Bragg scattering of Cooper pairs in an ultra-cold Fermi gas

We present a theoretical treatment of Bragg scattering of a degenerate Fermi gas in the weakly interacting BCS regime. Our numerical calculations predict correlated scattering of Cooper pairs into a spherical shell in momentum space. The scattered shell of correlated atoms is centered at half the usual Bragg momentum transfer, and can be clearly distinguished from atoms scattered by the usual single-particle Bragg mechanism. We develop an analytic model that explains key features of the correlated-pair Bragg scattering, and determine the dependence of this scattering on the initial pair correlations in the gas.Comment: Manuscript substantially revised. Version 2 contains a more detailed discussion of the collisional interaction used in our theory, and is based on three-dimensional solution

Mining microbial genomes for new natural products and biosynthetic pathways

Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products. This article summarizes the various methods that have been developed for discovering the products of cryptic biosynthetic gene clusters in microbes and gives an account of my group's discovery of the products of two such gene clusters in the model actinomycete Streptomyces coelicolor M145. These discoveries hint at new mechanisms, roles and specificities for natural product biosynthetic enzymes. Our efforts to elucidate these are described. The identification of new secondary metabolites of S. coelicolor raises the question: what is their biological function? Progress towards answering this question is also summarized

Five Years of Mid-Infrared Evolution of the Remnant of SN 1987A: The Encounter Between the Blast Wave and the Dusty Equatorial Ring

We have used the Spitzer satellite to monitor the mid-IR evolution of SN 1987A over a 5 year period spanning the epochs between days 6000 and 8000 since the explosion. The supernova (SN) has evolved into a supernova remnant (SNR) and its radiative output is dominated by the interaction of the SN blast wave with the pre-existing equatorial ring (ER). The mid-IR spectrum is dominated by emission from ~180 K silicate dust, collisionally-heated by the hot X-ray emitting gas with a temperature and density of ~5x10^6 K and 3x10^4 cm-3, respectively. The mass of the radiating dust is ~1.2x10^(-6) Msun on day 7554, and scales linearly with IR flux. The infrared to soft-X-ray flux ratio is roughly constant with a value of 2.5. Gas-grain collisions therefore dominate the cooling of the shocked gas. The constancy of of this ratio suggests that very little grain processing or gas cooling have occurred throughout this epoch. The shape of the dust spectrum remained unchanged during the observations while the total flux increased with a time dependence of t^(0.87), t being the time since the first encounter between the blast wave and the ER. These observations are consistent with the transitioning of the blast wave from free expansion to a Sedov phase as it propagates into the main body of the ER.Comment: Accepted for publication in the ApJ, 11 pages, 11 figure

Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis

Actinobacteria produce a variety of polyketide alkaloids with unusual structures. Recently, it was shown that a type I modular polyketide synthase (PKS) is involved in the assembly of coelimycin P1, a polyketide alkaloid produced by Streptomyces coelicolor M145. However, the mechanisms for converting the product of the PKS to coelimycin P1 remain to be elucidated. Here we show that the C-terminal thioester reductase (TR) domain of the PKS and an ω-transaminase are responsible for release of the polyketide chain as an aldehyde and its subsequent reductive amination. Bioinformatics analyses identified numerous gene clusters in actinobacterial genomes that encode modular PKSs with a C-terminal TR domain and a homolog of the ω-transaminase. These are predicted to direct the biosynthesis of both known and novel polyketide alkaloids, suggesting that reductive chain release and transamination constitutes a conserved mechanism for the biosynthesis of such metabolites

The effect of signal acquisition and processing choices on ApEn values: Towards a “gold standard” for distinguishing effort levels from isometric force records

Approximate Entropy (ApEn) is frequently used to identify changes in the complexity of isometric force records with ageing and disease. Different signal acquisition and processing parameters have been used, making comparison or confirmation of results difficult. This study determined the effect of sampling and parameter choices by examining changes in ApEn values across a range of submaximal isometric contractions of the First Dorsal Interosseus. Reducing the sample rate by decimation changed both the value and pattern of ApEn values dramatically. The pattern of ApEn values across the range of effort levels was not sensitive to the filter cut-off frequency, or the criterion used to extract the section of data for analysis. The complexity increased with increasing effort levels using a fixed ‘r’ value (which accounts for measurement noise) but decreased with increasing effort level when ‘r’ was set to 0.1 of the standard deviation of force. It is recommended isometric force records are sampled at frequencies >200 Hz, template length (‘m’) is set to 2, and 'r' set to measurement system noise or 0.1 SD depending on physiological process to be distinguished. It is demonstrated that changes in ApEn across effort levels are related to changes in force gradation strategy

Changes in Placental CRH, Urocortins, and CRH-Receptor mRNA Expression Associated with Preterm Delivery and Chorioamnionitis

