4 research outputs found
Anti- Sporothrix spp. activity of medicinal plants
ABSTRACT Cases of sporotrichosis in humans and animals without satisfactory clinical response have increased, a warning sign of strains resistant to conventional antifungal agents. The urgent search for alternative therapies was an incentive for research on medicinal plants with anti-Sporothrix spp. properties. A bibliographic survey was performed based on scientific papers about in vitro and in vivo antifungal activity of essential oils and extracts of plants in differents solvents against the fungal of the Sporothrix schenckii complex. The study methodology consisted of a literature review in Google Scholar, Science Direct, Pubmed, Bireme and Springer link with papers from 1986 to 2015. We found 141 species of plants that were investigated, of which 100 species were concentrated in 39 botanical families that had confirmed anti-Sporothrix activity. Combretaceae, Asteraceae and Lamiaceae represented the botanical families with the greatest number of plants species with antifungal potential, using different methodologies. However, there are few studies with medicinal plants in experimental infection in animals that prove their activity in the treatment of sporotrichosis. It reinforces the need for further research related to standardization of in vitro methodologies and in vivo studies related to safety and to toxicity potential of these plants with anti-Sporothrix spp. activity
TOPO-EUROPE: the geoscience of coupled deep earth-surface processes
TOPO-EUROPE addresses the 4-D topographic evolution of the orogens and intra-plate regions of Europe through a
multidisciplinary approach linking geology, geophysics, geodesy and geotechnology. TOPO-EUROPE integrates monitoring,
imaging, reconstruction and modelling of the interplay between processes controlling continental topography and related natural
hazards. Until now, research on neotectonics and related topography development of orogens and intra-plate regions has received
little attention. TOPO-EUROPE initiates a number of novel studies on the quantification of rates of vertical motions, related
tectonically controlled river evolution and land subsidence in carefully selected natural laboratories in Europe. From orogen
through platform to continental margin, these natural laboratories include the Alps/Carpathians–Pannonian Basin System, the West
and Central European Platform, the Apennines–Aegean–Anatolian region, the Iberian Peninsula, the Scandinavian Continental
Margin, the East-European Platform, and the Caucasus–Levant area. TOPO-EUROPE integrates European research facilities and
know-how essential to advance the understanding of the role of topography in Environmental Earth System Dynamics. The
principal objective of the network is twofold. Namely, to integrate national research programs into a common European network
and, furthermore, to integrate activities among TOPO-EUROPE institutes and participants. Key objectives are to provide an
interdisciplinary forum to share knowledge and information in the field of the neotectonic and topographic evolution of Europe, to promote and encourage multidisciplinary research on a truly European scale, to increase mobility of scientists and to train young
scientists. This paper provides an overview of the state-of-the-art of continental topography research, and of the challenges to
TOPO-EUROPE researchers in the targeted natural laboratorie