On the Whitham Hierarchies: Reductions and Hodograph Solutions

A general scheme for analyzing reductions of Whitham hierarchies is presented. It is based on a method for determining the $S$-function by means of a system of first order partial differential equations. Compatibility systems of differential equations characterizing both reductions and hodograph solutions of Whitham hierarchies are obtained. The method is illustrated by exhibiting solutions of integrable models such as the dispersionless Toda equation (heavenly equation) and the generalized Benney system.Comment: 24 page

Recycling probability and dynamical properties of germinal center reactions

We introduce a new model for the dynamics of centroblasts and centrocytes in a germinal center. The model reduces the germinal center reaction to the elements considered as essential and embeds proliferation of centroblasts, point mutations of the corresponding antibody types represented in a shape space, differentiation to centrocytes, selection with respect to initial antigens, differentiation of positively selected centrocytes to plasma or memory cells and recycling of centrocytes to centroblasts. We use exclusively parameters with a direct biological interpretation such that, once determined by experimental data, the model gains predictive power. Based on the experiment of Han et al. (1995b) we predict that a high rate of recycling of centrocytes to centroblasts is necessary for the germinal center reaction to work reliably. Furthermore, we find a delayed start of the production of plasma and memory cells with respect to the start of point mutations, which turns out to be necessary for the optimization process during the germinal center reaction. The dependence of the germinal center reaction on the recycling probability is analyzed.Comment: 30 pages, 8 figure