6 research outputs found

    Prevalencia, conocimientos, actitudes y prácticas de epilepsia en la parroquia de Quingeo de la provincia del Azuay, Cuenca 2009

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    Objetivo: Evaluar los conocimientos, actitudes y prácticas, y la prevalencia de la epilepsia en la parroquia de Quingeo del Cantón Cuenca. Métodos: Se realizó una entrevista con preguntas estandarizadas por neurólogos a 680 personas mayores de 12 años en el mes de Mayo del 2009. Para investigar los datos demográficas seleccionamos 4 variables: edad, género, instrucción y estado civil. Resultados: De los 557 habitantes consultados, el 2.7% resultó con sospecha de epilepsia; de estos, 1.6% resultó con diagnóstico de epilepsia confirmado por el neurólogo; de estos: el 66.6% tuvo crisis tónico-clónicas. La mayor prevalencia en edad fue de 21 a 60 años (66.7%); en género fue el femenino (66.7%). De acuerdo al nivel de conocimientos, el 50.4% ha oído o leído acerca de la enfermedad; el 47.1% desconoce la causa de la epilepsia y el 71.9% piensa que los médicos deben tratar la epilepsia. De acuerdo a las actitudes, el 65.3% cree que hay personas que discriminan a los epilépticos. De acuerdo a las prácticas de los habitantes, el 58.68% son buenas; de estas, el 66.20% recomienda ayuda profesional; las malas prácticas fueron el 41.32%, de estas, el 28% referían no hacer nada y otro 28% realizan maniobras populares.AUObjective: To assess knowledge, attitudes and practices and the prevalence of epilepsy in the parish of Quingeo the Canton Cuenca. Methods: We conducted an interview with standardized questions by neurologists to 680 people over 12 years in the month of May 2009. To investigate the selected demographic data we used 4 variables: age, gender, education and marital status. Results: Of the 557 people surveyed, 2.7% were suspected of epilepsy and of these, 1.6% were diagnosed with epilepsy confirmed by a neurologist, of these, 66.6% had tonic-clonic seizures. The most prevalent age was from 21 to 60 years (66.7%); in gender, was female gender (66.7%). According to the level of knowledge, 50.4% had heard or read about the disease, 47.1% know the cause of epilepsy and 71.9% believe that doctors should treat epilepsy. According to the attitudes, 65.3% believe that there are people who discriminate against people with epilepsy. According to the practices of the inhabitants, 58.68% are good, of these, the 66.20% recommended professional help malpractices were 41.32%, of these, 28% reported doing nothing and another 28% perform popular maneuvers. Keywords: epilepsy, prevalence, knowledge attitudes and practicesMédicoCuenc

    beta(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice

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    Brown adipose tissue (BAT) is predominantly regulated by the sympathetic nervous system (SNS) and the adrenergic receptor signaling pathway. Knowing that a mouse with triple beta-receptor knockout (KO) is cold intolerant and obese, we evaluated the independent role played by the beta(1) isoform in energy homeostasis. First, the 30 min i.v. infusion of norepinephrine (NE) or the beta(1) selective agonist dobutamine (DB) resulted in similar interscapular BAT (iBAT) thermal response in WT mice. Secondly, mice with targeted disruption of the beta(1) gene (KO of beta(1) adrenergic receptor (beta 1KO)) developed hypothermia during cold exposure and exhibited decreased iBAT thermal response to NE or DB infusion. Thirdly, when placed on a high-fat diet (HFD; 40% fat) for 5 weeks, beta 1KO mice were more susceptible to obesity than WT controls and failed to develop diet-induced thermogenesis as assessed by BAT Ucp1 mRNA levels and oxygen consumption. Furthermore, beta 1KO mice exhibited fasting hyperglycemia and more intense glucose intolerance, hypercholesterolemia, and hypertriglyceridemia when placed on the HFD, developing marked non-alcoholic steatohepatitis. In conclusion, the beta(1) signaling pathway mediates most of the SNS stimulation of adaptive thermogenesis. Journal of Endocrinology (2012) 214, 359-365Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)MackPesquisa, BrazilMackPesquisa, Brazi

    Paradigms of Dynamic Control of Thyroid Hormone Signaling

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