Polygonal Structures in the Gaseous Disk: Numerical Simulations

The results of numerical simulations of a gaseous disk in the potential of a stellar spiral density wave are presented. The conditions under which straightened spiral arm segments (rows) form in the gas component are studied. These features of the spiral structure were identified in a series of works by A.D. Chernin with coauthors. Gas-dynamic simulations have been performed for a wide range of model parameters: the pitch angle of the spiral pattern, the amplitude of the stellar spiral density wave, the disk rotation speed, and the temperature of the gas component. The results of 2D- and 3D-disk simulations are compared. The rows in the numerical simulations are shown to be an essentially nonstationary phenomenon. A statistical analysis of the distribution of geometric parameters for spiral patterns with rows in the observed galaxies and the constructed hydrodynamic models shows good agreement. In particular, the numerical simulations and observations of galaxies give $\simeq 120^\circ$ for the average angles between straight segments.Comment: 22 pages, 10 figure

The globular cluster system of NGC1316. I. Wide-field photometry in the Washington system

NGC 1316 (Fornax A) is a prominent merger remnant in the outskirts of the Fornax cluster. The cluster system has not yet been studied in its entirety. We therefore present a wide-field study of the globular cluster system of NGC 1316, investigating its properties in relation to the global morphology of NGC 1316. We used the MOSAIC II camera at the 4-m Blanco telescope at CTIO in the filters Washington C and Harris R. We identify globular cluster candidates and study their color distribution and the structural properties of the system. In an appendix, we also make morphological remarks, present color maps, and present new models for the brightness and color profiles of the galaxy. The cluster system is well confined to the optically visible outer contours of NGC 1316. The color distribution of the entire sample is unimodal, but the color distribution of bright subsamples in the bulge shows two peaks that, by comparison with theoretical Washington colors with solar metallicity, correspond to ages of about 2 Gyr and 0.8 Gyr, respectively. We also find a significant population of clusters in the color range 0.8 < C-R < 1.1 which must be populated by clusters younger than 0.8 Gyr, unless they are very metal-poor. The color interval 1.3 < C-R < 1.6 hosts the bulk of intermediate-age clusters which show a surface density profile with a sharp decline at about 4 arcmin. The outer cluster population shows an unimodal color distribution with a peak at C-R=1.1, indicating a larger contribution of old, metal-poor clusters. Their luminosity function does not show the expected turn-over, so the fraction of younger clusters is still significant. Cluster formation in NGC 1316 has continued after an initial burst, presumably related to the main merger. A toy model with two bursts of ages 2 Gyr and 0.8 Gyr is consistent with photometric properties and dynamical M/L-values.Comment: 19 pages, to appear in Astronomy and Astrophysics, abstract abridged, format slightly different from the printed versio

A 3D view of the outflow in the Orion Molecular Cloud 1 (OMC-1)

The fast outflow emerging from a region associated with massive star formation in the Orion Molecular Cloud 1 (OMC-1), located behind the Orion Nebula, appears to have been set in motion by an explosive event. Here we study the structure and dynamics of outflows in OMC-1. We combine radial velocity and proper motion data for near-IR emission of molecular hydrogen to obtain the first 3-dimensional (3D) structure of the OMC-1 outflow. Our work illustrates a new diagnostic tool for studies of star formation that will be exploited in the near future with the advent of high spatial resolution spectro-imaging in particular with data from the Atacama Large Millimeter Array (ALMA). We use published radial and proper motion velocities obtained from the shock-excited vibrational emission in the H2 v=1-0 S(1) line at 2.122 $\mu$m obtained with the GriF instrument on the Canada-France-Hawaii Telescope, the Apache Point Observatory, the Anglo-Australian Observatory and the Subaru Telescope. These data give the 3D velocity of ejecta yielding a 3D reconstruction of the outflows. This allows one to view the material from different vantage points in space giving considerable insight into the geometry. Our analysis indicates that the ejection occurred <720 years ago from a distorted ring-like structure of ~15" (6000 AU) in diameter centered on the proposed point of close encounter of the stars BN, source I and maybe also source n. We propose a simple model involving curvature of shock trajectories in magnetic fields through which the origin of the explosion and the centre defined by extrapolated proper motions of BN, I and n may be brought into spatial coincidence.Comment: Accepted for publication in Astronomy and Astrophysics (A&A), 12 pages, 9 figure

Generalized Kapchinskij-Vladimirskij Distribution and Beam Matrix for Phase-Space Manipulations of High-Intensity Beams

