436 research outputs found
Thermal conditions affecting heat transfer in FDM/FFE: a contribution towards the numerical modelling of the process
The performance of parts produced by Free Form Extrusion (FFE), an increasingly popular additive manufacturing technique, depends mainly on their dimensional accuracy, surface quality and mechanical performance. These attributes are strongly influenced by the evolution of the filament temperature and deformation during deposition and solidification. Consequently, the availability of adequate process modelling software would offer a powerful tool to support efficient process set-up and optimisation. This work examines the contribution to the overall heat transfer of various thermal phenomena developing during the manufacturing sequence, including convection and radiation with the environment, conduction with support and between adjacent filaments, radiation between adjacent filaments and convection with entrapped air. The magnitude of the mechanical deformation is also studied. Once this exercise is completed, it is possible to select the material properties, process variables and thermal phenomena that should be taken in for effective numerical modelling of FFE.This work was supported by Strategic Project - LA 25 - 2013–2014 [PEst-C/CTM/LA0025/2013]
Serum bactericidal activity as indicator of innate immunity in pacu Piaractus mesopotamicus (Holmberg, 1887)
Relic neutrino masses and the highest energy cosmic rays
We consider the possibility that a large fraction of the ultrahigh energy
cosmic rays are decay products of Z bosons which were produced in the
scattering of ultrahigh energy cosmic neutrinos on cosmological relic
neutrinos. We compare the observed ultrahigh energy cosmic ray spectrum with
the one predicted in the above Z-burst scenario and determine the required mass
of the heaviest relic neutrino as well as the necessary ultrahigh energy cosmic
neutrino flux via a maximum likelihood analysis. We show that the value of the
neutrino mass obtained in this way is fairly robust against variations in
presently unknown quantities, like the amount of neutrino clustering, the
universal radio background, and the extragalactic magnetic field, within their
anticipated uncertainties. Much stronger systematics arises from different
possible assumptions about the diffuse background of ordinary cosmic rays from
unresolved astrophysical sources. In the most plausible case that these
ordinary cosmic rays are protons of extragalactic origin, one is lead to a
required neutrino mass in the range 0.08 eV - 1.3 eV at the 68 % confidence
level. This range narrows down considerably if a particular universal radio
background is assumed, e.g. to 0.08 eV - 0.40 eV for a large one. The required
flux of ultrahigh energy cosmic neutrinos near the resonant energy should be
detected in the near future by AMANDA, RICE, and the Pierre Auger Observatory,
otherwise the Z-burst scenario will be ruled out.Comment: 19 pages, 22 figures, REVTeX
High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers
NWO184.034.014Computer Systems, Imagery and Medi
Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients
Plasmodium vivax is the major cause of human malaria in the Americas. How P. vivax infection can lead to poor clinical outcomes, despite low peripheral parasitaemia remains a matter of intense debate. Estimation of total P. vivax biomass based on circulating markers indicates existence of a predominant parasite population outside of circulation. In this study we investigate associations between both peripheral and total parasite biomass and host response in vivax malaria. We analysed parasite and host signatures in a cohort of uncomplicated vivax malaria patients from Manaus, Brazil, combining clinical and parasite parameters, multiplexed analysis of host responses and ex vivo assays. Patterns of clinical features, parasite burden and host signatures measured in plasma across the patient cohort were highly heterogenous. Further data deconvolution revealed two patient clusters, here termed Vivaxlow and Vivaxhigh. These patient subgroups were defined based on differences in total parasite biomass but not peripheral parasitaemia. Overall Vivaxlow patients clustered with healthy donors and Vivaxhigh patients showed more profound alterations in haematological parameters, endothelial cell (EC) activation and glycocalyx breakdown and levels of cytokines regulating different haematopoiesis pathways compared to Vivaxlow. Vivaxhigh patients presented more severe thrombocytopenia and lymphopenia, along with enrichment of neutrophils in the peripheral blood and increased neutrophil-to-lymphocyte ratio (NLCR). When patients' signatures were combined, high association of total parasite biomass with a subset of markers of EC activation, thrombocytopenia and lymphopenia severity was observed. Finally, machine learning models defined a combination of host parameters measured in the circulation that could predict the extent of parasite infection outside of circulation. Altogether, our data show that total parasite biomass is a better predictor of perturbations in host homeostasis in P. vivax patients than peripheral parasitaemia. This supports the emerging paradigm of a P. vivax tissue reservoir, in particular in the hematopoietic niche of bone marrow and spleen
Assessing the spatial pattern of a river water quality in southern Brazil by multivariate analysis of biological and chemical indicators
Avaliação da qualidade microbiológica de bebida láctea e creme de leite UAT por ATP-Bioluminescência
Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV
A search for a Higgs boson decaying into two photons is described. The
analysis is performed using a dataset recorded by the CMS experiment at the LHC
from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an
integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross
section of the standard model Higgs boson decaying to two photons. The expected
exclusion limit at 95% confidence level is between 1.4 and 2.4 times the
standard model cross section in the mass range between 110 and 150 GeV. The
analysis of the data excludes, at 95% confidence level, the standard model
Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The
largest excess of events above the expected standard model background is
observed for a Higgs boson mass hypothesis of 124 GeV with a local significance
of 3.1 sigma. The global significance of observing an excess with a local
significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is
estimated to be 1.8 sigma. More data are required to ascertain the origin of
this excess.Comment: Submitted to Physics Letters
- …