11 research outputs found
The Impact of Digital Storytelling on Social Agency: Early Experience at an Online University
Digital Storytelling\u27 is a term often used to refer to a number of different types of digital narrative including web-based stories, hypertexts, videoblogs and computer games. This emergent form of creative work has found an outlet in a wide variety of different domains ranging from community social history, to cookbooks, to the classroom. It is the latter domain that provides the focus for this paper, specifically the online classroom at the tertiary level...Early feedback from students suggests that listening to and telling \u27true stories\u27 was a compelling and emotionally-engaging experience, providing an opportunity for \u27transformative reflection\u27 (Lambert 2000). By including multimedia, learners were able to build upon the fundamentals, presenting content in an easy-to-absorb and compelling way. In terms of team assignments students learned to become more effective actors in collaborative work environments
Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin
Recent genomic analyses of pathologically-defined tumor types identify âwithin-a-tissueâ disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head & neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multi-platform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All datasets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies
Enantioselective Iodolactonization of Disubstituted Olefinic Acids Using a Bifunctional Catalyst
The enantioselective iodolactonizations of a series of diversely substituted olefinic carboxylic acids are promoted by a BINOL-derived, bifunctional catalyst. Reactions involving 5-alkyl- and 5-aryl-4(<i>Z</i>)-pentenoic acids and 6-alkyl- and 6-aryl-5(<i>Z</i>)-hexenoic acids provide the corresponding Îł- and ÎŽ-lactones having stereogenic CâI bonds in excellent yields and >97:3 er. Significantly, this represents the first organocatalyst that promotes both bromo- and iodolactonization with high enantioselectivities. The potential of this catalyst to induce kinetic resolutions of racemic unsaturated acids is also demonstrated
Enantioselective Iodolactonization of Disubstituted Olefinic Acids Using a Bifunctional Catalyst
The enantioselective iodolactonizations of a series of diversely substituted olefinic carboxylic acids are promoted by a BINOL-derived, bifunctional catalyst. Reactions involving 5-alkyl- and 5-aryl-4(<i>Z</i>)-pentenoic acids and 6-alkyl- and 6-aryl-5(<i>Z</i>)-hexenoic acids provide the corresponding Îł- and ÎŽ-lactones having stereogenic CâI bonds in excellent yields and >97:3 er. Significantly, this represents the first organocatalyst that promotes both bromo- and iodolactonization with high enantioselectivities. The potential of this catalyst to induce kinetic resolutions of racemic unsaturated acids is also demonstrated
Enantioselective Iodolactonization of Disubstituted Olefinic Acids Using a Bifunctional Catalyst
The enantioselective iodolactonizations of a series of diversely substituted olefinic carboxylic acids are promoted by a BINOL-derived, bifunctional catalyst. Reactions involving 5-alkyl- and 5-aryl-4(<i>Z</i>)-pentenoic acids and 6-alkyl- and 6-aryl-5(<i>Z</i>)-hexenoic acids provide the corresponding Îł- and ÎŽ-lactones having stereogenic CâI bonds in excellent yields and >97:3 er. Significantly, this represents the first organocatalyst that promotes both bromo- and iodolactonization with high enantioselectivities. The potential of this catalyst to induce kinetic resolutions of racemic unsaturated acids is also demonstrated
Shelf life prediction model for strawberry based on respiration and transpiration processes
Enantioselective Halolactonization Reactions using BINOL-Derived Bifunctional Catalysts: Methodology, Diversification, and Applications
A general
protocol is described for inducing enantioselective halolactonizations
of unsaturated carboxylic acids using novel bifunctional organic catalysts
derived from a chiral binaphthalene scaffold. Bromo- and iodolactonization
reactions of diversely substituted, unsaturated carboxylic acids proceed
with high degrees of enantioselectivity, regioselectivity, and diastereoselectivity.
Notably, these BINOL-derived catalysts are the first to induce the
bromo- and iodolactonizations of 5-alkyl-4Â(<i>Z</i>)-olefinic
acids via 5-<i>exo</i> mode cyclizations to give lactones
in which new carbonâhalogen bonds are created at a stereogenic
center with high diastereo- and enantioselectivities. Iodolactonizations
of 6-substituted-5Â(<i>Z</i>)-olefinic acids also occur via
6-<i>exo</i> cyclizations to provide ÎŽ-lactones with
excellent enantioselectivities. Several notable applications of this
halolactonization methodology were developed for desymmetrization,
kinetic resolution, and epoxidation of <i>Z-</i>alkenes.
The utility of these reactions is demonstrated by their application
to a synthesis of precursors of the F-ring subunit of kibdelone C
and to the shortest catalytic, enantioselective synthesis of (+)-disparlure
reported to date
Enantioselective Iodolactonization of Disubstituted Olefinic Acids Using a Bifunctional Catalyst
Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
Ă© 2014 Elsevier Inc. Recent genomic analyses of pathologically defined tumor types identify 'within-a-tissue' disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-oforigin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pancancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies