Transient Effects of Snow Cover Duration on Primary Growth and Leaf Traits in a Tundra Shrub

With the recent climate warming, tundra ecotones are facing a progressive acceleration of spring snowpack melting and extension of the growing season, with evident consequences to vegetation. Along with summer temperature, winter precipitation has been recently recognised as a crucial factor for tundra shrub growth and physiology. However, gaps of knowledge still exist on long-living plant responses to different snowpack duration, especially on how intra-specific and year-to-year variability together with multiple functional trait adjustments could influence the long-term responses. To fill this gap, we conducted a 3 years snow manipulation experiment above the Alpine treeline on the typical tundra species Juniperus communis, the conifer with the widest distributional range in the north emisphere. We tested shoot elongation, leaf area, stomatal density, leaf dry weight and leaf non-structural carbohydrate content of plants subjected to anticipated, natural and postponed snowpack duration. Anticipated snowpack melting enhanced new shoot elongation and increased stomatal density. However, plants under prolonged snow cover seemed to compensate for the shorter growing period, likely increasing carbon allocation to growth. In fact, these latter showed larger needles and low starch content at the beginning of the growing season. Variability between treatments slightly decreased over time, suggesting a progressive acclimation of juniper to new conditions. In the context of future warming scenarios, our results support the hypothesis of shrub biomass increase within the tundra biome. Yet, the picture is still far from being complete and further research should focus on transient and fading effects of changing conditions in the long term

Depression in Cancer: the many biobehavioural pathways driving tumor progression

Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer progression. Moreover, psychosocial stressors in cancer promote: (1) inflammation and oxidative/nitrosative stress; (2) a decreased immunosurveillance; and (3) a dysfunctional activation of the autonomic nervous system and of the hypothalamic-pituitary-adrenal axis. Consequently, the prompt recognition of depression among patients with cancer who may benefit of treatment strategies targeting depressive symptoms, cognitive dysfunction, fatigue and sleep disturbances, is a public health priority. Moreover, behavioral strategies aiming at reducing psychological distress and depressive symptoms, including addressing unhealthy diet and life-style choices, as well as physical inactivity and sleep dysfunction, may represent important strategies not only to treat depression, but also to improve wider cancer-related outcomes. Herein, we provide a comprehensive review of the intertwined biobehavioural pathways linking depression to cancer progression. In addition, the clinical implications of these findings are critically reviewed

Carbapenem-resistant and carbapenem-susceptible isogenic isolates of Klebsiella pneumoniae ST101 causing infection in a tertiary hospital

Background: In this study we describe the clinical and molecular characteristics of an outbreak due to carbapenem-resistant Klebsiella pneumoniae (CR-KP) producing CTX-M-15 and OXA-48 carbapenemase. Isogenic strains, carbapenem-susceptible K. pneumoniae (CS-KP) producing CTX-M-15, were also involved in the outbreak. Results: From October 2010 to December 2012 a total of 62 CR-KP and 23 CS-KP were isolated from clinical samples of 42 patients (22 had resistant isolates, 14 had susceptible isolates, and 6 had both CR and CS isolates). All patients had underlying diseases and 17 of them (14 patients with CR-KP and 3 with CS-KP) had received carbapenems previously. The range of carbapenem MICs for total isolates were: imipenem: 2 to >32 mu g/ml vs. <2 mu g/ml; meropenem: 4 to >32 mu g/ml vs. <2 mu g/ml; and ertapenem: 8 to >32 mu g/ml vs. <2 mu g/ml. All the isolates were also resistant to gentamicin, ciprofloxacin, and cotrimoxazole. Both types of isolates shared a common PFGE pattern associated with the multilocus sequence type 101 (ST101). The bla(CTX-M-15) gene was detected in all the isolates, whereas the bla(OXA-48) gene was only detected in CR-KP isolates on a 70 kb plasmid. Conclusions: The clonal spread of K. pneumoniae ST101 expressing the OXA-48 and CTX-M-15 beta-lactamases was the cause of an outbreak of CR-KP infections. CTX-M-15-producing isolates lacking the blaOXA-48 gene coexisted during the outbreak.This study was supported by CIBER de Enfermedades Respiratorias (CIBERES - CB06/06/0037), ISCIII - Instituto de Salud Carlos III, Madrid, Spain

Letter to the Editor: SFlt-1 and PlGF Levels in Pregnancies Complicated by SARS-CoV-2 Infection

We read with interest the work by Espino-y-Sosa and colleagues [...