In an uncoupled linear lattice system, the Kapchinskij-Vladimirskij (KV) distribution formulated on the basis of the single-particle Courant-Snyder invariants has served as a fundamental theoretical basis for the analyses of the equilibrium, stability, and transport properties of high-intensity beams for the past several decades. Recent applications of high-intensity beams, however, require beam phase-space manipulations by intentionally introducing strong coupling. In this Letter, we report the full generalization of the KV model by including all of the linear (both external and space-charge) coupling forces, beam energy variations, and arbitrary emittance partition, which all form essential elements for phase-space manipulations. The new generalized KV model yields spatially uniform density profiles and corresponding linear self-field forces as desired. The corresponding matrix envelope equations and beam matrix for the generalized KV model provide important new theoretical tools for the detailed design and analysis of high-intensity beam manipulations, for which previous theoretical models are not easily applicable.close0

Detailed Kinematic Study of the Ionized and Neutral Gas in the Complex of Star Formation in the Galaxy IC 1613

We carried out detailed kinematic studies of the complex of multiple HI and HII shells that represent the only region of ongoing star formation in the dwarf irregular galaxy IC 1613. We investigated the ionized-gas kinematics by using Fabry--Perot H-alpha observations with the 6-m Special Astrophysical Observatory telescope and the neutral-gas kinematics by using VLA 21-cm radio observations. We identified three extended (300-350 pc) neutral shells with which the brightest HII shells in the complex of star formation are associated. The neutral-gas kinematics in the complex has been studied for the first time and the H~I shells were found to expand at a velocity of 15--18 km/s. We constructed velocity ellipses for all HII shells in the complex and refined (increased) the expansion velocities of most of them. The nature of the interacting ionized and neutral shells is discussed.Comment: 14 pages, 9 EPS-figure

Functional identification of the prnABCD operon and its regulation in Serratia plymuthica

The antibiotic pyrrolnitrin (PRN) is a tryptophan-derived secondary metabolite that plays an important role in the biocontrol of plant diseases due to its broad-spectrum of antimicrobial activities. The PRN biosynthetic gene cluster remains to be characterised in Serratia plymuthica, though it is highly conserved in PRN-producing bacteria. To better understand PRN biosynthesis and its regulation in Serratia, the prnABCD operon from S. plymuthica G3 was cloned, sequenced and expressed in Escherichia coli DH5α. Furthermore, an engineered strain prnind which is a conditional mutant of G3 prnABCD under the control of the Ptac promoter was constructed. This mutant was able to overproduce PRN with isopropylthiogalactoside (IPTG) induction by overexpressing prnABCD, whilst behaving as a conditional mutant of G3 prnABCD in the absence of IPTG. These results confirmed that prnABCD is responsible for PRN biosynthesis in strain G3. Further experiments involving lux-/dsRed-based promoter fusions, combined with site-directed mutagenesis of the putative σS extended -10 region in the prnA promoter, and liquid chromatography-mass spectrometry (LC-MS) analysis extended our previous knowledge about G3, revealing that quorum sensing (QS) regulates PRN biosynthesis through cross talk with RpoS, which may directly activated prnABCD transcription. These findings suggest that PRN in S. plymuthica G3 is produced in a tightly controlled manner, and has diverse functions, such as modulation of cell motility, in addition to antimicrobial activities. Meanwhile, the construction of inducible mutants could be a powerful tool to improve PRN production, beyond its potential use for the investigation of the biological function of PRN

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Prospect and potential of Burkholderia sp. against Phytophthora capsici Leonian: a causative agent for foot rot disease of black pepper

Foot rot disease is a very destructive disease in black pepper in Malaysia. It is caused by Phytophthora capsici Leonian, which is a soilborne pathogenic protist (phylum, Oomycota) that infects aerial and subterranean structures of many host plants. This pathogen is a polycyclic, such that multiple cycles of infection and inoculum production occur in a single growing season. It is more prevalent in the tropics because of the favourable environmental conditions. The utilization of plant growth-promoting rhizobacteria (PGPR) as a biological control agent has been successfully implemented in controlling many plant pathogens. Many studies on the exploration of beneficial organisms have been carried out such as Pseudomonas fluorescens, which is one of the best examples used for the control of Fusarium wilt in tomato. Similarly, P. fluorescens is found to be an effective biocontrol agent against the foot rot disease in black pepper. Nowadays there is tremendous novel increase in the species of Burkholderia with either mutualistic or antagonistic interactions in the environment. Burkholderia sp. is an indigenous PGPR capable of producing a large number of commercially important hydrolytic enzymes and bioactive substances that promote plant growth and health; are eco-friendly, biodegradable and specific in their actions; and have a broad spectrum of antimicrobial activity in keeping down the population of phytopathogens, thus playing a great role in promoting sustainable agriculture today. Hence, in this book chapter, the potential applications of Burkholderia sp. to control foot rot disease of black pepper in Malaysia, their control mechanisms, plant growth promotion, commercial potentials and the future prospects as indigenous PGPR were discussed in relation to sustainable agriculture