Low Porosity Metallic Periodic Structures with Negative Poisson's Ratio

Auxetic behavior in low porosity metallic structures is demonstrated via a simple system of orthogonal elliptical voids. In this minimal 2D system, the Poisson's ratio can be effectively controlled by changing the aspect ratio of the voids. In this way, large negative values of Poisson's ratio can be achieved, indicating an effective strategy for designing auxetic structures with desired porosity.Engineering and Applied Science

In Vivo Efficacy of a Cocktail of Human Monoclonal Antibodies (CL184) Against Diverse North American Bat Rabies Virus Variants

Following rabies virus (RABV) exposure, a combination of thorough wound washing, multiple-dose vaccine administration and the local infiltration of rabies immune globulin (RIG) are essential components of modern post-exposure prophylaxis (PEP). Although modern cell-culture-based rabies vaccines are increasingly used in many countries, RIG is much less available. The prohibitive cost of polyclonal serum RIG products has prompted a search for alternatives and design of anti-RABV monoclonal antibodies (MAbs) that can be manufactured on a large scale with a consistent potency and lower production costs. Robust in vitro neutralization activity has been demonstrated for the CL184 MAb cocktail, a 1:1 protein mixture of two human anti-RABV MAbs (CR57/CR4098), against a large panel of RABV isolates. In this study, we used a hamster model to evaluate the efficacy of experimental PEP against a lethal challenge. Various doses of CL184 and commercial rabies vaccine were assessed for the ability to protect against lethal infection with representatives of four distinct bat RABV lineages of public health relevance: silver-haired bat (Ln RABV); western canyon bat (Ph RABV); big brown bat (Ef-w1 RABV) and Mexican free-tailed bat RABV (Tb RABV). 42–100% of animals survived bat RABV infection when CL184 (in combination with the vaccine) was administered. A dose-response relationship was observed with decreasing doses of CL184 resulting in increasing mortality. Importantly, CL184 was highly effective in neutralizing and clearing Ph RABV in vivo, even though CR4098 does not neutralize this virus in vitro. By comparison, 19–95% survivorship was observed if human RIG (20 IU/kg) and vaccine were used following challenge with different bat viruses. Based on our results, CL184 represents an efficacious alternative for RIG. Both large-scale and lower cost production could ensure better availability and affordability of this critical life-saving biologic in rabies enzootic countries and as such, significantly contribute to the reduction of human rabies deaths globally

Bodily crises in skilled performance: Considering the need for artistic habits

Empirical evidence demonstrates that performing artists are confronted by a variety of ‘bodily crises’ (e.g., injury, attrition of habits induced by ageing) over the course of their careers (Wainwright, Williams, & Turner, 2005). Such crises may present a serious threat to the embodied subject. Unfortunately, many prominent theories of skill acquisition (e.g., Fitts & Posner, 1967) appear to evacuate the body from performance by suggesting that any form of conscious processing (i.e., paying conscious attention to one's action during motor skill execution) will disrupt habitual behaviour. As a result, few researchers have considered how performers might tackle bodily anomalies. In the current paper, we seek to address this issue by discussing a variety of the ‘crises’ that confront the performing body. We start by discussing a number of disciplinary practices that may contribute to these crises. Next, we argue that habitual movements must be open to ‘acts of creativity’ in order to maintain a productive relationship between the performing body and the environment. Then we consider what this ‘creative action’ might involve and discuss a number of approaches (e.g., mindfulness, somaesthetic awareness) that could maintain and improve one's movement proficiency. Here, our argument draws on Dewey's (1922) pragmatist philosophy and his belief that ‘intelligent habit’ was required to help people to improve their movement functioning. Finally, we consider the implications of our argument for current conceptualisations of ‘habitual’ movement and recommend that researchers explore the adaptive and flexible capacity of the performing body

Researching the comparability of paper-based and computer-based delivery in a high-stakes writing test

International language testing bodies are now moving rapidly towards using computers for many areas of English language assessment, despite the fact that research on comparability with paper-based assessment is still relatively limited in key areas. This study contributes to the debate by researching the comparability of a highstakes EAP writing test (IELTS) in two delivery modes, paper-based (PB) and computer-based (CB). The study investigated 153 test takers' performances and their cognitive processes on IELTS Academic Writing Task 2 in the two modes, and the possible effect of computer familiarity on their test scores. Many-Facet Rasch Measurement (MFRM) was used to examine the difference in test takers' scores between the two modes, in relation to their overall and analytic scores. By means of questionnaires and interviews, we investigated the cognitive processes students employed under the two conditions of the test. A major contribution of our study is its use - for the first time in the computer-based writing assessment literature - of data from research into cognitive processes within realworld academic settings as a comparison with cognitive processing during academic writing under test conditions. In summary, this study offers important new insights into academic writing assessment in computer mode

Volume 08

Introduction from Interim Dean Dr. Jennifer Apperson Indigenous Peoples and the Modern Era by Meghan Enzinna Who Says : How Selena Gomez and the Scene Attempt to Subvert the Popular Standards of Beauty by Casey Dawn Gailey Art by Raven Collins Meltdown on Social Media: Amy\u27s Baking Company Meets Kitchen Nightmares by Nathena Haddrill Art by Chiara Enriquez Design by Amelia Mcconnell Worth More Than a Thousand Words: A Visual Rhetorical Discussion of Virtual Reality by Examining Clouds Over Sidra by Alexander Morton Design by Emma Beckett The Sonata: An Analysis of Piano Sonata No. 14 in C Minor, K. 457 by Wolfgang Amadeus Mozart by Leah G. Parr Art by Briana Adhikusuma Skewed Perceptions of Masculinity in Chris Lynch\u27s Inexcusable by Taylor Embrey Photography by Rowan Davis Joy Like Short Grass : Death in James Dickey\u27s the Eagle\u27s Mile by Danielle Sisson Poster by Bianca Cherry Design by Melissa Cacho A Writer\u27s Evolution: Connecting Academic and Workplace Writing Within the Field of Nursing by Chloé Woodward Background and Research Designs on Service Dogs for Children with an Autism Spectrum Disorder by Catherine Rollins Photography by Carson Reeher Design by Landon Cooper Wallace Stevens: Meaning in Nature and Its Elements by Haley Vasquez Photography by Marlisha Stewart Building an Arcade Machine to Do Interdisciplinary Research into What Makes People Like Video Games by Eric Whitehead Poster by Sabrina Walker Design by James Bate

An exploration of the influences on under-representation of male pre-registration nursing students

Background:- Worldwide, men are under-represented in the nursing profession. In Scotland less than 10% of pre-registration nursing students are male. Reasons for this imbalance need to be understood. Objectives:- To explore the views of male pre-registration nursing students, nursing lecturers and school teachers about this imbalance. Design:- Mixed methods study using focus groups and online survey. Settings:- Focus groups in four locations across Scotland. Online survey sent to teachers across Scotland. Participants and methods:- Eight focus groups with 33 male nursing students; four focus groups with 21 university and college nursing lecturers; 46 school teachers returned the online survey. Results:- Although nursing was considered a worthwhile career with job stability and many opportunities, it was also viewed as not being a career for men. Assumptions about the profession and femininity were challenging for men and use of the term ‘male nurse’ was felt to be anomalous. In some circumstances the provision of intimate care to particular patient groups caused difficulty. Positive encouragement from others, a positive role model or knowledge of nursing from significant others could be helpful. However concerns about low earning potential and negative media publicity about the NHS could be a disincentive. Being mature and having resilience were important to cope with being a male nursing student in a mainly female workplace. Some more ‘technical’ specialties were felt to be more attractive to men. Conclusions:- Nursing is viewed as a worthwhile career choice for men, but the gendered assumptions about the feminine nature of nursing can be a deterrent

A broadly implementable research course in phage discovery and genomics for first-year undergraduate students

Engaging large numbers of undergraduates in authentic scientific discovery is desirable but difficult to achieve. We have developed a general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a research course for first-year undergraduate students focused on bacteriophage discovery and genomics. The course is situated within a broader scientific context aimed at understanding viral diversity, such that faculty and students are collaborators with established researchers in the field. The Howard Hughes Medical Institute (HHMI) Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) course has been widely implemented and has been taken by over 4,800 students at 73 institutions. We show here that this alliance-sourced model not only substantially advances the field of phage genomics but also stimulates students\u27 interest in science, positively influences academic achievement, and enhances persistence in science, technology, engineering, and mathematics (STEM) disciplines. Broad application of this model by integrating other research areas with large numbers of early-career undergraduate students has the potential to be transformative in science education and research training

A Broadly Implementable Research Course in Phage Discovery and Genomics for First-Year Undergraduate Students

Engaging large numbers of undergraduates in authentic scientific discovery is desirable but difficult to achieve. We have developed a general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a research course for first-year undergraduate students focused on bacteriophage discovery and genomics. The course is situated within a broader scientific context aimed at understanding viral diversity, such that faculty and students are collaborators with established researchers in the field. The Howard Hughes Medical Institute (HHMI) Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) course has been widely implemented and has been taken by over 4,800 students at 73 institutions. We show here that this alliance-sourced model not only substantially advances the field of phage genomics but also stimulates students’ interest in science, positively influences academic achievement, and enhances persistence in science, technology, engineering, and mathematics (STEM) disciplines. Broad application of this model by integrating other research areas with large numbers of early-career undergraduate students has the potential to be transformative in science education and research training

Association Between Whole Blood-Derived Mitochondrial Dna Copy Number, Low-Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk

Background The relationship between mitochondrial DNA copy number (mtDNA CN) and cardiovascular disease remains elusive. Methods and Results We performed cross-sectional and prospective association analyses of blood-derived mtDNA CN and cardiovascular disease outcomes in 27 316 participants in 8 cohorts of multiple racial and ethnic groups with whole-genome sequencing. We also performed Mendelian randomization to explore causal relationships of mtDNA CN with coronary heart disease (CHD) and cardiometabolic risk factors (obesity, diabetes, hypertension, and hyperlipidemia)