PENGARUH PENDEKATAN REALISTIC MATHEMATICS EDUCATION TERHADAP KEMAMPUAN BERPIKIR KRITIS DAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIS SEKOLAH DASAR

Kemampuan berpikir kritis dan kemampuan pemecahan masalah matematis merupakan kemampuan yang sangat penting yang harus dimiliki siswa Sekolah Dasar. Hal ini akan membantu dalam mengembangkan potensi dirinya, dengan menitikberatkan pada kemampuan dalam berpikir dan bertindak secara normatif, dan siap bernalar dari apa yang dilihat maupun didengar sehingga dapat menyelesaikan permasalahan yang dihadapinya dalam kehidupan sehari-hari, oleh karena itu peranan guru sebagai tenaga pendidik secara professional menjadi penentu dalam menjembatani siswa melalui pembelajaran yang berkualitas. Namun kenyataannya berkaitan dengan proses pembelajaran matematika di SD proses pembelajaran yang dilaksanakan belum memberikan kesempatan siswa dalam menggali potensi dirinya dalam berpikir kritis dan menyelesaikan permasalahan. Sehingga perlu dicari alternatif pembelajaran yang dapat meningkatkan kemampuan berpikir kritis dan kemampuan pemecahan masalah. Pendekatan Realistic Mathematics Education merupakan salah satu alternatif yang digunakan untuk meningkatkan kemampuan berpikir kritis dan kemampuan pemecahan masalah matematis. Penelitian ini bertujuan untuk mengetahui apakah pendekatan Realistic Mathematics Education dapat meningkatkan kemampuan berpikir kritis dan kemampuan pemecahan masalah matematis dalam pembelajaran matematika di Sekolah Dasar. Penelitian ini dilaksanakan menggunakan metode kuasi eksperimen dengan desain kelompok kontrol non-Ekuivalen. Sampel dalam penelitian adalah siswa kelas IV pada salah satu SD di Kabupaten Garut. Pengumpulan data dilakukan dengan tes berbentuk uraian dan lembar observasi selama proses pembelajaran. Untuk pengolahan data digunakan program SPSS versi 20. Berdasarkan hasil penelitian berupa skor N-gain dianalisis dengan menggunakan uji t-tes. Hasil penelitian yang dianalisis menunjukkan bahwa terdapat peningkatan kemampuan berpikir kritis dan kemampuan pemecahan masalah matematis yang belajar melalui pendekatan Realistic Mathematics Education (RME) dengan yang menggunakan pembelajaran biasa. Jadi dapat disimpulkan peningkatan kemampuan berpikir kritis dan kemampuan pemecahan masalah matematis dengan menggunakan Realistic Mathematics Education (RME) lebih baik dari siswa yang mendapatkan pembelajaran biasa ---------- Critical thinking skills and mathematical problem solving ability is a very important capability that should be owned by elementary school students. These abilities would help students to improve their potential, with concern on the ability to think and act as normative, and ready to have a reason of what is seen and heard so that they can solve their problems in daily life, therefore the role of the teacher as professional educators be decisive in bridging the students through quality learning. But in the reality, relates to the process of learning mathematics in elementary school, learning process which implemented yet provide an opportunity for students to explore their potential in critical thinking to solve the problems. so it is necessary to find an alternative learning that can improve critical thinking skills and problem solving skills. Realistic Mathematics Education approach is one alternative that is used to improve critical thinking skills and mathematical problem-solving abilities. This research aims to determine whether Realistic Mathematics Education approach can improve the ability of critical thinking and mathematical problem solving ability in mathematics in elementary school. This research was conducted using a quasi-experimental design with a control group of non-Equivalent. Samples were fourth grade students in one elementary school in Garut. Data collected by the description and the sheet-shaped test observations during the learning process. For data processing used SPSS version 20. Based on the results of research in the form of N-gain scores were analyzed using t-test, which analyzed research results show that there are increasing in the ability of critical thinking and problem solving skills are learned through mathematical approach Realistic Mathematics Education (RME) with the use of regular learning. So we can conclude the increase in critical thinking skills and mathematical problem-solving abilities by using Realistic Mathematics Education (RME) is better than the students who get regular learnin

Modelos agrícolas alternativos en Argentina, Nueva Zelanda y Holanda: reflexiones comparativas

