Collagenous gastritis, a new spectrum of disease in pediatric patients: two case reports

Collagenous gastritis is a rare gastrointestinal disorder characterized in pediatrics by abdominal pain and anemia. The literature divides collagenous gastritis into distinct pediatric-onset and adult-onset phenotypes. As opposed to pediatric form, the adult form is associated with collagenous colitis and presents clinically with voluminous non-bloody diarrhea. There are over 25 case reports of collagenous gastritis of which 10 are pediatric cases. We present two cases of pediatric onset collagenous gastritis: one with a classic pediatric presentation, the other with findings typical of adult-onset disease. This is the first report of the adult-onset phenotype collagenous gastritis in a pediatric patient

Paleomagnetic Polarity Reversals in Marinoan (ca. 600 Ma) Glacial Deposits of Australia: Implications for the Duration of Low-Latitude Glaciation in Neoproterozoic Time

A paleomagnetic investigation of Marinoan glacial and preglacial deposits in Australia was conducted to reevaluate Australia's paleogeographic position at the time of glaciation (ca. 610–575 Ma). The paleomagnetic results from the Elatina Formation of the central Flinders Ranges yield the first positive regional-scale fold test (significant at the 99% level), as well as at least three magnetic polarity intervals. Stratigraphic discontinuities typical of glacial successions prevent the application of a magnetic polarity stratigraphy to regional correlation, but the positive fold test and multiple reversals confirm the previous low paleolatitude interpretation of these rocks (mean D = 214.9°, I = −14.7°, α95 = 12.7°, paleolatitude = 7.5°). The underlying preglacial Yaltipena Formation also carries low magnetic inclinations (mean D = 204.0°, I = −16.4°, α95 = 11.0°, paleolatitude = 8.4°), suggesting that Australia was located at low paleolatitude at the onset of glaciation. The number of magnetic polarity intervals present within the Elatina Formation and the Elatina's lithostratigraphic relationship to other Marinoan glacial deposits suggest that glaciation persisted at low latitudes in Australia for a minimum of several hundreds of thousands to millions of years

Current practice of physical activity counselling within physiotherapy usual care and influences on its use : a cross-sectional survey

Physical activity counselling has demonstrated effectiveness at increasing physical activity when delivered in healthcare, but is not routinely practised. This study aimed to determine (1) current use of physical activity counselling by physiotherapists working within publicly funded hospitals; and (2) influences on this behaviour. A cross‐sectional survey of physiotherapists was conducted across five hospitals within a local health district in Sydney, Australia. The survey investigated physiotherapists’ frequency of incorporating 15 different elements of physical activity counselling into their usual healthcare interactions, and 53 potential influences on their behaviour framed by the COM‐B (Capability, Opportunity, Motivation‐Behaviour) model. The sample comprised 84 physiotherapists (79% female, 48% 90% indicating their patients lacked financial and transport opportunities. These findings confirm that physical activity counselling is not routinely incorporated in physiotherapy practice and help to identify implementation strategies to build clinicians’ opportunities and capabilities to deliver physical activity counselling

Toxins and Secretion Systems of Photorhabdus luminescens

Photorhabdus luminescens is a nematode-symbiotic, gram negative, bioluminescent bacterium, belonging to the family of Enterobacteriaceae. Recent studies show the importance of this bacterium as an alternative source of insecticides, as well as an emerging human pathogen. Various toxins have been identified and characterized in this bacterium. These toxins are classified into four major groups: the toxin complexes (Tcs), the Photorhabdus insect related (Pir) proteins, the “makes caterpillars floppy” (Mcf) toxins and the Photorhabdus virulence cassettes (PVC); the mechanisms however of toxin secretion are not fully elucidated. Using bioinformatics analysis and comparison against the components of known secretion systems, multiple copies of components of all known secretion systems, except the ones composing a type IV secretion system, were identified throughout the entire genome of the bacterium. This indicates that Photorhabdus luminescens has all the necessary means for the secretion of virulence factors, thus it is capable of establishing a microbial infection

Conserving biodiversity in production landscapes

Alternative land uses make different contributions to the conservation of biodiversity and have different implementation and management costs. Conservation planning analyses to date have generally assumed that land is either protected or unprotected and that the unprotected portion does not contribute to conservation goals. We develop and apply a new planning approach that explicitly accounts for the contribution of a diverse range of land uses to achieving conservation goals. Using East Kalimantan (Indonesian Borneo) as a case study, we prioritize investments in alternative conservation strategies and account for the relative contribution of land uses ranging from production forest to well-managed protected areas. We employ data on the distribution of mammals and assign species-specific conservation targets to achieve equitable protection by accounting for life history characteristics and home range sizes. The relative sensitivity of each species to forest degradation determines the contribution of each land use to achieving targets. We compare the cost effectiveness of our approach to a plan that considers only the contribution of protected areas to biodiversity conservation, and to a plan that assumes that the cost of conservation is represented by only the opportunity costs of conservation to the timber industry. Our preliminary results will require further development and substantial stakeholder engagement prior to implementation; nonetheless we reveal that, by accounting for the contribution of unprotected land, we can obtain more refined estimates of the costs of conservation. Using traditional planning approaches would overestimate the cost of achieving the conservation targets by an order of magnitude. Our approach reveals not only where to invest, but which strategies to invest in, in order to effectively and efficiently conserve biodiversity. Copyright ESA. All rights reserved

