics properties.El propósito del estudio es conocer las propiedades psicométricas de una escala que mide la expectativa de comportamiento proambiental de otros, y observar si se con la conducta proambiental autoreportada. Se generaron 13 reactivos de escala tipo likert, aplicados a una muestra de 210 adultos. A través del análisis factorial exploratorio se obtuvo una estructura bifactorial que distingue entre la expectativa de comportamiento proambiental y anti-ambiental, cuyos índices de consistencia interna fueron alfa=.77 y alfa=.79, que explican el 57.65% de la varianza. Se les aplicó también una escala de conductas proambientales. Mediante un modelo de ecuaciones estructurales se mostró que el factor de expectativa de CPA tuvo un efecto significativo sobre la conducta proambiental. Los resultados muestran evidencia de una escala bifactorial con propiedades psicométricas aceptables