The predictive value of CysC combined with NGAL in critical newborns with acute kidney injury

To investigate the predictive value of cystatin C (CysC) combined with neutrophil gelatinase-associated lipocalin (NGAL) in critically ill newborns with acute kidney injury (AKI).The data of 143 critically ill newborns admitted to the NICU from October 2022 to October 2024 were retrospectively analyzed. They were divided into non-AKI group (114 cases) and AKI group (29 cases) based on whether they had AKI. The clinical data of the two groups were compared. CysC and NGAL were detected at admission to the NICU and 24 hours after admission to the NICU. The levels of CysC and NGAL were compared between the non-AKI group and the AKI group, and an ROC curve was drawn to evaluate the predictive value of CysC and NGAL on AKI in critical newborns.The levels of CysC and NGAL in the AKI group were measured upon admission to the NICU and 24 hours post-admission. Both markers were significantly higher compared to the non-AKI group (P < 0.05). The ROC curve showed that CysC and NGAL have predictive value for identifying critically ill neonates in the NICU. Specifically, the AUC values for predicting AKI in infants were 0.895 for CysC and 0.835 for NGAL, with a combined prediction AUC of 0.948. Furthermore, when measured 24 hours after NICU admission, the AUC values for predicting critical neonatal AKI were 0.798 for CysC and 0.806 for NGAL, with a combined forecast AUC of 0.847.CysC and NGAL have the value of predicting AKI in critically ill newborns. Compared with testing after admission to the NICU, the combined testing of CysC and NGAL when first admitted to the NICU has a better predictive effect on AKI

Efficacy of budesonide combined with cefoperazone sodium and sulbactam sodium in the treatment of neonatal pneumonia and its influence on serum inflammatory factors

To analyze the efficacy of budesonide combined with cefoperazone sodium and sulbactam sodium in neonatal pneumonia, and observe its effect on serum inflammatory indicators. 96 patients with neonatal pneumonia admitted to our hospital from January 2023 to January 2024 were selected as the research objects, and they were divided into a control group and an observation group using random number table method, with 48 cases in each group. The control group was treated with speridone and sulbactam, and the observation group was treated with budesonide on the basis of the control group. The clinical efficacy, lung function indicators [peak volume ratio (VPEF/VE), peak expiratory flow (TPEF/TE)], and serum inflammatory factors [C-reactive protein (CRP), interleukin-6 (IL-6), matrix metalloproteinase 9 (MMP- 9) and leukotriene B4 (LTB4)] levels were compared between the two groups. Compared the clinical efficacy of the two groups, the levels of VPEF/VE, TPEF/TE and PEF in the observation group were higher than those in the control group (

A review of the research progress of organ chips in the field of biomedicine

Organ chips is a cutting-edge frontier science in the field of life sciences. It has broad application prospects and development space in the fields of tissue and organ development, disease mechanism research, new drug evaluation and selection, and biological research, and it has significant strategic significance for supporting the development of innovative drugs and translational medicine. This review summarizes the current research status, challenges, and application prospects of organ chips technology in the field of biomedicine both at home and abroad

Strategies for chronic disease patients to cope with the health challenges of Post-Acute COVID-19 Syndrome

Background: SARS-CoV-2, the virus responsible for COVID-19, has undergone numerous mutations, resulting in widespread health challenges and significant economic burdens. Beyond acute illness, a substantial number of individuals experience lingering symptoms, collectively termed post-acute COVID-19 syndrome (PACS) or long COVID. These symptoms, including fatigue, dyspnoea, and cognitive impairments, persist or emerge after the acute phase, affecting 10% to 70% of recovering patients, especially those with pre-existing chronic illnesses. Chronic conditions such as cardiovascular diseases, diabetes, and respiratory disorders exacerbate the severity of PACS, complicating disease management and quality of life. Methods: A systematic review was conducted following PRISMA guidelines and the Joanna Briggs Institute methodology for qualitative reviews. A total of 25 articles were identified, with 10 meeting the inclusion criteria for qualitative synthesis, focusing on coping strategies used by chronic patients with PACS. Results: The review highlights the complexity of managing PACS symptoms alongside chronic illnesses. Coping strategies are essential for mitigating psychological strain, improving symptom management, and enhancing overall well-being. The findings underscore the need for targeted interventions to support this vulnerable population. Conclusion: Understanding the interplay between chronic illnesses and PACS is critical for developing effective coping mechanisms. Future research should prioritize integrative care approaches to reduce the dual burden of long COVID and chronic conditions

Huoxue Quscar granules combined with erbium-doped fiber laser therapeutic instrument in the treatment Clinical application of atrophic scars in acne

Objective: To compare the clinical efficacy and safety of Huoxue-Quscar granules combined with erbium-doped fiber laser therapeutic instrument and Huoxue-Quscar granules alone in the treatment of atrophic acne scars. Methods: A total of 350 patients with atrophic acne scars treated in our hospital were randomly divided into an experimental group and a control group. The patients in the experimental group were treated with Huoxue-Quscar granules combined with erbium-doped fiber laser therapeutic instrument, and the patients in the control group were treated with Huoxue-Quscar granules. The effective rate and incidence of adverse reactions were compared between the two groups. Results: The effective rate of the trial group was 97.14%, which was significantly higher than 92.00% of the control group (P < 0.05). The incidence of adverse events in the experimental group (0.57%) was lower than that in the control group (4.00%) (P < 0.05).Conclusions: Huoxue-Quscar granules combined with erbium-doped fiber laser therapeutic instrument has good efficacy and safety in the treatment of atrophic acne scars