La consolidación del modelo productivo convencional a nivel mundial, especialmente ligado a la incorporación de un paquete tecnológico derivado de la denominada Revolución Verde, ha sido objeto de estudio y análisis en los últimos años, dando espacio a numerosos cuestionamientos. Concomitantemente, emergen producciones alternativas. En este contexto, no son frecuentes los estudios que expliquen de forma comparativa el modo en que distintos países abordan estas respuestas alternativas. Este artículo analiza las alternativas al modelo de producción convencional en Argentina, Nueva Zelanda y Holanda considerando el tratamiento público de este tema, a través de normativas, programas y políticas públicas. El carácter metodológico de este estudio es cualitativo, basado en estudios previos de los autores, fuentes de información secundaria y entrevistas en profundidad. Los principales resultados muestran que: los tres casos de estudio, inmersos en disímiles contextos socio-históricos, generan respuestas alternativas diferenciales; las motivaciones para ello son específicas de cada caso, destacándose el interés por consumir alimentos sanos e inocuos, el cuidado del medio ambiente y mejores precios para los agricultores; en los tres casos se corrobora la coexistencia actual de producciones alternativas y convencionales. Las propuestas alternativas tienden a traer visiones más holísticas de los sistemas alimentarios, en las que los miembros de la comunidad son a la vez actores y beneficiarios de las transformaciones que se desarrollan a su alrededor. Al identificar y comparar las diferentes alternativas, es posible reflexionar sobre la forma en que se perciben los problemas y las soluciones en torno a los sistemas agroalimentarios.The consolidation of the conventional production model worldwide, especially linked to the implementation of a technological package derived from the socalled Green Revolution, has been subject of study and analysis in recent years. Concomitantly, alternative productions are emerging. In this context, there are not many studies that explain in a comparative way how different countries approach these alternative responses. This article analyses alternative responses to conventional production model in Argentina, New Zealand and the Netherlands considering the public treatment of this issue, through regulations, programs and public policies. The methodological nature of this study is qualitative, based on previous studies by the authors, sources of secondary information and in-depth interviews. Main results show that: the three case studies, immersed in dissimilar socio-historical contexts, generate differential alternative responses to the conventional production model; the motivations for this are specific to each case, as the interest in consuming healthy and safe food, the care of the environment and better prices for the farmers; in all three cases, the current coexistence of alternative and conventional productions is corroborated. The alternative proposals tend to bring more holistic views of food systems, in which the members of the community are at the same time actors and beneficiaries of the transformations unfolding around them. By identifying and comparing the different emerging alternatives in three countries with such dissimilar characteristics, it is possible to reflect on the way in which problems and solutions around agricultural food systems are perceived, providing useful insights for strategic planning.Fil: Molpeceres, María Celeste. Universidad Nacional de Mar del Plata. Facultad de Humanidades. Centro de Estudios Sociales y Politicos.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; ArgentinaFil: Romera, Álvaro. No especifíca;Fil: Jansma, Jan Eelco. No especifíca;Fil: Zulaica, Maria Laura. Universidad Nacional de Mar del Plata. Facultad de Arquitectura, Urbanismo y Diseño. Instituto de Hábitat y Medio Ambiente; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; ArgentinaFil: Mazzetto, Andre. No especifíca;Fil: Shah, Munir. No especifíca

Modelos agrícolas alternativos en Argentina, Nueva Zelanda y Holanda: reflexiones comparativas

La consolidación del modelo productivo convencional a nivel mundial, especialmente ligado a la incorporación de un paquete tecnológico derivado de la denominada Revolución Verde, ha sido objeto de estudio y análisis en los últimos años, dando espacio a numerosos. Concomitantemente, emergen producciones alternativas. En este contexto, no son frecuentes los estudios que expliquen de forma comparativa el modo en que distintos países abordan estas respuestas alternativas. Este artículo analiza las alternativas al modelo de producción convencional en Argentina, Nueva Zelanda y Holanda considerando el tratamiento público de este tema, a través de normativas, programas y políticas públicas. El carácter metodológico de este estudio es cualitativo, basado en estudios previos de los autores, fuentes de información secundaria y entrevistas en profundidad. Los principales resultados muestran que: los tres casos de estudio, inmersos en disímiles contextos sociohistóricos, generan respuestas alternativas diferenciales al modelo productivo convencional; las motivaciones para ello son específicas de cada caso, siendo entre los principales aspectos claves el interés por consumir alimentos sanos e inocuos, el cuidado del medio ambiente y mejores precios para los agricultores; en los tres casos se corrobora la coexistencia actual de producciones alternativas y convencionales. Las propuestas alternativas tienden a traer visiones más holísticas de los sistemas alimentarios, en las que los miembros de la comunidad son a la vez actores y beneficiarios de las transformaciones que se desarrollan a su alrededor. Al identificar y comparar las diferentes alternativas emergentes en tres países con características tan disímiles, es posible reflexionar sobre la forma en que se perciben los problemas y las soluciones en torno a los sistemas agroalimentarios.AcknowledgementsThis work was conducted through the research programme “The New Zealand bioeconomy in the digital age” funded by the AgResearch Strategic Science Investment Fund. We acknowledge the Flevo Campus programme for their support of the research in Almere Oosterwold

