2,506 research outputs found
Recommended from our members
Web Service Trust: Towards A Dynamic Assessment Framework
Trust in software services is a key prerequisite for the success and wide adoption of services-oriented computing (SOC) in an open Internet world. However, trust is poorly assessed by existing methods and technologies, especially in dynamically composed and deployed SOC systems. In this paper, we discuss current methods for assessing trust in service-oriented computing and identify gaps of current platforms, in particular with regards to runtime trust assessment. To address these gaps, we propose a model of runtime trust assessment of software services and introduce a framework for realizing the model. A key characteristic of our approach is the support that it offers for customizable assessment of trust based on evidence collected during the operation of software services and its ability to combine this evidence with subjective assessments coming from service clients
BumbleKey: an interactive key for the identification of bumblebees of Italy and Corsica (Hymenoptera, Apidae)
BumbleKey is a matrix-based, interactive key to all 45 species of bumblebees of Italy and Corsica. The key allows to identify adult males and females (queens and workers) using morphological characters. The key is published online, open-access, at http://www.interactive-keys.eu/bumblekey/default.aspx
Impact Of Zoo Residence On Gelada Social Life
The purpose of this study was to develop an ethogram of gelada behavior in two settings: In captivity and In the wild. Then to compare the two ethograms to determine the impact of captivity on individual gelada and their behavior
Dentistry and disability : myths to distroy
Es muy común oír hablar sobre la
dificultad que plantea la atención
odontológica en personas con discapacidad.
Muchas veces estos pacientes
se encuentran en desigualdad de
condiciones frente al resto, principalmente
por la realidad de su estado de
salud y muchas veces por prejuicios
instalados sobre la problemática que
genera la atención de su salud bucal.
La mayoría son mitos y es necesario
derribarlos.Fil: Lopresti, Walter.
Universidad Nacional de Cuyo. Facultad de Odontologí
INVOLVMENT OF THE CEREBELLUM IN VERABL WORKING MEMORY AND PHONOLOGICAL JUDGMENT: EVIDENCE FOR A ROLE IN PREDICTIVE PHONOLOGICAL CODING
Within recent decades, researchers have found evidence that the cerebellum contributes to language processing, yet exactly how it contributes remains a mystery. Researchers have attempted to map functional zones within the cerebellar cortex in an effort to determine precisely how the cerebellum contributes to language with limited success. We predict that the cerebellum’s functional zones are not strictly divisible by cognitive domains such as “language” or “executive control” and are instead delineated by task demands not unlike cognitive regions in the cerebral cortex. Prior neuropsychological results indicate that rhyme judgment and verbal working memory tasks impose task demands that require the cerebellum for normal levels of performance. In an effort to localize this shared functional process in the cerebellum, we used a slow event-related design to study the hemodynamic response in participants (N=12) as they performed rhyme judgment task and then compared to the results to separate pool of the subjects who performed a verbal working memory task (N=12). We hypothesized that these two tasks share cognitive processes and thereby neural substrates; in other words, they will engage the same functional regions in the cerebellum. Secondly, we hypothesized that these functional regions would be most engaged during task components negatively impacted by concurrent articulation, i.e., the encoding period of verbal working memory tasks and judgments involving mismatched non-rhyme pairs, e.g. “tint” and “pint.” We found three potential clusters engaged in both tasks, with one region (located in Crus I) demonstrating the predicted response patterns across different task components. Based upon these findings and the cognitive literature on verbal working memory and rhyme judgments, we suggest that this region contributes to an internal speech-based process that involves phonological error prediction
Chapter 07 - Government Sources
Learn about government documents, and how they contribute to the research process.https://cedar.wwu.edu/research_process/1012/thumbnail.jp
Potential role of curcumin for the treatment of major depressive disorder
Curcumin is the major biologically active polyphenolic constituent in the turmeric plant (Curcuma longa) that has been shown to have antioxidant, anti-inflammatory, neuroprotective, anticancer, antimicrobial, and cardioprotective effects. Interest in curcumin as a treatment for mental health conditions has increased and there is an expanding body of preclinical and clinical research examining its antidepressant and anxiolytic effects. In this narrative review, human trials investigating the effects of curcumin for the treatment of depression or depressive symptoms are summarised. Using findings from in vitro, animal, and human trials, possible biological mechanisms associated with the antidepressant effects of curcumin are also explored. To increase the understanding of curcumin for the treatment of depression, directions for future research are proposed
AGED MUSCLE ECM RECAPITULATES ALTERED HOST RESPONSE OBSERVED IN AGED MUSCLE INJURY
Extracellular matrix acts as the supporting structure of a tissue and dynamically changes in a reciprocal relationship with cells of that tissue. ECM changes with aging and disease and can affect the responses of cells in these altered states. ECM can be used as a model for aged microenvironments to more fully understand their effect on cellular function. The formation of advanced glycation end-products (AGEs) is a modification that occurs with age and causes aberrant inflammatory responses. Skeletal muscle strength and healing potential are known to decrease with aging. The immune response, which is integral to muscle regeneration, is also dysfunctional with age. Macrophage polarization has been shown to be necessary for appropriate skeletal muscle healing. This study used decellularized skeletal muscle ECM from young and aged mice to determine microenvironmental effects on macrophage phenotype both in vitro and in vivo using an abdominal wall injury reconstruction model.