Integrated Late Eocene-Oligocene Stratigraphy of the Alabama Coastal Plain: Correlation of Hiatuses and Stratal Surfaces to Glacioeustatic Lowerings

We integrated strontium and oxygen isotopic, biostratigraphic, and magnetostratigraphic studies of two upper Eocene-Oligocene boreholes drilled near Bay Minette and St. Stephens Quarry (SSQ), Alabama. Continuous coring provided fresh, unweathered material for magnetostratigraphic studies, minimizing problems reported from nearby outcrops. Difficulties with each technique were encountered because of diagenesis, absence of marker fossils, and the presence of unconformities; however, by integrating results from isotopic stratigraphy, biostratigraphy, and magnetostratigraphy, we correlated these relatively shallow-water deposits to the geomagnetic polarity time scale (GPTS). At the SSQ borehole, the upper Eocene to lower Oligocene section is apparently complete within our stratigraphic resolution (0.2-0.5 m.y.), allowing us to estimate the ages of several stratal surfaces. Late Eocene Sr isotope age estimates are as expected at the SSQ borehole, but Oligocene ages are ~1 m.y. older than expected due to diagenesis. At the Bay Minette borehole, a latest Eocene-earliest Oligocene and a late early Oligocene hiatus were detected. We correlate these two hiatuses and stratal surfaces at SSQ with global δ^18O increases inferred to represent glacioeustatic lowerings and with evidence for hiatuses on other continental margins: (1) a distinct disconformity at the base of the Chickasawhay Limestone at both boreholes and a hiatus at Bay Minette correlates with a global δ^18O increase; we revise the age of this surface (equivalent to the TB 1.1 sequence boundary) making it ~2 m.y. older than previously reported; and (2) a surface at the top of the Shubuta Member (lowermost Oligocene) has been interpreted both as a condensed section and a disconformity; this surface at SSQ and a hiatus at Bay Minette correlate with a sharp global δ^18O increase and with hiatuses on the New Jersey and Irish margins. The timing of the hiatuses and stratal surfaces correlates with the inflection of the δ^18O increases and not with the maximum values, supporting models that indicate that unconformities form during the maximum rates of sea level fall

Effects of a Cognitive Behavioral Therapy Intervention Trial to Improve Disease Outcomes in Children with Inflammatory Bowel Disease:

Studies testing the efficacy of behavioral interventions to modify psychosocial sequelae of IBD in children are limited. This report presents outcomes through a six month follow up from a large RCT testing the efficacy of a cognitive-behavioral intervention for children with IBD and their parents

Interventions for treating depression after stroke

Background: Depression is an important consequence of stroke that impacts on recovery yet is often not detected or inadequately treated. This is an update of a Cochrane review first published in 2004. Objectives: To determine whether pharmaceutical, psychological, or electroconvulsive treatment (ECT) of depression in patients with stroke can improve outcome. Search strategy: We searched the trials registers of the Cochrane Stroke Group (last searched October 2007) and the Cochrane Depression Anxiety and Neurosis Group (last searched February 2008). In addition, we searched the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 1, 2008), MEDLINE (1966 to May 2006), EMBASE (1980 to May 2006), CINAHL (1982 to May 2006), PsycINFO (1967 to May 2006) and other databases. We also searched reference lists, clinical trials registers, conference proceedings and dissertation abstracts, and contacted authors, researchers and pharmaceutical companies. Selection criteria: Randomised controlled trials comparing pharmaceutical agents with placebo, or various forms of psychotherapy or ECT with standard care (or attention control), in patients with stroke, with the intention of treating depression. Data collection and analysis: Two review authors selected trials for inclusion and assessed methodological quality; three review authors extracted, cross-checked and entered data. Primary analyses were the prevalence of diagnosable depressive disorder at the end of treatment. Secondary outcomes included depression scores on standard scales, physical function, death, recurrent stroke and adverse effects. Main results: Sixteen trials (17 interventions), with 1655 participants, were included in the review. Data were available for 13 pharmaceutical agents, and four trials of psychotherapy. There were no trials of ECT. The analyses were complicated by the lack of standardised diagnostic and outcome criteria, and differing analytic methods. There was some evidence of benefit of pharmacotherapy in terms of a complete remission of depression and a reduction (improvement) in scores on depression rating scales, but there was also evidence of an associated increase in adverse events. There was no evidence of benefit of psychotherapy. Authors' conclusions: A small but significant effect of pharmacotherapy (not psychotherapy) on treating depression and reducing depressive symptoms was found, as was a significant increase in adverse events. More research is required before recommendations can be made about the routine use of such treatments