Research Progress on the Correlation between Metabolic Syndrome and Benign Prostatic Hyperplasia

Metabolic syndrome is a group of clinical manifestations of metabolic abnormalities, which is closely related to the occurrence of various diseases and has become an important field in modern medical research. With the change of lifestyle, the incidence of metabolic syndrome has been increasing year by year. Research shows that its components, including obesity, insulin resistance, hypertension and dyslipidemia, may have a potential correlation with benign prostatic hyperplasia (BPH). Benign prostatic hyperplasia is a common male urinary system disease, and its occurrence mechanism is complex, involving multiple endocrine and metabolic pathways. Existing research has gradually revealed the role of the components of metabolic syndrome in the development of prostate hyperplasia, especially in aspects such as inflammatory response, changes in hormone levels and cell proliferation. However, although there have been preliminary research results, the specific mechanism between metabolic syndrome and prostate hyperplasia still needs to be further explored. Therefore, this review aims to systematically analyze the relationship between metabolic syndrome and its components and prostate hyperplasia, summarize the relevant mechanisms, and summarize the current research progress and future research directions, in order to provide a reference for clinical prevention and treatment

Clinical study of trastuzumab combined with chemotherapy in the treatment of HER2-positive breast cancer

Objective: To evaluate the efficacy of trastuzumab combined with chemotherapy in patients with human epidermal factor receptor 2 (HER2) positive breast cancer. Methods: A total of 88 patients with HER2 positive breast cancer treated in our hospital from 2023 to January 2024 were selected. They were divided into two groups according to the random number table method: the control group44 cases, treated with chemotherapy) and the observation group (44 cases, treated with trastuzumab combined with chemotherapy). The efficacy, incidence adverse reactions, recurrence rate, metastasis rate, tumor marker levels, T lymphocyte subsets, estrogen receptor levels, and progesterone receptor levels before and after were compared between the two groups. Results: The efficacy of the observation group was higher than that of the control group, and the recurrence and metastasis rates were (P0.05). Before treatment there were no significant differences in tumor marker levels, T lymphocyte subsets, estrogen receptor levels, and progesterone receptor levels between the two groups (P>.05). After treatment, the tumor marker levels in the observation group were lower than those in the control group, and the T lymphocyte subsets, estrogen levels, and progesterone receptor levels were higher (

Comparative analysis of visual function between Tecnis Symfony intraocular lens and monofocal aspheric intraocular lens implantation

Objective To compare and analyze the visual function of cataract patients after Tecnis Symfony intraocular lens (IOL) and monofocal aspheric IOL implantation. Methods Fifty cataract patients admitted to our hospital from October 2023 to December 2024 were selected and divided into experimental group (Tecnis Symfony IOL implanted，25 cases) and control group (Tecnis ZCB00 IOL implanted,25 case) according to the type of lens implanted. Postoperative vision, adjustment range, simultaneous viewing and fusing functions, far and near stereovision, Visual function satisfaction questionnaire survey, de-lens rate, defocus curve, contrast sensitivity. Results There was no significant difference in uncorrected visual acuity between the two groups at a distance of 5 m (P>0.05), but the visual acuity of the experimental group at a distance of 63 cm and 30 cm was significantly better than that of the control group (P0.05), and the near stereovision of the experimental group was better than that of the control group (P0.05). Compared with the experimental group, the number of patients with difficulty in medium and near vision was significantly higher in the control group (P 0.05).There were no significant differences in defocus curves and contrast sensitivity values between the two groups (P>0.05). Conclusion Tecnis Symfony IOL can better improve most visual functions of cataract patients than Tecnis ZCB00 IOL, but some aspects of visual function improvement still need to be optimized

Research on the Application and Value of Exercise Training in Cardiac Rehabilitation

This study focuses on the application and effect evaluation of exercise training in cardiac rehabilitation. In view of the high incidence trend of cardiovascular diseases, the importance of cardiac rehabilitation in promoting patient recovery and improving quality of life has become increasingly prominent. This paper elaborates on the implementation strategies of exercise training in cardiac rehabilitation, including the formulation of personalized exercise prescriptions, safety monitoring of exercise training, and guidance and support from professionals

Clinical application analysis of neonatal swimming combined with stroking

Objective: To investigate the effects of swimming combined with touch intervention on neonatal body weight, length, psychological development, immune response and skin health, and to provide scientific basis for clinical work. Methods: In this study, 200 newborns were randomly divided into experimental group (swimming combined with touch intervention group) and control group (routine care group) using a prospective randomized controlled experiment design. The experimental group swam and touched 2-3 times a week for 4 weeks; The control group received only routine care. Before and after the intervention, weight, length, psychological development, immune response and skin health were evaluated, and SPSS 26.0 software was used for data analysis. Result: In the experimental group, newborn body weight increased by 1.53 kg (P < 0.001), body length increased by 2.6 cm (P < 0.05), psychological development score increased by 7.8 points (P < 0.001), immune response increased (antibody titer increased by 18.7, P < 0.001), skin damage rate decreased (P = 0.003). There were also significant changes in the control group. Conclusion: Swimming combined with touch intervention can significantly promote the growth and immune function of newborns, improve their skin health, contribute to psychological development, and have high clinical application value