What is the definition of acute episodic and chronic pain in critically ill neonates and infants? : a global, four-stage consensus and validation study

Objectives To define and validate types of pain in critically ill neonates and infants by researchers and clinicians working in the neonatal intensive care unit (NICU) and high dependency unit (HDU). Design A qualitative descriptive mixed-methods design. Procedure/s Each stage of the study was built on and confirmed the previous stages. Stage 1 was an expert panel to develop definitions; stage 2 was a different expert panel made up of neonatal clinicians to propose clinical characteristics associated with the definitions from stage 1; stage 3 was a focus group of neonatal clinicians to provide clinical case scenarios associated with each definition and clinical characteristics; and stage 4 was a survey administered to neonatal clinicians internationally to test the validity of the definitions using the clinical case scenarios. Results In stage 1, the panel (n=10) developed consensus definitions for acute episodic pain and chronic pain in neonates and infants. In stage 2, a panel (n=8) established clinical characteristics that may be associated with each definition. In stage 3, a focus group (n=11) created clinical case scenarios of neonates and infants with acute episodic pain, chronic pain and no pain using the definitions and clinical characteristics. In stage 4, the survey (n=182) revealed that the definitions allowed an excellent level of discrimination between case scenarios that described neonates and infants with acute episodic pain and chronic pain (area under the receiver operating characteristic=0.87 and 0.89, respectively). Conclusions This four-stage study enabled the development of consensus-based and clinically valid definitions of acute episodic pain and chronic pain. There is a need to define and validate other pain types to inform a taxonomy of pain experienced by neonates and infants in the NICU and HDU

Management of Kaposi sarcoma after solid organ transplantation:A European retrospective study

Background: Systemic therapeutic management of post-transplant Kaposi sarcoma (KS) is mainly based on 3 axes: reduction of immunosuppression, conversion to mammalian target of rapamycin (mTOR) inhibitors, chemotherapy, or a combination of these.Objective: To obtain an overview of clinical strategies about the current treatment of KS.Methods: We conducted a multicenter retrospective cohort study including 145 solid organ transplant recipients diagnosed with KS between 1985 and 2011 to collect data regarding first-line treatment and response at 6 months.Results: Overall, 95%, 28%, and 16% of patients had reduction of immunosuppression, conversion to mTOR inhibitor, and chemotherapy, respectively. Patients treated with chemotherapy or mTOR inhibitor conversion were more likely to have visceral KS. At 6 months, 83% of patients had response, including 40% complete responses.Limitations: The retrospective design of the study.Conclusion: Currently available therapeutic options seem to be effective to control KS in most patients. Tapering down the immunosuppressive regimen remains the cornerstone of KS management.Dermatology-oncolog

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been identified, and there are more than 400 human genetic syndromes with a hearing loss component. Over 100 non-syndromic hearing loss genes have been identified in mouse and human, but we remain ignorant of the full extent of the genetic landscape involved in auditory dysfunction. As part of the International Mouse Phenotyping Consortium, we undertook a hearing loss screen in a cohort of 3006 mouse knockout strains. In total, we identify 67 candidate hearing loss genes. We detect known hearing loss genes, but the vast majority, 52, of the candidate genes were novel. Our analysis reveals a large and unexplored genetic landscape involved with auditory function

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.

BACKGROUND: Converging evidence suggests that immune-mediated dysfunction plays an important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies have shown that immune-associated loci are associated with increased FTD risk, a systematic investigation of genetic overlap between immune-mediated diseases and the spectrum of FTD-related disorders has not been performed. METHODS AND FINDINGS: Using large genome-wide association studies (GWASs) (total n = 192,886 cases and controls) and recently developed tools to quantify genetic overlap/pleiotropy, we systematically identified single nucleotide polymorphisms (SNPs) jointly associated with FTD-related disorders-namely, FTD, corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS)-and 1 or more immune-mediated diseases including Crohn disease, ulcerative colitis (UC), rheumatoid arthritis (RA), type 1 diabetes (T1D), celiac disease (CeD), and psoriasis. We found up to 270-fold genetic enrichment between FTD and RA, up to 160-fold genetic enrichment between FTD and UC, up to 180-fold genetic enrichment between FTD and T1D, and up to 175-fold genetic enrichment between FTD and CeD. In contrast, for CBD and PSP, only 1 of the 6 immune-mediated diseases produced genetic enrichment comparable to that seen for FTD, with up to 150-fold genetic enrichment between CBD and CeD and up to 180-fold enrichment between PSP and RA. Further, we found minimal enrichment between ALS and the immune-mediated diseases tested, with the highest levels of enrichment between ALS and RA (up to 20-fold). For FTD, at a conjunction false discovery rate < 0.05 and after excluding SNPs in linkage disequilibrium, we found that 8 of the 15 identified loci mapped to the human leukocyte antigen (HLA) region on Chromosome (Chr) 6. We also found novel candidate FTD susceptibility loci within LRRK2 (leucine rich repeat kinase 2), TBKBP1 (TBK1 binding protein 1), and PGBD5 (piggyBac transposable element derived 5). Functionally, we found that the expression of FTD-immune pleiotropic genes (particularly within the HLA region) is altered in postmortem brain tissue from patients with FTD and is enriched in microglia/macrophages compared to other central nervous system cell types. The main study limitation is that the results represent only clinically diagnosed individuals. Also, given the complex interconnectedness of the HLA region, we were not able to define the specific gene or genes on Chr 6 responsible for our pleiotropic signal. CONCLUSIONS: We show immune-mediated genetic enrichment specifically in FTD, particularly within the HLA region. Our genetic results suggest that for a subset of patients, immune dysfunction may contribute to FTD risk. These findings have potential implications for clinical trials targeting immune dysfunction in patients with FTD

