Lina Bo [Bardi] en Italia Nuevas líneas de investigación llevan al redescubrimiento de los proyectos de Bo y Pagani que habían caído en el olvido: dos instalaciones llevadas a cabo en Milán durante la Segunda Guerra Mundial

This paper shows that the years Lina Bo Bardi spent in Italy deserve further examination. In fact, bibliographical and archival research, which should be carried out in Italy and also at Lina Bo and P.M. Bardi Institute, can still reveal previously unknown materials. Following this line of research, a careful analysis of the magazine Lo Stile nella casa e nell’arredamento has revealed two forgotten designs of temporary structures for political events in Milan by the architects Bo and Pagani from 1942.Este artículo muestra que el período italiano de Lina Bo Bardi todavía tiene que ser examinado a fondo. La investigación del archivo y de la bibliografía, que debería ser efectuada sobre todo en Italia, pero también en el Instituto Lina Bo y P.M. Bardi, puede revelar materiales inéditos. Siguiendo esta línea de investigación, gracias al análisis minucioso de la revista Lo Stile nella casa e nell’arredamento han sido redescubiertos dos proyectos realizados por los arquitectos Lina Bo y Carlo Pagani en 1942, que habían caído en el olvido. Se trata de ejemplos de “arquitectura efímera” para unos eventos políticos en Milán.Esta contribuição mostra que o período italiano de Lina Bo Bardi é um tema ainda suscetível de aprofundamento e que a pesquisa de arquivo e bibliográfica, a ser realizada principalmente na Itália, mas também no Instituto Lina Bo e P.M. Bardi, pode restituir materiais inéditos. Seguindo essa linha de pesquisa, a análise cuidadosa da revista Lo Stile restituiu dois projetos realizados pelo ateliê Bo-Pagani que remontam a 1942 e caídos no esquecimento, exemplos de “arquitetura efêmera” por eventos políticos na cidade de Milão

Duursma Zeta Functions of Type IV Virtual Codes

This research project involves an investigation of error correcting codes. The safe and reliable transfer of information depends on coding theory. The problem of transferring dependable information is important and this research project attempts to continue incremental progress in the field. Specifically, the project will emphasize formally self dual codes and will expand upon Duursma\u27s ideas in Extremal Weight Enumerators and Ultraspherical Polynomials. Considerable work has been devoted to the study of self dual codes. Iwan M. Duursma has written numerous papers on the matter and the greater part of this project is centered on his work. In 1999, Iwan M. Duursma defined the zeta function for a linear code as a generating function of its Hamming weight enumerator. The modest goal of Midn Catalano\u27s project is to go through Duursma\u27s papers and evaluate its relevance for formally self dual codes. Therefore, the research projects aims to extend Duursma\u27s work in Extremal Weight Enumerators and Ultraspherical Polynomials to formally self dual codes. More specifically, the project expands Duursma\u27s work to zeta functions of formally self dual codes of Type IV

El edificio eclesial para Lina Bo Bardi

This intervention aims to investigate the figure of Lina Bo Bardi, an Italian architect who moved to Brazil in 1946, at the end of the Second World War, who during his years of activity in Italy was also collaborating with the architect Gio Ponti. Bo Bardi sacred architecture will be discussed in detail. Among the large number of works by the architect are, in fact, two small but significant churches built in Brazil in the seventies of the last century.What were the Lina Bo Bardi architectural references to the place of worship? How her Italian training has permeated her work and how they have been contaminated by the architecture of the new continent? A few years before, the Second Vatican Council had given new liturgical indications. We can wonder if the liturgical opening was seen in his work as part of the architectural discourse used or if it simply was took as a fact occurred.La intervención tiene como objetivo investigar la figura de Lina Bo Bardi, una arquitecta italiana que se trasladó a Brasil en 1946, al final de la Segunda Guerra Mundial, y que durante sus años de actividad en Italia fue también colaboradora del arquitecto Gio Ponti. Se analizará en detalle su arquitectura destinada al culto. Entre el gran número de obras de la arquitecta se encuentran, de hecho, dos pequeñas pero significativas iglesias construidas en Brasil durante los años setenta del siglo pasado.¿Cuáles fueron las referencias arquitectónicas de Lina Bo Bardi para el edificio de culto? ¿Cómo su formación italiana ha impregnado sus obras y cómo éstas han sido contaminadas por la arquitectura del nuevo continente? Pocos años atrás, el Concilio Vaticano II había dado nuevas indicaciones litúrgicas. Nos podemos preguntar si la apertura litúrgica fue considerada en su obra como parte del discurso arquitectónico utilizado o si, simplemente, se tomó como un dato sobrevenido

