On the Construction of Chinese Government Procurement of Public Service Assessment System

To improve the way of governments to provide public services is a hot spot in academic and political studies in recent years. CCP Eighteenth Congress Report points out that, “we must change the means of providing public services through reasonable approaches, while using reasonable methods to improve the existing social management system.” Chinese society has entered a stage of rapid economic and cultural development, and only based on the fulfillment of the principles and policies implemented by the government since the eighteenth Congress can we truly promote the socio-economic and cultural development. By analyzing the problems in current government procurement of public services, this paper puts forward corresponding solutions so that these policies can help the government to create more public service value

Optical biopsy identification and grading of gliomas using label-free visible resonance Raman spectroscopy.

Glioma is one of the most refractory types of brain tumor. Accurate tumor boundary identification and complete resection of the tumor are essential for glioma removal during brain surgery. We present a method based on visible resonance Raman (VRR) spectroscopy to identify glioma margins and grades. A set of diagnostic spectral biomarkers features are presented based on tissue composition changes revealed by VRR. The Raman spectra include molecular vibrational fingerprints of carotenoids, tryptophan, amide I/II/III, proteins, and lipids. These basic in situ spectral biomarkers are used to identify the tissue from the interface between brain cancer and normal tissue and to evaluate glioma grades. The VRR spectra are also analyzed using principal component analysis for dimension reduction and feature detection and support vector machine for classification. The cross-validated sensitivity, specificity, and accuracy are found to be 100%, 96.3%, and 99.6% to distinguish glioma tissues from normal brain tissues, respectively. The area under the receiver operating characteristic curve for the classification is about 1.0. The accuracies to distinguish normal, low grade (grades I and II), and high grade (grades III and IV) gliomas are found to be 96.3%, 53.7%, and 84.1% for the three groups, respectively, along with a total accuracy of 75.1%. A set of criteria for differentiating normal human brain tissues from normal control tissues is proposed and used to identify brain cancer margins, yielding a diagnostic sensitivity of 100% and specificity of 71%. Our study demonstrates the potential of VRR as a label-free optical molecular histopathology method used for in situ boundary line judgment for brain surgery in the margins

An Experimental Study on the Establishment of Pulmonary Hypertension Model in Rats induced by Monocrotaline

Pulmonary hypertension is called PH for short. It is caused by the pulmonary artery vascular disease leading to pulmonary vascular resistance, and the increase right lung compartment load, which resulting in weakening or even collapse of the right ventricular function. The establishment of rat PH model under the action of monocrotaline is a repeatable, simple and accessible operation technique, which has been widely used in the treatment of pulmonary hypertension. This paper discusses the principle and properties of the PH model on rats under the monocrotaline action

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Stability Analysis and Fracture Patterns of Hard Main Roof in Longwall Top Coal Caving with Large Mining Height

In order to study the fracture patterns of hard main roof in longwall top coal caving (LTCC) with large mining height, a two-dimensional physical similarity model was created to simulate the mining process of No. 8100 large mining height face in Tongxin coal mine, China. The results show that there are three positions of broken line in hard main roof presented with the advance of longwall face, and the underground pressure induced by hard main roof fracturing presents the effect of superposition of large and small periods. It is found that there are two fracture patterns of main roof during the mining process: composite structure of lower cantilever beam and upper voussoir beam with hard main roof and composite structure instability of lower and upper voussoir beam with hard main roof. The underground pressure induced by these two fracture patterns is also analyzed by building mechanical models. In the end, the hydraulic fracture technique is introduced to presplit the main roof and weaken the effect of dynamic loads induced by composite structures instability

Balancing Distributed Key-Value Stores with Efficient In-Network Redirecting

Today&rsquo;s cloud-based online services are underpinned by distributed key-value stores (KVSs). Keys and values are distributed across back-end servers in such scale-out systems. One primary real-life performance bottleneck occurs when storage servers suffer from load imbalance under skewed workloads. In this paper, we present KVSwitch, a centralized self-managing load balancer that leverages the power and flexibility of emerging programmable switches. The balance is achieved by dynamically predicting the hot items and by creating replication strategies according to KVS loading. To overcome the challenges in realizing KVSwitch given the limitations of the switch hardware, we decompose KVSwitch&rsquo;s functions and carefully design them for the heterogeneous processors inside the switch. We prototype KVSwitch in a Tofino switch. Experimental results show that our solution can effectively keep the KVS servers balanced even under highly skewed workloads. Furthermore, KVSwitch only replicates 70 % of hot items and consumes 9.88 % of server memory rather than simply replicating all hot items to each server