abstract Context: The pathogenesis of preterm delivery (PTD) is not clear, although inflammation/infection play a major role. Corticotropin releasing-hormone (CRH) and Urocortins (Ucns) are involved in the pathophysiology of PTD. Objective: This study evaluates trophoblast mRNA expression of CRH, Ucn, Ucn2, Ucn3, and their receptors [CRH-type 1 receptor (CRH-R1), CRH-R2] in infective conditions. To determine whether infection or glucocorticoids contribute to change their placental mRNA expression, the effects of lipopolysaccharide or dexamethasone was evaluated. Design: Placentas were obtained from spontaneous PTD; premature rupture of membranes (pPROM) and pPROM with chorioamnionitis. Setting: Placental specimens were collected from women receiving perinatal care at our Division of Obstetrics and Gynecology. Patients or Other Participants: Pregnant women delivered preterm were enrolled. Interventions: mRNA expression was evaluated by RT-PCR. Main Outcome Measure: Because CRH and Ucns are involved in immunological functions we evaluated their involvement in PTD with or without infection. Results: CRH, Ucn2, and CRH-R1 mRNA expression were higher, while Ucn and CRHR-2 were lower in pPROM with chorioamnionitis than in PTD and pPROM. Ucn3 mRNA expression was lower in pPROM with and without chorioamnionitis than in PTD. The addition of lipopolysaccharide in trophoblast explants decreased Ucn, Ucn3, and CRH-R2 and increased CRH, Ucn2, and CRH-R1 mRNA expression in a dose-dependent manner. Dexamethasone increased CRH and decreased Ucn2 mRNA expression in a dose dependent manner. Conclusions: Our findings showed a significant impact of pPROM with chorioamnionitis on placental CRH peptides and receptors, suggesting that placental expression of stress-related pathways is activated in infective process

The First VLBI Image of the Young, Oxygen-Rich Supernova Remnant in NGC 4449

We report on sensitive 1.4-GHz VLBI radio observations of the unusually luminous supernova remnant SNR 4449-1 in the galaxy NGC 4449, which gave us the first well-resolved image of this object. The remnant's radio morphology consists of two approximately parallel bright ridges, suggesting similarities to the barrel shape seen for many older Galactic supernova remnants or possibly to SN 1987A. The angular extent of the remnant is 65 x 40 mas, corresponding to (3.7 x 2.3) x 10^{18} (D/3.8 Mpc) cm. We also present a new, high signal-to-noise optical spectrum. By comparing the remnant's linear size to the maximum velocities measured from optical lines, as well as using constraints from historical images, we conclude that the supernova explosion occurred between ~1905 and 1961, likely around 1940. The age of the remnant is therefore likely ~70 yr. We find that SNR 4449-1's shock wave is likely still interacting with the circumstellar rather than interstellar medium.Comment: 7 pages, Accepted for publication in MNRA

Design of three dimensional isotropic microstructures for maximized stiffness and conductivity

The level-set method of topology optimization is used to design isotropic two-phase periodic multifunctional composites in three dimensions. One phase is stiff and insulating whereas the other is conductive and mechanically compliant. The optimization objective is to maximize a linear combination of the effective bulk modulus and conductivity of the composite. Composites with the Schwartz primitive and diamond minimal surfaces as the phase interface have been shown to have maximal bulk modulus and conductivity. Since these composites are not elastically isotropic their stiffness under uniaxial loading varies with the direction of the load. An isotropic composite is presented with similar conductivity which is at least 23% stiffer under uniaxial loading than the Schwartz structures when loaded uniaxially along their weakest direction. Other new near-optimal isotropic composites are presented, proving the capablities of the level-set method for microstructure design.Comment: 25 pages, 11 figures, to be submitted to International Journal of Solids and Structure

Limits from the Hubble Space Telescope on a Point Source in SN 1987A

We observed supernova 1987A (SN 1987A) with the Space Telescope Imaging Spectrograph (STIS) on the Hubble Space Telescope (HST) in 1999 September, and again with the Advanced Camera for Surveys (ACS) on the HST in 2003 November. No point source is observed in the remnant. We obtain a limiting flux of F_opt < 1.6 x 10^{-14} ergs/s/cm^2 in the wavelength range 2900-9650 Angstroms for any continuum emitter at the center of the supernova remnant (SNR). It is likely that the SNR contains opaque dust that absorbs UV and optical emission, resulting in an attenuation of ~35% due to dust absorption in the SNR. Taking into account dust absorption in the remnant, we find a limit of L_opt < 8 x 10^{33} ergs/s. We compare this upper bound with empirical evidence from point sources in other supernova remnants, and with theoretical models for possible compact sources. Bright young pulsars such as Kes 75 or the Crab pulsar are excluded by optical and X-ray limits on SN 1987A. Of the young pulsars known to be associated with SNRs, those with ages < 5000 years are all too bright in X-rays to be compatible with the limits on SN 1987A. Examining theoretical models for accretion onto a compact object, we find that spherical accretion onto a neutron star is firmly ruled out, and that spherical accretion onto a black hole is possible only if there is a larger amount of dust absorption in the remnant than predicted. In the case of thin-disk accretion, our flux limit requires a small disk, no larger than 10^{10} cm, with an accretion rate no more than 0.3 times the Eddington accretion rate. Possible ways to hide a surviving compact object include the removal of all surrounding material at early times by a photon-driven wind, a small accretion disk, or very high levels of dust absorption in the remnant.Comment: 40 pages, 5 figures. AAStex. Accepted, ApJ 04/28/200

Properties of the ultraviolet flux of type Ia supernovae: an analysis with synthetic spectra of SN 2001ep and SN 2001eh

The spectral properties of type Ia supernovae in the ultraviolet (UV) are investigated using the early-time spectra of SN 2001ep and SN 2001eh obtained using the Hubble Space Telescope (HST). A series of spectral models is computed with a Monte Carlo spectral synthesis code, and the dependence of the UV flux on the elemental abundances and the density gradient in the outer layers of the ejecta is tested. A large fraction of the UV flux is formed by reverse fluorescence scattering of photons from red to blue wavelengths. This process, combined with ionization shifts due to enhanced line blocking, can lead to a stronger UV flux as the iron-group abundance in the outer layers is increased, contrary to previous claims.Comment: 14 pages, 13 figures. Replaced with revised version accepted for publication in MNRA