Church Building by Lina Bo Bardi

[Resumen] La intervención tiene como objetivo investigar la figura de Lina Bo Bardi, una arquitecta italiana que se trasladó a Brasil en 1946, al final de la Segunda Guerra Mundial, y que durante sus años de actividad en Italia fue también colaboradora del arquitecto Gio Ponti. Se analizará en detalle su arquitectura destinada al culto. Entre el gran número de obras de la arquitecta se encuentran, de hecho, dos pequeñas pero significativas iglesias construidas en Brasil durante los años setenta del siglo pasado. ¿Cuáles fueron las referencias arquitectónicas de Lina Bo Bardi para el edificio de culto? ¿Cómo su formación italiana ha impregnado sus obras y cómo éstas han sido contaminadas por la arquitectura del nuevo continente? Pocos años atrás, el Concilio Vaticano II había dado nuevas indicaciones litúrgicas. Nos podemos preguntar si la apertura litúrgica fue considerada en su obra como parte del discurso arquitectónico utilizado o si, simplemente, se tomó como un dato sobrevenido.[Abstract] This intervention aims to investigate the figure of Lina Bo Bardi, an Italian architect who moved to Brazil in 1946, at the end of the Second World War, who during his years of activity in Italy was also collaborating with the architect Gio Ponti. Bo Bardi sacred architecture will be discussed in detail. Among the large number of works by the architect are, in fact, two small but significant churches built in Brazil in the seventies of the last century. What were the Lina Bo Bardi architectural references to the place of worship? How her Italian training has permeated her work and how they have been contaminated by the architecture of the new continent? A few years before, the Second Vatican Council had given new liturgical indications. We can wonder if the liturgical opening was seen in his work as part of the architectural discourse used or if it simply was took as a fact occurred

Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort

Background: Mycotoxins have been suggested to contribute to a spectrum of adverse health effects in humans, including at low concentrations. The recognition of these food contaminants being carcinogenic, as co-occurring rather than as singularly present, has emerged from recent research. The aim of this study was to assess the potential associations of single and multiple mycotoxin exposures with renal cell carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Food questionnaire data from the EPIC cohort were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority (EFSA) from European Member States to assess long-term dietary mycotoxin exposures, and to associate these with the risk of renal cell carcinoma (RCC, n = 911 cases) in 450,112 EPIC participants. Potential confounding factors were taken into account. Analyses were conducted using Cox's proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (95% CIs) with mycotoxin exposures expressed as mu g/kg body weight/day. Results: Demographic characteristics differed between the RCC cases and non-cases for body mass index, age, alcohol intake at recruitment, and other dietary factors. In addition, the mycotoxin exposure distributions showed that a large proportion of the EPIC population was exposed to some of the main mycotoxins present in European foods such as deoxynivalenol (DON) and derivatives, fumonisins, Fusarium toxins, Alternaria toxins, and total mycotoxins. Nevertheless, no statistically significant associations were observed between the studied mycotoxins and mycotoxin groups, and the risk of RCC development. Conclusions: These results show an absence of statistically significant associations between long-term dietary mycotoxin exposures and RCC risk. However, these results need to be validated in other cohorts and preferably using repeated dietary exposure measurements. In addition, more occurrence data of, e.g., citrinin and fumonisins in different food commodities and countries in the EFSA database are a prerequisite to establish a greater degree of certainty

The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy

Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post-partum haemorrhage. Uterine contractile patterns are controlled by the generation of complex electrical signals at the myometrial smooth muscle plasma membrane. To identify novel targets to treat conditions associated with uterine dysfunction, we undertook a genome-wide screen of potassium channels that are enriched in myometrial smooth muscle. Computational modelling identified Kir7.1 as potentially important in regulating uterine excitability during pregnancy. We demonstrate Kir7.1 current hyper-polarizes uterine myocytes and promotes quiescence during gestation. Labour is associated with a decline, but not loss, of Kir7.1 expression. Knockdown of Kir7.1 by lentiviral expression of miRNA was sufficient to increase uterine contractile force and duration significantly. Conversely, overexpression of Kir7.1 inhibited uterine contractility. Finally, we demonstrate that the Kir7.1 inhibitor VU590 as well as novel derivative compounds induces profound, long-lasting contractions in mouse and human myometrium; the activity of these inhibitors exceeds that of other uterotonic drugs. We conclude Kir7.1 regulates the transition from quiescence to contractions in the pregnant uterus and may be a target for therapies to control uterine contractility

