Simulation and analysis of differential global positioning system for civil helicopter operations

A Differential Global Positioning System (DGPS) computer simulation was developed, to provide a versatile tool for assessing DGPS referenced civil helicopter navigation. The civil helicopter community will probably be an early user of the GPS capability because of the unique mission requirements which include offshore exploration and low altitude transport into remote areas not currently served by ground based Navaids. The Monte Carlo simulation provided a sufficiently high fidelity dynamic motion and propagation environment to enable accurate comparisons of alternative differential GPS implementations and navigation filter tradeoffs. The analyst has provided the capability to adjust most aspects of the system, the helicopter flight profile, the receiver Kalman filter, and the signal propagation environment to assess differential GPS performance and parameter sensitivities. Preliminary analysis was conducted to evaluate alternative implementations of the differential navigation algorithm in both the position and measurement domain. Results are presented to show that significant performance gains are achieved when compared with conventional GPS but that differences due to DGPS implementation techniques were small. System performance was relatively insensitive to the update rates of the error correction information

A selective role for receptor activity‐modifying protein in sub‐chronic action of the amylin selective receptor agonist NN1213 compared to salmon calcitonin on body weight and food intake in male mice

The role of receptor activity-modifying proteins (RAMPs) in modulating the pharmacological effects of an amylin receptor selective agonist (NN1213) or the dual amylin-calcitonin receptor agonist (DACRA), salmon calcitonin (sCT), was tested in three RAMP KO mouse models, RAMP1, RAMP3 and RAMP1/3 KO. Male wild-type (WT) and knockout (KO) littermate mice were fed a 45% high-fat diet for 20 weeks prior to the 3-week treatment period. A decrease in body weight after NN1213 was observed in all WT mice, whereas sCT had no effect. The absence of RAMP1 had no significant effect on NN1213 efficacy, and sCT was still inactive. However, the absence of RAMP3 impeded NN1213 efficacy but improved sCT efficacy. Similar results were observed in RAMP1/3 KO suggesting that the amylin receptor 3 (AMY3 = CTR + RAMP3) is necessary for NN1213's maximal action on body weight and food intake and that the lack of AMY3 allowed sCT to be active. These results suggest that the chronic use of DACRA such as sCT can have unfavourable effect on body weight loss in mice (which differs from the situation in rats), whereas the use of the amylin receptor selective agonist does not. AMY3 seems to play a crucial role in modulating the action of these two compounds, but in opposite directions. The assessment of a long-term effect of amylin and DACRA in different rodent models is necessary to understand potential physiological beneficial and unfavourable effects on weight loss before its transition to clinical trials

Many Labs 2: Investigating Variation in Replicability Across Samples and Settings

We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance (p < .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion (p < .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely highpowered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small (< 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Instituto de Investigaciones Psicológicas (IIP

Mundos mesclados, espaços segregados: cultura material, mestiçagem e segmentação no sítio Aldeia em Santarém (PA)

This article discusses the processes of cultural exchange between Portuguese, Portuguese-Brazilian, Amerindians, and mestizos based on the analysis of the material culture from households of Santarém (PA), occupied during the eighteenth and nineteenth centuries,. Although these social groups manipulated material culture aiming to express different values, related to hierarchy, social segmentation, and affirmation of identities, ambiguity also characterizes these assemblages. This material ambiguity informs about the mixtures of both practices and cultural references that brought about the building of a mestizo society.Com base na análise da cultura material proveniente de unidades domésticas do núcleo urbano de Santarém (PA), ocupadas nos séculos XVIII e XIX, o presente artigo discute os processos de trocas culturais entre portugueses, luso-brasileiros, indígenas e mestiços. Embora esses grupos sociais tenham manipulado a cultura material visando expressar diferentes valores, relacionados à hierarquia, segmentação social e afirmação de identidades, a ambigüidade é uma característica das amostras analisadas, informando sobre as misturas de práticas e de referenciais culturais que levaram à construção de uma sociedade mestiça

Analiza planów zawodo wych i opiniistu dentów ostat niego roku studiów I stopnia reprezentujących wybrane kraje Europy na temat zatrudnienia w zawodzie fizjotera peuty

Background. Many factors, including legal regulations pertaining to the practice of physiotherapy and employment possibilities, can influence the vocational plans of physiotherapy graduates. The aim of the study was to analyse the vocational plans of students in selected European countries. Material and methods. 299 students: 20 from Bulgaria (BG), 100 from Spain (ES), 21 from Latvia (LV), 58 from Turkey (TUR), and 100 from Poland (PL), 225 females, with a mean age of 23.05 years (SD: 2.71; min/max: 21-39). An anonymous, voluntary questionnaire in national langua¬ges. Statistica 9.0, Kruskall-Wallis test, p<0.05. Results. Most PL students (58%) wanted to enrol in a second-cycle programme, ES (58%) wanted to take up work, TUR (48%) to continue education by attending training courses (p<0.01). TUR declared familiarity with employment opportunities more frequently (86%) than PL (31%) and ES (63%) (p<0.01). TUR declared more frequently (96%) than their PL (10%) and ES counterparts (22%) that it was easy to find work in their country (p<0.01). PL, ES and TUR were most likely to declare that it was easy to find work in EU countries. Conclusions. 1. Students believe that finding a job is easier in other EU countries than their own and so, when they enter university, they plan to look for a job abroad or they count on an improving situation on the domestic job market. 2. A professional information service on job opportunities in EU countries should be developed offering objective employment information for physiotherapists in EU. it should include predictions covering the next 3-4 years. © MEDSPORTPRESS, 2012

Analysis of satisfaction in studying physiotherapy among students from selected European countries in their final year

The organisation of degree programmes in European countries differs with duration of the programme, number and content of hours of courses. The aim of this study was to assess the degree of satisfaction with studying in students. 299 final-year students from 5 countries: 20 from Bulgaria (BG), 100 - Spain (ES), 21 - Latvia (LV), 58 - Turkey (TUR), and 100 - Poland (PL). An anonymous and voluntary questionnaire designed by the authors in national languages. The response rate: 86%. Statistica 9.0, the Kruskall-Wallis test, p < 0.05. While most students would choose to study Physiotherapy again, fewer PL would choose the same university (p < 0.05). 42%PL, 50%ES, 22% TUR stated that the number of class hours of practical courses was too low (p < 0.05). 39%PL, 58%ES, 22%TUR believed that the time of direct work with patients was too short (p < 0.05). TUR (4.13) declared a higher level of satisfaction with studying than PL (3.73) and ES (3.95) (p < 0.05). ES rated their competence in basic clinical areas as lower (p < 0.001) than PL and TUR. More ES (44%) than PL (24%) and TUR (37%) felt well-prepared to look for work (p < 0.05). Conclusion: 1 .The organization of a degree programme may influence the level of satisfaction with studying. 2. Regardless of the organization of a degree programme, it is necessary to increase the number of class hours of practical courses and the number of hours devoted to supplying students with qualified information about the latest methods in physiotherapy