Imbalanced Angiogenesis in Pregnancies Complicated by SARS-CoV-2 Infection

COVID-19 and preeclampsia (preE) share the ANG-II mediated endothelial dysfunction, resulting from a significant dysregulation of RAS and an imbalanced proportion of anti-angiogenic and pro-angiogenic soluble plasmatic factors. Of note, an increased incidence of preE has been reported among COVID-19-infected mothers compared to the general pregnant population. The two most promising angiogenic markers are the soluble fms-like tyrosine kinase receptor-1 (sFlt-1), the major antiangiogenic factor, and the placental growth factor (PlGF), a powerful angiogenic factor. Since these markers have proven useful in the prediction, diagnosis, and severity of preE, this study aimed to evaluate their maternal serum levels in pregnancies complicated by SARS-CoV-2 infection and to assess their potential use to guide the management of these women. A retrospective analysis of SARS-CoV-2-positive pregnant women was performed. The serum levels of sFlt-1 and PlGF were collected at the diagnosis of SARS-CoV-2 infection at the hospital, before the beginning of steroid/hydroxychloroquine and/or antithrombotic therapy. The sFlt-1/PlGF ratio was stratified using cut-off values clinically utilized in the diagnosis and prediction of preE (low &lt; 38, intermediate 38&ndash;85/110* and high &gt;85/110*, * if before or after the 34th week of gestation). A total of 57 women were included, of whom 20 (35%) had signs and symptoms of COVID-19 at hospital presentation and 37 (65%) were asymptomatic. None were vaccinated. The mean gestational age at diagnosis of SARS-CoV-2 infection was 32 weeks in symptomatic patients and 37 weeks and 5 days in asymptomatic ones (p = 0.089). sFlt-1 serum levels were higher in SARS-CoV-2 positive asymptomatic patients compared to women with COVID-19 related symptoms (4899 &plusmn; 4357 pg/mL vs. 3187 &plusmn; 2426 pg/mL, p = 0.005). sFlt-1/PlGF at admission was &lt;38 in 18 of the 20 symptomatic women (90%) compared to 22 (59%) of the asymptomatic patients (p = 0.018). Of note, two of the three women admitted to the intensive care unit had a very low ratio (&lt;2). In turn, rates of patients with sFlt-1/PlGF at admission &gt; 85/110 were not significantly different between the two groups: 11% in asymptomatic patients (4/37) vs. none of the symptomatic patients (p = 0.286), and all of them presented a placental dysfunction, like preE (n = 1) and FGR (n = 3). Of note, there were no stillbirths or maternal or neonatal deaths among symptomatic patients; also, no cases of preE, FGR, or small for gestational age neonates were diagnosed. In conclusion, our data suggest that SARS-CoV-2 infection during pregnancy could influence the angiogenic balance. A significant pathological alteration of the sFlt-1/PlGF ratio cannot be identified during the symptomatic phase; however, if left untreated, SARS-CoV-2 infection could potentially trigger placental dysfunction

Tracing volcanic eruptions and anthropogenic pollution in tree rings: preliminary results from synchrotron-light chemical analyses