CB1 Expression Is Attenuated in Fallopian Tube and Decidua of Women with Ectopic Pregnancy

BACKGROUND: Embryo retention in the Fallopian tube (FT) is thought to lead to ectopic pregnancy (EP), a considerable cause of morbidity. In mice, genetic/pharmacological silencing of cannabinoid receptor Cnr1, encoding CB1, causes retention of embryos in the oviduct. The role of the endocannabinoids in tubal implantation in humans is not known. METHODS AND FINDINGS: Timed FT biopsies (n = 18) were collected from women undergoing gynecological procedures for benign conditions. Endometrial biopsies and whole blood were collected from women undergoing surgery for EP (n = 11); management of miscarriage (n = 6), and termination of pregnancy (n = 8). Using RT-PCR and immunohistochemistry, CB1 mRNA and protein expression levels/patterns were examined in FT and endometrial biopsies. The distribution of two polymorphisms of CNR1 was examined by TaqMan analysis of genomic DNA from the whole blood samples. In normal FT, CB1 mRNA was higher in luteal compared to follicular-phase (p<0.05). CB1 protein was located in smooth muscle of the wall and of endothelial vessels, and luminal epithelium of FT. In FT from women with EP, CB1 mRNA expression was low. CB1 mRNA expression was also significantly lower (p<0.05) in endometrium of women with EP compared to intrauterine pregnancies (IUP). Although of 1359G/A (rs1049353) polymorphisms of CNR1 gene suggests differential distribution of genotypes between the small, available cohorts of women with EP and those with IUP, results were not statistically significant. CONCLUSIONS: CB1 mRNA shows temporal variation in expression in human FT, likely regulated by progesterone. CB1 mRNA is expressed in low levels in both the FT and endometrium of women with EP. We propose that aberrant endocannabinoid-signaling in human FT leads to EP. Furthermore, our finding of reduced mRNA expression along with a possible association between polymorphism genotypes of the CNR1 gene and EP, suggests a possible genetic predisposition to EP that warrants replication in a larger sample pool

Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.

No treatment for frontotemporal dementia (FTD), the second most common type of early-onset dementia, is available, but therapeutics are being investigated to target the 2 main proteins associated with FTD pathological subtypes: TDP-43 (FTLD-TDP) and tau (FTLD-tau). Testing potential therapies in clinical trials is hampered by our inability to distinguish between patients with FTLD-TDP and FTLD-tau. Therefore, we evaluated truncated stathmin-2 (STMN2) as a proxy of TDP-43 pathology, given the reports that TDP-43 dysfunction causes truncated STMN2 accumulation. Truncated STMN2 accumulated in human induced pluripotent stem cell-derived neurons depleted of TDP-43, but not in those with pathogenic TARDBP mutations in the absence of TDP-43 aggregation or loss of nuclear protein. In RNA-Seq analyses of human brain samples from the NYGC ALS cohort, truncated STMN2 RNA was confined to tissues and disease subtypes marked by TDP-43 inclusions. Last, we validated that truncated STMN2 RNA was elevated in the frontal cortex of a cohort of patients with FTLD-TDP but not in controls or patients with progressive supranuclear palsy, a type of FTLD-tau. Further, in patients with FTLD-TDP, we observed significant associations of truncated STMN2 RNA with phosphorylated TDP-43 levels and an earlier age of disease onset. Overall, our data uncovered truncated STMN2 as a marker for TDP-43 dysfunction in FTD

Mental Health and School Functioning for Girls in the Child Welfare System : the Mediating Role of Future Orientation and School Engagement

This study investigated the association between mental health problems and academic and behavioral school functioning for adolescent girls in the child welfare system and determined whether school engagement and future orientation meditated the relationship. Participants were 231 girls aged between 12 and 19 who had been involved with the child welfare system. Results indicated that 39% of girls reported depressive symptoms in the clinical range and 54% reported posttraumatic symptoms in the clinical range. The most common school functioning problems reported were failing a class (41%) and physical fights with other students (35%). Participants reported a mean number of 1.7 school functioning problems. Higher levels of depression and PTSD were significantly associated with more school functioning problems. School engagement fully mediated the relationship between depression and school functioning and between PTSD and school functioning, both models controlling for age, race, and placement stability. Future orientation was not significantly associated with school functioning problems at the bivariate level. Findings suggest that school engagement is a potentially modifiable target for interventions aiming to ameliorate the negative influence of mental health problems on school functioning for adolescent girls with histories of abuse or neglect