Advancing research for seamless Earth system prediction

Whether on an urban or planetary scale, covering time scales of a few minutes or a few decades, the societal need for more accurate weather, climate, water, and environmental information has led to a more seamless thinking across disciplines and communities. This challenge, at the intersection of scientific research and society’s need, is among the most important scientific and technological challenges of our time. The “Science Summit on Seamless Research for Weather, Climate, Water, and Environment” organized by the World Meteorological Organization (WMO) in 2017, has brought together researchers from a variety of institutions for a cross-disciplinary exchange of knowledge and ideas relating to seamless Earth system science. The outcomes of the Science Summit, and the interactions it sparked, highlight the benefit of a seamless Earth system science approach. Such an approach has the potential to break down artificial barriers that may exist due to different observing systems, models, time and space scales, and compartments of the Earth system. In this context, the main future challenges for research infrastructures have been identified. A value cycle approach has been proposed to guide innovation in seamless Earth system prediction. The engagement of researchers, users, and stakeholders will be crucial for the successful development of a seamless Earth system science that meets the needs of society

Immune-related genetic enrichment in frontotemporal dementia:An analysis of genome-wide association studies

Background: Converging evidence suggests that immune-mediated dysfunction plays an important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies have shown that immune-associated loci are associated with increased FTD risk, a systematic investigation of genetic overlap between immune-mediated diseases and the spectrum of FTD-related disorders has not been performed. Methods and findings: Using large genome-wide association studies (GWASs) (total n = 192,886 cases and controls) and recently developed tools to quantify genetic overlap/pleiotropy, we systematically identified single nucleotide polymorphisms (SNPs) jointly associated with FTD-related disorders—namely, FTD, corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS)—and 1 or more immune-mediated diseases including Crohn disease, ulcerative colitis (UC), rheumatoid arthritis (RA), type 1 diabetes (T1D), celiac disease (CeD), and psoriasis. We found up to 270-fold genetic enrichment between FTD and RA, up to 160-fold genetic enrichment between FTD and UC, up to 180-fold genetic enrichment between FTD and T1D, and up to 175-fold genetic enrichment between FTD and CeD. In contrast, for CBD and PSP, only 1 of the 6 immune-mediated diseases produced genetic enrichment comparable to that seen for FTD, with up to 150-fold genetic enrichment between CBD and CeD and up to 180-fold enrichment between PSP and RA. Further, we found minimal enrichment between ALS and the immune-mediated diseases tested, with the highest levels of enrichment between ALS and RA (up to 20-fold). For FTD, at a conjunction false discovery rate < 0.05 and after excluding SNPs in linkage disequilibrium, we found that 8 of the 15 identified loci mapped to the human leukocyte antigen (HLA) region on Chromosome (Chr) 6. We also found novel candidate FTD susceptibility loci within LRRK2 (leucine rich repeat kinase 2), TBKBP1 (TBK1 binding protein 1), and PGBD5 (piggyBac transposable element derived 5). Functionally, we found that the expression of FTD–immune pleiotropic genes (particularly within the HLA region) is altered in postmortem brain tissue from patients with FTD and is enriched in microglia/macrophages compared to other central nervous system cell types. The main study limitation is that the results represent only clinically diagnosed individuals. Also, given the complex interconnectedness of the HLA region, we were not able to define the specific gene or genes on Chr 6 responsible for our pleiotropic signal. Conclusions: We show immune-mediated genetic enrichment specifically in FTD, particularly within the HLA region. Our genetic results suggest that for a subset of patients, immune dysfunction may contribute to FTD risk. These findings have potential implications for clinical trials targeting immune dysfunction in patients with FTD