We analysed larch trees from high elevation in northern Italy for Hg with a Lumex RA-915M Mercury Analyzer with pyrolyzer PYRO-915+) and for S, Zn, Cu, Ni, Pb (by synchrotron light X-ray fluorescence at beamline i18 Diamond Light Source, UK). Hg analyses were performed on 11 single rings per sample centred on the year of a known volcanic eruption. The in-situ synchrotron analyses were carried out on longer timeseries of up to 150 years with a maximum replication of 5 samples. We detected significant peaks of volatile elements in tree rings matching periods of repeated volcanic eruptions with high volcanic explosivity indices (VEI 5-6, out of a maximum of 8). A good example is shown by increased Zr, Cu, S, Pb occurring during the decade 1875-1886 corresponding to eruptions of the volcanoes Askja (Iceland, year 1875, VEI 5), Vesuvius (Italy, 1875), Cotopaxi (Ecuador, 1877, VEI 4), Krakatoa (Indonesia, 1883 and 1884, VEI 6) and Okataina (New Zeland, 1886, VEI 5). Furthermore, during the last 3 decades of the XX century, we observed a monotonic long-term increase of the elements Pb, Ni, Zn and Cu in association with a significant reduction of the tree-ring widths. We consider the chemical shifts and the abrupt growth reduction as reflecting anthropogenic pollution mainly related to a sustained and increasing use of fossil fuel, in particular leaded gasoline. Notably, the chemical contamination in the analysed wood decreases significantly in the first decade of the XXI century, when unleaded gasoline was substituted the Pb-rich fuels. Both these approaches seems promising in detecting hidden effects of volcanic or pollution activities when other tree-ring traits do not show any other peculiar feauture

Organic Selenium induces ferroptosis in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDA) cells reprogram both mitochondrial and lysosomal functions to support growth. At the same time, this causes significant dishomeostasis of free radicals. While this is compensated by the upregulation of detoxification mechanisms, it also represents a potential vulnerability.Here we demonstrate that PDA cells are sensitive to the inhibition of the mevalonate pathway (MVP), which supports the biosynthesis of critical antioxidant intermediates and protect from ferroptosis. We attacked the susceptibility of PDA cells to ferroptotic death with selenorganic compounds, including dibenzyl diselenide (DBDS) that exhibits potent pro-oxidant properties and inhibits tumor growth in vitro and in vivo. DBDS treatment induces the mobilization of iron from mitochondria enabling uncontrolled lipid peroxidation. Finally, we showed that DBDS and statins act synergistically to promote ferroptosis and provide evidence that combined treatment is a viable strategy to combat PDA

Sicurezza collettiva e diritti fondamentali in tempo di terrorismo. Atti del workshop tenutosi a Ferrara il 26 settembre 2007

Il terrorismo internazionale ha catalizzato l’attenzione sulla necessità preminente di garantire la sicurezza collettiva, spingendo le organizzazioni internazionali ed i singoli stati ad adottare legislazioni preventive ed a potenziare le attività congiunte di intelligence internazionali. Ma le norme d’emergenza sono per loro natura inclini ad incidere sulle libertà fondamentali. Questo volume collettaneo, grazie alla poliedricità dei contributi pubblicati, offre alla curiosità del lettore innumerevoli spunti ed osservazioni che, sotto più profili, tendono alla ricerca di un possibile bilanciamento tra l’esigenza di sicurezza ed il rispetto dei diritti inviolabili della persona. Qui trovano, dunque, ampio spazio riflessioni riguardanti la tutela dei diritti dei migranti e degli stranieri, i limiti all’attività di intelligence, la prassi del black-listing e la tutela giurisdizionale delle libertà fondamentali offerta dai giudici interni, comunitari ed internazionali

Extensive Comparison Between a Set of European Dust Regional Models and Observations in the Western Mediterranean for the Summer 2012 Pre-ChArMEx/TRAQA Campaign

International audienceThe present analysis focuses on the model capability to properly simulate long-range Saharan dust transport for summer 2012 in the Western Mediterranean. The present contribution shows an intercomparison of a set of 9 European regional dust model simulations. An exhaustive comparison of model outputs against other models and observations can reveal weaknesses of individual models, provide an assessment of uncertainties in simulating the dust cycle and give additional information on sources for potential model improvement. The model outputs are compared against a variety of both ground-based and airborne in situ and remote sensing measurements performed during the pre-ChArMEx/TRAQA field campaign. For this kind of study, multiple and different observations are combined to deliver a detailed idea of the structure and evolution of the dust cloud and the state of the atmosphere at the different stages of the even