The first objective of this work was to characterize muscle ECM from young and aged mice and to observe its effect on macrophage phenotype and function. Results showed the young and aged muscle were able to be effectively and similarly decellularized using previously established methods. The major change in biochemical composition was a decrease in hydroxyproline content and collagen immunohistochemical staining with aging. Bone marrow-derived macrophages treated with muscle ECM showed increases in iNOS immunolabeling and nitric oxide production with aged muscle ECM indicative of a shift to a pro-inflammatory phenotype.
The second objective of this work was to characterize the macrophage response to artificially glycated ECM. Young muscle ECM was artificially glycated with low and high concentrations of glucose, ribose or fructose. The macrophage response to glycated muscle ECM showed an increased nitric oxide production compared to young ECM. ECM glycation caused a pro-inflammatory phenotype from bone marrow-derived macrophages.
The third objective of this work was to characterize the in vivo host response to young, aged and glycated muscle ECM implanted into an abdominal muscle injury. The host response to aged and glycated ECM was characterized by reduced infiltration of host cells including F4/80+ macrophages and delayed or prevented activation of macrophage polarization markers iNOS and arginase-1. Glycation led to increased collagen staining and reduced fast:slow muscle fiber type ratio by 90 days. In vivo results suggest that aged ECM delays inflammatory cascades while glycated ECM inhibits macrophage activation overall.
Aging and glycation of the skeletal muscle ECM microenvironment had direct effects on the macrophage response in vitro and in vivo. These results suggest that the deficiencies observed in aged muscle regeneration could be due to changes in the extracellular matrix. This provides evidence for a cell-extrinsic mechanism of aging which is separate from known changes in stem cell function and population with age
Analogous Reference Tools Produced by the U.S. and Canadian Federal Governments
This guide lists a number of U.S. government publications frequently used as reference tools in libraries and compares them to Canadian government publications that contain similar material and may be used in similar fashion. Some U.S. and Canadian publications with no equivalent in the other country are also indicated
Plant structural complexity and mechanical defenses mediate predator-prey interactions in an odonate-bird system.
Habitat-forming species provide refuges for a variety of associating species; these refuges may mediate interactions between species differently depending on the functional traits of the habitat-forming species. We investigated refuge provisioning by plants with different functional traits for dragonfly and damselfly (Odonata: Anisoptera and Zygoptera) nymphs emerging from water bodies to molt into their adult stage. During this period, nymphs experience high levels of predation by birds. On the shores of a small pond, plants with mechanical defenses (e.g., thorns and prickles) and high structural complexity had higher abundances of odonate exuviae than nearby plants which lacked mechanical defenses and exhibited low structural complexity. To disentangle the relative effects of these two potentially important functional traits on nymph emergence-site preference and survival, we conducted two fully crossed factorial field experiments using artificial plants. Nymphs showed a strong preference for artificial plants with high structural complexity and to a lesser extent, mechanical defenses. Both functional traits increased nymph survival but through different mechanisms. We suggest that future investigations attempt to experimentally separate the elements contributing to structural complexity to elucidate the mechanistic underpinnings of refuge provisioning
- …